0. DOCID:23876 SCORE: 0.00384243322074803
DOCNO: 7951271
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: methods
QUALIFIER: drug therapy
QUALIFIER: statistics & numerical data
AUTHOR: D Faries D
AFFILIATION: Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of biopharmaceutical statistics.
COUNTRY: UNITED STATES
TITLE: Practical modifications of the continual reassessment method for phase I cancer clinical trials.
PUBDATE: 19940701
The continual reassessment method (1) (CRM) for phase I cancer trials provides improved estimation of the maximum tolerated dose (MTD), and fewer patients receive ineffective dose levels compared to the traditionally used design. However, the CRM has not gained acceptance in practice owing to concerns with administering dose levels that are too toxic. In this article, several conservative modifications of the CRM are introduced. The result is a procedure that improves estimation of the MTD and decreases the use of ineffective doses, without significantly increasing the use of toxic dose levels. The CRM with modification outperforms the traditional method in a simulation study.

1. DOCID:16551 SCORE: 0.00323988422524013
DOCNO: 1958849
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: J A Wils JA
AFFILIATION: Department of Internal Medicine, Laurentius Hospital, Roermond, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Chemotherapy in pancreatic cancer: a rational pursuit?
PUBDATE: 19910201
A review on the chemotherapy in advanced pancreatic cancer is presented. Pancreatic cancer is an extremely chemotherapy resistant tumor and results of cytostatic drug treatment so far are unsatisfactory. For patients with locally advanced disease the combination of chemo- and radiotherapy may palliate some patients. To date no standard treatment is available and patients should be entered in clinical protocols assessing new treatment options.

2. DOCID:22340 SCORE: 0.00277148002950633
DOCNO: 9644184
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pathology
QUALIFIER: metabolism
AUTHOR: Q Ruan Q
AUTHOR: Q Liu Q
AUTHOR: S Tan S
AFFILIATION: Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan.
PUBTYPE: Journal Article
JOURNALTITLE: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology.
COUNTRY: CHINA
TITLE: [Effect of human recombinant gamma-interferon on proliferative activity of human laryngeal cancer cell lines]
PUBDATE: 19970201
The effect of human on PCNA expressions of HEP-2 lines was investigated using LSAB (Labelled streptacidin biotin method) with monoclonal antibody Ki-67 (anti-PCNA). The results showed that the PCNA expression which reflects the proliferative activity of cells was dependent on dose of rhu-IFN-gamma in HEP-2 cell lines. Thus, our data suggest that rhu-IFN-gamma might be useful in the treatment of laryngeal cancer because it provides effective cytostatic.

3. DOCID:19551 SCORE: 0.00274175534269548
DOCNO: 7691376
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Stents
QUALIFIER: complications
QUALIFIER: surgery
AUTHOR: P L Mitchell PL
AUTHOR: V J Harvey VJ
AUTHOR: M R Lane MR
AUTHOR: B D Evans BD
AUTHOR: P I Thompson PI
AUTHOR: I Hamilton I
AFFILIATION: Department of Medical Oncology, Auckland Hospital, New Zealand.
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Palliation of biliary obstruction in patients with advanced breast cancer using endoscopic stents.
PUBDATE: 19930901
Endoscopic insertion of a biliary endoprosthesis was successful in eight patients with extrahepatic biliary obstruction caused by breast cancer metastases. The serum bilirubin level was significantly reduced in seven patients and in four this was accompanied by marked symptomatic improvement. Endoprostheses required replacement after a median of 8 (range 3-127) weeks. Two patients responding to systemic anticancer therapy survived 27 and 43 months. Endoscopically placed stents offer effective palliation of extrahepatic biliary obstruction caused by metastatic breast cancer and long-term survival may be possible.

4. DOCID:17405 SCORE: 0.00273514061651874
DOCNO: 1493433
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R Weide R
AUTHOR: C Görg C
AUTHOR: K H Pflüger KH
AUTHOR: A Ramaswamy A
AUTHOR: A Steinmetz A
AUTHOR: S Falk S
AUTHOR: W B Schwerk WB
AFFILIATION: Department of Internal Medicine, Philipps University, Marburg, Germany.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Leukemia & lymphoma.
COUNTRY: SWITZERLAND
TITLE: Concomitant primary low grade non-Hodgkin's lymphoma of the spleen and breast carcinoma.
PUBDATE: 19920701
A case is described of a 71 year old woman with scirrhous breast cancer and multiple hypoechogenic lesions in the spleen. The patient was treated successfully by mastectomy and splenectomy. Morphologic examination of the spleen showed a primary, centroblastic-centrocytic, low grade non-Hodgkin's lymphoma. Eight months after splenectomy the patient still remains in complete remission.

5. DOCID:23055 SCORE: 0.00271759168369485
DOCNO: 8978796
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: Y Nomura Y
AFFILIATION: Dept. of Breast Surgery, National Kyushu Cancer Center.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Adriamycin--breast cancer]
PUBDATE: 19961201
The significance of doxorubicin (ADR) was reviewed in the treatment of advanced as well as early breast cancer. The history of ADR treatment, mainly as a combination of CAF, or FAC, has revealed that ADR is still the key drug for breast cancer, the response rate being 40-60%. A multivariate analysis in 182 advanced breast cancer cases showed that the predictive factor was the dominant site of metastasis, and performance status (PS). Overall survival was determined with the age, the dominant site of metastasis, and PS. Recently the combination chemotherapy including ADR was evaluated to be equivalent to CMF type chemotherapy in the adjuvant settings.

6. DOCID:21093 SCORE: 0.00246467476989902
DOCNO: 7705135
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, Emission-Computed
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: radionuclide imaging
AUTHOR: R W Ward RW
AUTHOR: R Chin R
AUTHOR: J W Keyes JW
AUTHOR: E F Haponik EF
AFFILIATION: Section on Pulmonary and Critical Care Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Digital clubbing. Demonstration with positron emission tomography.
PUBDATE: 19950401
Digital clubbing is a classic cutaneous manifestation of pulmonary disease, but its mechanism is unknown. We describe a patient with lung cancer and clubbing in whom positron emission tomography (PET) demonstrated, for the first time, that increased glucose metabolism occurs at the nailbed. PET may contribute to future investigations of digital clubbing.

7. DOCID:22904 SCORE: 0.00225407086764999
DOCNO: 8938272
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: pharmacology
AUTHOR: K R Irvine KR
AUTHOR: N P Restifo NP
AFFILIATION: Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: The next wave of recombinant and synthetic anticancer vaccines.
PUBDATE: 19951201
The identification of tumor-associated antigens (TAA) recognized by T lymphocytes makes the development of antigen-specific synthetic and recombinant vaccines possible. The expression of TAA within a recombinant vector increases control over the kinetics and quantity, the molecular form, and the subcellular location of the immunogen delivered. The next generation of antitumor vaccines employs cytokines and costimulatory molecules expressed in concert with TAA that are capable of augmenting the activation and proliferation of antitumor immune responses. The ultimate goal of these new strategies, the treatment of established cancer, is now being realized in animal models.

8. DOCID:19973 SCORE: 0.00223535261794064
DOCNO: 1831702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: methods
AUTHOR: Z Chen Z
AFFILIATION: Institute of Oncology, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
COUNTRY: CHINA
TITLE: [The development of DELFIA with novel tumor monoclonal antibodies E-11 and G-4]
PUBDATE: 19910201
Monoclonal antibodies E-11 and G-4 were purified by Sepharose 4B column chromatography and labelled with europium as tracer. The solid-phase antibodies were prepared by attaching pure E-11 and G-4 to polysterene strips. The supernatant of 8611 cell culture or perchloric acid extracts from ovarian cancer tissues provided standard antigens. The solid-phase sandwich-type DELFIAs for monoclonal antibodies E-11 and G-4 were thus established, and the resulting standard curves were extremely steep. The ratio of CPS in high-concentration tubes to CPS in the zero tube exceeded 300:1, indicating the very high sensitivity and accuracy of this method.

9. DOCID:19872 SCORE: 0.00218582899453816
DOCNO: 1286158
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: antagonists & inhibitors
AUTHOR: P Workman P
AUTHOR: V G Brunton VG
AUTHOR: D J Robins DJ
AFFILIATION: CRC Department of Medical Oncology, University of Glasgow, Bearsden, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Tyrosine kinase inhibitors.
PUBDATE: 19921201
Tyrosine kinases are associated with the cytoplasmic domains of growth factor receptors as well as oncoproteins and many have the potential to cause transformation if mutated or hyperexpressed. Tyrosine kinases therefore represent an excellent target for the development of cancer drugs. A large number of inhibitors have now been identified and many show promising cytostatic activity, particularly using in vitro models. Some in vivo activity has been reported. Progress with various structural classes is reviewed. It is not clear whether specific or broad spectrum tyrosine kinase inhibitors should be developed as potential anticancer drugs. It does seem likely, however, that tyrosine inhibitors will enter clinical trial in cancer patients.

10. DOCID:21761 SCORE: 0.00200135454023973
DOCNO: 8537874
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: J Alández J
AUTHOR: F Llanes F
AUTHOR: J I Herrera JI
AUTHOR: M Carasol M
AUTHOR: A Bascones A
AFFILIATION: Department of Periodontology, Faculty of Odontology, University Complutense of Madrid, Spain.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of periodontology.
COUNTRY: UNITED STATES
TITLE: Metastatic lung carcinoma involving the periodontium. Report of a case.
PUBDATE: 19951001
A case of metastatic bronchogenic carcinoma to the gingiva in a 47-year-old male is reported. The gingival lesion developed as a quickly growing mass and appeared 2 months after surgical excision and radiotherapy of the lung carcinoma were completed. The gingival tumor was histopathologically diagnosed as a poorly differentiated squamous carcinoma. Comparative cytologic studies showed similarities between the gingival metastasis and the previous lung cancer.

11. DOCID:23926 SCORE: 0.00200133645451997
DOCNO: 9004804
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: etiology
QUALIFIER: diagnosis
AUTHOR: J I Martín Parra JI
AUTHOR: J C Rodríguez Sanjuán JC
AUTHOR: A Naranjo Gómez A
AFFILIATION: Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario, Marqués de Valdecilla, Santander.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva.
COUNTRY: SPAIN
TITLE: [Obstructive jaundice as a presentation form of bronchogenic small cell carcinoma]
PUBDATE: 19960401
We report a patient having a non-diagnosed small cell lung cancer, presenting with a clinical picture comprising emaciation, hepatomegaly, progressive jaundice, bilirubinuria and clay-colored stools. Computed tomography showed intrahepatic and extrahepatic biliary duct dilatation. The cause was compression of the common bile duct by metastatic enlarged lymph nodes in the porta hepatis. Clinical suspicion arose because of a mass found on the chest X-ray film and a positive cytologic sputum examination. The definitive diagnosis was obtained by bronchoscopy and biopsy.

12. DOCID:21205 SCORE: 0.00199252717716762
DOCNO: 8131575
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: secondary
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: complications
QUALIFIER: secondary
AUTHOR: J C Ko JC
AUTHOR: P C Yang PC
AUTHOR: T S Huang TS
AUTHOR: K H Yeh KH
AUTHOR: S H Kuo SH
AUTHOR: K T Luh KT
AFFILIATION: Department of Internal Medicine, National Taiwan University Hospital, Taipei, China.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Panhypopituitarism caused by solitary parasellar metastasis from lung cancer.
PUBDATE: 19940301
Clinical panhypopituitarism caused by cancer with parasellar metastasis and hypothalamic invasion is very rare. This report concerns a lung cancer patient who had solitary parasellar metastasis with diabetes insipidus and panhypopituitarism as an initial manifestation, which was documented by contrast-enhanced computed tomographic scan, Gd-DTPA-enhanced magnetic resonance imaging, and endocrinologic studies.

13. DOCID:17293 SCORE: 0.00197295344678097
DOCNO: 1787682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: V P Vagner VP
AUTHOR: E G Voĭtkevich EG
AUTHOR: G I Zakora GI
AUTHOR: E D Chirvina ED
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia meditsina.
COUNTRY: USSR
TITLE: [Effectiveness of immunomodulators in multimodal treatment of patients with lung cancer]
PUBDATE: 19911201
The analysis of clinical and immunologic findings indicate that retinol and decaris influence functional activity of immune cells at stage II of lung cancer irrespective of histological structure. In stage III, retinol induced changes in proportion of lymphocyte subpopulations, more evident in glandular cancer. Both immunomodulators lowered the number of purulent complications after surgical interventions. It is only retinol that influenced metastatic dissemination in lung cancer stage II-III.

14. DOCID:16288 SCORE: 0.00197210863005027
DOCNO: 1846777
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: D M Hoffman DM
AUTHOR: B Brigham B
AFFILIATION: Department of Medical Oncology, Prince of Wales Hospital, Sydney, NSW, Australia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The use of ketoconazole in ectopic adrenocorticotropic hormone syndrome.
PUBDATE: 19910301
The authors report a patient with ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) resulting from small cell lung cancer. Treatment with ketoconazole (KCZ) resulted in significant suppression of serum cortisol levels. The authors confirmed KCZ to be a useful adjunct in the treatment of Cushing's syndrome.