The trains collided at 8:11 a.m., three kilometres west of London's Paddington Station.
Meanwhile, the search for more victims resumed at dawn
Of the 150 people taken to area hospitals, reports say at least 14 are seriously injured.
Many passengers cried as they described how they frantically crawled out broken windows in the aftermath. Others said they were haunted by the cries of those trapped in the wreckage.
Authorities could not determine the total number of passengers aboard the trains.
Great Western and Thames Trains are the companies that operate the two trains involved in the crash.
Great Western said as many as 500 people might have been on board its train, which originated in Cheltenham, northwest of London, and was minutes away from its destination of Paddington Station. The Thames train, which may have been carrying up to 150 passengers, had just pulled out of the London station.
Rail travel is a way of daily life for many people in London and its surrounding communities. About 800,000 people travel into and around London by train everyday.
1. What did the search for more victims resume at dawn?