Assitant Professor, Computational and Systems Biology
School of Medicine
University of Pittsburgh
Change and Innovation in Biological Systems
What makes each species unique? My research aims to understand how changes in DNA sequences translate into the evolution of phenotypes. My approach consists in modeling the evolution of molecular networks that mediate genotype-phenotype relationships. I will describe findings related to the evolution of mutations in protein-coding genes and in non-genic sequences, as well as a special case where mutations in non-genic sequences give rise to novel, species-specific, protein-coding genes.