Eric Poe Xing
605 Ohlone Ave. #620
Albany, CA 94706
510-527-6156 (home), 510-486-4923 (office)
e-mail: epxing@cs.berkeley.edu
Education
Ph.D. Student, Computer Science 1999-
Department of Electrical Engineering
and Computer Science, UC Berkeley, California
Ph.D., Biochemistry and Molecular Biology
1994-1999
Joint Graduate Program of Molecular BioSciences, Rutgers University, New
Jersey
M.S., Computer Science (double major)
1996-1998
Department of Computer Science, Rutgers University
B.S., Physics 1988-1993
Department of Physics, Tsinghua University, Beijing, China
Molecular Biology (minor) 1990-1993
Department of Biological Sciences and Biotechnology, Tsinghua University.
Honors and Awards
-
Regent's Fellowship, UC Berkeley, 1999
-
Anthony
Lu Best Paper Award, Rutgers University, 1999
-
Special Award for new researchers, National
Institute of Metrology, Beijing, China. 1994
-
Excellent Thesis Award, Tsinghua University,
Beijing, China. 1993
-
People's Scholarship, Tsinghua University,
1988-1993
Professional and Research
Experience
Present:
Graduate Fellow, Computer
Science Division, UC Berkeley, 1999-
Advisors: Professors Richard Karp, Stuart Russell and Michael Jordan
Research interest:
-
Machine Learning
Modeling complex stochastic dynamic
system using Dynamic Bayesian Network;
Learning with labled and unlabled
data;
Reinforcement learning.
-
Information retrieval
Bayesian text analysis; collaborative
filtering; link analysis.
-
Computational Biology
Clustering, classification and feature
selection on microarray data. Reconstruction of genetic regulatory network
using graphical models.
Past:
Computer Scientist, National Energy
Research Scientific Computing Division, Lawrence Berkeley National Laboratory,
1999-2000
-
Algorithms and software development for sequence
segmentation, clustering, phylogenetic inference.
-
Classification of protein structure using
support vector machine (SVM).
Research Assistant,
Lab for Cancer Research, College of Pharmacy, Rutgers University (1995-1999).
(Serve as Leader of Carcinogenesis Topic Group since 1997)
Advisor: Professors Chung S. Yang
-
The molecular mechanisms and
clinical effects of the p16-Rb pathway inactivation, and their association
with altered p53 pathway in Human Esophageal Cancer (Ph.D. Thesis project,
1995-1999)
-
Informatics of p53 gene mutation
in human esophageal cancer (1998)
Research Assistant,
Department of Computer Science, Rutgers University (1996-1998).
Advisor: Professor Casimir Kulikowski
-
Combinatorial clustering and
database organization of ribosomal RNA sequences (M.S. degree project,
1998)
Research Scientist,
National Institute of Metrology, Chinese National Standards Bureau (1993-1994).
-
NIM national standard length
unit CH2F2 laser system (1994)
-
Automated frequency detection
system (1993)
Research Assistant,
Lab of Atomic and Molecular Physics, Tsinghua University (1991-1993).
-
Continuously Tunable High-Pressure
Electron-Beam-Controlled CO2 Laser system (State Key Research
Project, 1991-1993)
Professional Organizations
American Association for Cancer Research.
Associate member since 1997.
The International Society for Computational
Biology, member since 2001.
Hobbies and Extracurricular
activities
Classical arts and literature, travel,
sports.
Interesting experiences:
-
College athlete of track and field, representing
Tsinghua University, 1988-1993.
-
University Champion of the 4x400 relay, Tsinghua
University, 1990.
-
Member, Tsinghua Mountaineering Association,
Tsinghua University, 1990-1993.
-
Captain of the Tsinghua Mountaineering Team
in 1990. Conquered Mt. Gela-Dandong (6642m) in Tibet near the source of
Yangtze River.
-
Member, Winter IceWater-Swimming Club of Beijing
City, 1990-1994.
Summary of Skills and Qualifications
Computer skill:
-
Language: C, C++, Java, matlab, Perl,
FORTRAN, Prolog, SML, UNIX shell script (sed, awk), Assembly.
-
Operating System and Platforms: UNIX,
Linux, Windows, DOS; Sun-Stations, DEC, SGI, CRAY, N-cube.
List of Publications
A) Journals:
-
Xing E.P., Spengler
S., Zorn M., Muchnik I., Classification of multi-aligned sequence using
monotone linkage clustering and alignment segmentation. Manuscript
in preparation.
-
Xing E.P., Wolf
D., Dubchak I., Spengler S., Zorn M., Kulikowski C., Muchnik I., Automatic
discovery of sub-molecular sequence domains in multi-aligned sequences:
a dynamic programming algorithm for multiple alignment segmentation, Journal
of Theoretical Biology, 2001 Sep 21;212(2):129-39.
-
Xing E.P., Karp R.M., CLIFF: clustering of high-dimensional
microarray data via iterative feature filtering using normalized cuts.
Bioinformatics. 2001 Jun;17 Suppl 1:S306-15.
-
Cai Y., Yang G-Y., Yan N., Wang L-D., Zhao X., Song Y-L., Seril D., Liao
J., Xing E.P. and Yang C.S., Molecular alteration of p73
in human esophageal squamous cell carcinomas: loss of heterozygosity occurs
frequently; loss of imprinting and elevation of p73 expression may be related
to defective p53. Carcinogenesis,
2000; 21(4):683-9.
-
Xing E.P., Wu
W., Wang L., Zhao X. and Yang C.S., Comparative Analysis of p53 Mutational
Spectrum of Esophageal Squamous Cell Carcinoma from Linxian, China with
Spectra of Other ESCC and Other Cancers, Carcinogenesis,
2001, in press.
-
Xing E.P., Nie
Y., Song Y-L., Yang G-Y., Cai C. C., Wang L-D., Chung C. S., Mechanisms
of inactivation of p14ARF, p15INK4b
and p16INK4a genes in human esophageal squamous cell
carcinoma: p14ARF is potentially another inactivation
hotspot within the 9p21 gene cluster, Clinical Cancer Research,
1999 Oct; 5(10): 2704-13.
-
Xing E. P., Yang
G-Y., Wang L-D., Yang C. S., Loss of Heterozygous of the Rb gene
correlates with pRb protein expression and associates with p53 alteration
in human esophageal cancer. Clinical Cancer Research, 1999
May; 5(5): 1231-40.
-
Shi S.T., Yang G-Y., Xue Z.,
Feng B., Ding W., Wang L-D., Xing E. P. and Yang C. S., Role
of p53 gene mutation in human esophageal carcinogenesis: result from immunohistochemistry
and mutation analysis of carcinomas and nearby non-cancerous lesions, Carcinogenesis,
1999
Apr; 20(4): 591-7.
-
Xing E. P., Nie
Y., Wang L-D., Yang G-Y., Yang C.S., Aberrant methylation
of p16INK4a and deletion of p15INK4b
are frequent events in human esophageal cancer, Carcinogenesis,
1999 Jan; 20(1): 77-84.
B) Conference Proceedings
and Technical Reports:
-
Xing E.P.,
Jordan M., and Karp R., Dimensionality reduction using a mixture of feature
evaluation
systems in classification
of high-dimensional molecular biology data. Proceedings of the Eighteenth
International Conference on Machine Learning (ICML 2001).
-
Xing E.P., and
Karp R., CINCAFF: Clustering via Iterative Normalized Cut and Feature Filtering
of high-dimensional microarray data, Proceedings of The Nineth International
Conference on Intelligence Systems for Molecular Biology (ISMB 2001).
-
Xing, E.P., Kulikowski,
C., Muchnik, I., Dukchak, I., Wolf, D., Spengler, S. and Zorn, M. Analysis
of ribosomal RNA sequences by combinatorial clustering. Proceedings,
The Seventh International Conference on Intelligence Systems for Molecular
Biology (ISMB99), (Eds. T. Lengauer et al.) AAAI/MIT Press, Menlo
Park, CA. P. 287-296..
-
Xing E.P., Yang
G-Y, Wang L-D., Yang C.S., The molecular alterations of tumor suppressor
genes p16INK4a and p15INK4b in human
esophageal cancer, Proceedings of The American Association For Cancer
Research, Vol 39:442, 1998.
-
Xing E.P., Shi
S.T., Wang L-D., Yang C.S., Loss of heterozygosity in Rb gene and
its relationship with p53 alteration in esophageal cancer, Proceedings
of The American Association For Cancer Research, Vol 38:510-511,
1997.
-
Xue P., Xing P.,
Huang Y., Zhao J., The Research of Continuous Tunable High-Pressure
Electron-Beam-Controlled CO2 Laser, Proceedings of the
1993 Shanghai World Optical Conference, 1993.
C) Invited Talks:
-
Feature selection for high-dimensional genomic
microarray data in concept learning and clustering analysis. AMS-IMS-SIAM
Summer Research Conference: Statistics in Functional Genomics,
June 10 - Thursday, June 14, 2001, South Hadley, MA, USA.