1) paraffin -> genentech

email his address -> fax me a release form -> 

2) Zeh contact -> Dan Laheru ==>> anecdotally after vaccine , also Ric Schluick (listeria vaccine)

Randy talk with Hedy about Avastin -> maybe good with 
	inthe arm that got avastin, that had whipples -> people who mestatsized after whipple?
	sense for subset analysis (even if not statistically significant?) -> "winners"
	
3) 






EARLIER EMAIL: 
One of my colleagues at the NCI just wrote a review that you may be interested in.  I am attaching.  Best regards.  Liz Jaffee  P.S.  I saw your lecture on the Web and all I can say is that you are remarkable!  
Dan:  I am thinking he would be a good candidate for our new listeria meso vaccine when he is done with chemo.  I do not think we can give him the original unless we asked for an exception.  This situation raises the question whether we should have a study we we keep sequencing chemo and vaccine.  Tricia was supposed to make you a copy of a review by the Schlom group who have observed a similar situation in their studies.  Liz


NOTES FROM Oct 9, 2007 conversation with Liz Jaffe:

Liz Jaffe is from Pittsburgh

requires FDA to say okay: Herculean effort: a lot of paperwork
	 can take a couple of weeks
	 don't wait until February: as quick as possible
	       immediately after or before next gemzar dose

their new vaccine is completely untested (phase I)

might learn a lot from one patient: take blood before and after: measure T cells before-and-after

abraxane -> in early trials for people who have failed with gemzar

Genentech: what would you do with the information?
	   a few preliminary things that predict for gemzar (we already know)


T-regulatory cells: normally these inhibit auto-immunity
	     vaccines inhibit them, so that T-cells can go more strongly

NEED TO GET ARTICLES FROM HER

NEW STUFF

SECOND CHOICE
1) 
    Listeria vaccine (listeria=bacteria, normally found in milk products)
    naturally knows how to access the immune system -> targets towards a specific antigen
    
new study: starting in next month

in mouse model: listeria boosting what I got was better than boosting with what I got

-> email Jaffe-> Dung ("young") Le, and Dan Laheru
   paper on prostate 


------------------

FIRST CHOICE 
2) give same vaccine I got, but combined with antictla-4 (ipilimumab) [through stage3 in human melanoma]
   -> good results in prostate cancer [9 patients, all had PSA drops and tumor shrinkage]
   THAT STUDY IS BEING HELD UP
      start regulatory process in November: again, not until february
 ---> could apply to BMS get compassionate care for drug: antictla-4 (ipilimumab)
	    

THIRD CHOICE -> what I've already had again (GVAX vaccine)

....... 

both are starting at *active* doses -> these are really stage-2 trials; starting at active dose in melanoma (feb- march)

Genentech -> 
	  famous immunoloogist: they are screening their drug libraries -> they found an agent that helped
		 not sure where the sequencing was done...
		 name of person at Genentech: Ira Mellman 
		      -> 
		 mine was stored in parrafin
		 

VACCINE ALONE IS NOT ENOUGH ONCE TUMORS ARE THERE....
	MUST BE DONE WITH OTHER STUFF




