0. DOCID:7455 SCORE: 0.00222856265482677
DOCNO: 7431681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gastrectomy
DESCRIPTOR: Splenectomy
QUALIFIER: immunology
AUTHOR: M Takahashi M
AUTHOR: S Fujimoto S
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Clinical studies on the correlation between immunologic status and total gastrectomy combined with splenectomy.
PUBDATE: 19800601
The influence of splenectomy on the immunologic status of stomach cancer patients was studied. Eight gastric cancer patients having undergone total gastrectomy combined with splenectomy were evaluated immunologically. Peripheral lymphocyte counts were depressed and continued to be so in splenectomized patients. PHA-induced lymphocyte blastogenesis decreased rapidly after total gastrectomy with splenectomy and thereafter increased gradually. PHA skin test seemed to take almost the same time course. These recoveries to the normal range were observed 4 weeks after operation. In 10 other patients who had undergone total gastrectomy with splenectomy for gastric cancer and had been recurrence-free for more than 6 months, peripheral lymphocyte and T lymphocyte counts significantly increased compared with 7 cases having undergone total gastrectomy only, though no difference was seen in both PHA skin test and PHA-induced lymphocyte blastogenesis between the 2 groups.

1. DOCID:7896 SCORE: 0.00217593176605327
DOCNO: 7449091
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: methods
QUALIFIER: blood
QUALIFIER: enzymology
AUTHOR: L Kahan L
AUTHOR: V L Go VL
AUTHOR: F C Larson FC
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Increased activity in serum of an alkaline phosphatase isoenzyme in cancer: analytical method and preliminary clinical studies.
PUBDATE: 19810101
Serum of cancer patients often contains high activities of a homoarginine-sensitive isoenzyme of alkaline phosphatase with high electrophoretic mobility, which is present in relatively low activities in sera from most normal persons and persons with benign disease. In earlier studies of this isoenzyme, in a semi-quantitative assay, electrophoresis was used in the separation step. This report describes a column separation procedure, which provides quantitative data. We tested the revised procedure by assaying a mixed panel of 192 sera (cancer, benign disease, and normal). The organ sites of cancer and benign disease in this study were: lung, pancreas, uterus, and ovaries. The isoenzyme showed moderate sensitivity for lung (0.6) and pancreas (0.8) cancer and high specificity for all cancers tested. Thus the assay may be useful for discriminating between cancer sera and non-cancer sera for these cancer types.

2. DOCID:6481 SCORE: 0.0020414847292413
DOCNO: 7272951
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J L Tullis JL
AUTHOR: H Honegger H
AUTHOR: O Fleischaker O
AUTHOR: L Hewitt L
AUTHOR: D Kenney D
AUTHOR: F C Chao FC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Thrombin inhibition by malignant and normal cells: a cell-bound antithrombin effect.
PUBDATE: 19810901
Analysis of fresh surgical specimens of normal tissue and tumor tissue show a cellular antithrombin activity to be present in certain organs. In normal tissues it was noted chiefly in normal colon, testes, breast, and uterus. In malignant tissues it was prominent in adenocarcinomas of the colon, breast, and lung. No epidermoid tumors showed evidence of thrombin binding. The thrombin- binding activity required the presence of intact cells and was distinct from the soluble antithrombins normally present in plasma and serum. There is growing evidence to suggest an interrelationship between clotting and the growth and dissemination of cancer. The implications of cellular antithrombins are reviewed in this context.

3. DOCID:7876 SCORE: 0.00200221691049829
DOCNO: 7315315
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Takubo K
AUTHOR: S Tsuchiya S
AUTHOR: K Fukushi K
AUTHOR: A Shirota A
AUTHOR: Y Mitomo Y
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: Dysplasia and reserve cell hyperplasia-like change in human esophagus.
PUBDATE: 19811101
The esophagus was totally examined in 264 autopsied cases and 61 operated cases, for a total of 325 cases, to clarify the histogenesis of squamous cell carcinoma of the esophagus. Epithelial dysplasia of the mucosa was present in 27% and subclinical carcinoma was found in 2.4%. Hyperplasia of the duct of the esophageal gland proper was present in 34% and cysplasia of the ductal epithelium in 3%. Reserve cell hyperplasia-like change of the islet of the ectopic gastric mucosa was found in 4% and reserve cell hyperplasia-like change of the esophagogastric junction zone in 13%. Of the seven cases of microcarcinoma, two showed dysplasia and gradual transition and one presented dysplasia and abrupt transition. Another two were considered to have originated in the ductal epithelium. These findings suggested that they could all be the sites of origin of cancer development.

4. DOCID:7631 SCORE: 0.00196209414456682
DOCNO: 436114
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: P Pour P
AUTHOR: S Z Salmasi SZ
AUTHOR: R G Runge RG
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Ductular origin of pancreatic cancer and its multiplicity in man comparable to experimentally induced tumors. A preliminary study.
PUBDATE: 19790201
The histologic features of 3 randomly selected pancreatic cancer cases are compared with those found in Syrian hamsters after treatment with N-nitrosobis(2-oxopropyl)amine (BOP). The 3 human cases all exhibited hyperplastic, preneoplastic and malignant changes which were markedly multicentric, and which arose predominantly from ductules, as well as from small ducts. The findings were comparable to those in the hamster mode. Proliferation and malignant alterations of the intrainsular ductules were commonly seen in both human and experimental tumors. The data is consistent with the concept that cells of the small ducts and especially of the ductules represent a potential source of human, as well as experimental, tumors. The small number of human cases studied does not allow generalization, but the marked resemblances in all 3 randomly selected pancreatic cancer cases were remarkable.

5. DOCID:6922 SCORE: 0.00192158947269341
DOCNO: 6944532
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: urine
QUALIFIER: urine
AUTHOR: D Trichopoulos D
AUTHOR: J B Brown JB
AUTHOR: J Garas J
AUTHOR: A Papaioannou A
AUTHOR: B MacMahon B
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Elevated urine estrogen and pregnanediol levels in daughters of breast cancer patients.
PUBDATE: 19810901
Urine levels of three major estrogens and of pregnanediol were measured for 76 nulliparous daughters of breast cancer patients and for 115 control women of similar age and parity. Concentrations of estrone and estradiol tended to be higher in the daughters of breast cancer patients than in the controls; total estrogens were elevated in both phases than in the controls; total estrogens were elevated in both phases of the menstrual cycle and significantly so in the luteal phase. There was little difference between the daughters and the controls in estriol ratios--the ratios of the concentration of estriol to the sum of the concentrations of estrone and estradiol. Pregnanediol levels were higher in the daughters than in the controls.

6. DOCID:6008 SCORE: 0.00191976164277995
DOCNO: 6777451
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Enzyme Tests
QUALIFIER: trends
QUALIFIER: diagnosis
AUTHOR: N W Tietz NW
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie.
COUNTRY: GERMANY, WEST
TITLE: Present and future trends in selected areas of clinical enzymology.
PUBDATE: 19801101
Recently developed enzyme tests that are used in (a) identifying high risk populations, (b) diagnosing cancer, (c) following treatment response of cancer patients, and (d) the selection of cancer therapy are summarized. The diagnostic role of methionine adenosyltransferase and CSF monoamine oxidase activity measurements in the diagnosis of schizophrenia are discussed. The role of N-acetyltransferase in the conversion of serotonin to melatonin in the pineal gland and the importance of these changes for the synchronization of the functioning of cells throughout the organism are described. New developments in the determination of immunoreactive trypsin in the early diagnosis of pancreatic diseases are summarized.

7. DOCID:6785 SCORE: 0.00191630851081813
DOCNO: 7326641
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: methods
QUALIFIER: epidemiology
AUTHOR: A A Starreveld AA
AUTHOR: G B Hill GB
AUTHOR: L B Brown LB
AUTHOR: M Koch M
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Effect of screening on the incidence of cervical cancer in Alberta.
PUBDATE: 19811101
The rates of registration of cases of in-situ and invasive cancer of the cervix in Alberta have fallen for women aged 35 and over since the introduction of screening in the early 1960s, as predicted by theory and described in Finland. However, for women aged 15 to 34 years of age the predicted pattern was followed only initially: the registration rate for in-situ and probably also invasive cancer increased after 1973. This could be due to an actual increase in the incidence of in-situ cancer of the cervix among younger women, as might be expected from the epidemiologic aspects of the disease, but it might also be due to increased recruitment of younger women to the screening program.

8. DOCID:7090 SCORE: 0.00187942817528631
DOCNO: 6165505
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: E H Cooper EH
AUTHOR: R Glashan R
AUTHOR: M R Robinson MR
AUTHOR: D B Morgan DB
AUTHOR: K Trautner K
PUBTYPE: Journal Article
JOURNALTITLE: Clinica chimica acta; international journal of clinical chemistry.
COUNTRY: NETHERLANDS
TITLE: The evaluation of a new enzyme immunoassay for the measurement of prostatic acid phosphatase.
PUBDATE: 19810601
An enzyme immunoassay for prostatic acid phosphatase (PAP) has been assessed. An upper limit normal is set at 1.8 microgram/1. There is a very low incidence of raised levels in chronic diseases or cancers other than those of the prostate. Patients with well-controlled prostatic cancer have levels less than 1.8 microgram/1 and show little variation about their own mean. PAP can rise exponentially with a doubling time of 1-5 months. This assay is unlikely to increase the detection of asymptomatic prostatic cancer as 66% of T0-2NXM0 cases had PAP less than 1.8 microgram/1. The main advantages over routine enzyme assays are its sensitivity and accuracy in the lower range.

9. DOCID:6973 SCORE: 0.00182070885025611
DOCNO: 657089
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chemotaxis, Leukocyte
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: C R Kjeldsberg CR
AUTHOR: G D Pay GD
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A qualitative and quantitative study of monocytes in patients with malignant solid tumors.
PUBDATE: 19780601
Monocytes from 21 patients with cancer of the lung and cancer of the prostate were studied prior to treatment. The absolute circulating monocyte count, serum lysozyme levels and monocyte IgG surface receptors were normal at all stages of the disease. Monocyte chemotaxis was defective in 45% of the patients. Serum chemotatic factor inactivator(s) that inhibit chemotaxis of normal monocytes were detected in 90% of the patients. In two of four patients the chemotactic factor(s) disappeared following surgical removal of localized tumors. The results of the chemotaxis studies may explain the data of defective delayed hypersensitivity reactions frequently seen in patients with malignancies. The defective chemotaxis and the presence of chemotatic factor inactivator(s) may interfere with the ability of monocytes to accumulate as macrophages in tumor sites.

10. DOCID:6715 SCORE: 0.00179986081927157
DOCNO: 7388802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: L D Papsidero LD
AUTHOR: M C Wang MC
AUTHOR: L A Valenzuela LA
AUTHOR: G P Murphy GP
AUTHOR: T M Chu TM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: A prostate antigen in sera of prostatic cancer patients.
PUBDATE: 19800701
A prostate antigen has been detected by a rocket immunoelectrophoresis technique in 17 of 219 sera obtained from patients with advanced prostatic cancer. Sera from 175 patients with nonprostatic cancers, including those with late-stage disease of the breast, lung, colon, rectum, stomach, and pancreas, were antigen negative as were 20 samples each from normal adults and age-matched males. Antigen in sera showed immunological identity with antigen in prostate tissue as determined by immunoprecipitation peak enhancement experiments. Using antibody affinity chromatography and radioimmunoprecipitation techniques, the antigen in sera was purified and subjected to sodium dodecyl sulfate electrophoresis; it exhibited a molecular weight of approximately 36,000, similar to that of antigen isolated from prostatic tissue.

11. DOCID:6486 SCORE: 0.00179548520754634
DOCNO: 6785615
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: H Oeser H
AUTHOR: P Koeppe P
PUBTYPE: Journal Article
JOURNALTITLE: MMW, Münchener medizinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: [Prospective development of cancer mortality in the German Federal Republic (author's transl)]
PUBDATE: 19810401
The absolute number of cancer deaths in males will rise considerably up to the year 2070 from about 76,000 per year in 1976 to an estimated 92,000 in 2070. The numbers will then fall to an extent which is dependent on the future birth rate. The absolute number of cancer deaths among females will remain at the present level until about the third decade of the next millenium and then fall variably depending on the development of the birth rate. The expected increase in cancer deaths among males with a rate of increase of up to 20% (!) is explained by the incipient change in the age structure of the German population alone and needs no reference to carcinogens in our environment.

12. DOCID:7885 SCORE: 0.00175226107422009
DOCNO: 7241554
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cognition
DESCRIPTOR: Students, Medical
DESCRIPTOR: Teaching Materials
AUTHOR: N Scott N
AUTHOR: D U Smith DU
AUTHOR: I K Rosenberg IK
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Journal of medical education.
COUNTRY: UNITED STATES
TITLE: Cognitive style and instructional materials for medical students.
PUBDATE: 19810701
The study assessed the effects of matching, or mismatching, third-year medical students by cognitive style and instructional mode. At the beginning of each of four rotations of the third-year surgery clerkship, all students (n = 245) were administered the Group Embedded Figures Test and then classified as either field-independent or field-dependent. The students in rotations one to three (n = 180) were randomly assigned to either a highly structured sequence or to an unstructured sequence on colorectal cancer, and in the fourth rotation all students (n = 65) took the colorectal cancer self-instructional sequence currently in use. Following the instructional period, the students were administered an inventory of instruction, a simulation game, and a multiple-choice posttest of the content. Results showed few effects favoring matching cognitive style with instructional materials. Implications for highly motivated, high-achieving students were discussed.

13. DOCID:7319 SCORE: 0.00173499648436467
DOCNO: 6773105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: C T Chung CT
AUTHOR: R H Sagerman RH
AUTHOR: M C Ryoo MC
AUTHOR: G A King GA
AUTHOR: W S Yu WS
AUTHOR: P S Dalal PS
AUTHOR: I G Emmanuel IG
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: External irradiation for malignant thyroid tumors.
PUBDATE: 19800901
Thirty-eight patients with residual or recurrent primary thyroid cancers which did not take up 1-131 were treated with external beam irradiation. Excluding 5 patients with malignant lymphoma, there were 23 patients with local disease and 10 with distant metastases. Doses ranged from 3,500 to 7,000 rads (35-70 Gy) among the 23 with local disease; local tumor control was achieved in 8. Six are alive and well 2-11 years later. External beam irradiation should be considered in locally advanced, incompletely resected, recurrent and metastatic thyroid malignancies of all histological types without 1-131 uptake. Reviewed are the age and sex distribution, histology, stage, extent of surgery, and dose and radiotherapy technique as they affect survival and patterns of failure.

14. DOCID:7735 SCORE: 0.00172110797886175
DOCNO: 213337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: ultrastructure
QUALIFIER: immunology
AUTHOR: H Ogawa H
AUTHOR: H Tanaka H
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Occurrence of antibody against intracytoplasmic A-particles of mouse mammary tumor virus in sera from breast cancer patients.
PUBDATE: 19780801
Acetone-fixed smears of DBA/2 mouse leukemia cells that produce clusters of intracytoplasmic A-particles (pronucleocapsids of mouse mammary tumor virus) were employed as an indirect immunofluorescence system to detect the antibody to A-particles in human sera. With positive test sera, specific fluorescence was easily detectable as discrete cytoplasmic granules at the site of A-particle clusters. The antibody was found in 26 (60%) out of 43 breast cancer patient sera and 4 (25%) of 16 mammary fibroadenoma patient sera, while only 4 (11%) out of 37 control woman sera were antibody-positive. In the case of breast cancer patients, occurrence of tha antibody was not specifically related to a particular type of tumor histology. In a considerable number of positive cases, the antibody tended to disappear within various lengths of time after surgical operation of the breast cancer.