0. DOCID:31841 SCORE: 0.00342231862524653
DOCNO: 12063828
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Christophe Rosty C
AUTHOR: Michael Goggins M
AFFILIATION: Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205-2196, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: United States
TITLE: Early detection of pancreatic carcinoma.
PUBDATE: 20020201
The poor prognosis and late presentation of pancreatic cancer patients emphasize the importance of an effective early detection strategy for patients at risk of developing pancreatic cancer. In current practice, the use of CA 19-9 levels and imaging techniques is not optimal for detecting small pancreatic lesions. It is hoped that the understanding of genetic alterations in combination with the development of high-throughput sensitive techniques will lead to the rapid discovery of a panel of biomarkers that will save lives by enabling aggressive therapy at the time when tumors are curable.


1. DOCID:31747 SCORE: 0.00342231781702016
DOCNO: 16195752
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: veterinary
QUALIFIER: epidemiology
AUTHOR: Vladimir N Anisimov VN
AUTHOR: Svetlana V Ukraintseva SV
AUTHOR: Anatoly I Yashin AI
AFFILIATION: Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg 197758, Russia. aging@mail.ru
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Cancer in rodents: does it tell us about cancer in humans?
PUBDATE: 20051001
Information obtained from animal models (mostly mice and rats) has contributed substantially to the development of treatments for human cancers. However, important interspecies differences have to be taken into account when considering the mechanisms of cancer development and extrapolating the results from mice to humans. Comparative studies of cancer in humans and animal models mostly focus on genetic factors. This review discusses the bio-epidemiological aspects of cancer manifestation in humans and rodents that have been underrepresented in the literature.


2. DOCID:26170 SCORE: 0.00283806564276213
DOCNO: 9794815
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: S A Kliewer SA
AUTHOR: T M Willson TM
AFFILIATION: Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina, 27709, USA. sak15922@glaxowellcome.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: The nuclear receptor PPARgamma - bigger than fat.
PUBDATE: 19981001
Work reported over the past year has provided insights into the mechanisms whereby ligand activation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) regulates systemic glucose and lipid homeostasis. PPARgamma has also been implicated recently in the biology of monocytes and in cell-cycle regulation and cancer. Polyunsaturated fatty acids and eicosanoids bind and activate PPARgamma, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes.


3. DOCID:31264 SCORE: 0.00282504370138493
DOCNO: 15770342
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Peter B Kahla PB
AUTHOR: Sebastiano Cassaro S
AUTHOR: Felix G Vladimir FG
AUTHOR: Michael G Wayne MG
AUTHOR: Angelo Cammarata A
AFFILIATION: Cabrini Medical Center, Department of Surgery, Mount Sinai School of Medicine, D-309, 227 East 19th Street, New York, NY 10003, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Mount Sinai journal of medicine, New York.
COUNTRY: United States
TITLE: Bilateral synchronous breast cancer in a male.
PUBDATE: 20050301
Breast cancer in males is rare, accounting for less than 1% of all cases. Bilateral male breast cancer is reported to occur in fewer than 2% of all the diagnosed cases of male breast cancer, and synchronous tumors are exceedingly rare. The authors report a case of male breast cancer that is bilateral and synchronous, and review the literature on male breast cancer.


4. DOCID:27174 SCORE: 0.00275212378130337
DOCNO: 10680076
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: B Zachariah B
AUTHOR: L Balducci L
AFFILIATION: Department of Radiology, University of South Florida College of Medicine, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Radiation therapy of the older patient.
PUBDATE: 20000201
Radiotherapy has a major role in the multidisciplinary approach to cancer therapy. It is widely used for curative and palliative treatment of cancer involving various sites. Radiotherapy is of particular benefit to older and frail cancer patients as an alternative to surgery and to systemic therapy. The available data on the sensitivity of normal tissues to radiotherapy in elderly patients strongly suggest that older patients with good functional status tolerate radiotherapy as well as younger patients and have comparable tumor response and survival rates. Aggressive radiotherapy should not be withheld from older patients because of chronological age alone.


5. DOCID:31474 SCORE: 0.00246412440616144
DOCNO: 16277930
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: Michael Patrick Achiam MP
AUTHOR: Elizaveta Chabanova E
AUTHOR: Vibeke Berg L√łgager VB
AUTHOR: Henrik S Thomsen HS
AUTHOR: Ole Haagen Nielsen OH
AFFILIATION: Amtssygehuset i Herlev, Afdelingen for Diagnostisk Radiologi, Herlev.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Magnetic resonance colonography: a new diagnostic tool]
PUBDATE: 20051101
Magnetic resonance colonography (MR colonography) is a three-dimensional imaging of the colon. Data postprocessing also allows for virtual colonoscopy, depicting the intraluminal morphology. Acquisition and postprocessing of high-resolution images require a state-of the-art modern MR scanner and a workstation. Regarding patient preparation, a bowel cleansing is necessary. The results of cancer screening have shown MR colonography to be superior to the traditional double-contrast barium enema. In inflammatory bowel disease, MR colonography can be used to assess disease activity, including spreading.


6. DOCID:31365 SCORE: 0.00246412287072372
DOCNO: 16164103
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
DESCRIPTOR: Women's Health
QUALIFIER: diagnosis
QUALIFIER: prevention & control
AUTHOR: Mary B Barton MB
AFFILIATION: Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, MA 02215, USA. mary_barton@hms.harvard.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: United States
TITLE: Breast cancer screening. Benefits, risks, and current controversies.
PUBDATE: 20050801
Mammography is the best tool available for screening for breast cancer. Although the data supporting clinical breast examination are not as strong, this procedure continues to be widely used in the United States. To maximize accuracy of results, women who undergo screening during their premenopausal years should attempt to schedule mammography during the follicular phase of the menstrual cycle. All women should be educated about the benefits and the harms of screening, including the risk of being called back for further testing.


7. DOCID:25396 SCORE: 0.00236229869650318
DOCNO: 11140867
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: methods
QUALIFIER: pathology
AUTHOR: A J Cochran AJ
AFFILIATION: Department of Pathology, University of California Los Angeles School of Medicine, 90095-1713, USA. acochran@mednet.ucla.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: United States
TITLE: Melanoma metastases through the lymphatic system.
PUBDATE: 20001201
Pathologists can expect to receive sentinel nodes from patients with cancers other than melanoma, such as breast, vulvar, thyroid, and colon cancers. Many of the recommendations in this article can be extrapolated to cancers other than melanoma, but there are some peculiarities that relate to each type of tumor. The pathologist should carefully review the published literature before attempting to evaluate sentinel nodes from patients with an unfamiliar form of cancer.


8. DOCID:26654 SCORE: 0.00230118531298908
DOCNO: 11170679
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: pharmacology
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: pharmacology
AUTHOR: J E van Der Kaaden JE
AUTHOR: T K Hemscheidt TK
AUTHOR: S L Mooberry SL
AFFILIATION: Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii, 96822, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa.
PUBDATE: 20010101
A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC(50) value of 1.3 microM in both cases.


9. DOCID:26139 SCORE: 0.00225810398797578
DOCNO: 10945003
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Etoposide
QUALIFIER: therapeutic use
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S Negoro S
AUTHOR: N Masuda N
AFFILIATION: Dept. of Respiratory Disease, Osaka City General Hospital.
PUBTYPE: Clinical Trial
PUBTYPE: Clinical Trial, Phase II
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Combination of irinotecan hydrochloride and etoposide for treatment of refractory or relapsed small-cell lung cancer]
PUBDATE: 20000701
We used a combination of irinotecan and etoposide with recombinant human granulocyte colony-stimulating factor as a support therapy for refractory or relapsed small-cell lung cancer (SCLC). This combination regimen was active against refractory or relapsed SCLC as gauged by a response rate of 71% and a median survival time of 271 days. Further studies of this combination regimen in refractory or relapsed SCLC are warranted.


10. DOCID:24312 SCORE: 0.00221556048840088
DOCNO: 10603758
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: radiotherapy
AUTHOR: L Kempf L
AUTHOR: N Keldsen N
AUTHOR: K L Rasmussen KL
AFFILIATION: Arhus Universitetshospital, onkologisk afdeling.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Cancer of the endometrium following radiotherapy of cervical cancer]
PUBDATE: 19991101
We describe three cases of women who have been treated with radiotherapy for cervical cancer and then many years later develop cancer of the uterine endometrium. Apparently there may be active endometrium left in the uterus after radiotherapy, for which reason we recommend combined hormone therapy with oestrogen and progesterone.


11. DOCID:26243 SCORE: 0.00198723611905769
DOCNO: 10611683
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: etiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: F McCormick F
AFFILIATION: UCSF Cancer Center, Cancer Research Institute, 2340 Sutter St, San Francisco, CA 94115, USA. mccormick@cc.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in cell biology.
COUNTRY: ENGLAND
TITLE: Signalling networks that cause cancer.
PUBDATE: 19991201
Cancer is caused by the stepwise accumulation of mutations that affect growth control, differentiation and survival. The view that mutations affect discrete signalling pathways, each contributing to a specific aspect of the full malignant phenotype, has proved to be too simplistic. We now know that oncogenes and tumour suppressors depend on one another for their selective advantage, and that they affect multiple pathways that intersect and overlap. The interactive nature of each genetic change has important implications for cancer therapy and for the stepwise model of carcinogenesis.


12. DOCID:30058 SCORE: 0.001858978480519
DOCNO: 14976427
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: MAP Kinase Signaling System
DESCRIPTOR: Protein Biosynthesis
QUALIFIER: pathology
QUALIFIER: metabolism
AUTHOR: Eric C Holland EC
AFFILIATION: Memorial Sloan Kettering Cancer Center, Department of Surgery (Neurosurgery), New York, New York 10021, USA. hollande@mskcc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cell cycle (Georgetown, Tex.)
COUNTRY: United States
TITLE: Regulation of translation and cancer.
PUBDATE: 20040401
One of the effects of oncogenic signaling appears to be differentiated recruitment of mRNA's to ribosomes. The mRNA's so affected frequently encode proteins involved in growth regulation cell-cell interaction. These functions are critical for both cancer and development, potentially suggesting that the normal role of differential translation may be during development. It is not known whether this effect is sufficient to induce cancer from cells with an initial non-neoplastic gene expression profile.


13. DOCID:27209 SCORE: 0.00180820558843293
DOCNO: 9795714
AUTHOR: D Hader D
AUTHOR: K Moss K
AUTHOR: N Geier N
AFFILIATION: Community Memorial Hospital, Menomonee Falls, Wis., USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: AORN journal.
COUNTRY: UNITED STATES
TITLE: Sentinel lymph node biopsy using lymphoscintigraphy.
PUBDATE: 19981001
Cancer surgery has existed as an elective treatment modality for more than 150 years, yet it is relatively unsophisticated in light of the advances seen in other medical disciplines. Using the nuclear medicine technique of lymphoscintigraphy (i.e., mapping lymph nodes using a radioactive isotope), the surgeon can perform a sentinel lymph node biopsy that targets only the lymph nodes that first drain a primary tumor site. This procedure can provide accurate staging information without risking the potential morbidity associated with lymph node dissection. This type of precise biopsy is made possible by using a gamma-detecting instrument coupled with an ultrasensitive probe designed for intraoperative use.


14. DOCID:29302 SCORE: 0.00177274886946943
DOCNO: 14763134
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: David Bates D
AFFILIATION: Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Southwell Street, Bristol, BS2 8EJ, UK. Dave.Bates@bris.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in investigational drugs (London, England : 2000)
COUNTRY: England
TITLE: ZD-6474. AstraZeneca.
PUBDATE: 20031201
ZD-6474, one of a series of inhibitors of vascular endothelial growth factor receptor tyrosine kinase, which also has activity against the epidermal growth factor receptor tyrosine kinase, is under development by AstraZeneca for the potential treatment of solid tumors. Phase II trials in non-small-cell lung cancer, small-cell lung cancer and myeloma were ongoing in January 2003.