0. DOCID:3984 SCORE: 0.00354263618891072
DOCNO: 199443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
AUTHOR: R Moreau R
AUTHOR: F Soussaline F
AUTHOR: S Chauvaud S
AUTHOR: C Parmentier C
AUTHOR: R Di Paola R
AUTHOR: P Charbord P
AUTHOR: M Tubiana M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of nuclear medicine.
COUNTRY: GERMANY, WEST
TITLE: Detection of hepatoma in liver cirrhosis.
PUBDATE: 19770901
The analogic liver scintigram using 99mTc sulfur colloid in cirrhotic patients does not permit determination of the nature of the areas of decreased uptake. Scintigrams with 67Ga citrate generally show increased activity in cases of hepatoma. In some cases, however, 67Ga citrate is less concentrated in neoplasic tissue, and it is not possible to detect a tumoral lesion in a cirrhotic liver. This is why we used double isotope scintigraphies with 67Ga citrate and 99mTc sulfur colloid, with digital subtraction, after simultaneous recording of 99mTc and 67Ga data on magnetic tape by means of an interface. In our series of 22 patients, the comparison of the results obtained by this double isotope technique with histology showed no false positive in substraction scintigrams. There was one false negative because of the lack of significance in the subtracted image for one of the six patients with cancer of the liver. For three of the six patients with hepatoma, the gallium scintigram showed an increased uptake in the tumor area. For the three other cases, the gallium uptake was equilibrated throughout the liver scintigraphy. It was therefore in cases where the gallium scintigram showed no increased activity that the subtraction technique was of greatest value, for it permitted the diagnosis of hepatoma in two cases.

1. DOCID:3887 SCORE: 0.0034635335057115
DOCNO: 803873
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: biosynthesis
QUALIFIER: immunology
AUTHOR: C Waterhouse C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: GammaG-globulin production and light-chain metabolism in patients with metastatic cancer.
PUBDATE: 19750401
GammaG-Globulin and excess light-chain metabolism were studied in eight subjects with progressive metastatic malignant disease by determining the plasma radioactivity curves following the administration of appropriately labeled substances. In addition to the plasma die-away curves, which required about 3 weeks for full expression for gamma-globulin, but only 3 to 4 days for light-chain, urinary excretion of the label from metabolized protein was determined. The data are compared to similar studies in control individuals. The metabolism of excess light chain was similar to normal in all respects. The total synthesis of gammaG-globulin was increased with a mean value about twice normal. The mean survival time of a circulating immunoglobulin molecule was short, indicating rapid loss from the system. Other aspects of immunoglobulin metabolism were similar to normal with a normal percentage of the labeled protein appearing in the urine, suggesting no abnormality in the utilization pattern but simply an increased rate of turnover. The capability of malnourished patients with cancer to produce large quantities of immunoglobulin is not specific for this disease, since similar patterns may be seen in response to infections in protein-depleted individuals. However, there is the possibility that the cancer itself acts as an inciting agent in these subjects. Furthermore, such sustained protein synthesis may place an additional burden on already compromised host metabolism.

2. DOCID:3732 SCORE: 0.00303859704226155
DOCNO: 128144
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypersensitivity, Delayed
QUALIFIER: methods
QUALIFIER: immunology
QUALIFIER: methods
AUTHOR: J F Burdick JF
AUTHOR: S A Wells SA
AUTHOR: R B Herberman RB
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions.
PUBDATE: 19751101
Testing of delayed hypersensitivity responses to recall antigens, newly encountered antigens and tumor antigens has contributed to the understanding of several immunologic factors in human neoplasia. Patients with Hodgkin's disease tend to have depressed responses to both newly encountered and recall antigens. Patients with solid tumors are more likely to be deficient only in the response to newly encountered antigens. In patients who have intact response to recall antigens, reactivity to antigen preparations from tumor and control tissue may be studied. Tumor-associated or organ-associated antigens have been demonstrated by delayed hypersensitivity responses in leukemia, Burkitt's lymphoma, malignant melanoma and carcinoma of the lung, breast, cervix uteri and intestine. Approaches to a definition of the specificity of these reactions are described. The results with these tumor antigen tests correlate strongly with the clinical course. This is a promising technique for monitoring immunotherapy. The results from tests with recall and newly encountered antigens also correlate with the clinical status and perhaps with prognosis. Various possible interpretations of these changes are discussed. Further work should be directed toward an exact definition of immunologic defects in patients with cancer and toward the use of this understanding for a rational program of immunotherapy.

3. DOCID:11914 SCORE: 0.00285461104846652
DOCNO: 6318725
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: analysis
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: E Kaneto E
AUTHOR: H Sasaki H
AUTHOR: I Tamura I
AUTHOR: O Kurimura O
AUTHOR: T Kurimura T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Biken journal.
COUNTRY: JAPAN
TITLE: Interferon-alpha in serum and carcinomatous pleural effusion after repeated intrapleural injections of antitumor agents.
PUBDATE: 19830601
Pleural effusions and sera of two patients with lung cancer were tested after intrapleural injection of OK-432 as an anticancer drug for IFN-alpha activity by biological assay and for IFN-alpha as an antigen by radioimmunoassay. The titers by radioimmunoassay were fairly consistent with those by biological assay, but were usually higher. In Case 1, IFN-alpha was observed fairly early after administration of OK-432 and only in pleural effusions. In Case 2, induction of IFN-alpha at low level was observed late after the first administration of OK-432 both in the pleural effusion and serum and was detected only by radioimmunoassay.

4. DOCID:11487 SCORE: 0.00281539680622669
DOCNO: 6764113
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: T Ise T
AUTHOR: M Ohira M
AUTHOR: A Omiya A
AUTHOR: M Hirose M
AUTHOR: T Shibata T
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Clinical evaluation of antiemetics for vomiting due to cancer chemotherapy in children]
PUBDATE: 19820701
Comparative study of antiemetic effect on vomiting due to cancer chemotherapy was performed in 62 children with various malignant diseases. Twenty-one children were treated with metoclopramide, 23 children with domperidone and remaining 18 children received methylprednisolone. Each drug was administered intravenously after administration of anticancer agents, and repeated if necessary. The most effective antiemetics was methyl-prednisolone with effective rate of 89% in comparison with 51% of domperidone and 17% of metoclopromide treated group, respectively. Methyl-prednisolone may be useful for severe vomiting due to anticancer drugs. Safer and significantly better therapeutic efficacy was observed in the group treated with domperidone than that with metoclopromide.

5. DOCID:11548 SCORE: 0.00264515233953599
DOCNO: 6711294
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: N Hejgaard N
AUTHOR: E Larsen E
PUBTYPE: Journal Article
JOURNALTITLE: Acta orthopaedica Scandinavica.
COUNTRY: DENMARK
TITLE: Value of early attention to spinal compression syndromes.
PUBDATE: 19840401
In a consecutive series of 125 patients with spinal compression syndromes, neurological regression was evaluated in relation to the time interval from (a) initial symptoms (patient delay), (b) diagnostic recognition (diagnostic delay), and (c) decision on treatment (therapeutic delay) until the time of definitive treatment. Patients with benign lesions showed a statistically significant negative correlation between the duration of (a) + (b) + (c) and the therapeutic result. In cancer patients there was a tendency for rapid progression of the disease to give a poorer result than in patients in whom the course was more insidious. In all, 77 patients improved after a short therapeutic delay (14 h), while in the remaining 48 the status was unchanged or worse after a long delay (34 h); this is a highly significant difference.

6. DOCID:7057 SCORE: 0.00259273550876607
DOCNO: 7350696
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Sedimentation
QUALIFIER: analysis
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: N J DeYoung NJ
AUTHOR: L K Ashman LK
AUTHOR: J Ludbrook J
AUTHOR: V R Marshall VR
PUBTYPE: Journal Article
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: A comparison of three blood tests for cancer.
PUBDATE: 19800101
Plasma carcinoembryonic antigen concentration, serum phosphohexose isomerase activity and the erythrocyte sedimentation rate were determined in patients with cancer, patients being treated for various benign conditions and healthy young persons. This was to make an intercomparison between the ability of these assays to distinguish patients who have cancer from those who do not and from normal persons. The upper boundaries of the assays were defined by the one-sided, distribution-free, upper tolerance limits of the reference populations. Only by means of the assay for carcinoembryonic antigen was it possible to distinguish patients who had cancer from those who did not. Twenty-two per cent of patients with cancer could be identified by this assay with a false-positive error rate of less than 5 per cent.

7. DOCID:3236 SCORE: 0.00258214751768665
DOCNO: 872124
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: chemically induced
AUTHOR: R M Hicks RM
AUTHOR: J Chowaniec J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
PUBDATE: 19770801
It is now well established that the interaction of multiple environmental factors may increase the incidence of some human cancers more than exposure to a single carcinogen. With an in vivo experimental rat model, we have demonstrated a synergistic effect in bladder carcinogenesis between a subcarcinogenic dose of the strong bladder carcinogen, N-methyl-N-nitrosourea, and saccharin- or cyclamate-containing diets. If these artificial sweeteners are capable of interacting with other environmental bladder carcinogens, their potential for increasing the incidence of human bladder cancer is greater than many more potent chemical carcinogens, because of their wide distribution as food additives to all sections of the population. Retrospective epidemiology shows no evidence of such risk from saccharin at current levels of consumption. No comparable studies are available for cyclamate, which was consumed in greater quantities but for relatively few years. It is emphasized that it is possible for interaction between multiple factors to contribute to the incidence of human bladder cancer as it does in other human organs and in other animal species.

8. DOCID:15728 SCORE: 0.00250110618535663
DOCNO: 3472698
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Renal Dialysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: D Docci D
AUTHOR: E Pistocchi E
AUTHOR: F Turci F
AUTHOR: L Baldrati L
AUTHOR: S Urbini S
AUTHOR: S Scaioli S
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nephrology.
COUNTRY: GERMANY, WEST
TITLE: Serum CA 19-9 and CA 50 antigens in hemodialysis patients.
PUBDATE: 19870401
Serum concentrations of monoclonal antibody-defined tumor markers CA 19-9 and CA 50 were measured in 64 uncomplicated hemodialysis patients (Group 1) and in 8 hemodialysis patients with cancer (Group 2) in comparison with corresponding CEA determinations. From our results in Group 1 patients it appears that both CA 19-9 and CA 50 maintained an excellent specificity in these patients. As to the sensitivity of these tests, our findings in Group 2 patients are comparable with those reported in patients with cancer and normal renal function. It is concluded that, unlike CEA, these new tumor markers maintain their clinical value in chronic renal failure.

9. DOCID:3317 SCORE: 0.00249708600196345
DOCNO: 12276787
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Health Planning
PUBTYPE: Journal Article
JOURNALTITLE: IPPF/WHR news service. International Planned Parenthood Federation. Western Hemisphere Region.
COUNTRY: United States
TITLE: Ecuador officially adopts family planning.
PUBDATE: 19740201
The Ecuadorian government has officially announced its plan to extend family planning services to all citizens via its public health service. This September 21 announcement by Raul Maldonado Mejia, Minister of Public Health, indicated that family planning will be integrated into health services on the basis of the following principles: 1) Ecuadorian family planning programs are a medical action aimed at improving the health of mothers and children; 2) family planning must be established as part of a total health service for in this way it can be available to all people; 3) the government, through the Ministry of Health, will control and supervise all family planning services that are provided by private and public organizations; 4) information and education is recognized as an important requisite that allows women to freely and responsibly seek out these services; 5) family planning programs will include in their efforts the early detection of gynecological cancer and the study and treatment of the infertile couple; and 6) the national government can conduct family planning programs with the criterion of responsible parenthood through its own technical facilities or through qualified institutions and organizations.

10. DOCID:11468 SCORE: 0.00248901619021748
DOCNO: 6351704
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M Baum M
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Current thinking on the management of primary carcinoma of the breast.
PUBDATE: 19830901
The most important advance in the management of early breast cancer over the last 20 years, has been the conceptual revolution whereby the mechanistic/anatomical view of the disease has been replaced by a more complex biological model. As a result of this paradigm shift, the role of local therapy has been redefined and a steady momentum towards a more conservative approach has been initiated. Furthermore, the trials of adjuvant systemic therapy, although not producing the anticipated major breakthrough, have at least demonstrated that the natural history of the disease can be influenced in a favourable direction. Future progress depends on a continuing involvement of all surgeons in multicentre trials and resistance to the establishment of a new therapeutic dogma.

11. DOCID:3882 SCORE: 0.0024096151670303
DOCNO: 1245005
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: P F Richard PF
AUTHOR: J Cantin J
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Primary carcinoma of the gallbladder: study of 108 cases.
PUBDATE: 19760101
From 1948 through 1970, 108 causes of primary carcinoma of the gallbladder were recorded out of a total of 17 698 cases of cancer exclusive of skin cancer (incidence, 0.6%). This review indicated that the following are the chief features of this condition: Primary gallbladder carcinoma is mainly a disease of women older than 60 years; abdominal pain occurs in most patients and jaundice in more than half, and weight loss is also common; laboratory and radiographic features are nonspecific; the diagnosis is made or strongly suspected in only one-quarter and, moreover, in many patients the disease may not be discovered until pathologic examination is conducted postoperatively. Resection was possible in 41 of the 93 patients who underwent operation but treatment was conservative because it was palliative in 20, and in 20 of the other underwent cholecystectomy the disease was not recognized at operation. Overall, the 5-year survival rate was 6.4%; for those who underwent curative resection it was 33%; and for patients without visible metastases at operation the mean survival was 3 years. Improvement in survival will come from more frequent recognition of the cancer at operation so that an operation so that an operation more adequate than cholecystectomy may be performed; that is, cholecystectomy, wedge resection of liver and resection of regional lymph nodes.

12. DOCID:13633 SCORE: 0.00240958006660386
DOCNO: 3335036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pathology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: J A McBain JA
AUTHOR: G R Pettit GR
AUTHOR: G C Mueller GC
AFFILIATION: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
PUBTYPE: Journal Article
JOURNALTITLE: Carcinogenesis.
COUNTRY: UNITED STATES
TITLE: Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
PUBDATE: 19880101
12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatin 1, a macrocyclic lactone, completely counteracts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.

13. DOCID:13766 SCORE: 0.00240956182164911
DOCNO: 2922868
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: P R Olsen PR
AUTHOR: F Lund F
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Laser treatment of penile cancer]
PUBDATE: 19890201
The treatment of localized penile cancer has hitherto been surgical amputation of the penis. In our 12 cases, tumorectomy was performed by CO2 or ND:YAG-laser radiation with minimal tissue ablation. Local recurrences occurred and the patients must be followed regularly in the outpatient clinic. The recurrences were treated by repeated laser radiation. No patients died of penile cancer during a mean observation of 16 months (range 3-50). Laser tumorectomy has definitive therapeutic advantages compared with penile amputation, because the result is acceptable for the patient and his micturition and sexual life are not altered.

14. DOCID:7887 SCORE: 0.00239698758712599
DOCNO: 7235853
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: psychology
QUALIFIER: methods
QUALIFIER: psychology
AUTHOR: D Spiegel D
AUTHOR: J R Bloom JR
AUTHOR: I Yalom I
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Archives of general psychiatry.
COUNTRY: UNITED STATES
TITLE: Group support for patients with metastatic cancer. A randomized outcome study.
PUBDATE: 19810501
The effects of weekly supportive group meetings for women with metastatic carcinoma of the breast were systematically evaluated in a one-year, randomized, prospective outcome study. The groups focused on the problems of terminal illness, including improving relationships with family, friends, and physicians and living as fully as possible in the face of death. We hypothesized that this invention would lead to improved mood, coping strategies, and self-esteem among those in the treatment group. Eighty-six patients were tested at four-month intervals. The treatment group had significantly lower mood-disturbance scores on the Profile of Mood States scale, had fewer maladaptive coping responses, and were less phobic than the control group. This study provides objective evidence that a supportive group intervention for patients with metastatic cancer results in psychological benefit. Mechanisms underlying the effectiveness of this group intervention are explored.