0. DOCID:3734 SCORE: 0.00279695560822604
DOCNO: 1176552
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: surgery
QUALIFIER: complications
AUTHOR: M Guivarc'h M
AUTHOR: J Marquand J
AUTHOR: B Chiche B
AUTHOR: A Mouchet A
PUBTYPE: Journal Article
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Surgical methods in non-traumatic perforations of the colon into the free peritoneum (36 cases)]
PUBDATE: 19750301
When operating as an emergency for a perforation of the colon should one carry out a by-pass operation, colostomy or restore intestinal continuity? 36 colonic perforations are reported here, as a complication of cancer in 50 p. 100 of cases, or sigmoiditis in 38 p. 100 of cases. The perforation was situated on the sigmoid in 77 p. 100 of cases. 13 by-pass operations were carried out with a 23 p. 100 mortality, 12 colectomies without anastomosis with a 50 p. 100 mortality, and 2 colectomies with restoration of continuity, 9 p. 100 mortality. The overall mortality was 27.7 p. 100 much less than reported by other authors but, nevertheless partly due to the severity of peritonitis due to the presence of feces and, partly due to the operation adopted. The present attitude of the authors depends on the merits of each case. A large incision is made and the peritoneum thoroughly cleaned. If the surgeon is experienced, colonic resection is advisable for perforated cnacer and certain cases of sigmoiditis. Restoration of continuity depends, above all, on the anatomical condition of the colon above the lesion. Hartmann's resections or by-pass operations thus still have indications.


1. DOCID:14674 SCORE: 0.00253279603876608
DOCNO: 3175558
AUTHOR: C E Minder CE
AUTHOR: J P Vader JP
AFFILIATION: Department of Social and Preventive Medicine, University of Berne, Switzerland.
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of work, environment & health.
COUNTRY: FINLAND
TITLE: Malignant pleural mesothelioma among Swiss furniture workers. A new high-risk group.
PUBDATE: 19880801
Within the framework of a research project concerning occupational mortality, attention was drawn to a highly significant standardized mortality ratio for mesothelioma among furniture workers. From information drawn from the mortality records for the years 1979-1985 and from the 1980 national census, the number of pleural mesotheliomas among this occupational group was examined. The expected number of deaths from pleural mesothelioma among Swiss furniture workers for this period was 4.4; the observed number was 12. This finding indicates a 2.7-fold relative risk (P = 0.004) for death due to these cancers among Swiss furniture workers.


2. DOCID:3418 SCORE: 0.00242029040338402
DOCNO: 3117
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: M A Batata MA
AUTHOR: W F Whitmore WF
AUTHOR: B S Hilaris BS
AUTHOR: N Tokita N
AUTHOR: H Grabstald H
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Cancer of the undescended or maldescended testis.
PUBDATE: 19760201
An analysis of 45 cryptorchids (by history or examination) with a testicular cancer treated at Memorial Hospital, between 1934 and 1973, is presented. Twenty-five patients had the cryptorchid state repaired at ages four to 27 years, either spontaneously or by orchiopexy or hormonal therapy. Ipsilateral (24) or contralateral (one) intrascrotal testis tumors developed four to 47 years later. Twenty cryptorchid patients presented with ipsilateral inguinal (eleven), abdominal (seven), or contralateral intrascrotal (two) tumors. There were 18 pure seminomas, 17 embryonal carcinomas, nine teratocarcinomas, and one reticulum cell sarcoma. Five year survival rates as estimated by the product-limit method were 60% for the unrepaired cases and 41% for the repaired cases. The survival seems to follow histologic type and anatomical stage, whether the testis is within the scrotum or not. Five year survival similarly estimated was 78% in the seminomas and 29% in the other tumors. Twelve of thirteen survivors (including nine with seminoma) received postoperative irradiation to the regional lymphatics and eleven were without recurrent tumor for periods ranging from six to 28 years.


3. DOCID:11968 SCORE: 0.00240928374794398
DOCNO: 6702939
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ascitic Fluid
QUALIFIER: diagnosis
AUTHOR: S Yoshimura S
AUTHOR: R E Scully RE
AUTHOR: D A Bell DA
AUTHOR: P D Taft PD
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Correlation of ascitic fluid cytology with histologic findings before and after treatment of ovarian cancer.
PUBDATE: 19840301
One hundred thirteen specimens of ascitic fluid from 97 patients with primary, persistent, or recurrent ovarian cancer were examined cytologically. Advanced stage of disease, involvement of the ovarian surface, a moderate or large volume of fluid, and nonbloody serous ascites were factors that correlated with a high rate of positive findings in ascites in these patients. Other factors influencing the positive rate appeared to be the invasive as opposed to borderline malignant histology of the tumor. Involved external surface and volume of ascites were influencing factors only in advanced cases. Therefore, the most important factor influencing the positive rate of ascites cytology was the proportion of cases in advanced stages to total cases.


4. DOCID:3837 SCORE: 0.00233030131418485
DOCNO: 856959
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: G J Draper GJ
AUTHOR: M M Heaf MM
AUTHOR: L M Kinnier Wilson LM
PUBTYPE: Journal Article
JOURNALTITLE: Journal of medical genetics.
COUNTRY: UNITED STATES
TITLE: Occurrence of childhood cancers among sibs and estimation of familial risks.
PUBDATE: 19770401
An analysis which includes the majority of the cases of childhood cancer occurring in Britain over a period of about 20 years suggests that there is a small familial element in the aetiology of these diseases; aggregations within sibships were observed more frequently than would be expected by chance. Possible explanations of these findings are considered. Some, perhaps many, of the cases within such sibships may be due to associations between malignant disease and various genetically determined conditions at a suclinical level or in the heterozygous state. Alternatively, the observed familial aggregations may be attributable to the fact that sibs share a common environment. Childhood cancer in twins is discussed and findings compared with those from the United States. Attention is drawn to a number of interesting combinations of tumours in sibs, particularly brain tumours and bone cancers. The implications of the findings for genetic counselling are discussed; it is emphasized that, though there appears to be an increased risk that sibs of children with malignant disease will also be affected by such diseases, this amounts overall only to a doubling of the general population risk. Whether or not the explanation is a genetic one, the actual magnitude of the risk for such sibs is only about 1 in 300.


5. DOCID:3283 SCORE: 0.00232524980339228
DOCNO: 195975
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Complement Fixation Tests
DESCRIPTOR: Cytotoxicity Tests, Immunologic
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Subramanian T
AUTHOR: W E Rawls WE
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical microbiology.
COUNTRY: UNITED STATES
TITLE: Comparison of antibody-dependent cellular cytotoxicity and complement-dependent antibody lysis of herpes simplex virus-infected cells as methods of detecting antiviral antibodies in human sera.
PUBDATE: 19770601
An antibody-dependent cellular cytotoxicity (ADCC) assay was used to detect antibodies to the herpes simplex viruses in humans sera. The assay utilized the release of 51Cr from BHK-21 cells infected with the viruses, hamster peritoneal exudate cells as effector cells, and antiviral antibodies in human sera. The technique was found to be far more sensitive than complement-dependent antibody lysis of infected cells and virus neutralization. The ADCC assay was useful in detecting antibodies in sera that had low titers or no antibodies detectable by other methods. In a sample of 100 sera from university students, 40 were positive by complement-dependent lysis whereas 73 were positive by ADCC. Of 400 sera from women with cervical cancer, 17 did not have detectable antibodies by microneutralization or complement-dependent lysis; however, all sera were positive by ADCC, suggesting that all of the women had been infected in the past with one or both types of herpes simplex virus.


6. DOCID:3449 SCORE: 0.00230746522269689
DOCNO: 1160463
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Glottis
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: E Bocca E
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Supraglottic cancer.
PUBDATE: 19750801
Supraglottic cancer, because of the embryological development of the larynx, and of the arrangement of its lymphatic network, tends to remain limited within the vestibule of the larynx and the pre-epiglottic space also in its advanced stages of evolution. The cancer spread may superiorly involve the epilarynx, the vallecula, the base of the tongue, and the pyriform fossa; however, inferiorly, the invasion of the glottis is quite exceptional (1 percent of cases); therefore, supraglottic laryngectomy is the operation of choice. The lower the location of cancer in the vestibule, the safer the indication. The higher location generally requires an extension of surgical excision toward the tongue, arytenoids and hypopharnx. In view of the high percentage of lymph node metastases, supraglottic laryngectomy should be associated with neck dissection, mainly bilateral, also in cases with no evidence of enlarged lymph nodes. Supraglottic laryngectomy has been performed in 240 cases in the course of the last 14 years and the five-year cure rate has been 79 percent. Five postoperative deaths have been recorded. Rehabilitation time for the breathing and swallowing function has been three weeks as an average. Complications, such as fistula or infection have been exceedingly rare: uneventful recovery followed in all cases.


7. DOCID:11800 SCORE: 0.00229334473748117
DOCNO: 6181700
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M B Spaulding MB
AUTHOR: A Kahn A
AUTHOR: R De Los Santos R
AUTHOR: D Klotch D
AUTHOR: J M Loré JM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Adjuvant chemotherapy in advanced head and neck cancer. An update.
PUBDATE: 19821001
Two courses of triple-agent chemotherapy were given to 47 patients with advanced head and neck cancer. All but one patient with a nasopharyngeal carcinoma had resectable stage III and IV squamous cell carcinoma. Eighty-eight percent of the patients responded to the chemotherapy with a 50 percent or greater decrease in tumor size. Forty-three patients underwent surgical resection and 19 were histologically upgraded to stage II or better (T less than 2 cm, N0). None of these 19 patients have relapsed, with follow-up ranging from 12 to 42 months. In 12 of the 47 patients, recurrent tumor developed within the first 18 months of follow-up.


8. DOCID:7455 SCORE: 0.00222856265482677
DOCNO: 7431681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gastrectomy
DESCRIPTOR: Splenectomy
QUALIFIER: immunology
AUTHOR: M Takahashi M
AUTHOR: S Fujimoto S
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Clinical studies on the correlation between immunologic status and total gastrectomy combined with splenectomy.
PUBDATE: 19800601
The influence of splenectomy on the immunologic status of stomach cancer patients was studied. Eight gastric cancer patients having undergone total gastrectomy combined with splenectomy were evaluated immunologically. Peripheral lymphocyte counts were depressed and continued to be so in splenectomized patients. PHA-induced lymphocyte blastogenesis decreased rapidly after total gastrectomy with splenectomy and thereafter increased gradually. PHA skin test seemed to take almost the same time course. These recoveries to the normal range were observed 4 weeks after operation. In 10 other patients who had undergone total gastrectomy with splenectomy for gastric cancer and had been recurrence-free for more than 6 months, peripheral lymphocyte and T lymphocyte counts significantly increased compared with 7 cases having undergone total gastrectomy only, though no difference was seen in both PHA skin test and PHA-induced lymphocyte blastogenesis between the 2 groups.


9. DOCID:3945 SCORE: 0.00220355303357132
DOCNO: 185398
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: diagnosis
AUTHOR: M F Notter MF
AUTHOR: J J Docherty JJ
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Comparative diagnostic aspects of herpes simplex virus tumor-associated antigens.
PUBDATE: 19760901
Sera from cancer patients and healthy individuals, obtained from two independent sources, were examined for their abilities to react with herpes simplex virus-associated tumor antigens, AG-4 and NVA-TAA (nonvirion antigen-tumor-associated antigen). Both antigens were prepared by infection of HEp-2 cells with herpes simplex virus type 2, and all antigen-antibody interactions were measured by the micro-complement fixation test. Of sera from 16 patients with cancer of the uterine cervix, 81% (P less than 0.01) reacted with NVA-TAA, whereas 78% (P less than 0.001) of 18 sera examined reacted with AG-4. These values differed significantly from those for normal sera, of which 14% reacted with NVA-TAA and 13% with AG-4. Of sera for 8 patients with squamous cell carcinoma of head and neck or vulva, 75% (P less than 0.02) reacted with NVA-TAA, whereas 63% (P less than 0.05) reacted with AG-4. As a group, other cancers (including adenocarcinoma of lung, breast, ovary, and cervix; liposarcoma; sarcoma; melanoma; and carcinoma of the endometrium) did not differ significantly from controls in reactive patterns with AG-4 or NVA-TAA. These studies partly supported the reported preferential reactivity of AG-4 and NVA-TAA with sera of patients with squamous cell carcinoma, especially of the uterine cervix.


10. DOCID:3434 SCORE: 0.0022014429571082
DOCNO: 1220760
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: E Langvad E
AUTHOR: H Hydén H
AUTHOR: H Wolf H
AUTHOR: N Kroeigaard N
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Extracorporeal immunoadsorption of circulating specific serum factors in cancer patients.
PUBDATE: 19751201
Circulating serum factors have been said to abrogate the effects of immune response in cancer, i.e. "blocking" and "antigenic inhibition". The aim of this investigation was to isolate such specific factors in a purified and native state. F(ab)2 fragments isolated from hypernephroma were insolubilized on the surfaces of an extracorporeal perfusion chamber which was inserted into the circulation by means of an arterio-venous shunt. As a result, 3 proteins not present in normal serum were isolated and eluted for further study. In immunoelectrophoresis the 3 proteins were specifically precipitated by heterolgous (rabbit) antihypernephroma serum but not by anti-serum directed against normal serum components. Moreover C9 components, C3 activator and C3 were isolated in the chamber, the latter complement factor in large concentrations. This further sustained that specific antigen-antibody reactions had occurred in the chamber. One of the 2 patients studied were perfused for 60 h and 40 min. During this period 450 litres of blood were brought into intimate contact with the immunoadsorbent. Proteins in amounts sufficient for immunochemical analysis were isolated within 3 h.


11. DOCID:7896 SCORE: 0.00217593176605327
DOCNO: 7449091
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: methods
QUALIFIER: blood
QUALIFIER: enzymology
AUTHOR: L Kahan L
AUTHOR: V L Go VL
AUTHOR: F C Larson FC
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Increased activity in serum of an alkaline phosphatase isoenzyme in cancer: analytical method and preliminary clinical studies.
PUBDATE: 19810101
Serum of cancer patients often contains high activities of a homoarginine-sensitive isoenzyme of alkaline phosphatase with high electrophoretic mobility, which is present in relatively low activities in sera from most normal persons and persons with benign disease. In earlier studies of this isoenzyme, in a semi-quantitative assay, electrophoresis was used in the separation step. This report describes a column separation procedure, which provides quantitative data. We tested the revised procedure by assaying a mixed panel of 192 sera (cancer, benign disease, and normal). The organ sites of cancer and benign disease in this study were: lung, pancreas, uterus, and ovaries. The isoenzyme showed moderate sensitivity for lung (0.6) and pancreas (0.8) cancer and high specificity for all cancers tested. Thus the assay may be useful for discriminating between cancer sera and non-cancer sera for these cancer types.


12. DOCID:15317 SCORE: 0.0021656532228423
DOCNO: 3798569
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: M Reinfuss M
AUTHOR: S Korzeniowski S
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Results of combined radiotherapy and multidrug chemotherapy in advanced squamous cell cancer of the head and neck.
PUBDATE: 19861001
Treatment results of combined radiotherapy and polychemotherapy in a group of 38 patients with advanced squamous cell of the head and neck cancer are presented. The radio-chemotherapy schedule included 60Co irradiation with 20 Gy in 10 fractions over two weeks followed by multidrug chemotherapy with vincristine, bleomycin, methotrexate and leucovorin. Three series of radio-chemotherapy were given. In 14 patients the total dose of irradiation was increased to 70-105 Gy. The probabilities of overall and symptom-free survival at 2 years were 32% and 20%, respectively. Treatment results correlated with stage of the disease. Patients who received higher doses of radiation seemed to have better chances of symptom-free survival.


13. DOCID:15391 SCORE: 0.00216563295465211
DOCNO: 2820741
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: D A Morgan DA
AUTHOR: D Gilson D
AUTHOR: J Fletcher J
AFFILIATION: Hogarth Centre of Radiotherapy and Oncology, General Hospital, Nottingham, England.
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Vincristine and etoposide: an effective chemotherapy regimen with reduced toxicity in extensive small-cell lung cancer.
PUBDATE: 19870601
Chemotherapy prolongs survival of patients with small-cell lung cancer, but very few are cured, and the treatment is unpleasant. Thirty patients, 28 with advanced disease, were treated with etoposide 250 mg/m2 orally, daily for 5 days, plus vincristine 2 mg intravenously on the first day, the cycle being repeated 3-weekly, to a maximum of 6. There was a response rate of 70%, a median survival of 249 days, and an 11% 2-year survival. Symptomatic side-effects were less pronounced than with most other regimens of comparable efficacy.


14. DOCID:3880 SCORE: 0.00214487315255739
DOCNO: 177201
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: K Sato K
AUTHOR: K Satoh K
AUTHOR: T Sato T
AUTHOR: F Imai F
AUTHOR: H P Morris HP
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Isozyme patterns of glycogen phosphorylase in rat tissues and transplantable hepatomas.
PUBDATE: 19760201
Isozyme patterns of glycogen phosphorylase in the Morris and Yoshida hepatomas were compared electrophoretically and immunochemically with those in rat tissues during development. A 3rd phosphorylase isozyme, observed previously in hepatomas and fetal tissues by isoelectric focusing and by immunochemical titration, was also separated by polyacrylamide disc gel electrophoresis. It was observed commonly in various rat hepatomas, together with variable activities of the liver type, depending on the degree of differentiation. This isozyme is nearly the sole type in placenta and early embryo, and in liver and skeletal muscle it is replaced during fetal development with the organ-specific liver and muscle type. In adult rat brain the fetal type is retained at low levels, together with the muscle type. In kidney, spleen, testis, uterus, lung, and stomach, the fetal type is present together with the liver type. This isozyme in hepatomas and adult brain is identical with the fetal-type, as determined by Ouchterlony double diffusion and activity inhibition tests. Thus, it is considered to be a prototype whose appearance in hepatomas is one of many known examples of fetal protein expression in cancer. In some poorly differentiated hepatomas, the liver-type isozyme migrated slightly more slowly in polyacrylamide gel but could not be distinguished from the liver isozyme immunochemically.