0. DOCID:27426 SCORE: 0.0032230461843606
DOCNO: 11766910
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fruit
DESCRIPTOR: Vegetables
QUALIFIER: etiology
AUTHOR: Y I Kim YI
AFFILIATION: Department of Medicine, University of Toronto, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: United States
TITLE: Vegetables, fruits, and colorectal cancer risk: what should we believe?
PUBDATE: 20011201
Among dietary factors implicated in the development of colorectal cancer (CRC), the inverse relationship between vegetable and fruit consumption and CRC risk has long been believed to represent the strongest epidemiologic evidence. However, recently published large prospective studies have produced conflicting results and the results of one randomized intervention human trial do not support the protective role of vegetable and fruit consumption in colorectal carcinogenesis. Conflicting data with regard to the effect of dietary factors, including vegetables and fruits, on CRC risk likely reflect inherent, probably irresolvable, limitations of currently available tools to detect a real beneficial or harmful effect associated with these factors.


1. DOCID:27334 SCORE: 0.00315689260540416
DOCNO: 11573372
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gallbladder Neoplasms
DESCRIPTOR: Polyps
AUTHOR: S Afzal S
AUTHOR: V B Kristiansen VB
AUTHOR: J Rosenberg J
AFFILIATION: Kirurgisk afdeling D, Amtssygehuset i Glostrup.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Gallbladder polyps]
PUBDATE: 20010901
Polyps in the gall bladder are detected in 4-5% of the population and most of them are benign. However, they can be premalignant and the prognosis for gall bladder carcinoma is still poor. As with other cancers, treatment at an early stage is therefore, considered essential to improve the prognosis. Because of the very low morbidity after laparoscopic cholecystectomy we recommend laparoscopic cholecystectomy when a polyp in the gall bladder is detected by ultrasonography. A wait and see attitude with repeated ultrasonography twice a year may be chosen, if there are contra-indications to laparoscopic cholecystectomy. If the lesion increases in size, cholecystectomy should be performed.


2. DOCID:26677 SCORE: 0.00284390859614366
DOCNO: 10530960
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
AUTHOR: H B Mereyala HB
AUTHOR: R R Gadikota RR
AUTHOR: M Joe M
AUTHOR: S K Arora SK
AUTHOR: S G Dastidar SG
AUTHOR: S Agarwal S
AFFILIATION: Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad. root@csiict.ren.nic.in
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: ENGLAND
TITLE: Synthesis and antitumor activity of goniofufurone analogues.
PUBDATE: 19990901
Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.


3. DOCID:24356 SCORE: 0.00256147873539054
DOCNO: 10459365
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
AUTHOR: D Shoupe D
AFFILIATION: University of Southern California School of Medicine, Los Angeles, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Hospital practice (Office ed.)
COUNTRY: UNITED STATES
TITLE: Hormone replacement therapy: reassessing the risks and benefits.
PUBDATE: 19990801
Although the association between postmenopausal hormone use and breast cancer has not been clarified, there is nothing indefinite about the survival advantage conferred by hormone replacement therapy. Cardiovascular and fracture-related deaths so outnumber breast cancer deaths that even women with family histories of the latter are likely to benefit from low-potency estrogen replacement.


4. DOCID:26688 SCORE: 0.00251834875180475
DOCNO: 10210489
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Circulating Cells
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
AUTHOR: A E Kim AE
AUTHOR: L B Haramati LB
AUTHOR: D Janus D
AUTHOR: A Borczuk A
AFFILIATION: Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of thoracic imaging.
COUNTRY: UNITED STATES
TITLE: Pulmonary tumor embolism presenting as infarcts on computed tomography.
PUBDATE: 19990401
Pulmonary tumor embolism is a rare cause of respiratory failure in patients with cancer and is only infrequently diagnosed during life. Chest radiographs are usually normal. Dilated and beaded peripheral pulmonary arteries may be present on computed tomography scans. The authors describe an unusual case of pulmonary tumor embolism presenting on computed tomography scans as bilateral, peripheral, wedge-shaped opacities. On autopsy, these opacities corresponded to areas of pulmonary infarction.


5. DOCID:26034 SCORE: 0.00243916085363937
DOCNO: 11480546
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemistry
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: J J Hélesbeux JJ
AUTHOR: D Séraphin D
AUTHOR: O Duval O
AUTHOR: P Richomme P
AUTHOR: J Bruneton J
AFFILIATION: SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, France.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pharmacy and pharmacology.
COUNTRY: England
TITLE: Studies on the reactivity of a tertiary allylic alcohol in an acetophenonic series, a model for natural products synthesis.
PUBDATE: 20010701
The synthesis of benzopyranic simplified analogues of dibenzopyranic natural compounds is described, together with the access to a precursor of a new furobenzopyranic natural product. These natural products have anti-cancer activity. The 1,3-diacetoxy-2-acetyl-4-(3-hydroxy-3-methylbut-1-enyl)benzene synthone is used as a common precursor to these structures.


6. DOCID:27505 SCORE: 0.00214861306922296
DOCNO: 9744494
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Preferences
DESCRIPTOR: Nutrition Assessment
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: J A Levine JA
AUTHOR: M Y Morgan MY
AFFILIATION: Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Preservation of macronutrient preferences in cancer anorexia.
PUBDATE: 19980901
Indirect evidence suggests that cancer anorexia is associated with specific aversions to macronutrients. To investigate this, patients with cancer anorexia and hospitalized control subjects devised 3-day menus comprising foods that they wished to eat. These foods were then provided for 3 days and the intakes of each food carefully measured. As expected, patients with cancer anorexia consumed substantially less energy than hospitalized control subjects (6.0 +/- 0.9 MJ vs 9.5 +/- 0.5 MJ, P < 0.001). However, macronutrient composition was consistently maintained in the patients with cancer anorexia. These data argue against cancer anorexia representing a state of macronutrient aversion.


7. DOCID:27866 SCORE: 0.00214361274664156
DOCNO: 10344150
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: P Potemski P
AUTHOR: A Płuzańska A
AFFILIATION: Zakładu Farmakologii Akademii Medycznej w Lodzi.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Pharmacological action of paclitaxel]
PUBDATE: 19990101
Paclitaxel (taxol, Tax) is a novel plant product isolated from the Pacific yew (Taxus brevifolia). It has a unique mechanism of action, because it induces very stable and dysfunctional microtubules. Paclitaxel has a broad spectrum of antineoplastic activity. It has been successfully used in the treatment of ovarian cancer, metastatic breast cancer, lung cancer, carcinoma of the head and neck, malignant melanoma and other human neoplasms. Tax has response rates of 20-36% in patients with refractory ovarian cancer. Toxic effects include myelosuppresion, hypersensitivity reactions, peripheral neuropathy, cardiac disturbances, alopecia. However, studies evaluating the drug still are ongoing paclitaxel seems to be one of the most promising antineoplastic agents.


8. DOCID:27807 SCORE: 0.00214361127615299
DOCNO: 10901588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: etiology
QUALIFIER: therapeutic use
QUALIFIER: complications
AUTHOR: A J Erslev AJ
AFFILIATION: Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5099, USA. Allan.J.Erslev@mail.tju.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of haematology.
COUNTRY: DENMARK
TITLE: Erythropoietin and anemia of cancer.
PUBDATE: 20000601
Anemia is a common complication of cancer but its causes differ widely. However, a significant number of patients with even early cancer experience a suppression of the action of erythropoietin on the bone marrow, presumably caused by the release of cytokines. The ensuing anemia may be mild and "asymptomatic". Nevertheless, it drains physical and emotional vigor so necessary in the fight against the underlying disorder. The therapeutic use of recombinant human erythropoietin has been gratifying and in many cases restored to near normal not only the hemoglobin concentration but also the quality of life.


9. DOCID:26884 SCORE: 0.00208305196471183
DOCNO: 9867246
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Telomere
QUALIFIER: enzymology
QUALIFIER: ultrastructure
QUALIFIER: enzymology
QUALIFIER: ultrastructure
QUALIFIER: metabolism
AUTHOR: G Kontogeorgos G
AUTHOR: K Kovacs K
AFFILIATION: Department of Pathology, G. Gennimatas Athens General Hospital, Greece. gkonto@atlas.uoa.gr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Endocrine.
COUNTRY: UNITED STATES
TITLE: Telomeres and telomerase in endocrine pathology.
PUBDATE: 19981001
Telomeres representing repetitive DNA sequences of chromosome ends are necessary for maintaining chromosomal integrity. The enzyme telomerase synthesizes de novo telomeric repeats and incorporates them onto the DNA 3'-ends of chromosomes. Stability of chromosome ends and activation of telomerase are elementary requirements for cell immortalization and tumor progression. The telomeric length and telomerase activity have been recently studied in several human neoplasms, including those of endocrine tissues. Assessment of telomerase activity may help to distinguish normal or hyperplastic from neoplastic tissues. Inhibition or inactivation of telomerase activity may provide novel strategies for cancer therapy.


10. DOCID:27097 SCORE: 0.00207774757610896
DOCNO: 9648240
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: analogs & derivatives
QUALIFIER: drug effects
AUTHOR: M Sazuka M
AUTHOR: M Isemura M
AUTHOR: S Isemura S
AFFILIATION: School of Food and Nutritional Sciences, University of Shizuoka, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Bioscience, biotechnology, and biochemistry.
COUNTRY: JAPAN
TITLE: Interaction between the carboxyl-terminal heparin-binding domain of fibronectin and (-)-epigallocatechin gallate.
PUBDATE: 19980501
We have previously reported that (-)-epigallocatechin gallate (EGCg) inhibited lung carcinoma cell adhesion to fibronectin (FN) and demonstrated its interaction with FN. In the present work, we studied the interaction between thermolysin fragments of FN and EGCg. An amino acid sequence analysis of the fragment bound by EGCg-agarose provided its identification as a carboxyl-terminal heparin-binding domain. Thus, the inhibition of cancer cell adhesion to FN by EGCg is not caused by its direct binding to the cell-binding domain containing an Arg-Gly-Asp-sequence.


11. DOCID:26700 SCORE: 0.00197624819109762
DOCNO: 9805752
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Renal Dialysis
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: B Guillou B
AUTHOR: G Robinet G
AUTHOR: S Gouva S
AUTHOR: M P Guillodo MP
AUTHOR: C Daniel C
AUTHOR: J Clavier J
AFFILIATION: Service d'Oncologie broncho-pulmonaire, CHR Morvan, Brest.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue de pneumologie clinique.
COUNTRY: FRANCE
TITLE: [Chemotherapy of small cell bronchogenic carcinoma in a patient on hemodialysis for chronic renal failure. Apropos of a case]
PUBDATE: 19980901
Optimal dosage for chemotherapy administered to patients on chronic hemodialysis remains a difficult question. We report the case of a patient with chronic renal failure on hemodialysis for 9 years who was treated for small-cell lung cancer. The chemotherapy protocol combined carboplatin and etoposide at doses adapted to creatinine clearance. Tumor regression was observed after 6 cycles without major intolerance.


12. DOCID:27539 SCORE: 0.00190594949875036
DOCNO: 11469512
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: toxicity
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: toxicity
AUTHOR: R K Dawra RK
AUTHOR: O P Sharma OP
AUTHOR: R Somvanshi R
AFFILIATION: Indian Veterinary Research Institute, Regional Station, Palampur, HP. ivriplp@nde.vsnl.net.in
PUBTYPE: Journal Article
JOURNALTITLE: Veterinary research communications.
COUNTRY: Netherlands
TITLE: A preliminary study on the carcinogenicity of the common fern Onychium contiguum.
PUBDATE: 20010701
Onychium contiguum (Family Cryptogrammaceae) is a common terrestrial fern in the Himalayas and in many other parts of the world. It is also present on the pastures in areas where grazing animals suffer from bovine urinary bladder cancer. This fern is occasionally grazed by animals and in some areas it is present as a contaminant in grasses stored for winter feeding. Certain species of the genus Onychium are used in folk medicine. Long-term exposure of experimental animals to O. contiguum appeared to cause tumours of the ileum. urinary bladder and mammary glands.


13. DOCID:27064 SCORE: 0.0018498265273904
DOCNO: 10737395
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms
QUALIFIER: standards
AUTHOR: J Bullard J
AUTHOR: M P Coleman MP
AUTHOR: D Robinson D
AUTHOR: J M Lutz JM
AUTHOR: J Bell J
AUTHOR: J Peto J
AFFILIATION: Thames Cancer Registry, London, UK.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Completeness of cancer registration: a new method for routine use.
PUBDATE: 20000301
We report a new method of estimating the completeness of cancer registration, in which the proportions of unregistered patients are derived from the time distributions of three probabilities, each of which can be directly estimated from the registry's own data--the probabilities of survival, of registration of the cancer during the patient's life, and of the mention of cancer on the death certificate of a cancer patient who dies. This method allows completeness to be assessed routinely by factors such as age, sex, geographical area and tumour type.


14. DOCID:25255 SCORE: 0.00179006795175423
DOCNO: 10452933
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: A M Leitch AM
AFFILIATION: Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9155, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Breast cancer screening: success amid conflict.
PUBDATE: 19991001
In randomized trials, screening mammography has been shown to reduce breast cancer mortality. There has been controversy, however, about the segment of the population that should be screened and the frequency at which screening should occur. This article details these controversial issues. The benefits that have been realized from mammography screening in overall breast cancer mortality and diagnosis of earlier stage cancers are also reviewed.