0. DOCID:3841 SCORE: 0.00332696027959982
DOCNO: 1036616
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: H Siebner H
AUTHOR: W Weber W
PUBTYPE: Journal Article
JOURNALTITLE: Österreichische Zeitschrift für Onkologie. Austrian journal of oncology.
COUNTRY: AUSTRIA
TITLE: [Five years treatment of advanced solid malignomas with a combination of four cytostatic drugs (author's transl)]
PUBDATE: 19760501
132 patients with advanced solid malignomas were treated with a combination of four cytostatic drugs (vinblastine, amethopterine, 5-fluorouracil and cyclophosphamid) given on one day. This was repeated once every 2-3 weeks. In every case the diagnosis was made histologically and the tumour was staged according to the TNM-system. The treatment of breast and ovarian cancer brought the best results, improved by a synchronisation therapy. Good results were achieved also in the treatment of special kind of sarcomas and of carcinoma of the urine bladder. The general condition of patients with colon carcinoma could be improved in about 30%. Only one patient died by drug-induced pancytopenia, otherwise severe side-effects were not noted. Before beginning the therapy the cell-mediated immunity of 31 patients was tested by skin-tests with tuberkulin purified protein derivative (PPD) and dinitrochlorbenzole (DNCB). Before and during cytostatic therapy PPD reactions were proven by 23 patients. In accordance to other authors we found that cell-mediated immunity is decreased in the advanced stage of malignoma. Further we noted that delayed hypersensitivity and the number of lymphocytes and monocytes in peripherel blood are important to prognosis and course in patients with cancer.

1. DOCID:18071 SCORE: 0.00321402048025523
DOCNO: 1792785
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: administration & dosage
QUALIFIER: radiotherapy
AUTHOR: V A Chernichenko VA
AUTHOR: V S Ivankova VS
AUTHOR: E A Demina EA
AUTHOR: L L Zlochevskaia LL
PUBTYPE: Journal Article
JOURNALTITLE: Vrachebnoe delo.
COUNTRY: USSR
TITLE: [The treatment of patients with cancer of the corpus uteri using the gamma emitter 137Cs]
PUBDATE: 19911201
A study is presented of 51 patients (age 52-77 years) suffering of uterine body cancer with marked extragenital pathology. It is shown that treatment of inoperable cancer of the uterine body using the SELECTRON apparatus for contact irradiation (cesium-137 source, 066-MEV photons). With this method exact dose control is possible. The preferred regime of dose fractionation in intracavitary radiation of endometrium cancer is a single dose of 1000 cGr weekly and a summary dose of 7000-8000 cGr.

2. DOCID:27780 SCORE: 0.00305507307074491
DOCNO: 11382941
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Trials
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: diagnosis
AUTHOR: T B Julian TB
AFFILIATION: Division of Surgical Oncology, Western Pennsylvania Allegheny Health System, Pittsburgh, PA 15212, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of magnetic resonance imaging : JMRI.
COUNTRY: United States
TITLE: MRI: a role in clinical trials.
PUBDATE: 20010601
The diagnosis and treatment of breast cancer has evolved significantly over the last 20 years. Breast-conserving therapy is replacing the Halstedian concept of "en bloc" resection. Difficulties in detection, pre- and postoperative planning and follow up continue to challenge the clinician. Women at high risk present a significant clinical dilemma. MRI technology in many of these areas is providing more information about detection, tumor size, extent, and response to treatment. The careful and thoughtful inclusion of MRI in clinical trials may help continue the advancement of breast cancer care. J. Magn. Reson. Imaging 2001;13:837-841.

3. DOCID:7721 SCORE: 0.00251387402674185
DOCNO: 508570
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Alcohol Drinking
QUALIFIER: adverse effects
QUALIFIER: mortality
AUTHOR: S Kono S
AUTHOR: M Ikeda M
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Correlation between cancer mortality and alcoholic beverage in Japan.
PUBDATE: 19790901
Geographical correlations between standardized, mortality ratios (SMRs) of cancers and consumption of different types of alcoholic beverages (saké synthetic saké, shochu, beer, wine, and whisky), of cigarettes, and urbanization were examined for all 46 prefectures in Japan. Suggestive correlations were observed between cancer of the oesophagus in males and both shochu and whisky (r = 0.27 and 0.22 respectively), between cancer of the rectum in males and wine (r = 0.45), and between cancer of the prostate and shochu (r = 0.50). These correlations were also confirmed in the partial correlations between SMRs of cancers and consumption of alcoholic beverages, controlling for the two variables urbanization and consumption of cigarettes. Alhtough cancers of other sites were also correlated with certain types of alcoholic beverages, their associations seemed to be secondary to other factors. The validity of higher-order partial correlations and the problems of correlation study are also referred to.

4. DOCID:19904 SCORE: 0.00231965700924742
DOCNO: 1831733
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Preservation
DESCRIPTOR: Vegetables
QUALIFIER: analysis
QUALIFIER: etiology
AUTHOR: C Ji C
AUTHOR: M Li M
AFFILIATION: Institute of Oncology, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
COUNTRY: CHINA
TITLE: [Studies of pickled vegetables and cause of esophageal cancer in Linxian. II. Determination of nitrosamines and their precursors]
PUBDATE: 19910601
Pickled vegetables are daily food consumed in the high-risk areas for esophageal cancer in China. We analyzed the nitrosamine content of Linxian pickles by GC/TEA and found that trace amounts of six nitrosamines (NDMA, NDEA, NMBA, NMAMBA, NDPA, NPYR) were present, with the highest concentrations being NDMA and NDEA (1.7 and 1.9 micrograms/kg wet weight respectively). The average level of nitrosamine precursors, such as nitrate (111.22 mg/L), nitrite (0.152 mg/L) and secondary amines (4.223 mg/L), in pickled vegetables were determined, and their pH values ranged from 3 to 5.

5. DOCID:26906 SCORE: 0.00225476360549229
DOCNO: 11578733
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brachytherapy
QUALIFIER: radiation effects
QUALIFIER: radiotherapy
AUTHOR: A M Olszewska AM
AUTHOR: A E Saarnak AE
AUTHOR: R W de Boer RW
AUTHOR: B N van Bunningen BN
AUTHOR: M J Steggerda MJ
AFFILIATION: Medical Physics Department, M. Sklodowska-Curie Memorial Cancer Center, W.K. Roentgen 5, 02-781, Warsaw, Poland.
PUBTYPE: Journal Article
JOURNALTITLE: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
COUNTRY: Ireland
TITLE: Comparison of dose-volume histograms and dose-wall histograms of the rectum of patients treated with intracavitary brachytherapy.
PUBDATE: 20011001
The correlation between dose values from dose-volume histograms (DVHs) and dose values from dose-wall histograms (DWHs) of the rectum tissue of patient with uterine cervix cancer was determined. The minimum dose in 2 cm3 in the high-dose region of the DVH is a good estimate of the dose in the rectum wall.

6. DOCID:5705 SCORE: 0.00213938936373296
DOCNO: 7278725
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diet
DESCRIPTOR: Plants, Medicinal
DESCRIPTOR: Seaweed
QUALIFIER: prevention & control
AUTHOR: J Teas J
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: The consumption of seaweed as a protective factor in the etiology of breast cancer.
PUBDATE: 19810501
A review of the biological properties of seaweed is presented and the role of seaweed as a breast cancer anticarcinogen is suggested. Proposed mechanisms of action are: reduction of plasma cholesterol, binding of biliary steroids, inhibition of carcinogenic fecal flora, binding of pollutants, stimulation of the immune system, and the protective effects of beta-sitosterols. In an experiment using sarcoma-180 in mice, seaweed extract appeared to have an antitumor effect. Thus it is suggested that breast cancer may be prevented and that this dietary habit among the Japanese could be an important factor in understanding the lower breast cancer rates reported in Japan.

7. DOCID:18081 SCORE: 0.00212824017757673
DOCNO: 1933212
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J M Dixon JM
AFFILIATION: University Department of Surgery, Royal Infirmary of Edinburgh, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: British medical bulletin.
COUNTRY: ENGLAND
TITLE: Cystic disease and fibroadenoma of the breast: natural history and relation to breast cancer risk.
PUBDATE: 19910401
Approximately 25% of all 'discrete' breast lesions are fibroadenomas or breast cysts and they more commonly cause a breast lump than breast cancer. Despite their frequency, their natural history and relationship to subsequent breast cancer have not been clearly defined, although it would appear that palpable breast cysts, but not fibroadenomas, are associated with some increased risk of breast cancer. The diagnosis of these two entities is now possible by fine needle aspiration and excision of these lesions is only indicated in certain circumstances.

8. DOCID:23616 SCORE: 0.00204735583186001
DOCNO: 8979633
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
AUTHOR: P B Desai PB
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of medical sciences.
COUNTRY: INDIA
TITLE: Cancer control in the Asia Pacific region--the next lap.
PUBDATE: 19960201
Cancer control in any part of the world has to be a multi-directional effort addressed in a holistic manner. The general impression that cancer control means only collation of epidemiological data and efforts at primary prevention needs to be redefined because preventive and educative oncology, though an important component of cancer control, can achieve long-term goals only after 20 years or more. Along with such long-term objectives, methodology needs to be developed which takes care of immediate and recent needs in early diagnosis, effective treatment, and appropriate basic research for the ultimate control and cure of cancer. A holistic approach to the cancer control effort will, therefore, need the combined skills of many different specialists.

9. DOCID:20479 SCORE: 0.00203218791357207
DOCNO: 9447659
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Betaretrovirus
QUALIFIER: virology
QUALIFIER: virology
AUTHOR: M Palmarini M
AUTHOR: H Fan H
AUTHOR: J M Sharp JM
AFFILIATION: Cancer Research Institute, University of California Irvine 92697, USA. massimo@darwin.bio.uci.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in microbiology.
COUNTRY: ENGLAND
TITLE: Sheep pulmonary adenomatosis: a unique model of retrovirus-associated lung cancer.
PUBDATE: 19971201
Sheep pulmonary adenomatosis (SPA) is a contagious bronchiolo-alveolar carcinoma of sheep associated with an exogenous type D/B retrovirus known as jaagsiekte sheep retrovirus (JSRV). SPA represents a unique model for lung cancer, and studies on its aetiopathogenesis can provide further insight into the mechanisms of epithelial neoplasms.

10. DOCID:3581 SCORE: 0.0020262392426557
DOCNO: 180188
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
AUTHOR: M Pruniéras M
AUTHOR: C Delescluse C
AUTHOR: M Regnier M
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of investigative dermatology.
COUNTRY: UNITED STATES
TITLE: The culture of skin. A review of theories and experimental methods.
PUBDATE: 19760701
Two main criticisms can be leveled against the standard methods of skin culture: they are poorly quantifiable and the cultured cell populations are heterogeneous. A new technique based mainly on enzymatic dissociation allows specific cell types to be extracted from the skin before cultivation. In this way, separate cultures of epidermal keratinocytes and dermal fibroblasts can be obtained from the same piece of skin. These purified systems have been used to study the kinetics of epidermal cell growth and to quantify the effect of various chemically defined substances on the growth and differentiation of keratinocytes. With further refinements in technique, purified populations of melanocytes can be extracted. The co-culture of pigmented melanocytes with albino keratinocytes has been proposed as a model to study pigment donation in vitro. The usual organ culture technique, including the use of large explants of skin immersed in the culture fluid, has been modified to show that adult human skin partially regenerates in vitro and that mitotic activity goes on for months in the regenerated epidermis. The use of nucleic acid hybridization techniques, combined with skin cell cultures from human tumors, opens new avenues of research on human cancer.

11. DOCID:13218 SCORE: 0.00202617794879824
DOCNO: 2664681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Circumcision
AUTHOR: G F Anderson GF
AFFILIATION: Minneapolis Children's Medical Center, MN.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pediatric annals.
COUNTRY: UNITED STATES
TITLE: Circumcision.
PUBDATE: 19890301
There are no absolutes regarding circumcision, and the decision to circumcise a child as a newborn or otherwise must be made after carefully weighing the alternatives to, and risks and benefits of, this common surgical procedure. These alternatives, risks, and benefits must be fully explained to parents considering circumcision, and informed consent must be obtained. In well-trained, experienced hands, circumcision is a safe procedure that effectively eliminates proven problems such as cancer of the penis, and may eliminate the problems of increased risk of urinary tract infection and sexually transmitted diseases.

12. DOCID:2554 SCORE: 0.00200972033545572
DOCNO: 1104154
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: W Haenszel W
AUTHOR: P Correa P
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Developments in the epidemiology of stomach cancer over the past decade.
PUBDATE: 19751101
The history of stomach cancer epidemiology is reviewed. The introduction of migrant population studies in the 1960 decade that described the critical role of exposures to this disease in early life was a key event. Companion pathology studies have indicated different epidemiological patterns for 2 histological entities, intestinal and diffuse type carcinomas, and confirmed an excess of intestinal metaplasia in populations at high risk to stomach cancer. Recent results suggest that epidemiology of stomach cancer can be transformed into the epidemiology of precursor lesions, and introduction of the fiberoptic gastroscope makes technically feasible detailed studies of the relationship of precursor lesions to suspect factors, including diet, in selected geographic areas. Nitroso compounds have been identified as candidate carcinogens and the epidemiological, pathological, and chemical data display signs of internal consistency. Feeding experiments with N-methyl-N'-nitro-N-nitrosoguanidine have led to animal models that permit a coordinated epidemiological-experimental approach to stomach cancer.

13. DOCID:3749 SCORE: 0.00199021316315107
DOCNO: 4856712
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: therapy
AUTHOR: M M Abitbol MM
AUTHOR: J H Davenport JH
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Sexual dysfunction after therapy for cervical carcinoma.
PUBDATE: 19740501
Until the Kinsey report there had been very little published concerning sexual activity in the aging woman. Since then other authors have stated that chronic illness or lack of a sexual partner rather than age have placed limitations on their sexual activity. This study reports the effect of different modes of therapy for invasive carcinoma of the cervix on subsequent sexual function, and also tries to establish a correlation with the type of changes of the vaginal anatomy. Radiotherapy alone had been performed on 28 patients, surgery alone on 32, and combined treatment on 15. All were clinically free of cancer for 1 year after treatment was completed. The youngest was aged 23 and the oldest 68. Of the 28 patients treated with radiotherapy alone 22 had developed shortening or narrowing of the vagina sufficient to interfere markedly with sexual function. Only 2 of the 32 surgically treated patients had such a sexual interference. With combined treatment 60% showed some vaginal alterations and 33% sexual dysfunction. Questioning of patients revealed the importance of sexual function in the lives of middle-aged women. Therefore preference is expressed for radical surgery in the treatment of early carcinoma of the cervix because this mode of therapy interfers minimally with the sexual function.

14. DOCID:3744 SCORE: 0.00199015814395741
DOCNO: 831918
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: C A Joslin CA
AUTHOR: G V Vaishampayan GV
AUTHOR: A Mallik A
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of radiology.
COUNTRY: ENGLAND
TITLE: The treatment of early cancer of the corpus uteri.
PUBDATE: 19770101
This paper analyses the results of post-operative radiotherapy in 256 cases of cancer of the corpus uteri. Myometrial invasion by tumour was shown to be significantly related to histological grading (p less than 0.001) as it was to recurrence rates (p less than 0.025). By placing patients into one of three subsets according to the depth of myometrial invasion, survival was sufficiently different for each subset to validate their use, not only for prognostic purposes but to determine the type of radiotherapy indicated. Radiotherapy was given as either local intravaginal treatment using an obturator loaded with 60Co or by a combination of this and external beam teletherapy. The value of using radiotherapy to treat the whole pelvis as opposed to treating only the vaginal tissues was significant (p less than 0.01) in terms of local disease control for the deep myometrial invasive group. In terms of survival, external beam therapy was of benefit for all three subsets, i.e. superficial, not more than half and more than half myometrial invasion. A planned approach to post-operative radiotherapy was significantly better for the series as a whole compared to previous ad hoc approaches (p less than 0.01). The treatment methods used did not produce unacceptable morbidity.