0. DOCID:15728 SCORE: 0.00250110618535663
DOCNO: 3472698
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Renal Dialysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: D Docci D
AUTHOR: E Pistocchi E
AUTHOR: F Turci F
AUTHOR: L Baldrati L
AUTHOR: S Urbini S
AUTHOR: S Scaioli S
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nephrology.
COUNTRY: GERMANY, WEST
TITLE: Serum CA 19-9 and CA 50 antigens in hemodialysis patients.
PUBDATE: 19870401
Serum concentrations of monoclonal antibody-defined tumor markers CA 19-9 and CA 50 were measured in 64 uncomplicated hemodialysis patients (Group 1) and in 8 hemodialysis patients with cancer (Group 2) in comparison with corresponding CEA determinations. From our results in Group 1 patients it appears that both CA 19-9 and CA 50 maintained an excellent specificity in these patients. As to the sensitivity of these tests, our findings in Group 2 patients are comparable with those reported in patients with cancer and normal renal function. It is concluded that, unlike CEA, these new tumor markers maintain their clinical value in chronic renal failure.


1. DOCID:13633 SCORE: 0.00240958006660386
DOCNO: 3335036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pathology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: J A McBain JA
AUTHOR: G R Pettit GR
AUTHOR: G C Mueller GC
AFFILIATION: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
PUBTYPE: Journal Article
JOURNALTITLE: Carcinogenesis.
COUNTRY: UNITED STATES
TITLE: Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
PUBDATE: 19880101
12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatin 1, a macrocyclic lactone, completely counteracts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.


2. DOCID:13766 SCORE: 0.00240956182164911
DOCNO: 2922868
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: P R Olsen PR
AUTHOR: F Lund F
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Laser treatment of penile cancer]
PUBDATE: 19890201
The treatment of localized penile cancer has hitherto been surgical amputation of the penis. In our 12 cases, tumorectomy was performed by CO2 or ND:YAG-laser radiation with minimal tissue ablation. Local recurrences occurred and the patients must be followed regularly in the outpatient clinic. The recurrences were treated by repeated laser radiation. No patients died of penile cancer during a mean observation of 16 months (range 3-50). Laser tumorectomy has definitive therapeutic advantages compared with penile amputation, because the result is acceptable for the patient and his micturition and sexual life are not altered.


3. DOCID:15262 SCORE: 0.00234648484153329
DOCNO: 2718294
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cystoscopes
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnostic use
QUALIFIER: instrumentation
AUTHOR: D Jocham D
AUTHOR: R Baumgartner R
AUTHOR: N Fuchs N
AUTHOR: H Lenz H
AUTHOR: H Stepp H
AUTHOR: E Unsöld E
AFFILIATION: Urologische Klinik und Poliklinik LMU München.
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Fluorescence diagnosis of porphyrin-marked urothelial tumors. Status of experimental development]
PUBDATE: 19890301
On the basis of selective storage of fluorescing hematoporphyrin derivative (HpD) in tumors, a method has been developed that enables the endoscopic detection of early-stage cancer by monitoring fluorescent images. The contrast-reducing portion of the superposed tissue autofluorescence is suppressed by the use of two-wavelength excitation and subsequent image processing in realtime. The amount of photosensitizing HpD necessary for diagnostic purposes is considerably reduced by means of sensitive detection devices. A clear distinction between benign and malignant bladder tissue seems possible according to the results of animal studies.


4. DOCID:15729 SCORE: 0.00227025305355971
DOCNO: 3565656
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hispanic Americans
DESCRIPTOR: Mortality
AUTHOR: I Rosenwaike I
PUBTYPE: Journal Article
JOURNALTITLE: American journal of public health.
COUNTRY: UNITED STATES
TITLE: Mortality differentials among persons born in Cuba, Mexico, and Puerto Rico residing in the United States, 1979-81.
PUBDATE: 19870501
This paper examines the mortality experience in 1979-81 of three first generation Hispanic subpopulations in the United States, as defined by area of birth (Cuba, Mexico, Puerto Rico). Numerators were derived from National Center for Health Statistics (NCHS) mortality tapes, which included codes for selected places of birth appearing on the death certificate. Denominators were based on decennial census data for these migrant populations from the 1980 census. Generally, mortality is relatively high among Cuban-born, Mexican-born and Puerto Rican-born adolescents and young adults, particularly males, largely due to violent deaths. Aged migrants, despite their disadvantaged socioeconomic status, exhibit relatively low death rates from heart disease and cancer.


5. DOCID:14985 SCORE: 0.00212637196207438
DOCNO: 2625105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnostic use
QUALIFIER: analysis
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: H Wu H
AFFILIATION: Peking Union Medical College Hospital, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Imaging and biodistribution of 111In-labeled anti-carcinoembryonic antigen monoclonal antibodies in nude mice bearing human colon cancer xenografts]
PUBDATE: 19890701
Anti-CEA monoclonal antibody was labeled with 111In using DTPA cyclic anhydride. The radiochemical purity of the product was more than 99% and specific binding was 38%. Imaging and biodistribution of this radiopharmaceutical in nude mice bearing human colon cancer xenografts were investigated. The results showed that a clear image of tumor was obtained by gamma camera between 24 to 120 hrs, best in 72 hrs, after injection. A high uptake of 111In-labeled monoclonal antibodies in tumor tissue was also observed, although the radioactivity in liver was considerable.


6. DOCID:13352 SCORE: 0.00212043817482877
DOCNO: 3779355
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Orchiectomy
QUALIFIER: analogs & derivatives
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: R Haapiainen R
AUTHOR: S Rannikko S
AUTHOR: O Alfthan O
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Comparison of primary orchiectomy with oestrogen therapy in advanced prostatic cancer. A 2-year follow-up report of a national, prospective prostatic cancer study.
PUBDATE: 19861001
Two hundred and seventy-seven patients with advanced prostatic cancer were treated by either orchiectomy or oestrogen. During the 2-year follow-up period, the response to treatment was considered more favourable in the oestrogen group, and this response was particularly emphasised in patients with poorly differentiated tumour and metastases at the time of diagnosis. Further evaluations included the cardiovascular side effects of oestrogen therapy.


7. DOCID:15678 SCORE: 0.00206851884680757
DOCNO: 3488029
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: T Tominaga T
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Chemotherapy of advanced and recurrent colorectal cancer]
PUBDATE: 19860701
Colorectal cancer is one of the most resistant tumors to chemotherapy. The efficacy of many kinds of anti-tumor drugs to the patients with colorectal cancer had been investigated, however most of the drugs was not effective or showed low response rates. As a few effective anti-tumor drug, 5-FU and its derivatives, nitrosoureas and mitomycin C were indicated. Response rates of combinations of these drugs were 20-30%. Methotrexate-5-FU with leucovorin therapy at proper administration intervals showed relatively high response rate to the patients. Effects of intra-arterial infusion of the drugs which often performed to the liver metastases were not so well as expected. Developments of new anti-tumor agents were essential.


8. DOCID:14491 SCORE: 0.00204533710678563
DOCNO: 3052986
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacokinetics
QUALIFIER: drug therapy
AUTHOR: V J Wiebe VJ
AUTHOR: C C Benz CC
AUTHOR: M W DeGregorio MW
AFFILIATION: Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinical pharmacokinetics.
COUNTRY: NEW ZEALAND
TITLE: Clinical pharmacokinetics of drugs used in the treatment of breast cancer.
PUBDATE: 19880901
This article reviews the absorption, bioavailability, distribution, metabolism, and elimination patterns of the agents most commonly used for the treatment of breast cancer. Although the majority of the pharmacokinetic studies reviewed have been examined in non-breast cancer patients, the kinetic findings are not significantly altered by disease state. The anthracyclines, antimetabolites, alkylating agents, antioestrogens and mitotic inhibitors are among the classes of agents used to treat breast cancer. Although extensively examined, cancer pharmacokinetic research has resulted in very few clinically relevant findings in breast cancer.


9. DOCID:15449 SCORE: 0.00202121291890646
DOCNO: 3030347
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: physiology
AUTHOR: G R Pearson GR
PUBTYPE: Journal Article
JOURNALTITLE: AIDS research.
COUNTRY: UNITED STATES
TITLE: The Epstein-Barr virus genome and phenotypic expression during lytic cycle.
PUBDATE: 19861201
The Epstein-Barr Virus (EBV) has been studied extensively as a human cancer virus. Until recently, however, little was known about the viral genes encoding for different proteins involved in the virus immortalization and replication cycles. Most of the efforts have been directed at those genes expressed in immortalized cells. However, more recently, there has also been advances in the mapping of genes encoding for polypeptides expressed in the virus replication cycle and in the characterization of the proteins encoded by these genes. The purpose of this article is to review some of these new developments in identifying viral genes and their products. In addition, the current status of the development of a subviral vaccine against this virus is discussed.


10. DOCID:14470 SCORE: 0.00198575975618248
DOCNO: 3731148
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: K S Wilson KS
AUTHOR: A H Paterson AH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: First-line mitoxantrone chemotherapy for advanced breast cancer.
PUBDATE: 19860801
Results of first-line mitoxantrone chemotherapy for advanced breast cancer are presented. Full dose (14 mg/m2 iv every 3 weeks) was given to 22 patients who had received no previous adjuvant chemotherapy; five (23%) partial responses were seen. No responses were seen in eight patients who had failed adjuvant chemotherapy, of whom seven received full dose. No responses were seen in nine patients receiving lower doses (mean, 10 mg/m2). The overall response rate was 13%. Treatment was well tolerated. Moderate or severe nausea/vomiting and alopecia were infrequent. One patient developed heart failure without predisposing risk factors.


11. DOCID:13495 SCORE: 0.00186934765486096
DOCNO: 2535920
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colectomy
DESCRIPTOR: Neoplasm Recurrence, Local
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: W R Waddell WR
AUTHOR: G F Ganser GF
AUTHOR: E J Cerise EJ
AUTHOR: R W Loughry RW
AFFILIATION: Department of Surgery, University of Colorado, Denver.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Sulindac for polyposis of the colon.
PUBDATE: 19890101
The effect of sulindac, a nonsteroid antiinflammatory drug, on colon polyposis has been evaluated in seven patients after subtotal colectomy and ileoproctostomy and in four patients with intact colons. The patients all had Gardner's syndrome or familial polyposis coli. All polyps were eliminated, except for a few that arose in the rectal mucosa and the anal canal. No cancers developed in these patients on follow-up.


12. DOCID:13287 SCORE: 0.00185167680269814
DOCNO: 3309256
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Light
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: H H Tønnesen HH
AUTHOR: H de Vries H
AUTHOR: J Karlsen J
AUTHOR: G Beijersbergen van Henegouwen G
AFFILIATION: Institute of Pharmacy, University of Oslo, Norway.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pharmaceutical sciences.
COUNTRY: UNITED STATES
TITLE: Studies on curcumin and curcuminoids. IX: Investigation of the photobiological activity of curcumin using bacterial indicator systems.
PUBDATE: 19870501
The dye curcumin is a natural, nontoxic food constituent. On irradiation with visible light, curcumin proves to be phototoxic for Salmonella typhimurium and Escherichia coli, even at very low concentrations. The observed phototoxicity makes curcumin a potential photosensitizing drug which might find application in the phototherapy of, for example, psoriasis, cancer, and bacterial and viral diseases.


13. DOCID:15791 SCORE: 0.00178853849501427
DOCNO: 3079327
AUTHOR: G L Schechter GL
AUTHOR: J T Kalafsky JT
AFFILIATION: Dept of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Cancer of the hypopharynx and cervical esophagus: management concepts.
PUBDATE: 19880501
Treatment of cancer of the pharyngoesophageal region requires a multidisciplinary team approach using combined radiotherapy and surgery. Since patients with this cancer usually present for treatment after their tumors have reached advanced stages, their nutritional status is usually poor and must be dealt with prior to instituting therapy. Resection must be radical and usually produces a multifunctional defect. Reconstructive choices are varied, depending on the patient's general condition, the abilities of the head and neck surgeon, and the availability of other surgical specialties to help with reconstruction. Although treatment has become safer and provides a more functional existence, pharyngoesophageal cancer is still a deadly disease that kills two out of three patients.


14. DOCID:15037 SCORE: 0.00178240350710092
DOCNO: 3572217
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: H J Shaw HJ
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: A view of partial laryngectomy in the treatment of laryngeal cancer.
PUBDATE: 19870201
Attention is drawn to the problems of surgical resection by partial laryngectomy after full therapeutic dosage of telecobalt irradiation. Material is presented from two treatment centres to indicate trends in surgical treatment and the complications experienced. Results will be given which confirm a reasonable expectation of cure and functional conservation by vertical partial laryngectomy for recurrence of glottic cancer after irradiation. The results of treatment of recurrent supraglottic cancer by horizontal partial laryngectomy gave more cause for concern in terms of complications and survival. In conclusion an attempt is made, based on the quoted experience, to define the position of conservation surgery in two centres for laryngeal cancer in the United Kingdom.