0. DOCID:11968 SCORE: 0.00240928374794398
DOCNO: 6702939
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ascitic Fluid
QUALIFIER: diagnosis
AUTHOR: S Yoshimura S
AUTHOR: R E Scully RE
AUTHOR: D A Bell DA
AUTHOR: P D Taft PD
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Correlation of ascitic fluid cytology with histologic findings before and after treatment of ovarian cancer.
PUBDATE: 19840301
One hundred thirteen specimens of ascitic fluid from 97 patients with primary, persistent, or recurrent ovarian cancer were examined cytologically. Advanced stage of disease, involvement of the ovarian surface, a moderate or large volume of fluid, and nonbloody serous ascites were factors that correlated with a high rate of positive findings in ascites in these patients. Other factors influencing the positive rate appeared to be the invasive as opposed to borderline malignant histology of the tumor. Involved external surface and volume of ascites were influencing factors only in advanced cases. Therefore, the most important factor influencing the positive rate of ascites cytology was the proportion of cases in advanced stages to total cases.


1. DOCID:11800 SCORE: 0.00229334473748117
DOCNO: 6181700
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M B Spaulding MB
AUTHOR: A Kahn A
AUTHOR: R De Los Santos R
AUTHOR: D Klotch D
AUTHOR: J M Loré JM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Adjuvant chemotherapy in advanced head and neck cancer. An update.
PUBDATE: 19821001
Two courses of triple-agent chemotherapy were given to 47 patients with advanced head and neck cancer. All but one patient with a nasopharyngeal carcinoma had resectable stage III and IV squamous cell carcinoma. Eighty-eight percent of the patients responded to the chemotherapy with a 50 percent or greater decrease in tumor size. Forty-three patients underwent surgical resection and 19 were histologically upgraded to stage II or better (T less than 2 cm, N0). None of these 19 patients have relapsed, with follow-up ranging from 12 to 42 months. In 12 of the 47 patients, recurrent tumor developed within the first 18 months of follow-up.


2. DOCID:10867 SCORE: 0.00212001902972315
DOCNO: 2981417
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lumbosacral Plexus
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: K A Jaeckle KA
AUTHOR: D F Young DF
AUTHOR: K M Foley KM
PUBTYPE: Journal Article
JOURNALTITLE: Neurology.
COUNTRY: UNITED STATES
TITLE: The natural history of lumbosacral plexopathy in cancer.
PUBDATE: 19850101
We studied 85 cancer patients with lumbosacral plexopathy and documented pelvic tumor by CT or biopsy. Three clinical syndromes were delineated: lower (L4-S1), 51%; upper (L1-L4), 31%; and pan-plexopathy (L1-S3), 18%. Seventy percent of patients had the insidious onset of pelvic or radicular leg pain, followed weeks to months later by sensory symptoms and weakness. The quintet of leg pain, weakness, edema, rectal mass, and hydronephrosis suggests plexopathy due to cancer. CT showed pelvic tumor in 96%. On myelography, epidural extension, usually below the conus medullaris, was seen in 45%. With treatment, only 28% of patients had objective responses on CT and 17% on examination.


3. DOCID:10917 SCORE: 0.00201783788310885
DOCNO: 4081729
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Environmental Exposure
DESCRIPTOR: Housing
QUALIFIER: etiology
QUALIFIER: analysis
AUTHOR: O Castren O
AUTHOR: A Voutilainen A
AUTHOR: K Winqvist K
AUTHOR: I Mäkeläinen I
PUBTYPE: Journal Article
JOURNALTITLE: The Science of the total environment.
COUNTRY: NETHERLANDS
TITLE: Studies of high indoor radon areas in Finland.
PUBDATE: 19851001
Solid state nuclear track detectors were used in a regional survey of radon in indoor air. The study area comprises seven rural municipalities and two towns in an area of 80 X 50 km2 with a population of about 65,000. Measurements were made in 754 houses in 31 subareas. The highest and lowest subarea means were 1,200 Bq/m3 and 95 Bq/m3, respectively. The estimated mean for the whole area was 370 Bq/m3. The concentrations 2,000 Bq/m3 and 800 Bq/m3 were exceeded in 32 and 90 houses, respectively. The present lung cancer incidence does not differ significantly from the national mean.


4. DOCID:11981 SCORE: 0.00189571174971245
DOCNO: 6876422
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: secondary
AUTHOR: N Horikoshi N
AUTHOR: J Inagaki J
AUTHOR: K Ezaki K
AUTHOR: K Inoue K
AUTHOR: M Ogawa M
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Clinical features and managements of breast cancer patients with pulmonary metastasis]
PUBDATE: 19830501
One hundred-thirty-nine patients with advanced breast cancer were treated during five years since 1977 in our Department. Treatments consisted of chemotherapy (ACF and ACFM), hormone therapy (tamoxifen) and their combination (ACFT). Seventy patients had lung metastases at the initiation of these therapies. An overall response rate was 41%, whereas a response rate for metastatic lung lesions was 26% (18/69). Breast cancer is known as a systemic disease, thus other therapies such as pulmonary resection or irradiation had a limited indication to control the lung metastasis. Our result indicates that favorable responses to advanced breast cancer with systemic therapies will improve the prognosis of breast cancer patients with lung metastasis.


5. DOCID:11910 SCORE: 0.00182883583664472
DOCNO: 6678468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
AUTHOR: J F Gaeta JF
AUTHOR: J E Asirwatham JE
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in urology.
COUNTRY: UNITED STATES
TITLE: Prostate cancer grading: the NPCP system.
PUBDATE: 19830801
The use of the NPCP grading system does not contradict the principle that an accurate prediction of tumor volume, presence, and extent of metastases, therapeutic response, and clinical behavior of prostate cancer cannot be entirely based on the grade of the disease at the time of initial diagnosis. The morphology of prostate cancer, like any other cancer, is probably no more than one of a group of parameters that are decisive for the prediction of the biology and clinical course of the disease. Nevertheless, the present data support the premise that the NPCP system of grading prostate cancer, among others, is a very helpful indicator of the extent and behavior of prostate malignancy. Table 6 illustrates the correlation between grades and stages of prostatic carcinoma that can be drawn from the preceding data.


6. DOCID:9691 SCORE: 0.00182832962473503
DOCNO: 7083188
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: physiopathology
AUTHOR: B M Sherman BM
AUTHOR: R B Wallace RB
AUTHOR: J A Bean JA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Cyclic ovarian function and breast cancer.
PUBDATE: 19820801
We postulated previously that systematic differences in menstrual cycle length and/or variability might be used as indicators of underlying hormonal abnormalities that could help explain the endocrine biology of some breast cancer risk factors. In the present study, we prospectively and retrospectively analyzed menstrual cycle patterns in breast cancer cases and controls in two populations. No significant differences were found. This and previous studies emphasize that contemporary women have a long reproductive experience characterized by uninterrupted, regular menses, which is a condition of maximum ovulation potential and which contributes to estrogen stimulation over time.


7. DOCID:11829 SCORE: 0.00180692487483019
DOCNO: 6098080
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
AUTHOR: W Bartl W
AUTHOR: G Bernaschek G
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Forms of manifestations of breast cancer in sonography]
PUBDATE: 19841001
40 women with breast cancer were checked by the ultrasound Octoson technique and the results compared with the histological tumour types. We grouped the carcinomas into 3 types: scirrhous, solid or medullary, and the invasive lobular tumour. Our diagnostic ultrasound criteria: internal echoes, as well as contour and boundary echo, showed a close relationship to the histological types. Irregular internal echoes, spiculated contours and weak boundary echoes were seen in most cases with scirrhous or lobular carcinomas, whilst the other histological types also showed characteristics similar to benign tumours such as absent internal echoes, regular contours and strong boundary reflexions. The criterion "shadowing" was not closely related to the degree of internal echoes either. Hence, a needle biopsy under ultrasound control should be performed to verify the diagnosis in all doubtful cases.


8. DOCID:11950 SCORE: 0.00174999431587635
DOCNO: 4023542
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: P Curie P
AUTHOR: M Sussmann M
AUTHOR: A Treisser A
AUTHOR: R Renaud R
PUBTYPE: Journal Article
JOURNALTITLE: Revue française de gynécologie et d'obstétrique.
COUNTRY: FRANCE
TITLE: [Epidemiologic factors in ovarian cancer]
PUBDATE: 19850501
Ovarian carcinoma is the most severe gynecological cancer with an overall incidence of 12 per 1000 Americans or Europeans developing it over 40 years of age. Only 3 of the 12 cases will receive efficient care because the diagnosis will be made too late. This study reveals the principal risk factors i.e. upper socioeconomic echelon, ovarian function uninterrupted by a pregnancy or usage of oral contraceptives, anamnestic evidence of ovarian carcinoma in the family, some hereditary disorders, external insults (talcum powder). The synthesis of these various risk factors permits a comprehensive review of the hypotheses of pathogenesis concerning recurrence of tumors. But corollary epidemiologic studies are still needed to try to define better the high risk groups whose follow-up systematic detection and testing is a priority.


9. DOCID:11997 SCORE: 0.00174997341473964
DOCNO: 16829394
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: L Dominioni L
AUTHOR: R Dionigi R
AUTHOR: V Jemos V
AUTHOR: E Bonomi E
AUTHOR: G V Melzi d'Eril GV
AUTHOR: P Dal Ri P
AFFILIATION: Istituto di Patologia Chirurgica, University of Pavia, 271000 Pavia, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nutrition (Edinburgh, Scotland)
COUNTRY: England
TITLE: Effects of malnutrition on the acute phase response of plasma proteins in patients undergoing total gastrectomy.
PUBDATE: 19830301
The serum level of six acute phase proteins (APP) has been evaluated preoperatively and for a few days in the postoperative period. Thirty patients undergoing total gastrectomy for gastric cancer have been studied in two subgroups according to their nutritional status. Those with gastric cancer had significantly higher baseline serum levels of alpha 1 acid glycoprotein (alpha1AGP) and C-reactive protein (CRP) than a control group. Malnourished patients also had reduced acute phase response for alpha1AGP and alpha 1 antitrypsin (alpha1AT) a higher increase of CRP and fibrinogen, and a lower decrease for transferrin and retinol binding protein (RBP).


10. DOCID:11390 SCORE: 0.001749777160286
DOCNO: 6196491
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Seeding
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: drug therapy
AUTHOR: M Kamer M
AUTHOR: R G Rowland RG
AUTHOR: L H Einhorn LH
AUTHOR: J P Donohue JP
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Recurrent testis cancer: seeding from retroperitoneal nodes after complete remissions by chemotherapy.
PUBDATE: 19831201
Routine retroperitoneal lymph node dissection is generally not required after a complete remission is achieved by chemotherapy in initially disseminated nonseminomatous testis cancer. However, in patients with multiple relapses retroperitoneal lymph node dissection should be considered even if the retroperitoneum is unremarkable by radiographic staging. We report on a patient with initial stage III disease in whom a complete clinical response to chemotherapy was achieved multiple times but there was repeatedly re-seeding of the lungs from an undetected focus of nodal cancer later proved by retroperitoneal lymph node dissection. Controversies in management as well as potential mechanisms of drug resistance are discussed.


11. DOCID:11885 SCORE: 0.00174232303702067
DOCNO: 6527406
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Multiple Primary
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T Yokoe T
AUTHOR: T Ishida T
AUTHOR: U Iino U
AUTHOR: T Kawai T
AUTHOR: M Izuo M
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Clinicopathological study of breast cancers associated with other primary cancers]
PUBDATE: 19841201
Thirty six cases of breast cancer associated with other primary cancer were found out among 1160 patients with primary breast cancer. They consisted of 6 synchronous combination and 30 metachronous, in which 23 were detected as the first lesion and 7 were the second. The other organs involved by cancer were the stomach (11), thyroid (9), colon or rectum (5), uterus (3), and others (8). Although the TNM stage of the breast cancer was mostly in stage I or II (91.6%), the prognosis was poor in the metachronous cases, depending on the nature of the second primary cancer. It is important to detect and treat a second primary cancer in the early stage.


12. DOCID:10407 SCORE: 0.00172524034898502
DOCNO: 2983900
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: pharmacology
QUALIFIER: metabolism
QUALIFIER: toxicity
QUALIFIER: metabolism
QUALIFIER: toxicity
AUTHOR: J M Whitcomb JM
AUTHOR: A G Schwartz AG
PUBTYPE: Journal Article
JOURNALTITLE: Carcinogenesis.
COUNTRY: UNITED STATES
TITLE: Dehydroepiandrosterone and 16 alpha-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of superoxide radical production by human polymorphonuclear leukocytes.
PUBDATE: 19850301
Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. DHEA has previously been shown to inhibit the development of spontaneous breast cancer and chemically induced tumors of the lung and colon as well as TPA promoted skin tumors in the mouse. The inhibition of TPA stimulated O2- formation by DHEA may contribute to the cancer preventive activity of this steroid.


13. DOCID:10864 SCORE: 0.00165622714124785
DOCNO: 3974248
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: Y F Wu YF
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Adjuvant chemotherapy of gastric carcinoma: a pilot study of oral administration of injectable 5-fluorouracil.
PUBDATE: 19850301
During the past three years we have entered 54 patients with gastric adenocarcinoma into a clinical trial of oral administration of injectable 5-fluorouracil (5-Fu). Of the 20 unresectable advanced cases, the median survival was 6.2 months, and for 34 resectable ones, median survival was 22 months. These results were comparable to those reported in the literature. It is also safe, easy to administer, well tolerated, and does not have any apparent side effects. The author discovered for the first time that oral administration of 5-Fu could improve the liver function as manifested by a marked decrease of serum GPT level in advanced gastric cancer.


14. DOCID:11404 SCORE: 0.00164923868929159
DOCNO: 7157905
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: K W Steegmüller KW
AUTHOR: H M Märklin HM
AUTHOR: R Fischer R
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Gastroenterologie.
COUNTRY: GERMANY, WEST
TITLE: [Partial duodenopancreatectomy and intraoperative occlusion of the pancreatic duct: preliminary results]
PUBDATE: 19821001
From March 1980 to December 1981 partial duodenopancreatectomy and occlusion of the pancreatic duct of the remaining tail of the pancreas was carried out in 22 patients. Indication was severe chronic pancreatitis in 17 cases, cancer of the ampulla of Vater in 4 cases and cancer of the duodenum in 1 case. 1 patient (duodenal cancer) died because of necrosis of the residual pancreas. The treatment of exocrine pancreatic insufficiency does not create problems. Only patients presenting with preoperative latent diabetic metabolism seem to develop postoperatively a manifest Insulin dependent diabetes mellitus. The obtained results are very satisfactory and justify to conclude that this operative procedure gives real help to patients with severe chronic relapsing pancreatitis.