Contact Information Email adress my first name at cs.cmu.edu Mailing Address Language Technologies Institute Carnegie Mellon University 5000 Forbes Avenue GHC 5407 Pittsburgh, PA 15213 Office Gates-Hillman Center 5511

I am a fifth year PhD student in Language Technologies Institute ofSchool of Computer Science inCarnegie Mellon University. Prior toCMU, I was an undergraduate inBiological Sciences and Bioengineering Program inSabanci University, Turkey.

I am interested in computational approaches for solving biological problems. I have worked in transmembrane protein structures/folding related problems and recently started working on protein interaction networks in the context of host pathogen interactions. I am a member of Pittsburgh Center for HIV Host Interactions. In Fall 2009, I am teaching assistant for the Machine Learning Course, 10601.

Journal Publications

• Tastan O, Yu E, Ganapathiraju M, Aref A, Rader AJ and Klein-Seetharaman, J. Comparison of stability predictions and simulated unfolding of rhodopsin structures. Photobiology and photochemistry, Volume 63, Issue 2, pp 351-363, 2006.Supplementary Website

• Tastan O, Meirovitch H, Klein-Seetharaman, J. The effect of loops on the structural organization of α-helical membrane proteins. Biophysical Journal. Volume 96, Issue 6, 2299-2312, 2009. Supplementary Website

• Venkatachari NJ, Le T, Tastan O, Timothy MD, Walker L, Ricciuti A, Yanamala N, Srinivasan A, Klein-Seetharaman J, Ramachandran M, Montelaro RC, and Ayyavoo,V. Oligomerization of HIV-1 Vpr: Identification of essential domains/residues using structure based approaches and evaluation of its relevance to Vpr functions.(In revision).

• Balakrishnan S, Tastan O, Carbonell JC and Klein-Seetharaman J.Alternative paths in HIV-1 targeted human signal transduction pathways. BMC Genomics (Accepted, in press).

Peer Reviewed Conference Publications

• Tastan O, Qi Y, Carbonell, JG, and Klein-Seetharaman, J. Prediction of Interactions between HIV-1 and Human Proteins by Information Integration. Pacific Symposium on Biocomputing 14:516-527(2009).Supplementary Website

Selected Peer Reviewed Conference Posters and Talks

• Tastan O, Yu E, Rader  AJ and Klein-Seetharaman J. Comparison of simulated unfoldings of alpha-helical membrane proteins. Biophysical Society Annual Meeting 2007, Baltimore, Maryland, USA.

• Tastan O,Klein-Seetharaman J, Meirovitch H. The effect of loops on the structural organization of α-helical membrane proteins. Biophysical Society Annual Meeting 2008, Long Beach, California, USA.

• Tastan O , Carbonell JG, and Klein-Seetharaman J. Refining the HIV-1, human protein interaction network with multiple expert opinions .The 23rd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design. June 25-26, 2009. Bethesda, Maryland,USA.

• Tastan O, Qi Y, Carbonell JG, and Klein-Seetharaman J  . Prediction of HIV-1 human protein interactome. VIII European Symposium of The Protein Society June 14-18, 2009. Zurich, Switzerland.

• Venkatachari NJ, Le T, Tastan O, Timothy MD, Walker L, Ricciuti A, Yanamala N, Srinivasan A, Klein-Seetharaman J, Ramachandran M, Montelaro RC, and Ayyavoo,V. Oligomerization of HIV-1 Vpr:Identification of essential domains/residues using structure based approaches and evaluation of its relevance to Vpr functions. The 23rd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design. June 25-26, 2009. Bethesda, Maryland, 2009.

• Tastan O, Meirovitch H, Klein-Seetharaman, J. The effect of loops on the structural organization of  α-helical membrane proteins. 3Dsig. Structural Bioinformatics and Computational Biophysics an ISMB satellite meeting Stockholm, 27-28 June, 2009.Stockholm, Sweeden.