0. DOCID:27957 SCORE: 0.00336827515183928
DOCNO: 9512826
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Lishner M
AUTHOR: G Koren G
AFFILIATION: Hospital for Sick Children, Toronto.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Canadian family physician Médecin de famille canadien.
COUNTRY: CANADA
TITLE: Breast cancer during pregnancy. Approach to rational management.
PUBDATE: 19980201
QUESTION: A 35-year-old woman attending my clinic in the 20th week of pregnancy had a lump in her breast. Open biopsy revealed ductal carcinoma. Radical mastectomy with axillary lymph node biopsy showed three out of 10 nodes positive. What are the short- and long-term implications of chemotherapy during pregnancy? ANSWER: Patients with breast cancer during pregnancy should be treated using the same criteria as their nonpregnant counterparts, with the modifications required by pregnancy. The benefits of the diagnostic workup and use of chemotherapy, radiotherapy, and surgery have to be weighed carefully against their risk to the unborn baby.

1. DOCID:27331 SCORE: 0.0032182166621738
DOCNO: 11769474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: T Ito T
AUTHOR: Y Okubo Y
AUTHOR: M Tachibana M
AFFILIATION: Department of Urology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023.
PUBTYPE: Journal Article
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Detection of PSA mRNA in prostate cancer patients' blood]
PUBDATE: 20011001
A sensitive technique using reverse transcriptase-polymerase chain reaction (RT-PCR) for PSA mRNA has been used to detect circulating tumor cells in the peripheral blood of prostate cancer patients. We evaluated the clinical utility of this method for staging and monitoring for prostate cancer. The number of patients who were RT-PCR positive was increased in higher clinical stages. This technique may provide useful information for treating patients with prostate cancer, especially candidates for radical prostatectomy. Confirming the value of this modality as a prognostic factor will require further study.

2. DOCID:27575 SCORE: 0.00289097706364174
DOCNO: 10786894
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
AUTHOR: C Sarto C
AUTHOR: P A Binz PA
AUTHOR: P Mocarelli P
AFFILIATION: University Department of Clinical Pathology, Desio Hospital, Desio-Milan, Italy. sarto@uds.unimib.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Electrophoresis.
COUNTRY: GERMANY
TITLE: Heat shock proteins in human cancer.
PUBDATE: 20000401
The heat shock proteins (hsp) are ubiquitous molecules induced in cells exposed to sublethal heat shock, present in all living cells, and highly conserved during evolution. Their function is to protect cells from environmental stress damage by binding to partially denatured proteins, dissociating protein aggregates, to regulate the correct folding, and to cooperate in transporting newly synthesized polypeptides to the target organelles. The molecular chaperones are involved in numerous diseases, including cancer, revealing changes of expression. In this review, we mainly describe the relationship of hsp expression with human cancer, and discuss what is known about their post-translational modifications according to malignancies.

3. DOCID:27382 SCORE: 0.00258652887192637
DOCNO: 12532841
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: W Wang W
AUTHOR: T J Tong TJ
AFFILIATION: Department of Biochemistry and Molecular Biology, Beijing Medical University, Beijing 100083.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Sheng li ke xue jin zhan [Progress in physiology].
COUNTRY: China
TITLE: [The key enzyme of cholesterol synthesis pathway: HMG-CoA reductase and disease]
PUBDATE: 19990101
In eukaryotes, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non-sterol isoprenoids, mevalonate. The regulation of the enzyme activity occurs at the transcription, post-transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non-sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers. At present, the enzyme is the target of several drugs effective against atherosclerosis.

4. DOCID:26239 SCORE: 0.00242907301470305
DOCNO: 10030302
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liver Transplantation
QUALIFIER: surgery
QUALIFIER: etiology
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: J Adams J
AUTHOR: J P Lodge JP
AUTHOR: D Parker D
AFFILIATION: Professional Medical Oncology Unit, St. James's University Hospital, Leeds, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Transplantation.
COUNTRY: UNITED STATES
TITLE: Liver transplantation for metastatic hemangiopericytoma associated with hypoglycemia.
PUBDATE: 19990201
We report a case of successful liver transplantation in a young man with metastatic hemangiopericytoma confined to the liver. He had a primary retroperitoneal hemangiopericytoma removed in 1982 and was diagnosed as having liver metastases 8 years later. Subsequently, he developed hypoglycemia, which did not respond to chemotherapy. Hepatectomy and transplantation resolved his hypoglycemic attacks. He remained well and symptom free for 4 years. Liver transplantation can provide effective palliation and should be considered in carefully selected patients with localized metastatic cancer.

5. DOCID:24852 SCORE: 0.00237082962045054
DOCNO: 10319432
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
QUALIFIER: chemistry
QUALIFIER: pharmacology
QUALIFIER: analogs & derivatives
AUTHOR: K Ikeda K
AUTHOR: K Miyajima K
AUTHOR: Y Maruyama Y
AUTHOR: K Achiwa K
AFFILIATION: School of Pharmaceutical Sciences, University of Shizuoka, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: JAPAN
TITLE: Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines.
PUBDATE: 19990401
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.

6. DOCID:27530 SCORE: 0.00228222823348307
DOCNO: 11764709
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fertility
DESCRIPTOR: Interpersonal Relations
DESCRIPTOR: Neoplasms
DESCRIPTOR: Sexuality
QUALIFIER: trends
AUTHOR: D Thaler-DeMers D
AFFILIATION: Department of Hematology-Oncology, Stanford Hospital and Clinics, Stanford, CA, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: Intimacy issues: sexuality, fertility, and relationships.
PUBDATE: 20011101
OBJECTIVES: To provide a review of the intimacy issues, (sexuality, fertility, and interpersonal relationships) that have an impact on the lives of cancer survivors. DATA SOURCES: Published articles, research studies, and textbook chapters. CONCLUSION: The experience of living with cancer impacts the survivors interpersonal relationships, sexuality, and fertility. As cancer treatments become more effective in prolonging life, options that preserve sexual function and fertility will be more prevalent. IMPLICATIONS FOR NURSING PRACTICE: It is the responsibility of the oncology health care professional to become educated about options that preserve sexual function and fertility and inform patients before treatment decisions are made.

7. DOCID:26130 SCORE: 0.00223546190644493
DOCNO: 11253362
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Replication
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: genetics
QUALIFIER: metabolism
AUTHOR: M F Goodman MF
AUTHOR: B Tippin B
AFFILIATION: University of Southern California, Department of Biological Sciences and Chemistry, Stauffer Hall of Science 172, Los Angeles, California 90089-1340, USA. mgoodman@rcf.usc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Molecular cell biology.
COUNTRY: England
TITLE: The expanding polymerase universe.
PUBDATE: 20001101
Over the past year, the number of known prokaryotic and eukaryotic DNA polymerases has exploded. Many of these newly discovered enzymes copy aberrant bases in the DNA template over which 'respectable' polymerases fear to tread. The next step is to unravel their functions, which are thought to range from error-prone copying of DNA lesions, somatic hypermutation and avoidance of skin cancer, to restarting stalled replication forks and repairing double-stranded DNA breaks.

8. DOCID:25754 SCORE: 0.00209923058778743
DOCNO: 10479265
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mind-Body Relations (Metaphysics)
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: E T Creagan ET
AFFILIATION: Mayo Clinic, Rochester, MN 55905, USA. creagan.edward@mayo.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of prosthetic dentistry.
COUNTRY: UNITED STATES
TITLE: Attitude and disposition: Do they make a difference in cancer survival?
PUBDATE: 19990901
STATEMENT OF PROBLEM: Investigators have attempted to resolve the question: do psychosocial, emotional, and attitudinal factors have any effect on cancer survival? PURPOSE: This article presents a literature review and an overview of the developments in the mind-body connection to examine the influence of attitude in cancer survival. CONCLUSION: Even though a causal effect of emotional issues on the initiation and promotion of cancer is speculative, the effect of emotions on numerous medical conditions cannot be ignored.

9. DOCID:24584 SCORE: 0.00206791075372181
DOCNO: 9782897
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse Practitioners
QUALIFIER: methods
QUALIFIER: prevention & control
AUTHOR: P A Spencer-Cisek PA
AFFILIATION: Oncology Services, Glens Falls Hospital, NY 12804, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nurse practitioner forum.
COUNTRY: UNITED STATES
TITLE: Overview of cancer prevention, screening, and detection.
PUBDATE: 19980901
Greater than one in three Americans will be diagnosed with cancer during their lifetime. Nurse practitioners are in an ideal position to significantly impact the health and well-being of their clients by implementing cancer prevention and screening strategies. This article reviews current recommendations from major authorities and outlines cancer prevention and screening strategies to be incorporated into primary care practice.

10. DOCID:27240 SCORE: 0.00201771530518515
DOCNO: 11484892
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Z W Baloch ZW
AUTHOR: V A LiVolsi VA
AFFILIATION: Department of Pathology & Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Thyroid : official journal of the American Thyroid Association.
COUNTRY: United States
TITLE: Prognostic factors in well-differentiated follicular-derived carcinoma and medullary thyroid carcinoma.
PUBDATE: 20010701
This paper reviews both clinicopathologic and biological factors in differentiated thyroid carcinoma of follicular and C-cell derivation. The value of specific histological parameters including tumor subtypes, vascular invasion as predictors of prognosis in these tumors is discussed and the pertinent literature reviewed. The utility of ploidy analysis and immunohistochemical assessment of hormonal and tumor markers are described. Current information on biological and molecular markers that may be helpful in predicting behavior is discussed. The commonly used staging systems for thyroid cancer are briefly described.

11. DOCID:27297 SCORE: 0.00197849907943299
DOCNO: 10321108
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Polyamines
AUTHOR: G Dandrifosse G
AUTHOR: P Deloyer P
AUTHOR: C Grandfils C
AUTHOR: S Loret S
AUTHOR: O Peulen O
AUTHOR: A C Dandrifosse AC
AFFILIATION: Service de Biochimie et de Physiologie générale, Université de Liège, Faculté de Médecine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue médicale de Liège.
COUNTRY: BELGIUM
TITLE: [Statement on polyamines]
PUBDATE: 19990301
Polyamines are ubiquitous substances. Their intracellular concentration is controlled quickly and rigorously by extremely sophisticated systems. It depends on metabolism and cellular permeability. Polyamines act as structural and functional elements in the cell (nucleic acid conformation, cytoskeleton, radioprotection, apoptosis, proliferation and differentiation of cells...). They also play a role in various diseases (origin of food allergy, cancers...). They present a great therapeutic interest (oncology, molecular transfer to cell nucleus, transfer across the blood-brain barrier, parasitosis, effects on NMDA and GABA receptors in the central nervous system...).

12. DOCID:26151 SCORE: 0.00191659149059271
DOCNO: 10388861
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Metals
DESCRIPTOR: Stents
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: instrumentation
AUTHOR: S K Lo SK
AFFILIATION: Department of Medicine, University of California, Los Angeles, California, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastrointestinal endoscopy clinics of North America.
COUNTRY: UNITED STATES
TITLE: Metallic stenting for colorectal obstruction.
PUBDATE: 19990701
Intestinal obstruction is a major complication of colorectal cancer. Acute surgical decompression frequently requires subsequent operative interventions and is associated with mortality in more than 3% of the cases. Transanal metallic stenting is now possible to perform on an outpatient basis, thus providing quick symptom relief and the opportunity to cleanse the bowel for work-up or surgery. This stenting provides temporary relief for patients and is gaining acceptance rapidly. Randomized controlled trials are needed to help pinpoint refinements that can minimize the difficulty of stent insertion.

13. DOCID:24158 SCORE: 0.00190692441519533
DOCNO: 10095878
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Invasiveness
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S J Schnitt SJ
AFFILIATION: Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Advances in anatomic pathology.
COUNTRY: UNITED STATES
TITLE: Microinvasive carcinoma of the breast: a diagnosis in search of a definition.
PUBDATE: 19981101
This commentary addresses the problems and lack of consensus with regard to the definition of microinvasive breast cancer; the problems in identification of stromal invasion in ductal carcinoma in situ; and the clinical significance of microinvasion.

14. DOCID:24983 SCORE: 0.00187626451387441
DOCNO: 10722523
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacokinetics
QUALIFIER: pharmacology
QUALIFIER: pharmacokinetics
QUALIFIER: pharmacology
AUTHOR: K E Warren KE
AUTHOR: C M McCully CM
AUTHOR: T J Walsh TJ
AUTHOR: F M Balis FM
AFFILIATION: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-1928, USA. warrenk@exchange.nih.gov
PUBTYPE: Journal Article
JOURNALTITLE: Antimicrobial agents and chemotherapy.
COUNTRY: UNITED STATES
TITLE: Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates.
PUBDATE: 20000401
Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.