0. DOCID:11914 SCORE: 0.00285461104846652
DOCNO: 6318725
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: analysis
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: E Kaneto E
AUTHOR: H Sasaki H
AUTHOR: I Tamura I
AUTHOR: O Kurimura O
AUTHOR: T Kurimura T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Biken journal.
COUNTRY: JAPAN
TITLE: Interferon-alpha in serum and carcinomatous pleural effusion after repeated intrapleural injections of antitumor agents.
PUBDATE: 19830601
Pleural effusions and sera of two patients with lung cancer were tested after intrapleural injection of OK-432 as an anticancer drug for IFN-alpha activity by biological assay and for IFN-alpha as an antigen by radioimmunoassay. The titers by radioimmunoassay were fairly consistent with those by biological assay, but were usually higher. In Case 1, IFN-alpha was observed fairly early after administration of OK-432 and only in pleural effusions. In Case 2, induction of IFN-alpha at low level was observed late after the first administration of OK-432 both in the pleural effusion and serum and was detected only by radioimmunoassay.


1. DOCID:11487 SCORE: 0.00281539680622669
DOCNO: 6764113
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: T Ise T
AUTHOR: M Ohira M
AUTHOR: A Omiya A
AUTHOR: M Hirose M
AUTHOR: T Shibata T
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Clinical evaluation of antiemetics for vomiting due to cancer chemotherapy in children]
PUBDATE: 19820701
Comparative study of antiemetic effect on vomiting due to cancer chemotherapy was performed in 62 children with various malignant diseases. Twenty-one children were treated with metoclopramide, 23 children with domperidone and remaining 18 children received methylprednisolone. Each drug was administered intravenously after administration of anticancer agents, and repeated if necessary. The most effective antiemetics was methyl-prednisolone with effective rate of 89% in comparison with 51% of domperidone and 17% of metoclopromide treated group, respectively. Methyl-prednisolone may be useful for severe vomiting due to anticancer drugs. Safer and significantly better therapeutic efficacy was observed in the group treated with domperidone than that with metoclopromide.


2. DOCID:11548 SCORE: 0.00264515233953599
DOCNO: 6711294
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: N Hejgaard N
AUTHOR: E Larsen E
PUBTYPE: Journal Article
JOURNALTITLE: Acta orthopaedica Scandinavica.
COUNTRY: DENMARK
TITLE: Value of early attention to spinal compression syndromes.
PUBDATE: 19840401
In a consecutive series of 125 patients with spinal compression syndromes, neurological regression was evaluated in relation to the time interval from (a) initial symptoms (patient delay), (b) diagnostic recognition (diagnostic delay), and (c) decision on treatment (therapeutic delay) until the time of definitive treatment. Patients with benign lesions showed a statistically significant negative correlation between the duration of (a) + (b) + (c) and the therapeutic result. In cancer patients there was a tendency for rapid progression of the disease to give a poorer result than in patients in whom the course was more insidious. In all, 77 patients improved after a short therapeutic delay (14 h), while in the remaining 48 the status was unchanged or worse after a long delay (34 h); this is a highly significant difference.


3. DOCID:11468 SCORE: 0.00248901619021748
DOCNO: 6351704
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M Baum M
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Current thinking on the management of primary carcinoma of the breast.
PUBDATE: 19830901
The most important advance in the management of early breast cancer over the last 20 years, has been the conceptual revolution whereby the mechanistic/anatomical view of the disease has been replaced by a more complex biological model. As a result of this paradigm shift, the role of local therapy has been redefined and a steady momentum towards a more conservative approach has been initiated. Furthermore, the trials of adjuvant systemic therapy, although not producing the anticipated major breakthrough, have at least demonstrated that the natural history of the disease can be influenced in a favourable direction. Future progress depends on a continuing involvement of all surgeons in multicentre trials and resistance to the establishment of a new therapeutic dogma.


4. DOCID:11159 SCORE: 0.00236238823800086
DOCNO: 6704117
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: M S Stevens MS
AUTHOR: Z Aliabadi Z
AUTHOR: M R Moore MR
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Associated effects of sodium butyrate on histone acetylation and estrogen receptor in the human breast cancer cell line MCF-7.
PUBDATE: 19840201
Sodium butyrate at a concentration of 5mM causes significant hyperacetylation of the core histones in the human breast cancer cell line MCF-7. Histone hyperacetylation was achieved in rapidly-growing cells at 40% confluency after 24 hours in 5mM sodium butyrate. More nearly confluent cells did not reach as high a level of histone hyperacetylation. Upon assaying the estrogen receptors, both cytosolic and KCl-extractable nuclear, we found that butyrate treatment had lowered the estrogen receptor levels in both compartments. To our knowledge this is the first report of an effect of sodium butyrate on estrogen receptor levels.


5. DOCID:11031 SCORE: 0.00235782052821864
DOCNO: 6702745
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T A Garland TA
AUTHOR: D J Innes DJ
AUTHOR: R E Fechner RE
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Salivary duct carcinoma: an analysis of four cases with review of literature.
PUBDATE: 19840401
Salivary duct carcinoma (SDC) is a histologically distinctive neoplasm of the parotid gland. The criteria for the diagnosis of SDC are circumscribed epithelial nests having a papillary, cribriform, and/or solid architecture coupled with central necrosis. The infiltrating cancer can be papillary, resembling the intraductal component or have a nonspecific, undifferentiated pattern. The authors are presenting four cases and compare them with 11 other acceptable cases from the literature. The neoplasm occurs beyond the age of 50 (median 63 years) and has a dismal prognosis with nearly two-thirds of the patients developing distant metastases. All surviving patients have been treated with combined parotidectomy and radiotherapy.


6. DOCID:9915 SCORE: 0.00234730215514434
DOCNO: 4005498
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: complications
AUTHOR: M A Ghoneim MA
AUTHOR: A Ashamalla A
AUTHOR: M A Gaballa MA
AUTHOR: E I Ibrahim EI
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Cystectomy for carcinoma of the bilharzial bladder. 126 patients 10 years later.
PUBDATE: 19850601
Our experience with 126 cases of bilharzial bladder cancer treated by radical cystectomy and followed up for at least 10 years is outlined. The operative mortality rate was 13.5%. The 5- and 10-year survival rates were 32.6 and 23% respectively. The difference between the two figures can be attributed to mortality from natural ageing rather than recurrence of cancer. Analysis of survival figures revealed that the tumour grade was the most important prognostic factor. Most treatment failures were due to local recurrence which developed soon after treatment.


7. DOCID:11319 SCORE: 0.00227979096513094
DOCNO: 7066880
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: I Granberg-Ohman I
AUTHOR: B Tribukait B
AUTHOR: H Wijkström H
AUTHOR: A Alim A
AUTHOR: T Berlin T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Chromosome and DNA cytometric study of a papillary carcinoma of the bladder with a high stemline and numerous double minutes.
PUBDATE: 19820301
A papillary cancer of the bladder [WHO grade 3] was studied with chromosome and DNA analysis. A high frequency of mitoses was noted, and analysis of 151 metaphases revealed a dominating stemline in the pentaploid region. More than 95% of the cells contained double minutes (dm). Flow cytometry showed the dominant stemline to be in the hexaploid region, that is, about 20% above the numerical chromosome value. This difference is generally obtained when these two methods are compared and is not influenced by the presence of dm. Both methods have been complementary in the evaluation of this tumor.


8. DOCID:10760 SCORE: 0.00227263002005601
DOCNO: 10262084
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: legislation & jurisprudence
QUALIFIER: standards
PUBTYPE: Journal Article
JOURNALTITLE: Federal register.
COUNTRY: UNITED STATES
TITLE: Privacy Act of 1974; altered system of records--PHS. Notification of altered Privacy Act system of records 09-25-0074.
PUBDATE: 19830601
In accordance with the requirements of the Privacy Act, the Public Health Service (PHS) is publishing notice of a proposal to alter system of records 09-25-0074, "Clinical Research: Veterans Administration Bladder and Prostate Cancer Clinical Trials, HHS/NIH/NCI." The purpose of the alteration is to modify an existing system of records into an umbrella system by broadening both the categories of individuals under this system and the purposes for which the system is used. The names of the system of records is also being changed to reflect the alteration. The new name is "Clinical Research: Division of Cancer Biology and Diagnosis Patient Trials, HHS/NIH/NCI."


9. DOCID:11515 SCORE: 0.00218621498953364
DOCNO: 6689385
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: M Fazio M
AUTHOR: F Badellino F
AUTHOR: G L Sannazzari GL
AUTHOR: V Vercellino V
AUTHOR: M Airoldi M
AUTHOR: A Manca A
AUTHOR: S Gandolfo S
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Oral and pharyngeal cancer: combined approach for multimodal therapy.
PUBDATE: 19831201
Five-year results in 60 oral and pharyngeal cancer patients treated with combined approach chemoradiotherapy (39 patients) and chemoradiotherapy plus lymph node surgery (21 patients) are reported. Complete remission (CR) was achieved in 16/39 (41%) patients treated with chemoradiotherapy alone, and in 16/21 (76%) patients who had chemoradiotherapy plus surgery. The number of CR was statistically (chi-square test) higher (p less than 0.025) in the second group. The 5-year actuarial survival was 39.7% in the group of patients treated with chemoradiotherapy plus surgery. After 5 years 53% of the patients who reached CR are living free of disease in the first group and 76% in the second group.


10. DOCID:10660 SCORE: 0.00210260713760373
DOCNO: 3897734
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Fragility
AUTHOR: V V Michels VV
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mayo Clinic proceedings. Mayo Clinic.
COUNTRY: UNITED STATES
TITLE: Fragile sites on human chromosomes: description and clinical significance.
PUBDATE: 19851001
The fragile sites of human chromosomes are specific sites that are characterized by a tendency to show gaps, multiradial figures, acentric fragments, and deleted chromosomes on microscopy. These characteristics seem to reflect an inherent fragility at the site, although the underlying biochemical cause of fragile sites is unknown. Investigators have proposed several categories of fragile sites: "rare" or "heritable," "common," and "constitutive." Although the clinical significance of most fragile sites is unknown, fragile site Xq27.3 is associated with one form of X-linked mental retardation. In this article, the three types of chromosome fragile sites are described, and their possible relevance to chromosomal breakage that results in birth defects or cancer is discussed.


11. DOCID:11211 SCORE: 0.00209868368711013
DOCNO: 6610802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Aboud A
AUTHOR: A U Buzdar AU
AUTHOR: H Y Yap HY
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate.
PUBDATE: 19840701
Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue. Of 24 evaluable patients, one achieved a complete remission and 17 had partial responses. The overall objective response rate was 75%. The median survival from initiation of chemotherapy for the responding patients was 18 months. Four patients (17%) with stable disease had a median survival of 25 months. The addition of MTX to FAC chemotherapy did not improve the therapeutic efficacy of this combination; it did, however, increase the overall toxicity, especially the infectious complications when compared to FAC alone.


12. DOCID:10788 SCORE: 0.0020629413948143
DOCNO: 6750057
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Dust
DESCRIPTOR: Wood
QUALIFIER: etiology
QUALIFIER: chemically induced
AUTHOR: J H Wills JH
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of occupational medicine. : official publication of the Industrial Medical Association.
COUNTRY: UNITED STATES
TITLE: Nasal carcinoma in woodworkers: a review.
PUBDATE: 19820701
Analysis of data from 12 countries revealed that 61.3% of cases of primary cancer of the upper respiratory tract, and 78.5% of those classified as adenocarcinoma, observed in areas in which furniture making or other manipulation of wood was an important occupation, had occurred in woodworkers. Machine sanding of hardwoods may entail an especially high risk of development of cancer within the sinonasal area. The data suggest that, although the mean period of latency for development of sinonasal cancers is of the order of 40 to 45 years, the period of exposure to wood dust that may result in the development of mucosal neoplasms may be considerably shorter.


13. DOCID:9513 SCORE: 0.00203695954704335
DOCNO: 6326291
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: C Barre C
AUTHOR: C Caron-Poitreau C
AUTHOR: H François H
AUTHOR: L Rognon L
PUBTYPE: Journal Article
JOURNALTITLE: La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris.
COUNTRY: FRANCE
TITLE: [Computed x-ray tomography in the detection of venous extension in renal cancer]
PUBDATE: 19840401
With reference to eleven cases of renal cancer with involvement of the inferior vena cava, CT semeiology of this venous complication is detailed. Furthermore, the authors suggest that the images are capable of a pathological interpretation which may indicate whether the obstruction is caused by the tumor or a thrombus. Lastly, the value and limitations of CT scan for detecting caval obstructions associated with renal cancer are analyzed.


14. DOCID:10821 SCORE: 0.00201666694620474
DOCNO: 6361675
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: J L Borgna JL
AUTHOR: H Rochefort H
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: [Effects and mechanism of action of antiestrogens in breast cancer]
PUBDATE: 19831101
Tamoxifen, a non-steroidal antioestrogen, is currently used to treat post-menopausal breast cancer. In oestrogen-sensitive breast cancer cell lines, tamoxifen and some of its metabolites display, for the induction of oestrogen-regulated proteins, a partial agonist/antagonist activity. They also inhibit totally the proliferation of these cells. Evidence is given, which suggests that the pharmacological properties of these antioestrogens are mediated by the oestrogen receptor. These antioestrogens interact with the oestrogen receptor but they appear to induce only a partial or altered activation of the receptor. This partial or altered activation and the competition with oestrogens for binding to the oestrogen receptor could explain the oestrogen agonist/antagonist properties of antioestrogens.