This paper introduces a new method for computing conformal transformations of triangle meshes in R³. Conformal maps are desirable in digital geometry processing because they do not exhibit shear, and therefore preserve texture fidelity as well as the quality of the mesh itself. Traditional discretizations consider maps into the complex plane, which are useful only for problems such as surface parameterization and planar shape deformation where the target surface is flat. We instead consider maps into the quaternions, which allows us to work directly with surfaces sitting in R³. In particular, we introduce a quaternionic Dirac operator and use it to develop a novel integrability condition on conformal deformations. Our discretization of this condition results in a sparse linear system that is simple to build and can be used to efficiently edit surfaces by manipulating curvature and boundary data, as demonstrated via several mesh processing applications.