0. DOCID:23267 SCORE: 0.00256685937500105
DOCNO: 7658533
AUTHOR: K J Ho KJ
AFFILIATION: Department of Laboratory Medicine, National Taiwan University, College of Medicine, Taipei.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Urinary beta-glucuronidase in screening and followup of primary urinary tract malignancy.
PUBDATE: 19951001
PURPOSE: The usefulness of urinary beta-glucuronidase in screening and followup of urinary tract malignancy was tested. MATERIALS AND METHODS: The activity and concentration of urinary beta-glucuronidase were determined in 80 healthy subjects, 113 urology patients with no cancer, and 60 with transitional cell and 23 with renal cell carcinoma. Patients with cancer were followed for 3 to 33 weeks. RESULTS: The enzyme activity and concentration were significantly greater in the cancer group, including residual tumor or recurrence after therapy, than in the controls with excellent discrimination. CONCLUSIONS: Urinary beta-glucuronidase was indeed useful in screening and followup of urinary tract malignancy.


1. DOCID:23917 SCORE: 0.00225374623685073
DOCNO: 9155138
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: M Kamiyoshihara M
AUTHOR: T Hirai T
AUTHOR: O Kawashima O
AUTHOR: Y Morishita Y
AFFILIATION: Department of Surgery, National Sanatorium Nishigunma Hospital, Gunma, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: [Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai.
COUNTRY: JAPAN
TITLE: [Video-assisted thoracoscopic surgery for a 89-year-old patient with primary lung cancer--report of a case]
PUBDATE: 19970401
A 89-year-old woman was referred to our hospital because of a relatively defined shadow of the right peripheral lung in chest roentgenograms. Although this case couldn't be diagnosed with transbronchial lung biopsy, adenocarcinoma of the lung (c-T1N0M0) was suspected because of radiological findings. We planned video-assisted pulmonary partial resection of the S6 in consideration of age and general status. Her postoperative courses was uneventful with no complications. Video-assisted thoracoscopic surgery is one of the treatments for elderly patients with peripheral early stage lung cancer.


2. DOCID:23980 SCORE: 0.00225372643738775
DOCNO: 9257067
AUTHOR: J E Herndon JE
AUTHOR: S Fleishman S
AUTHOR: M P Kosty MP
AUTHOR: M R Green MR
AFFILIATION: CALGB Statistical Center, Duke University Medical Center, Durham, North Carolina 27705, USA.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Controlled clinical trials.
COUNTRY: UNITED STATES
TITLE: A longitudinal study of quality of life in advanced non-small cell lung cancer: Cancer and Leukemia Group B (CALGB) 8931.
PUBDATE: 19970801
A quality of life (QOL) endpoint supplemented standard clinical endpoints of survival, tumor response, and toxicity in a double-blind study conducted by the Cancer and Leukemia Group B (CALGB) where 291 patients with advanced non-small cell lung cancer (NSCLC) were randomly assigned to receive cisplatin/vinblastine with either hydrazine sulfate (HS) or placebo. The difficulties associated with the analysis of the longitudinal QOL data, and the contributions that the QOL endpoint made to the understanding of treatment differences, will be the focus of this paper.


3. DOCID:22799 SCORE: 0.00212433795295185
DOCNO: 8896111
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography, Mammary
AUTHOR: V P Jackson VP
AUTHOR: H E Reynolds HE
AUTHOR: D R Hawes DR
AFFILIATION: Department of Radiology, Indiana University School of Medicine, Indianapolis 46202, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in ultrasound, CT, and MR.
COUNTRY: UNITED STATES
TITLE: Sonography of the breast.
PUBDATE: 19961001
Quality mammography remains the primary modality used to image the breast. Sonography currently is the most useful adjunctive technique to mammography, having roles in differentiating cystic from solid masses and in guiding interventional procedures. This article reviews these and other indications for breast ultrasound studies, including evaluation of palpable masses not visible in radiographically dense breasts, masses not completely evaluable with mammography, young patients especially susceptible to radiation damage, and abscesses. Ultrasound interpretation of cysts and solid masses are discussed, as are the relative disadvantages of ultrasound as a breast cancer screening tool.


4. DOCID:23390 SCORE: 0.00200725949771955
DOCNO: 7603429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Pneumonia and influenza death rates--United States, 1979-1994.
PUBDATE: 19950701
The combined cause-of-death category pneumonia and influenza (P&I) (International Classification of Diseases, Ninth Revision, codes 480-487) ranks as the sixth leading cause of death in the United States following heart disease, cancer, stroke, unintentional injuries, and chronic obstructive pulmonary disease. Changes in the epidemiology of Streptococcus pneumoniae and other recognized respiratory pathogens, the increasing occurrence of drug-resistant microorganisms, and the detection of new respiratory pathogens have heightened awareness of the public health importance of severe respiratory infections. To characterize the epidemiology of P&I deaths in the United States, CDC further analyzed underlying and multiple cause-of-death mortality files for 1979-1994. This report summarizes the results of this analysis.


5. DOCID:23481 SCORE: 0.00200723186839025
DOCNO: 9273210
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: C Brzozowski C
AUTHOR: T Krzeski T
AUTHOR: A Borówka A
AFFILIATION: Katedry i Kliniki Urologii Instytutu AM w Warszawie.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Analysis of clinical symptoms of renal clear cell carcinoma]
PUBDATE: 19961101
An analysis of the clinical symptoms has been carried out in the group of 110 patients who underwent nephrectomy for a clear-cell carcinoma. Total hematuria (47.3% of patients) has been a predominant symptom of the tumour. Pain felt in the back has been noted in 39.1% of patients. Palpable tumour has been noted in 34.5% of patients. Such symptoms have been present simultaneously (Israel's triad) in 12.3% of patients. Tumour has been diagnosed accidentally, mainly with USG, in 37.3% of patients. It has been found that classic clinical symptoms of this cancer are nowadays less frequent than before introducing ultrasound examination.


6. DOCID:21938 SCORE: 0.00197423993343832
DOCNO: 8725706
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: V E Cullins VE
AFFILIATION: Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of reproductive medicine.
COUNTRY: UNITED STATES
TITLE: Noncontraceptive benefits and therapeutic uses of depot medroxyprogesterone acetate.
PUBDATE: 19960501
This paper reviews the noncontraceptive benefits and therapeutic uses of depot medroxyprogesterone acetate (DMPA). Relevant articles were reviewed using a computerized Medline search of the literature from 1966 to 1995. Good evidence shows that DMPA use is associated with reduced iron-deficiency anemia, protection against pelvic inflammatory disease, protection from endometrial cancer and improved hematologic parameters among users with sickle cell disease. More studies are needed to fully assess DMPA's impact on other disorders.


7. DOCID:23955 SCORE: 0.00194489380521195
DOCNO: 7675647
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: radionuclide imaging
QUALIFIER: surgery
QUALIFIER: instrumentation
QUALIFIER: analogs & derivatives
AUTHOR: S Adams S
AUTHOR: L Hovy L
AUTHOR: R P Baum RP
AUTHOR: M Adams M
AUTHOR: F D Maul FD
AUTHOR: H Kahla-Witzsch H
AUTHOR: L Zichner L
AUTHOR: D Jonas D
AUTHOR: G Hör G
AFFILIATION: Klinik und Poliklinik für Nuklearmedizin, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main, FRG.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Nuklearmedizin.
COUNTRY: GERMANY
TITLE: [Intraoperative localization of metastases with a hand-held gamma probe]
PUBDATE: 19950801
A 50-y-old male patient with prostate cancer showed two suspicious lesions in bone scintigrams. They were assessed to be bone metastases by biopsy of the os ilium. After i.v. injection of 99mTc-HMDP a probe-guided localization permitted optimal surgical treatment. A bone metastasis in the os ilium was confirmed. The intraoperative detection with a hand-held gamma probe permitted accurate and complete excision of the tumour; the bone defect could thus be reduced to a minimum.


8. DOCID:22813 SCORE: 0.00184915815722428
DOCNO: 8541395
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: M A Bookman MA
AFFILIATION: Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Biologic therapies for gynecologic cancer.
PUBDATE: 19950901
Recent advances in gynecologic tumor biology are discussed with an emphasis on the development of biologic therapy. Emerging knowledge regarding growth factors, regulatory cytokines, and cellular receptors offers new insight regarding tumor biology and the interaction of tumors with the host peritoneal cavity and immune system. Efforts to target ovarian cancer with antibodies directed against tumor-associated antigens have begun to take advantage of molecular engineering techniques and have also explored an expanded panel of radionuclides with improved conjugation technology. It is hoped that these efforts will translate into successful strategies to improve the long-term survival of patients in conjunction with conventional chemotherapy.


9. DOCID:23242 SCORE: 0.0017740397231064
DOCNO: 8665232
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colorectal Neoplasms
QUALIFIER: secondary
AUTHOR: I Taylor I
AFFILIATION: Department of Surgery, UCL Medical School, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Liver metastases from colorectal cancer: lessons from past and present clinical studies.
PUBDATE: 19960401
In patients with primary colorectal cancer the development of liver metastases has traditionally been equated with imminent demise. This metastatic event is remarkably common; indeed, liver metastases are present in some 25 per cent of patients at the time of initial colorectal resection and over 50 per cent of patients will eventually develop them. Some 90 per cent of patients who die from colorectal cancer have liver metastases. There are few cancers in which the metastatic pattern has such a high degree of predictability. Information from past and present clinical studies should, therefore, provide a basis for logical approaches to prevention and treatment.


10. DOCID:23984 SCORE: 0.00177370552690138
DOCNO: 7597868
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
AUTHOR: Y Luo Y
AUTHOR: Z X Sun ZX
AUTHOR: S X Xia SX
AFFILIATION: Institute of Radiation Medicine, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Shi yan sheng wu xue bao.
COUNTRY: CHINA
TITLE: [The application of halo assay in analysis of cell chromatin structure]
PUBDATE: 19950301
Halo assay, a method for quantitative analysis of chromatin structure in cell, was developed recently. Due to visualization, feasibility, rapidity, and sensitivity of the method, it has been applied in radiobiology and cancer research. According to previous reports, with some improvement, this method has been established in our laboratory. Employing halo assay, the chromatin structure of two kinds of cell strain with similar genetic background and different radiosensitivity was analyzed and the results show that radiosensitive strain has looser chromatin structure than radioresistant one. It is possible that this difference is related to their different radiosensitivity, thus it's a proof for the relation of chromatin structure and radiosensitivity.


11. DOCID:23614 SCORE: 0.00173388604613454
DOCNO: 9114831
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammaplasty
DESCRIPTOR: Mammography
AUTHOR: K Snodgrass K
AUTHOR: J Yu J
AUTHOR: E Doster E
AUTHOR: M Camp M
AUTHOR: D Moody D
AUTHOR: K Given K
AFFILIATION: Section of Plastic Surgery, Medical College of Georgia, Augusta 30912-4080, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: The value of preoperative mammograms in nononcologic breast surgery.
PUBDATE: 19970401
It remains unclear whether preoperative mammograms are necessary in young patients having nononcologic breast surgery. Various authors have recommended mammography in all such cases, in conflict with guidelines from the American Cancer Society. We conducted a retrospective study to determine the utility of preoperative mammograms in young women. From 1989 through 1994, 208 patients under 35 years of age had elective breast surgery in our institution. Fifty-one (24.5%) had preoperative mammography. No malignancies were diagnosed. We believe mammograms are not routinely needed before elective breast surgery in patients under 35 years of age.


12. DOCID:23398 SCORE: 0.00173035902103764
DOCNO: 9238286
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, Tumor Suppressor
DESCRIPTOR: Oncogenes
QUALIFIER: genetics
AUTHOR: M Koffa M
AUTHOR: D A Spandidos DA
AFFILIATION: Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the New York Academy of Sciences.
COUNTRY: UNITED STATES
TITLE: Oncogenes and onco-suppressor genes in female genital cancer.
PUBDATE: 19970601
Cancer is a multistep process resulting in the accumulation of genetic lesions in proto-oncogenes or tumor suppressor genes. In recent years, many biological studies have focused on the analysis of the genetic and molecular events occurring in genital tumors in order to identify genes involved in their initiation and progression. Understanding the genetic events that lead to initiation and progression of a disease remains an important challenge in gynecological research and ultimately may enable the development of better approaches for earlier diagnosis, in cases where current therapeutic strategies have a high cure rate.


13. DOCID:23328 SCORE: 0.00164907745456624
DOCNO: 8971472
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug therapy
AUTHOR: R N Rao RN
AFFILIATION: Division of Cancer Research, Lilly Research Laboratories, Indianapolis, IN 46285-0424, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Targets for cancer therapy in the cell cycle pathway.
PUBDATE: 19961101
Progression through the cell cycle is a complex process that is regulated at many levels by several proteins. We are just beginning to understand how these proteins accomplish this regulation. The p16-cyclin D1.cdk4-pRb pathway is one of the most important pathways, which is altered in a majority of cancers of different types. This review focuses on some of the proteins in this pathway that offer new opportunities for drug discovery. Some guidelines to evaluate the relevance of these proteins as targets for cancer therapy and the importance of developing a combination therapy targeting multiple pathways are also discussed.


14. DOCID:22104 SCORE: 0.00164410456596029
DOCNO: 9335672
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: etiology
QUALIFIER: nursing
AUTHOR: A N Davies AN
AFFILIATION: St Christopher's Hospice, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer care.
COUNTRY: ENGLAND
TITLE: The management of xerostomia: a review.
PUBDATE: 19970901
Xerostomia causes a great deal of morbidity in patients with advanced cancer. However, it is an area which has received little attention. Indeed current management of xerostomia in palliative care units is based largely on anecdotal evidence. There are a number of studies in progress specifically looking at patients with advanced cancer, but until these are published we should take note of studies done in other patient groups. This article reviews the medical literature on the symptomatic management of xerostomia as a whole, with particular reference to treatments that are currently available in the United Kingdom.