0. DOCID:23781 SCORE: 0.00377015519157891
DOCNO: 10136203
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Protocols
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: S G Yackzan SG
AFFILIATION: Saint Louis University Hospital, MO.
PUBTYPE: Journal Article
JOURNALTITLE: Topics in hospital pharmacy management / Aspen Systems Corporation.
COUNTRY: UNITED STATES
TITLE: Chemotherapy administration.
PUBDATE: 19940701
The administration of cancer chemotherapy is a unique combination of scientific exercise and clinical practice. The clinical practice involves the holistic care of a human being whose cancer and normal physiology are unique. The scientific exercise includes the manipulation of doses, combinations, and administration schemes of the small number of chemicals known as chemotherapy. Bringing science and clinical practice together to formulate a treatment plan that offers the most favorable outcomes and that minimizes short- and long-term toxicities is a challenge. This article discusses the scientific rationale for various methods of chemotherapy administration and outlines the specific clinical steps necessary to achieve the most safe and efficacious administration plan possible.


1. DOCID:22642 SCORE: 0.00354037718717013
DOCNO: 8847778
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sepsis Syndrome
QUALIFIER: physiology
QUALIFIER: etiology
AUTHOR: T Kawamura T
AFFILIATION: Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Masui. The Japanese journal of anesthesiology.
COUNTRY: JAPAN
TITLE: [Cytokines during the perisurgical period]
PUBDATE: 19960501
Systematic inflammatory response syndrome, SIRS, is one of the biological responses to surgical and anesthetic invasions. SIRS itself is a defense response, but excessive SIRS may result in post-operative failure of major organs. There is evidence that inflammatory cytokines play an important role in SIRS. Therefore it may be treated by regulating these inflammatory cytokines. Changes in inflammatory cytokines during the perisurgical period were discussed in relation to post-operative organ injury in patients who had undergone highly invasive procedures such as open heart surgery or resection of esophageal cancer to explore the possibility of anticytokine therapy.


2. DOCID:22747 SCORE: 0.00303533152516375
DOCNO: 7719485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: metabolism
QUALIFIER: analysis
AUTHOR: T M Phillips TM
AFFILIATION: Immunochemistry Laboratory, George Washington University Medical Center, Washington, D.C. 20037.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography. B, Biomedical applications.
COUNTRY: NETHERLANDS
TITLE: Immunoaffinity measurement of recombinant granulocyte colony stimulating factor in patients with chemotherapy-induced neutropenia.
PUBDATE: 19941201
A high-performance immunoaffinity chromatographic technique has been developed for the measurement of recombinant human granulocyte colony stimulating factor in human patients receiving this agent, following neutropenia, arising from cancer chemotherapy. The technique employs a short, biocompatible polymer column packed with minute, antibody-coated glass beads. This system was applied to the analysis of recombinant human granulocyte colony stimulating factor in three different human body fluids. A reasonable degree of correlation was achieved when comparing the immunoaffinity technique to a conventional immunoassay, although the immunoaffinity technique displayed greater specificity.


3. DOCID:22162 SCORE: 0.00297089403419083
DOCNO: 8066936
AUTHOR: H F Jespersen HF
AUTHOR: M E Cortsen ME
AUTHOR: H Videbaek H
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Intracranial venous thrombosis]
PUBDATE: 19940701
Thrombosis of intracranial sinuses and veins is a rare but potentially lethal syndrome. It often affects young adults, but occurs in all ages. It is frequently seen in association with hormonal changes (puerperium, pregnancy and the use of oral contraceptives), inflammatory bowel disease, cancer, and various states of hypercoagulability, or as a consequence of infection. The clinical picture is extremely variable and the diagnosis can be difficult unless one specifically searches for it. The combination of magnetic resonance imaging and magnetic resonance angiography is a powerful and non-invasive tool for diagnosing the syndrome. Treatment with heparin (and for the septic form antibiotics) improves the outcome.


4. DOCID:22952 SCORE: 0.00258766054064321
DOCNO: 7562398
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood-Brain Barrier
QUALIFIER: pharmacokinetics
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: physiology
AUTHOR: T Tsuruo T
AFFILIATION: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
COUNTRY: JAPAN
TITLE: [Mechanism of resistance to antitumor agents--its involvement in blood-brain barrier]
PUBDATE: 19950701
Resistance of tumors to a variety of chemotherapeutic agents presents a major problem in cancer treatment. The gene responsible for multidrug resistance, termed mdr1, encodes a membrane glycoprotein (P-glycoprotein) that acts as a pump to transport various cytotoxic agents. The P-glycoprotein has been shown to bind anticancer drugs and several resistance-reversing agents including calcium channel blockers, and to be an ATPase. The P-glycoprotein was found to function in the blood-brain barrier. The physiological function of the P-glycoprotein in relation to therapy is discussed.


5. DOCID:22937 SCORE: 0.0025876605351073
DOCNO: 7914827
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: O Hino O
AUTHOR: H Mitani H
AUTHOR: H Katsuyama H
AUTHOR: Y Kubo Y
AFFILIATION: Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: IRELAND
TITLE: A novel cancer predisposition syndrome in the Eker rat model.
PUBDATE: 19940801
Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extrarenal primary tumors occurring in Eker rats late in life (at 2 years) additionally revealed pituitary adenomas (17/31 = 54.8% (carrier) vs 7/32 = 21.9% (non-carrier siblings of affected animals), P < 0.01), sarcomas of the spleen (21/31 = 67.7% vs. 0/32 = 0%, P < 0.001) and sarcomas (of probable stromal origin) of the uterus (8/17 = 47.1% vs. 0/15 = 0%, P < 0.01). Thus, the Eker rat might provide a novel animal model of cancer predisposition syndromes.


6. DOCID:22382 SCORE: 0.00258492273607669
DOCNO: 7501539
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: J M Robison JM
AUTHOR: D J Wilkie DJ
AUTHOR: B Campbell B
AFFILIATION: School of Nursing, Lewis-Clark State College, Lewiston, Idaho, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Nursing clinics of North America.
COUNTRY: UNITED STATES
TITLE: Sublingual and oral morphine administration. Review and new findings.
PUBDATE: 19951201
Clinical reports rave about the efficacy of sublingual morphine, but most research data suggest that sublingual morphine lacks the necessary physical characteristics to be absorbed through sublingual tissues. This article clarifies these assertions by reviewing the clinical literature that supports sublingual administration, the theories relevant to sublingual morphine administration, and the pharmacokinetic research that supports or negates the benefit of this route. Recommendations for clinical nursing practice are provided to guide decision-making in care of patients with cancer pain.


7. DOCID:22918 SCORE: 0.00253357630610132
DOCNO: 7675283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Diseases
QUALIFIER: secretion
AUTHOR: P Cottu P
AUTHOR: M L Cossu ML
AUTHOR: A M Scanu AM
AUTHOR: A Gadeddu A
AUTHOR: G Noya G
AUTHOR: G Dettori G
AFFILIATION: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi, Sassari.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Mammary secretion: retrospective study of diagnostic and therapeutic problems]
PUBDATE: 19950401
Nipple secretion is an important clinical symptom in the context of breast pathology second only, in terms of incidence and diagnostic role, to the presence of a mammary nodule. Its importance derives from its possible association with cancer (from 3% to 47%) of which it may be the earliest sign, even if it is most often in relation to a benign pathology. The authors report their experience from 1988 to the present in 60 cases of mammary secretion out of 1200 patients attending the clinic.


8. DOCID:22914 SCORE: 0.00245905917695414
DOCNO: 7494130
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Tanaka S
AUTHOR: Y Kimura Y
AUTHOR: M Furukawa M
AFFILIATION: Department of Otorhinolaryngology, School of Medicine, Kanazawa University, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: Pseudoaneurysm of the carotid artery with haemorrhage into the hypopharynx.
PUBDATE: 19950901
Pseudoaneurysms of the extracranial carotid arteries are rarely seen following irradiation for cancers of the head and neck. We present a patient with a pseudoaneurysm of the common carotid artery following a radical neck dissection and irradiation for thyroid carcinoma 20 years earlier. Following oesophagoscopical examination, a pseudoaneurysm of the right common carotid artery ruptured into the piriform sinus. The common carotid artery was embolized with multiple coils and the bleeding was halted. The relationship between the carotid artery aneurysm and irradiation, and the treatment of carotid artery aneurysm, is discussed.


9. DOCID:23116 SCORE: 0.00211978512589473
DOCNO: 9309175
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drosophila Proteins
DESCRIPTOR: Trans-Activators
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R Cavallo R
AUTHOR: D Rubenstein D
AUTHOR: M Peifer M
AFFILIATION: Department of Dermatology, University of North Carolina at Chapel Hill 27599-3280, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: Armadillo and dTCF: a marriage made in the nucleus.
PUBDATE: 19970801
Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.


10. DOCID:22278 SCORE: 0.00207412701719155
DOCNO: 8935748
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ambulatory Care
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S Sleijfer S
AUTHOR: H S Koops HS
AUTHOR: W T van der Graaf WT
AFFILIATION: Department of Internal Medicine, University Hospital, Groningen, Netherlands.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Netherlands journal of medicine.
COUNTRY: NETHERLANDS
TITLE: Successful treatment on an out-patient basis of a patient with Down's syndrome and disseminated testicular seminoma.
PUBDATE: 19960301
Due to a high incidence of undescended testicles, patients with Down's syndrome have an increased risk of testicular cancer. The treatment of these patients with the successful cisplatin-containing regimens, which are however toxic and require hospitalization, can cause several problems. We present a patient with Down's syndrome suffering from a disseminated seminomatous tumour of the testis who has been successfully treated with combination chemotherapy on an out-patient basis.


11. DOCID:20988 SCORE: 0.00202978836772377
DOCNO: 8948557
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: complications
QUALIFIER: methods
AUTHOR: M Okada M
AUTHOR: H Yamamoto H
AUTHOR: S Satake S
AUTHOR: K Kujime K
AUTHOR: T Sugio T
AUTHOR: K Jinnai K
AUTHOR: K Takahashi K
AFFILIATION: Department of Thoracic Surgery and Neurology, National Hyogo Central Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Thoracic and cardiovascular surgeon.
COUNTRY: GERMANY
TITLE: Sleeve lobectomy for lung carcinoma in a patient with muscular dystrophy.
PUBDATE: 19961001
We performed a sleeve lobectomy on a patient with squamous-cell carcinoma of the lung who had poor pulmonary function and could not move his extremities or trunk, due to a muscular dystrophy. Lung cancer in a highly disabled patient can be resected even with a bronchoplastic procedure.


12. DOCID:21290 SCORE: 0.00202614538805106
DOCNO: 7669599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: J W Mant JW
AUTHOR: M P Vessey MP
AFFILIATION: Department of Public Health and Primary Care, University of Oxford, Radcliffe Infirmary, UK.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Trends in mortality from primary liver cancer in England and Wales 1975-92: influence of oral contraceptives.
PUBDATE: 19950901
Numerous case-control studies have suggested a link between the oral contraceptive pill and liver cancer. The secular trends in liver cancer mortality rates for England and Wales from 1975 to 1992 were examined to determine whether an effect of the pill was apparent. Liver cancer mortality has remained constant in women in the age groups that have had major exposure to the pill.


13. DOCID:21822 SCORE: 0.00195115952201517
DOCNO: 7752460
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation, Neoplastic
DESCRIPTOR: Genomic Imprinting
QUALIFIER: genetics
AUTHOR: O Ogawa O
AUTHOR: M Mishina M
AUTHOR: O Yoshida O
AFFILIATION: Department of Urology, Faculty of Medicine, Kyoto University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Activation of imprinted genes in human carcinogenesis]
PUBDATE: 19950401
Genomic imprinting is defined as a differential expression of genes depending on their parental origin. IGF2 gene on chromosome 11p, which is maternally imprinted in normal human development, has been demonstrated to be activated by loss of imprinting (LOI) during tumorigenesis of Wilms tumor or other kidney neoplasms in childhood. Although the molecular mechanism of genomic imprinting is not clarified yet, it is certain that disruption of the imprinting mechanism has a causative role in some human cancers.


14. DOCID:21366 SCORE: 0.00192377403300538
DOCNO: 9214732
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
AUTHOR: T S Wu TS
AUTHOR: M J Liou MJ
AUTHOR: C S Kuoh CS
AUTHOR: C M Teng CM
AUTHOR: T Nagao T
AUTHOR: K H Lee KH
AFFILIATION: Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.
PUBDATE: 19970601
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.