0. DOCID:11914 SCORE: 0.00285461104846652
DOCNO: 6318725
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: analysis
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: E Kaneto E
AUTHOR: H Sasaki H
AUTHOR: I Tamura I
AUTHOR: O Kurimura O
AUTHOR: T Kurimura T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Biken journal.
COUNTRY: JAPAN
TITLE: Interferon-alpha in serum and carcinomatous pleural effusion after repeated intrapleural injections of antitumor agents.
PUBDATE: 19830601
Pleural effusions and sera of two patients with lung cancer were tested after intrapleural injection of OK-432 as an anticancer drug for IFN-alpha activity by biological assay and for IFN-alpha as an antigen by radioimmunoassay. The titers by radioimmunoassay were fairly consistent with those by biological assay, but were usually higher. In Case 1, IFN-alpha was observed fairly early after administration of OK-432 and only in pleural effusions. In Case 2, induction of IFN-alpha at low level was observed late after the first administration of OK-432 both in the pleural effusion and serum and was detected only by radioimmunoassay.


1. DOCID:11487 SCORE: 0.00281539680622669
DOCNO: 6764113
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: T Ise T
AUTHOR: M Ohira M
AUTHOR: A Omiya A
AUTHOR: M Hirose M
AUTHOR: T Shibata T
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Clinical evaluation of antiemetics for vomiting due to cancer chemotherapy in children]
PUBDATE: 19820701
Comparative study of antiemetic effect on vomiting due to cancer chemotherapy was performed in 62 children with various malignant diseases. Twenty-one children were treated with metoclopramide, 23 children with domperidone and remaining 18 children received methylprednisolone. Each drug was administered intravenously after administration of anticancer agents, and repeated if necessary. The most effective antiemetics was methyl-prednisolone with effective rate of 89% in comparison with 51% of domperidone and 17% of metoclopromide treated group, respectively. Methyl-prednisolone may be useful for severe vomiting due to anticancer drugs. Safer and significantly better therapeutic efficacy was observed in the group treated with domperidone than that with metoclopromide.


2. DOCID:11548 SCORE: 0.00264515233953599
DOCNO: 6711294
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: N Hejgaard N
AUTHOR: E Larsen E
PUBTYPE: Journal Article
JOURNALTITLE: Acta orthopaedica Scandinavica.
COUNTRY: DENMARK
TITLE: Value of early attention to spinal compression syndromes.
PUBDATE: 19840401
In a consecutive series of 125 patients with spinal compression syndromes, neurological regression was evaluated in relation to the time interval from (a) initial symptoms (patient delay), (b) diagnostic recognition (diagnostic delay), and (c) decision on treatment (therapeutic delay) until the time of definitive treatment. Patients with benign lesions showed a statistically significant negative correlation between the duration of (a) + (b) + (c) and the therapeutic result. In cancer patients there was a tendency for rapid progression of the disease to give a poorer result than in patients in whom the course was more insidious. In all, 77 patients improved after a short therapeutic delay (14 h), while in the remaining 48 the status was unchanged or worse after a long delay (34 h); this is a highly significant difference.


3. DOCID:15728 SCORE: 0.00250110618535663
DOCNO: 3472698
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Renal Dialysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: D Docci D
AUTHOR: E Pistocchi E
AUTHOR: F Turci F
AUTHOR: L Baldrati L
AUTHOR: S Urbini S
AUTHOR: S Scaioli S
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nephrology.
COUNTRY: GERMANY, WEST
TITLE: Serum CA 19-9 and CA 50 antigens in hemodialysis patients.
PUBDATE: 19870401
Serum concentrations of monoclonal antibody-defined tumor markers CA 19-9 and CA 50 were measured in 64 uncomplicated hemodialysis patients (Group 1) and in 8 hemodialysis patients with cancer (Group 2) in comparison with corresponding CEA determinations. From our results in Group 1 patients it appears that both CA 19-9 and CA 50 maintained an excellent specificity in these patients. As to the sensitivity of these tests, our findings in Group 2 patients are comparable with those reported in patients with cancer and normal renal function. It is concluded that, unlike CEA, these new tumor markers maintain their clinical value in chronic renal failure.


4. DOCID:11468 SCORE: 0.00248901619021748
DOCNO: 6351704
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M Baum M
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Current thinking on the management of primary carcinoma of the breast.
PUBDATE: 19830901
The most important advance in the management of early breast cancer over the last 20 years, has been the conceptual revolution whereby the mechanistic/anatomical view of the disease has been replaced by a more complex biological model. As a result of this paradigm shift, the role of local therapy has been redefined and a steady momentum towards a more conservative approach has been initiated. Furthermore, the trials of adjuvant systemic therapy, although not producing the anticipated major breakthrough, have at least demonstrated that the natural history of the disease can be influenced in a favourable direction. Future progress depends on a continuing involvement of all surgeons in multicentre trials and resistance to the establishment of a new therapeutic dogma.


5. DOCID:13633 SCORE: 0.00240958006660386
DOCNO: 3335036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pathology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: J A McBain JA
AUTHOR: G R Pettit GR
AUTHOR: G C Mueller GC
AFFILIATION: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
PUBTYPE: Journal Article
JOURNALTITLE: Carcinogenesis.
COUNTRY: UNITED STATES
TITLE: Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
PUBDATE: 19880101
12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatin 1, a macrocyclic lactone, completely counteracts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.


6. DOCID:13766 SCORE: 0.00240956182164911
DOCNO: 2922868
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: P R Olsen PR
AUTHOR: F Lund F
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Laser treatment of penile cancer]
PUBDATE: 19890201
The treatment of localized penile cancer has hitherto been surgical amputation of the penis. In our 12 cases, tumorectomy was performed by CO2 or ND:YAG-laser radiation with minimal tissue ablation. Local recurrences occurred and the patients must be followed regularly in the outpatient clinic. The recurrences were treated by repeated laser radiation. No patients died of penile cancer during a mean observation of 16 months (range 3-50). Laser tumorectomy has definitive therapeutic advantages compared with penile amputation, because the result is acceptable for the patient and his micturition and sexual life are not altered.


7. DOCID:11159 SCORE: 0.00236238823800086
DOCNO: 6704117
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: M S Stevens MS
AUTHOR: Z Aliabadi Z
AUTHOR: M R Moore MR
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Associated effects of sodium butyrate on histone acetylation and estrogen receptor in the human breast cancer cell line MCF-7.
PUBDATE: 19840201
Sodium butyrate at a concentration of 5mM causes significant hyperacetylation of the core histones in the human breast cancer cell line MCF-7. Histone hyperacetylation was achieved in rapidly-growing cells at 40% confluency after 24 hours in 5mM sodium butyrate. More nearly confluent cells did not reach as high a level of histone hyperacetylation. Upon assaying the estrogen receptors, both cytosolic and KCl-extractable nuclear, we found that butyrate treatment had lowered the estrogen receptor levels in both compartments. To our knowledge this is the first report of an effect of sodium butyrate on estrogen receptor levels.


8. DOCID:11031 SCORE: 0.00235782052821864
DOCNO: 6702745
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T A Garland TA
AUTHOR: D J Innes DJ
AUTHOR: R E Fechner RE
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Salivary duct carcinoma: an analysis of four cases with review of literature.
PUBDATE: 19840401
Salivary duct carcinoma (SDC) is a histologically distinctive neoplasm of the parotid gland. The criteria for the diagnosis of SDC are circumscribed epithelial nests having a papillary, cribriform, and/or solid architecture coupled with central necrosis. The infiltrating cancer can be papillary, resembling the intraductal component or have a nonspecific, undifferentiated pattern. The authors are presenting four cases and compare them with 11 other acceptable cases from the literature. The neoplasm occurs beyond the age of 50 (median 63 years) and has a dismal prognosis with nearly two-thirds of the patients developing distant metastases. All surviving patients have been treated with combined parotidectomy and radiotherapy.


9. DOCID:9915 SCORE: 0.00234730215514434
DOCNO: 4005498
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: complications
AUTHOR: M A Ghoneim MA
AUTHOR: A Ashamalla A
AUTHOR: M A Gaballa MA
AUTHOR: E I Ibrahim EI
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Cystectomy for carcinoma of the bilharzial bladder. 126 patients 10 years later.
PUBDATE: 19850601
Our experience with 126 cases of bilharzial bladder cancer treated by radical cystectomy and followed up for at least 10 years is outlined. The operative mortality rate was 13.5%. The 5- and 10-year survival rates were 32.6 and 23% respectively. The difference between the two figures can be attributed to mortality from natural ageing rather than recurrence of cancer. Analysis of survival figures revealed that the tumour grade was the most important prognostic factor. Most treatment failures were due to local recurrence which developed soon after treatment.


10. DOCID:15262 SCORE: 0.00234648484153329
DOCNO: 2718294
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cystoscopes
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnostic use
QUALIFIER: instrumentation
AUTHOR: D Jocham D
AUTHOR: R Baumgartner R
AUTHOR: N Fuchs N
AUTHOR: H Lenz H
AUTHOR: H Stepp H
AUTHOR: E Unsöld E
AFFILIATION: Urologische Klinik und Poliklinik LMU München.
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Fluorescence diagnosis of porphyrin-marked urothelial tumors. Status of experimental development]
PUBDATE: 19890301
On the basis of selective storage of fluorescing hematoporphyrin derivative (HpD) in tumors, a method has been developed that enables the endoscopic detection of early-stage cancer by monitoring fluorescent images. The contrast-reducing portion of the superposed tissue autofluorescence is suppressed by the use of two-wavelength excitation and subsequent image processing in realtime. The amount of photosensitizing HpD necessary for diagnostic purposes is considerably reduced by means of sensitive detection devices. A clear distinction between benign and malignant bladder tissue seems possible according to the results of animal studies.


11. DOCID:11319 SCORE: 0.00227979096513094
DOCNO: 7066880
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: I Granberg-Ohman I
AUTHOR: B Tribukait B
AUTHOR: H Wijkström H
AUTHOR: A Alim A
AUTHOR: T Berlin T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Chromosome and DNA cytometric study of a papillary carcinoma of the bladder with a high stemline and numerous double minutes.
PUBDATE: 19820301
A papillary cancer of the bladder [WHO grade 3] was studied with chromosome and DNA analysis. A high frequency of mitoses was noted, and analysis of 151 metaphases revealed a dominating stemline in the pentaploid region. More than 95% of the cells contained double minutes (dm). Flow cytometry showed the dominant stemline to be in the hexaploid region, that is, about 20% above the numerical chromosome value. This difference is generally obtained when these two methods are compared and is not influenced by the presence of dm. Both methods have been complementary in the evaluation of this tumor.


12. DOCID:10760 SCORE: 0.00227263002005601
DOCNO: 10262084
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: legislation & jurisprudence
QUALIFIER: standards
PUBTYPE: Journal Article
JOURNALTITLE: Federal register.
COUNTRY: UNITED STATES
TITLE: Privacy Act of 1974; altered system of records--PHS. Notification of altered Privacy Act system of records 09-25-0074.
PUBDATE: 19830601
In accordance with the requirements of the Privacy Act, the Public Health Service (PHS) is publishing notice of a proposal to alter system of records 09-25-0074, "Clinical Research: Veterans Administration Bladder and Prostate Cancer Clinical Trials, HHS/NIH/NCI." The purpose of the alteration is to modify an existing system of records into an umbrella system by broadening both the categories of individuals under this system and the purposes for which the system is used. The names of the system of records is also being changed to reflect the alteration. The new name is "Clinical Research: Division of Cancer Biology and Diagnosis Patient Trials, HHS/NIH/NCI."


13. DOCID:15729 SCORE: 0.00227025305355971
DOCNO: 3565656
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hispanic Americans
DESCRIPTOR: Mortality
AUTHOR: I Rosenwaike I
PUBTYPE: Journal Article
JOURNALTITLE: American journal of public health.
COUNTRY: UNITED STATES
TITLE: Mortality differentials among persons born in Cuba, Mexico, and Puerto Rico residing in the United States, 1979-81.
PUBDATE: 19870501
This paper examines the mortality experience in 1979-81 of three first generation Hispanic subpopulations in the United States, as defined by area of birth (Cuba, Mexico, Puerto Rico). Numerators were derived from National Center for Health Statistics (NCHS) mortality tapes, which included codes for selected places of birth appearing on the death certificate. Denominators were based on decennial census data for these migrant populations from the 1980 census. Generally, mortality is relatively high among Cuban-born, Mexican-born and Puerto Rican-born adolescents and young adults, particularly males, largely due to violent deaths. Aged migrants, despite their disadvantaged socioeconomic status, exhibit relatively low death rates from heart disease and cancer.


14. DOCID:11515 SCORE: 0.00218621498953364
DOCNO: 6689385
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: M Fazio M
AUTHOR: F Badellino F
AUTHOR: G L Sannazzari GL
AUTHOR: V Vercellino V
AUTHOR: M Airoldi M
AUTHOR: A Manca A
AUTHOR: S Gandolfo S
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Oral and pharyngeal cancer: combined approach for multimodal therapy.
PUBDATE: 19831201
Five-year results in 60 oral and pharyngeal cancer patients treated with combined approach chemoradiotherapy (39 patients) and chemoradiotherapy plus lymph node surgery (21 patients) are reported. Complete remission (CR) was achieved in 16/39 (41%) patients treated with chemoradiotherapy alone, and in 16/21 (76%) patients who had chemoradiotherapy plus surgery. The number of CR was statistically (chi-square test) higher (p less than 0.025) in the second group. The 5-year actuarial survival was 39.7% in the group of patients treated with chemoradiotherapy plus surgery. After 5 years 53% of the patients who reached CR are living free of disease in the first group and 76% in the second group.