0. DOCID:18608 SCORE: 0.00354941957189094
DOCNO: 7798818
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: A Panich A
AUTHOR: L Charnvej L
AFFILIATION: Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Thailand.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
COUNTRY: THAILAND
TITLE: Comparison of morphine slow release tablet (MST) and morphine sulphate solution (MSS) in the treatment of cancer pain.
PUBDATE: 19931201
A cross-over, single blind trial of MST and MSS in relieving pain of advanced cancer patients is described. Forty-nine cases completed the study. Both MST and MSS gave equally excellent pain relief in the patients as judged by the pain score of VAS and pain rating scale by a nurse, and the duration of sleep. The daily effective dose was 55.5 +/- 19.7 mg for MST and 61.0 +/- 11.0 mg of MSS.


1. DOCID:19617 SCORE: 0.00287802877331552
DOCNO: 1991303
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: U Lönn U
AUTHOR: S Lönn S
AUTHOR: U Nylen U
AUTHOR: G Winblad G
AUTHOR: B Stenkvist B
AFFILIATION: Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Amplification of oncogenes in mammary carcinoma shown by fine-needle biopsy.
PUBDATE: 19910301
A procedure that measures the amplification of oncogenes in human cancer cells is described. The cells were obtained by fine-needle biopsy to allow repeated sampling from individual metastases. A drawback was the low number of cells obtained, but this could be overcome by using a slot-blot hybridization technique to measure gene amplification. Two patients with mammary cancer (primary tumors or metastases), analyzed for the levels of amplification of the oncogene erb-B2, are described in detail. This technique is suitable for analyzing alterations occurring during cancer progression and for identifying subgroups of mammary cancer with different characteristics.


2. DOCID:18853 SCORE: 0.00269779453849065
DOCNO: 8256943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: A D Tabuenca AD
AUTHOR: D R Aitken DR
AUTHOR: J K Ihde JK
AUTHOR: J Smith J
AUTHOR: C Garberoglio C
AFFILIATION: Dept. of Surgery, Loma Linda University Medical Center, CA 92354.
PUBTYPE: Journal Article
JOURNALTITLE: The American surgeon.
COUNTRY: UNITED STATES
TITLE: Factors influencing survival in advanced gastric cancer.
PUBDATE: 19931201
Even though the incidence of gastric carcinoma is decreasing, the prognosis remains poor. A review of 88 patients with advanced gastric cancer was evaluated by univariate and multivariate analysis to determine prognostic factors. Univariate analysis showed that both "curative" resection (P = 0.006) and adjuvant chemotherapy (P = 0.02) were important therapy variables. These factors were not independent when evaluated by multivariate analysis. However, when they were combined and re-evaluated by multivariate analysis, the combination of "curative" surgery and adjuvant chemotherapy significantly improved survival in advanced gastric cancer (P = 0.04).


3. DOCID:18922 SCORE: 0.00269779342367443
DOCNO: 2297418
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: G J Petruzzelli GJ
AUTHOR: J T Johnson JT
AUTHOR: E J de Vries EJ
AFFILIATION: Department of Otolaryngology, University of Pittsburgh, School of Medicine, Eye and Ear Institute, PA 15213.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Neutropenic enterocolitis. A new complication of head and neck cancer chemotherapy.
PUBDATE: 19900201
Neutropenic enterocolitis is a recognized complication of immunosuppression or chemotherapy for leukemia. It presents as severe abdominal pain and tenderness, fever, and diarrhea associated with granulocytopenia. Gastrointestinal symptoms associated with chemotherapy for head and neck neoplasms include nausea and emesis, but not acute abdominal distress. We present, to our knowledge, the first case of neutropenic enterocolitis in a patient receiving cisplatin and fluorouracil chemotherapy for metastatic head and neck cancer.


4. DOCID:18403 SCORE: 0.0024798270571459
DOCNO: 8389419
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: L Gutmann L
AUTHOR: D Weidman D
AUTHOR: A Gutiérrez A
AFFILIATION: Department of Neurology, West Virginia University Health Sciences Center, Morgantown 26506.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Muscle & nerve.
COUNTRY: UNITED STATES
TITLE: Lambert-Eaton myasthenic syndrome with prominent postexercise exhaustion.
PUBDATE: 19930701
A 66-year-old man with Lambert-Eaton myasthenic syndrome, polyneuropathy, and small cell lung cancer, developed profound muscle weakness with a prolonged period of ventilatory dependency. Electrophysiological studies demonstrated very small compound muscle action potentials in response to supramaximal nerve stimulation, limited tetanic and postexercise facilitation, and prolonged prominent postexercise exhaustion (40-60% of baseline value) persisting up to 20 minutes. It is hypothesized that these changes may reflect both a severe defect in acetylcholine release and decreased availability of releasible acetylcholine from the terminal axon.


5. DOCID:17841 SCORE: 0.00242871280243848
DOCNO: 2269520
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J H Grendell JH
AFFILIATION: University of California, San Francisco.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastroenterology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Idiopathic acute pancreatitis.
PUBDATE: 19901201
In most patients presenting with acute pancreatitis, the cause can be established on the basis of initial history, physical examination, laboratory studies, and abdominal sonography. Patients with unexplained pancreatitis at that point are often considered to have idiopathic disease. However, a cause and, often, effective treatment to prevent recurrent pancreatitis are possible in many of these patients if an aggressive diagnostic approach is taken to discover undiagnosed hyperlipidemia, occult gallstones, abnormalities of the bile and pancreatic ducts, sphincter of Oddi dysfunction, pancreatic cancer and other tumors, and cystic fibrosis (in children and young adults).


6. DOCID:18429 SCORE: 0.00239411604174653
DOCNO: 1729961
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proto-Oncogenes
QUALIFIER: genetics
AUTHOR: H Inaji H
AUTHOR: K Motomura K
AUTHOR: S Noguchi S
AUTHOR: H Yamamoto H
AUTHOR: H Koyama H
AFFILIATION: Dept. of Surgery, Center for Adult Diseases, Osaka, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [New factors of possible prognostic value in breast cancer]
PUBDATE: 19920101
Over the past 10 years, we have witnessed a variety of potential prognostic factors of breast cancer including proliferative rate, ploidy, growth factor receptors, oncogenes and cathepsin D production. Some of these variables seem to predict the prognosis of the patients but the available data are conflicting and call for carefully conducted quality-control studies to analyze intra- and interlaboratory variations. In this review, we provided a framework from which prognostic factor information can be used directly to make treatment decisions.


7. DOCID:18097 SCORE: 0.00233907843873363
DOCNO: 2322213
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: methods
AUTHOR: P H Chapuis PH
AUTHOR: R C Newland RC
AUTHOR: O F Dent OF
AUTHOR: E L Bokey EL
AUTHOR: J M Hinder JM
AFFILIATION: University of Sydney, Department of Colon and Rectal Surgery, Concord Hospital, New South Wales, Australia.
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Current perspectives in staging large bowel cancer.
PUBDATE: 19900401
Today, a standardized method of staging that is internationally accepted is urgently needed for the management of patients with colorectal cancer. The use of a uniform, sensitive staging system would greatly improve case selection and avoid unnecessary bias when entering patients into adjuvant therapy trials. This would allow a more accurate evaluation of new treatment protocols and assist in the development of more effective follow-up programmes.


8. DOCID:17403 SCORE: 0.00230779559674992
DOCNO: 1284918
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: P Trucco P
AUTHOR: A Frullini A
AUTHOR: L Nocentini L
AUTHOR: G Poggesi G
AUTHOR: P Fabbrucci P
AFFILIATION: U.O. Chirurgia Generale, U.S.L. 20/B, Figline Valdarno (FI).
PUBTYPE: Journal Article
JOURNALTITLE: Il Giornale di chirurgia.
COUNTRY: ITALY
TITLE: [Carcinoma of the gallbladder. Our experience]
PUBDATE: 19920501
A series of 11 patients (3 males and 8 females, mean age 63.4 yrs.) suffering from gallbladder cancer has been reviewed. Authors' purpose in reviewing their experience was to identify factors either in patient characteristics or treatment, that may influence statistic data. Symptoms, signs, laboratory and imaging studies were uniformly unhelpful in determining the diagnosis. Early diagnosis at a stage amenable to surgical excision remains the only therapeutical possibility.


9. DOCID:18618 SCORE: 0.00229616708911939
DOCNO: 8483268
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
AUTHOR: K Tsukida K
AFFILIATION: Kobe Women's College of Pharmacy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Retinoids]
PUBDATE: 19930401
Retinoid includes vitamins A and synthetic relatives except provitamins A such as carotenes. In this review, recent developments on the chemistry and physiological functions of retinoid (retinol, retinal and retinoic acid etc.) were surveyed, special emphasis being laid on the following subjects: (1) vision (retinal and photo-sensitivities; molecular mechanism of scotopic and photopic vision). (2) systemic actions of vitamins A (multiple physiological functions and their active intermediates). (3) reproduction and morphogenesis (extracellular-transport proteins, intracellular-cytoplasmic transfer proteins, and intracellular-nuclear transacting factors; RAR and RXR; morphogen). (4) chemical prevention of cancer (synthetic retinoid derived from retinoic acid). (5) biological significance of cis-retinoid.


10. DOCID:19803 SCORE: 0.00220449714528209
DOCNO: 11648615
OWNER: KIE
STATUS: MEDLINE
DESCRIPTOR: Disclosure
DESCRIPTOR: Informed Consent
DESCRIPTOR: Jurisprudence
DESCRIPTOR: Liability, Legal
DESCRIPTOR: Neoplasms
DESCRIPTOR: Physicians
DESCRIPTOR: Prognosis
DESCRIPTOR: Truth Disclosure
PUBTYPE: Legal Cases
JOURNALTITLE: West's California reporter.
COUNTRY: United States
TITLE: Arato v. Avedon.
PUBDATE: 19920801
A California appellate court reversed a jury verdict in favor of a doctor who had been accused of negligence by surviving family members for not disclosing life expectancy information to a patient suffering from pancreatic cancer. The Court of Appeal determined that a physician has a fiduciary duty to disclose information about life expectancy to a patient who has indicated his desire to make a fully informed decision. In addition, the court held that expert testimony concerning medical community standards regarding disclosure of life expectancy was erroneously admitted because the duty to disclose is mandated by law. Also, the instructions given to the jury at the trial were misleading because they implied, "...the physician, not the patient, ultimately knows what is best...."


11. DOCID:18951 SCORE: 0.00193149399077952
DOCNO: 1503333
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: M B Sporn MB
AUTHOR: A B Roberts AB
AFFILIATION: National Cancer Institute, Bethesda, Maryland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Autocrine secretion--10 years later.
PUBDATE: 19920901
The concept of autocrine secretion, its subsequent modifications, its application for understanding pathogenesis of disease, and its potential for developing new approaches to prevention and treatment are reviewed. Peptide growth factors (cytokines) act as local autocrine and paracrine mediators of tissue homeostasis. Many diseases, including cancer, atherosclerosis, rheumatoid arthritis, and other fibrotic diseases characterized by chronic inflammation, are associated with aberrant expression and cellular coordination of the homeostatic action of these regulatory molecules. Modern biotechnology and pharmacology offer unique opportunities for the therapeutic prevention and treatment of these molecular and cellular lesions, using either cytokines or other agents that modify their synthesis and activity.


12. DOCID:16689 SCORE: 0.00193037380674505
DOCNO: 2269528
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cholangiopancreatography, Endoscopic Retrograde
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: S K Irani SK
AFFILIATION: George Washington University School of Medicine, Washington, DC.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastroenterology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Endoscopic management of pancreatic disorders.
PUBDATE: 19901201
Endoscopic management of pancreatic diseases is a rapidly developing area. Many innovative techniques and types of equipment have become available. The indications for diagnostic and therapeutic intervention in may disease states are in evolution. Diseases such as acute gallstone pancreatitis, pancreatic cancer, and complications of chronic pancreatitis are being approached more aggressively. Controversy concerning application of these techniques is discussed in this article.


13. DOCID:18028 SCORE: 0.00191089383507809
DOCNO: 1310891
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: O A Batson OA
AUTHOR: D M Fantle DM
AUTHOR: J A Stewart JA
AFFILIATION: Vermont Regional Cancer Center, University of Vermont, Burlington 05401.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Paraneoplastic encephalomyelitis. Dramatic response to chemotherapy alone.
PUBDATE: 19920301
Neurologic paraneoplastic syndromes are usually a debilitating and untreatable manifestation of malignancy. The case is presented of a woman with severe paraneoplastic encephalomyelitis that was characterized predominantly by cerebellar degeneration associated with small cell lung cancer, both of which responded rapidly to cytotoxic chemotherapy alone. She is alive with some neurologic residua but no signs of recurrent cancer more than 2 years after diagnosis. Recommendations for aggressive management of this rare but disabling syndrome are outlined.


14. DOCID:18006 SCORE: 0.00191089287938966
DOCNO: 2068829
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: M Kohli-Kumar M
AUTHOR: A D Pearson AD
AUTHOR: I Sharkey I
AUTHOR: A W Craft AW
AFFILIATION: Children's Hospital Medical Center, Cincinnati, OH.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: DICP : the annals of pharmacotherapy.
COUNTRY: UNITED STATES
TITLE: Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion.
PUBDATE: 19910501
Vomiting is one of the most distressing adverse effects of cancer chemotherapy. Metoclopramide by continuous infusion (400 micrograms/kg/h after a loading dose of 2.5 mg/kg) is a novel administration method for optimizing efficacy. A two-year-old boy developed urinary retention on three occasions, once accompanied by priapism and slurred speech, while receiving a continuous infusion. This was reversed by procyclidine, suggesting that it may have been a dystonic reaction.