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Continuous Hidden Process Model for Time Series

Expression Experiments


This webpage provides supporting information for:

Yanxin Shi, Michael Klutstein, Itamar Simon, Tom Mitchell, Ziv Bar-Joseph
Continuous Hidden Process Model for Time Series Expression Experiments


 

Dataset List

 

Process List

Methods (model derivations)

 

Biological Experiment

 

Software Implementation

(a) A color screenshot from our software displaying inferred profiles of 5 significant processes for the H2O2 experiment. Red represents induced activity, green repressed activity and black no change. The 5 processes are (from top to bottom): response to oxidative stress; ubiquitin-dependent protein catabolism; chromatin silencing; ribosome biogenesis and G1/S transition of mitotic cell cycle. (b) Squared error for reconstructed gene expressions as a function of the number of processes kept. (c) Budding index counts. The percentage of G1, S and G2/M cells are plotted at 10 min intervals. (d) Schematic diagram of the yeast cell cycle.

 

 

 

 

 

 

Last updated at 6th Feb., 2007.