0. DOCID:3984 SCORE: 0.00354263618891072
DOCNO: 199443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
AUTHOR: R Moreau R
AUTHOR: F Soussaline F
AUTHOR: S Chauvaud S
AUTHOR: C Parmentier C
AUTHOR: R Di Paola R
AUTHOR: P Charbord P
AUTHOR: M Tubiana M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of nuclear medicine.
COUNTRY: GERMANY, WEST
TITLE: Detection of hepatoma in liver cirrhosis.
PUBDATE: 19770901
The analogic liver scintigram using 99mTc sulfur colloid in cirrhotic patients does not permit determination of the nature of the areas of decreased uptake. Scintigrams with 67Ga citrate generally show increased activity in cases of hepatoma. In some cases, however, 67Ga citrate is less concentrated in neoplasic tissue, and it is not possible to detect a tumoral lesion in a cirrhotic liver. This is why we used double isotope scintigraphies with 67Ga citrate and 99mTc sulfur colloid, with digital subtraction, after simultaneous recording of 99mTc and 67Ga data on magnetic tape by means of an interface. In our series of 22 patients, the comparison of the results obtained by this double isotope technique with histology showed no false positive in substraction scintigrams. There was one false negative because of the lack of significance in the subtracted image for one of the six patients with cancer of the liver. For three of the six patients with hepatoma, the gallium scintigram showed an increased uptake in the tumor area. For the three other cases, the gallium uptake was equilibrated throughout the liver scintigraphy. It was therefore in cases where the gallium scintigram showed no increased activity that the subtraction technique was of greatest value, for it permitted the diagnosis of hepatoma in two cases.

1. DOCID:3887 SCORE: 0.0034635335057115
DOCNO: 803873
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: biosynthesis
QUALIFIER: immunology
AUTHOR: C Waterhouse C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: GammaG-globulin production and light-chain metabolism in patients with metastatic cancer.
PUBDATE: 19750401
GammaG-Globulin and excess light-chain metabolism were studied in eight subjects with progressive metastatic malignant disease by determining the plasma radioactivity curves following the administration of appropriately labeled substances. In addition to the plasma die-away curves, which required about 3 weeks for full expression for gamma-globulin, but only 3 to 4 days for light-chain, urinary excretion of the label from metabolized protein was determined. The data are compared to similar studies in control individuals. The metabolism of excess light chain was similar to normal in all respects. The total synthesis of gammaG-globulin was increased with a mean value about twice normal. The mean survival time of a circulating immunoglobulin molecule was short, indicating rapid loss from the system. Other aspects of immunoglobulin metabolism were similar to normal with a normal percentage of the labeled protein appearing in the urine, suggesting no abnormality in the utilization pattern but simply an increased rate of turnover. The capability of malnourished patients with cancer to produce large quantities of immunoglobulin is not specific for this disease, since similar patterns may be seen in response to infections in protein-depleted individuals. However, there is the possibility that the cancer itself acts as an inciting agent in these subjects. Furthermore, such sustained protein synthesis may place an additional burden on already compromised host metabolism.

2. DOCID:26927 SCORE: 0.00336956141981329
DOCNO: 11140227
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: adverse effects
QUALIFIER: administration & dosage
QUALIFIER: adverse effects
QUALIFIER: drug therapy
AUTHOR: J A Low JA
AUTHOR: R Chye R
AFFILIATION: Department of Palliative Care, Prince of Wales Hospital, New South Wales. jamesalvinlow@hotmail.com
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: Australia
TITLE: A pitfall to avoid when starting a patient on transdermal fentanyl.
PUBDATE: 20001201
BACKGROUND: A woman with advanced carcinoma of the ovary developed fentanyl toxicity while being changed from oral morphine to transdermal fentanyl. OBJECTIVE: To explain the reason for the toxicity and ways to avoid it. DISCUSSION: The transdermal fentanyl patch is proving to be a safe, well tolerated and effective treatment modality in the control of cancer pain, but care has to be exercised when using this drug, especially at the time of initiation, as the consequences may be disastrous for the patient.

3. DOCID:23961 SCORE: 0.00312046074347326
DOCNO: 7796196
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Women, Working
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: G Wingren G
AUTHOR: A Hallquist A
AUTHOR: A Degerman A
AUTHOR: L Hardell L
AFFILIATION: Department of Occupational Medicine, University Hospital, Linköping, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine.
COUNTRY: UNITED STATES
TITLE: Occupation and female papillary cancer of the thyroid.
PUBDATE: 19950301
This article presents the joint results of two Swedish case-control studies regarding occupational exposure and female papillary thyroid cancer. Questionnaires inquiring about lifetime occupations and specific occupational exposures were mailed to cases and controls, aged 20 to 70 years. Some 185 female papillary or mixed cancer cases and 426 female controls were included in the analysis. Increased risks were seen for women who had worked as a dentist/dental assistant, teacher, shoemaker, or warehouse worker. In addition, occupational contacts with undefined chemicals, x-rays, or video display terminals were indicated as risk factors.

4. DOCID:3732 SCORE: 0.00303859704226155
DOCNO: 128144
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypersensitivity, Delayed
QUALIFIER: methods
QUALIFIER: immunology
QUALIFIER: methods
AUTHOR: J F Burdick JF
AUTHOR: S A Wells SA
AUTHOR: R B Herberman RB
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions.
PUBDATE: 19751101
Testing of delayed hypersensitivity responses to recall antigens, newly encountered antigens and tumor antigens has contributed to the understanding of several immunologic factors in human neoplasia. Patients with Hodgkin's disease tend to have depressed responses to both newly encountered and recall antigens. Patients with solid tumors are more likely to be deficient only in the response to newly encountered antigens. In patients who have intact response to recall antigens, reactivity to antigen preparations from tumor and control tissue may be studied. Tumor-associated or organ-associated antigens have been demonstrated by delayed hypersensitivity responses in leukemia, Burkitt's lymphoma, malignant melanoma and carcinoma of the lung, breast, cervix uteri and intestine. Approaches to a definition of the specificity of these reactions are described. The results with these tumor antigen tests correlate strongly with the clinical course. This is a promising technique for monitoring immunotherapy. The results from tests with recall and newly encountered antigens also correlate with the clinical status and perhaps with prognosis. Various possible interpretations of these changes are discussed. Further work should be directed toward an exact definition of immunologic defects in patients with cancer and toward the use of this understanding for a rational program of immunotherapy.

5. DOCID:19924 SCORE: 0.00287605695582356
DOCNO: 2161782
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adenocarcinoma
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Carcinoma, Intraductal, Noninfiltrating
DESCRIPTOR: Neoplasms, Multiple Primary
DESCRIPTOR: Uterine Neoplasms
AUTHOR: G Atlante G
AUTHOR: M Pozzi M
AUTHOR: C Vincenzoni C
AUTHOR: G Vocaturo G
AFFILIATION: Department of Gynecological Oncology, Regina Elena National Cancer Institute, Rome, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Four case reports presenting new acquisitions on the association between breast and endometrial carcinoma.
PUBDATE: 19900601
In recent years, the association between breast and endometrial cancer has been the subject of many studies. The present report describes four cases of this association in which tamoxifen had been administered to all of the patients. Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients. The authors intend to carry out a case-control study on patients treated with tamoxifen for breast carcinoma to reveal the possible presence of endometrial carcinoma.

6. DOCID:11914 SCORE: 0.00285461104846652
DOCNO: 6318725
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: analysis
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: E Kaneto E
AUTHOR: H Sasaki H
AUTHOR: I Tamura I
AUTHOR: O Kurimura O
AUTHOR: T Kurimura T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Biken journal.
COUNTRY: JAPAN
TITLE: Interferon-alpha in serum and carcinomatous pleural effusion after repeated intrapleural injections of antitumor agents.
PUBDATE: 19830601
Pleural effusions and sera of two patients with lung cancer were tested after intrapleural injection of OK-432 as an anticancer drug for IFN-alpha activity by biological assay and for IFN-alpha as an antigen by radioimmunoassay. The titers by radioimmunoassay were fairly consistent with those by biological assay, but were usually higher. In Case 1, IFN-alpha was observed fairly early after administration of OK-432 and only in pleural effusions. In Case 2, induction of IFN-alpha at low level was observed late after the first administration of OK-432 both in the pleural effusion and serum and was detected only by radioimmunoassay.

7. DOCID:26990 SCORE: 0.00285209022784133
DOCNO: 9666047
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: L D Tomei LD
AUTHOR: S R Umansky SR
AFFILIATION: LXR Biotechnology Incorporated, Richmond, California 94804, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Neurologic clinics.
COUNTRY: UNITED STATES
TITLE: Aging and apoptosis control.
PUBDATE: 19980801
The phenomenon of aging is distinct from processes associated with advanced age known to increase risk of diseases, such as cancer. Furthermore, the process of aging is not necessarily related to phenomena such as in vitro replicative senescence; however, any unifying hypothesis of aging must account for all age-dependent phenomena, including senescence. It is proposed that apoptosis forms the ultimate protective process for preservation of phenotypic fidelity in multicellular organisms since it is the process by which the organism detects damage and replaces the defective cell. Time-dependent degeneration of apoptosis control is the rate-limiting step in the process of aging.

8. DOCID:11487 SCORE: 0.00281539680622669
DOCNO: 6764113
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: T Ise T
AUTHOR: M Ohira M
AUTHOR: A Omiya A
AUTHOR: M Hirose M
AUTHOR: T Shibata T
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Clinical evaluation of antiemetics for vomiting due to cancer chemotherapy in children]
PUBDATE: 19820701
Comparative study of antiemetic effect on vomiting due to cancer chemotherapy was performed in 62 children with various malignant diseases. Twenty-one children were treated with metoclopramide, 23 children with domperidone and remaining 18 children received methylprednisolone. Each drug was administered intravenously after administration of anticancer agents, and repeated if necessary. The most effective antiemetics was methyl-prednisolone with effective rate of 89% in comparison with 51% of domperidone and 17% of metoclopromide treated group, respectively. Methyl-prednisolone may be useful for severe vomiting due to anticancer drugs. Safer and significantly better therapeutic efficacy was observed in the group treated with domperidone than that with metoclopromide.

9. DOCID:28642 SCORE: 0.00279742518057137
DOCNO: 15350945
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: therapy
AUTHOR: Henry Q Xiong HQ
AUTHOR: James L Abbruzzese JL
AFFILIATION: Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: United States
TITLE: Adjuvant therapy for pancreatic cancer: current status and future directions.
PUBDATE: 20041001
This article summarizes the important past and ongoing adjuvant therapy trials for pancreatic cancer. The recent developments in the fields of radiosensitization, chemotherapy, and molecular-targeted therapy are outlined. Finally, the future study strategies for adjuvant therapy trials are discussed.

10. DOCID:19970 SCORE: 0.00271480511787259
DOCNO: 1717224
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: P A Todd PA
AUTHOR: A Fitton A
AFFILIATION: Adis International Limited, Auckland, New Zealand.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Drugs.
COUNTRY: NEW ZEALAND
TITLE: Gallium nitrate. A review of its pharmacological properties and therapeutic potential in cancer related hypercalcaemia.
PUBDATE: 19910801
Gallium nitrate, a novel drug for the treatment of cancer-related hypercalcaemia, inhibits osteoclast activity but does not affect osteoclast morphology or viability. Limited clinical experience in patients with cancer-related hypercalcaemia indicates that gallium nitrate is effective in restoring normocalcaemia in 75 to 85% of patients and is well tolerated in those with preserved renal function, producing few clinically relevant adverse effects. In comparative clinical trials it proved a more effective antihypercalcaemic agent than calcitonin or etidronate and produced a longer lasting normocalcaemic response. Gallium nitrate would appear to be indicated in symptomatic patients with cancer-related hypercalcaemia who have failed to respond to adequate rehydration.

11. DOCID:23782 SCORE: 0.00270098085977145
DOCNO: 8085087
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J A Pérez JA
AUTHOR: R Silva R
AUTHOR: M del Pozo M
AUTHOR: E Henning E
AFFILIATION: Instituto de Cirugía, Facultad de Medicina, Universidad Austral de Chile, Valdivia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revista médica de Chile.
COUNTRY: CHILE
TITLE: [Diffuse hyperthyroid goiter associated with occult papillary carcinoma of the thyroid. Report of 2 cases]
PUBDATE: 19940201
The association of diffuse hyperthyroid goiter and thyroid cancer is rare and interesting, considering that both diseases affect the same organ but have different pathogenesis and prognosis. We report two patients that consulted for diffuse hyperthyroid goiter and were subjected to a subtotal bilateral thyroidectomy due to antithyroid drug failure. Pathological study revealed the coexistence of diffuse gland hyperplasia and a papillary thyroid carcinoma of less than 7 mm phi. In both cases, the thyroid remanent was ablated with radioactive iodine during the postoperative period and thyroid substitution was started.

12. DOCID:29582 SCORE: 0.00267545561060353
DOCNO: 12663955
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Reproductive Medicine
QUALIFIER: therapy
AUTHOR: Helena Davies H
AUTHOR: Diana Greenfield D
AUTHOR: William Ledger W
AFFILIATION: Academic Unit of Child Health, Sheffield University, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Human fertility (Cambridge, England)
COUNTRY: England
TITLE: Reproductive medicine in a late effects of cancer clinic.
PUBDATE: 20030201
This review discusses the most commonly observed problems in young people who have survived childhood cancer, with particular emphasis on the issues of fertility. It also describes the role of the late effects clinic in transitional care and the multidisciplinarity of the clinicians required to meet the needs of these young people. There is a need for evidence-based guidelines for management of long-term survivors.

13. DOCID:21397 SCORE: 0.00267228308057991
DOCNO: 7734605
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
DESCRIPTOR: Patient Acceptance of Health Care
DESCRIPTOR: Vaginal Smears
QUALIFIER: statistics & numerical data
QUALIFIER: prevention & control
AUTHOR: A Ruge A
AUTHOR: C Lee C
AUTHOR: W J Brown WJ
AFFILIATION: Department of Psychology, University of Newcastle.
PUBTYPE: Journal Article
JOURNALTITLE: Australian journal of public health.
COUNTRY: AUSTRALIA
TITLE: Inpatient cervical screening: a survey of patient acceptability.
PUBDATE: 19950201
Offering Pap tests to hospital inpatients could increase cervical screening rates. A survey to examine the acceptability of this concept was conducted with female inpatients in a rural public hospital. A large majority reported that they would find hospital Pap tests acceptable. Acceptability was not related to Pap test status, attitudes, or knowledge of cervical cancer. This strategy may provide access to cervical screening for underscreened groups.

14. DOCID:26823 SCORE: 0.00266622761179925
DOCNO: 11424473
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Anesthesia, Epidural
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: complications
AUTHOR: T Hamada T
AUTHOR: K Katori K
AUTHOR: K Nitahara K
AUTHOR: T Shiratake T
AUTHOR: T Kaneko T
AUTHOR: K Higa K
AFFILIATION: Department of Anesthesiology, School of Medicine, Fukuoka University, Fukuoka 814-0180.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Masui. The Japanese journal of anesthesiology.
COUNTRY: Japan
TITLE: [Anesthetic management of a patient with tetanus using epidural anesthesia]
PUBDATE: 20010501
A 75-year-old woman with breast cancer complicated with tetanus was scheduled for mastectomy. Since severe bradycardia (17 beats.min-1) was detected by preoperative Holter monitoring, a temporary pacing catheter was inserted. She underwent mastectomy under general anesthesia using propofol combined with thoracic epidural anesthesia. She also received postoperative thoracic epidural block. Her perioperative heart rate was 80-105 beats.min-1 and the rhythm was sinus. There was no marked perioperative cardiovascular derangement.