0. DOCID:26927 SCORE: 0.00336956141981329
DOCNO: 11140227
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: adverse effects
QUALIFIER: administration & dosage
QUALIFIER: adverse effects
QUALIFIER: drug therapy
AUTHOR: J A Low JA
AUTHOR: R Chye R
AFFILIATION: Department of Palliative Care, Prince of Wales Hospital, New South Wales. jamesalvinlow@hotmail.com
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: Australia
TITLE: A pitfall to avoid when starting a patient on transdermal fentanyl.
PUBDATE: 20001201
BACKGROUND: A woman with advanced carcinoma of the ovary developed fentanyl toxicity while being changed from oral morphine to transdermal fentanyl. OBJECTIVE: To explain the reason for the toxicity and ways to avoid it. DISCUSSION: The transdermal fentanyl patch is proving to be a safe, well tolerated and effective treatment modality in the control of cancer pain, but care has to be exercised when using this drug, especially at the time of initiation, as the consequences may be disastrous for the patient.

1. DOCID:26990 SCORE: 0.00285209022784133
DOCNO: 9666047
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: L D Tomei LD
AUTHOR: S R Umansky SR
AFFILIATION: LXR Biotechnology Incorporated, Richmond, California 94804, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Neurologic clinics.
COUNTRY: UNITED STATES
TITLE: Aging and apoptosis control.
PUBDATE: 19980801
The phenomenon of aging is distinct from processes associated with advanced age known to increase risk of diseases, such as cancer. Furthermore, the process of aging is not necessarily related to phenomena such as in vitro replicative senescence; however, any unifying hypothesis of aging must account for all age-dependent phenomena, including senescence. It is proposed that apoptosis forms the ultimate protective process for preservation of phenotypic fidelity in multicellular organisms since it is the process by which the organism detects damage and replaces the defective cell. Time-dependent degeneration of apoptosis control is the rate-limiting step in the process of aging.

2. DOCID:28642 SCORE: 0.00279742518057137
DOCNO: 15350945
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: therapy
AUTHOR: Henry Q Xiong HQ
AUTHOR: James L Abbruzzese JL
AFFILIATION: Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: United States
TITLE: Adjuvant therapy for pancreatic cancer: current status and future directions.
PUBDATE: 20041001
This article summarizes the important past and ongoing adjuvant therapy trials for pancreatic cancer. The recent developments in the fields of radiosensitization, chemotherapy, and molecular-targeted therapy are outlined. Finally, the future study strategies for adjuvant therapy trials are discussed.

3. DOCID:29582 SCORE: 0.00267545561060353
DOCNO: 12663955
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Reproductive Medicine
QUALIFIER: therapy
AUTHOR: Helena Davies H
AUTHOR: Diana Greenfield D
AUTHOR: William Ledger W
AFFILIATION: Academic Unit of Child Health, Sheffield University, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Human fertility (Cambridge, England)
COUNTRY: England
TITLE: Reproductive medicine in a late effects of cancer clinic.
PUBDATE: 20030201
This review discusses the most commonly observed problems in young people who have survived childhood cancer, with particular emphasis on the issues of fertility. It also describes the role of the late effects clinic in transitional care and the multidisciplinarity of the clinicians required to meet the needs of these young people. There is a need for evidence-based guidelines for management of long-term survivors.

4. DOCID:26823 SCORE: 0.00266622761179925
DOCNO: 11424473
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Anesthesia, Epidural
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: complications
AUTHOR: T Hamada T
AUTHOR: K Katori K
AUTHOR: K Nitahara K
AUTHOR: T Shiratake T
AUTHOR: T Kaneko T
AUTHOR: K Higa K
AFFILIATION: Department of Anesthesiology, School of Medicine, Fukuoka University, Fukuoka 814-0180.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Masui. The Japanese journal of anesthesiology.
COUNTRY: Japan
TITLE: [Anesthetic management of a patient with tetanus using epidural anesthesia]
PUBDATE: 20010501
A 75-year-old woman with breast cancer complicated with tetanus was scheduled for mastectomy. Since severe bradycardia (17 beats.min-1) was detected by preoperative Holter monitoring, a temporary pacing catheter was inserted. She underwent mastectomy under general anesthesia using propofol combined with thoracic epidural anesthesia. She also received postoperative thoracic epidural block. Her perioperative heart rate was 80-105 beats.min-1 and the rhythm was sinus. There was no marked perioperative cardiovascular derangement.

5. DOCID:31107 SCORE: 0.00265512673401437
DOCNO: 15775352
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: Toshio Okano T
AUTHOR: Kimie Nakagawa K
AFFILIATION: Kobe Pharmaceutical University, Department of Hygienic Science.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical calcium.
COUNTRY: Japan
TITLE: [Novel vitamin d analogues with selective biological activities]
PUBDATE: 20020501
1alpha,25-dihydroxyvitamin D(3) (1alpha,25 (OH)(2)D(3)) is a naturally occuring organic compound showing strong calcemic activity and anti-proliferative/differentiation-inducing activity. 1alpha,25 (OH)(2)D(3) is expected to be a therapeutic agent for metabolic bone diseases and cancer treatment. To enhance its selectivity, specificity, and safety as a therapeutic agent, it is required to separate its calcium-regulating activity from its non-calcium-regulating activity. For this reason, a variety of vitamin D analogues have been developed. The analogues with modification of A-ring are promising candidates for this purpose.

6. DOCID:27186 SCORE: 0.00262587146839029
DOCNO: 10082411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J H Bond JH
AFFILIATION: Gastroenterology Section, Minneapolis Veterans' Association Medical Center and University of Minnesota, 55417, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Endoscopy.
COUNTRY: GERMANY
TITLE: Colon polyps and cancer.
PUBDATE: 19990101
A number of recent publications dealing with colon polyps and cancer emphasize cost-effectiveness and the outcomes of screening and follow-up surveillance of high-risk groups. These groups include patients with either a past personal history or a family history of colorectal adenomas or cancer. Several papers address the effectiveness and compliance with different methods of screening of the asymptomatic, average-risk population for colorectal neoplasia. Other important publications deal with colorectal cancer prevention, the natural history of the adenoma-carcinoma sequence, diagnosis of polyps and cancer, colonoscopic polypectomy, management of the patient with a malignant polyp, and endoscopic treatment of obstructing cancer.

7. DOCID:26673 SCORE: 0.00262268948242086
DOCNO: 10748670
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: chemically induced
QUALIFIER: chemically induced
AUTHOR: A Bergeret A
AUTHOR: J C Normand JC
AFFILIATION: Service des maladies professionnelles et de médecine du travail, Centre hospitalier Lyon-Sud, Pierre-Bénite.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Chemical-induced cancers]
PUBDATE: 20000201
Most chemical carcinogenic agents are industrial. About 4% of all cancers have an occupational origin, but the percentage is higher in exposed populations. Evidence of carcinogenicity is provided by epidemiological studies, animal experiments and other biological sources like experimental mutagenesis. The IARC (International Agency for Research on Cancer) classification and the European Union classification of carcinogenic agents for humans are useful for prevention and regulation. Some cancers are classified as occupational diseases but only a few persons receive compensation given the difficulties of aetiologic diagnosis and the frequent absence of declaration.

8. DOCID:26714 SCORE: 0.00262268770613575
DOCNO: 11503270
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: antagonists & inhibitors
AUTHOR: M Dzielska-Olczak M
AUTHOR: S Olczak S
AFFILIATION: Zakład Farmakologii Akademii Medycznej w łodzi.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: Poland
TITLE: [Clinical application of cyclooxygenase-2 inhibitors]
PUBDATE: 20010601
Nonsteroidal antiinflammatory drugs (NSAIDs) are a group of compounds with similar therapeutic and side effects. Their therapeutic effects depend on blockade of prostaglandin synthesis through enzyme cyclooxygenase (COX) inhibition. Two isoforms of the enzyme cyclooxygenase have been identified: COX-1 and COX-2. Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects. Highly selective COX-2 inhibitors may also be active in colonic polyposis, colorectal cancer and Alzheimer's disease.

9. DOCID:27446 SCORE: 0.00258508104948782
DOCNO: 11283468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: diagnosis
QUALIFIER: immunology
QUALIFIER: diagnosis
QUALIFIER: immunology
QUALIFIER: diagnosis
AUTHOR: G Auf G
AUTHOR: B Benyahia B
AUTHOR: B Orcel B
AUTHOR: C Beigelman C
AUTHOR: J Y Delattre JY
AFFILIATION: Fédération de Neurologie Mazarin, INSERM U.495, Paris.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revue neurologique.
COUNTRY: France
TITLE: [Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody]
PUBDATE: 20010201
We report the case of a patient presenting a subacute, predominantly sensory neuropathy. The work up revealed a Sjögren's syndrome and a breast carcinoma. The presence of anti-Hu antibodies, identified by Western Blot using purified recombinant HuD protein, and the absence of the Hu antigen in the breast carcinoma ruled out the responsibility of the Sjögren's syndrome or breast carcinoma. In this context, the most likely diagnosis was a subacute neuropathy associated with small cell lung cancer, which was indeed discovered 3 years later.

10. DOCID:30173 SCORE: 0.00255627659300647
DOCNO: 15239339
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: antagonists & inhibitors
QUALIFIER: drug therapy
AUTHOR: Pascal Eschwege P
AFFILIATION: Service d'Urologie, Hôpital Bicêtre, Faculté de Médecine Paris-Sud Département de Chirurgie, Institut Gustave-Roussy, avenue Camille-Desmoulins, 94805 Villejuif.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Cyclooxygenase 2 inhibitors and urologic and gynaecologic cancers]
PUBDATE: 20040501
PGE2 is one of the most important prostaglandin involved in the oncogenesis. PGE2 is found at high concentration level in the most of epithelial cancer. Urologic and gynaecologic cancer express the enzyme which are at the origin of PGE2: cyclooxygenase 2. Cox2 inhibitors present anticancer properties demonstrated in wide varieties of cellular and animal models. Human applications are currently tested in many clinical trials for bladder, prostate and uterine carcinomas.

11. DOCID:27568 SCORE: 0.00251200791608061
DOCNO: 10985095
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Spirostans
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: S X Qiu SX
AUTHOR: X C Li XC
AUTHOR: Y Xiong Y
AUTHOR: Y Dong Y
AUTHOR: H Chai H
AUTHOR: N R Fransworth NR
AUTHOR: J M Pezzuto JM
AUTHOR: H H Fong HH
PUBTYPE: Letter
JOURNALTITLE: Planta medica.
COUNTRY: GERMANY
TITLE: Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense.
PUBDATE: 20000801
A cytotoxic steroidal glycoside was isolated from Chlorophytum malayense Ridley and its structure was characterized as a known compound, neohecogenin 3-O-beta-D-glucopyranosyl(1-->2)-[beta-D-xylopyranosyl(1-->3)]-beta-D- glucopyranosyl(1-->4)-beta-D-galactopyranoside (chloromaloside A). The structural identification was performed using 2D-NMR and LC/MS/MS analysis. The previous, erroneously assigned 1H-NMR spectral data were revised whereas the published 13C-NMR spectral assignments were confirmed. This compound showed in vitro cytotoxicity against several human cancer cell lines.

12. DOCID:27627 SCORE: 0.00251200052653109
DOCNO: 10565376
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Physiological
QUALIFIER: physiology
QUALIFIER: physiopathology
AUTHOR: R F Grimble RF
AFFILIATION: Institute of Human Nutrition, University of Southampton, Hants, UK. iohn@soton.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in clinical nutrition and metabolic care.
COUNTRY: ENGLAND
TITLE: Fasting in healthy individuals and adaption to undernutrition during chronic disease.
PUBDATE: 19980701
During long-term fasting, gluconeogenesis from amino acids was thought to lessen, when ketone bodies from lipolysis became a major fuel source. Thus, muscle mass is conserved. However, recent studies show that this adaptation does not occur in chronic undernourishment. In cancer, chronic undernutrition without disease, and HIV infection, carbohydrate utilization is high. Enhanced hepatic glucose production occurs in active inflammatory bowel disease and in underweight cancer patients. Repletion of tissue after undernutrition is energetically inefficient because of enhanced diet induced thermogenesis (following anorexia nervosa) and decreased fat, and increased protein, oxidation (in tuberculosis).

13. DOCID:26638 SCORE: 0.00246188206009666
DOCNO: 11561984
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: C Sweeney C
AFFILIATION: Department of Medicine, Indiana University Medical Center, Indianapolis, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urologic oncology.
COUNTRY: United States
TITLE: History of testicular cancer chemotherapy: maximizing efficacy, minimizing toxicity.
PUBDATE: 20010801
All patients presenting with metastatic testis cancer should be treated with the goal of cure. However, all physicians treating patients with germ cell tumors need to be aware of the toxicities of chemotherapy. Because many patients are cured of their disease, both short-term and long-term toxicities have been identified. The short-term toxicities are myelosuppression, nausea and vomiting, pulmonary toxicity, nephropathy, and neuropathy. The longer term toxicities often discussed are ototoxicity, impairment of fertility, persistent neuropathy or ototoxicity, cardiovascular diseases, and secondary malignancies, which are all described in this review.

14. DOCID:30664 SCORE: 0.00244346142744965
DOCNO: 12185221
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: A Leslie A
AUTHOR: R J C Steele RJ
AFFILIATION: Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: England
TITLE: Management of colorectal cancer.
PUBDATE: 20020801
Colorectal cancer is the second most common cause of cancer death in the UK. Prompt investigation of suspicious symptoms is important, but there is increasing evidence that screening for the disease can produce significant reductions in mortality. High quality surgery is of paramount importance in achieving good outcomes, particularly in rectal cancer, but adjuvant radiotherapy and chemotherapy have important parts to play. The treatment of advanced disease is still essentially palliative, although surgery for limited hepatic metastases may be curative in a small proportion of patients.