0. DOCID:15330 SCORE: 0.00399430880346287
DOCNO: 2654502
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunotherapy
DESCRIPTOR: Lymphokines
QUALIFIER: therapeutic use
QUALIFIER: immunology
QUALIFIER: therapy
AUTHOR: C M van Haelst-Pisani CM
AUTHOR: R J Pisani RJ
AUTHOR: J S Kovach JS
AFFILIATION: Department of Oncology, Mayo Clinic, Rochester, MN 55905.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mayo Clinic proceedings. Mayo Clinic.
COUNTRY: UNITED STATES
TITLE: Cancer immunotherapy: current status of treatment with interleukin 2 and lymphokine-activated killer cells.
PUBDATE: 19890401
In recent years, the medical community has witnessed a growing interest in the use of adoptive immunotherapy in patients with malignant lesions refractory to standard treatments. Systemic administration of interleukin 2, in combination with the adoptive transfer of a patient's own activated immune cells, has resulted in objective regression of several types of advanced cancers. Pronounced regression of tumor has also been observed with use of systemic interleukin 2 alone. This ability to augment the immune defense system of the host against cancer has stimulated intense clinical and laboratory investigations.


1. DOCID:12734 SCORE: 0.00282992903006514
DOCNO: 2727940
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: R Yazigi R
PUBTYPE: Journal Article
JOURNALTITLE: Texas medicine.
COUNTRY: UNITED STATES
TITLE: Early diagnosis of gynecologic cancer.
PUBDATE: 19890401
Malignant gynecologic neoplasms comprise about 15% of cancers in American females. Analysis of cancer treatment results indicates that the most important prognostic factor is stage of disease; thus any strategy to improve survival must include early diagnosis. This can be accomplished by identification of the women at risk, adequate use of screening techniques, updating the primary care physician with clinical and laboratory diagnostic features, and prompt referral to the subspecialist. This approach should drastically reduce the incidence and mortality of invasive gynecologic cancers.


2. DOCID:12862 SCORE: 0.00271578036110848
DOCNO: 3463819
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Information Systems
QUALIFIER: mortality
AUTHOR: B H Patterson BH
AUTHOR: R Bilgrad R
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Use of the National Death Index in cancer studies.
PUBDATE: 19861001
The National Death Index (NDI) is a central file of identifying information on all deaths occurring in the United States since 1979. Potential uses of the NDI as a tool for both short-term and long-term follow-up in cancer treatment, prevention, and occupational studies are suggested. The various steps involved in using the NDI and interpreting the results are described, along with factors influencing the effectiveness of the matching process.


3. DOCID:12868 SCORE: 0.00271577921524267
DOCNO: 3703330
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: blood
QUALIFIER: analysis
AUTHOR: E Leonardo E
AUTHOR: C Dogliotti C
AUTHOR: M Mancuso M
AUTHOR: B Sanfilippo B
AUTHOR: A Oliaro A
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Distribution and prognostic value of CEA and TPA in cancer of the lung]
PUBDATE: 19860301
Serum levels of carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) were investigated in 53 lung cancer patients. The higher percentage of patients with serum CEA positivity was observed within the anaplastic lung cancer group. TPA serum positivity was found in similar percentage in all the examined groups. Relationship between serum CEA positivity and/or serum TPA positivity and survival were then carried out.


4. DOCID:14880 SCORE: 0.00265740269902413
DOCNO: 2820673
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Thigh
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: M H Torosian MH
AUTHOR: J F Botet JF
AUTHOR: M Paglia M
AFFILIATION: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Diseases of the colon and rectum.
COUNTRY: UNITED STATES
TITLE: Colon carcinoma metastatic to the thigh--an unusual site of metastasis. Report of a case.
PUBDATE: 19871001
Metastasis from colorectal carcinoma occurs by either lymphatic or hematogenous spread. The pattern of metastasis in patients with colorectal malignancy has been characterized by numerous clinical, surgical, and autopsy studies. The most common sites of colorectal metastasis are the liver and lung. Only two previous instances of colorectal carcinoma metastatic to skeletal muscle have been reported. The present report documents the third case of colorectal cancer metastatic to skeletal muscle and reviews the typical pattern of distant metastasis from colorectal carcinoma.


5. DOCID:13472 SCORE: 0.00246566148526394
DOCNO: 3013434
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: G Buzzelli G
AUTHOR: C Smorlesi C
AUTHOR: R Mazzanti R
AUTHOR: A Pampana A
AUTHOR: L Matassi L
AUTHOR: P Simondi P
AUTHOR: P Gentilini P
PUBTYPE: Journal Article
JOURNALTITLE: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
COUNTRY: ITALY
TITLE: Chemotherapy of primary and secondary liver cancer: is it useful?
PUBDATE: 19860601
The therapeutic efficacy of three different antiblastic regimens was tested in patients affected by primary or secondary liver cancer. The association of cyclophosphamide and adriamycin gave the best results, despite no partial remission observed with any treatment. As regards the efficacy of antiblastic therapy in this type of tumor, we must conclude that the only detectable effect is a transient improvement of the course of the disease.


6. DOCID:14906 SCORE: 0.0023402848687647
DOCNO: 3300957
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug therapy
QUALIFIER: pharmacology
AUTHOR: P J O'Dwyer PJ
AUTHOR: S A King SA
AUTHOR: D F Hoth DF
AUTHOR: B Leyland-Jones B
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Role of thymidine in biochemical modulation: a review.
PUBDATE: 19870801
The role of thymidine in the treatment of cancer has been under clinical investigation for nearly a decade. Clinical trials have demonstrated that it lacks antitumor activity in its own right. In this review, the mechanism of action and rationale for the use of thymidine as a biochemical modulator of standard agents such as 5-fluorouracil, 1-beta-D-arabinofuranosylcytosine, and methotrexate are summarized. With this background, the clinical trials which have been conducted with thymidine, either alone or in combination, are described. We suggest a number of further studies of the role of thymidine in the biochemical modulation of antimetabolites.


7. DOCID:14899 SCORE: 0.00234028452256137
DOCNO: 3756896
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Organoselenium Compounds
QUALIFIER: metabolism
QUALIFIER: toxicity
AUTHOR: G Batist G
AUTHOR: A G Katki AG
AUTHOR: R W Klecker RW
AUTHOR: C E Myers CE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Selenium-induced cytotoxicity of human leukemia cells: interaction with reduced glutathione.
PUBDATE: 19861101
Selenium exists in a number of forms with differing valence states, some of which have shown antitumor activity. We studied the tumoricidal activity of four currently available selenium forms against a human leukemia cell line and exploited the differences among them to investigate the mechanism of antitumor action. Only selenocystine and sodium selenite showed antitumor activity, and these were also the only compounds which demonstrated significant redox chemistry, including depletion of cellular glutathione, stimulation of glutathione reductase, and stimulation of oxygen consumption. The interaction of these two compounds with glutathione suggests an intriguing potential role for them in cancer therapy.


8. DOCID:13249 SCORE: 0.00215687017493877
DOCNO: 3773094
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: G P Haas GP
AUTHOR: B P Shumaker BP
AUTHOR: J C Cerny JC
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: The high incidence of benign testicular tumors.
PUBDATE: 19861201
Of 2,800 testicular procedures performed at our institution between 1965 and 1985, 233 inguinal explorations were done for suspicion of cancer. Malignancy was present in 161 patients but in 72 cases (31 per cent) benign lesions were found. Despite the benign nature of the lesion 51 of these patients (70 per cent) underwent radical orchiectomy. The incidence of benign testicular tumors is much higher than previously suspected and awareness of this condition should lead to increased testicular preservation in selected cases.


9. DOCID:13205 SCORE: 0.00210915355960866
DOCNO: 3821291
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Continuity of Patient Care
DESCRIPTOR: Models, Theoretical
DESCRIPTOR: Primary Health Care
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: N Coyle N
PUBTYPE: Journal Article
JOURNALTITLE: The Medical clinics of North America.
COUNTRY: UNITED STATES
TITLE: A model of continuity of care for cancer patients with chronic pain.
PUBDATE: 19870301
A patient and family-centered, nurse-coordinated model is presented in which a collaborative approach among nurse, physician, and social worker is used. The team is based at a hospital or cancer center, but is oriented toward the community. In the model, the nurse is responsible for the day to day management of the patient's pain, and works with the patient, family, and community physicians and nurses in symptom control and supportive care.


10. DOCID:14913 SCORE: 0.00210056837684988
DOCNO: 2796641
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: physiology
QUALIFIER: prevention & control
QUALIFIER: radiotherapy
AUTHOR: M I Khvorostenko MI
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Radiotherapy of stomach cancer under conditions of severe exogenous hypoxia (8% O2)]
PUBDATE: 19890901
Irradiation of 116 stomach cancer patients was performed under the conditions of hypoxia caused by the inhalation of a gaseous mixture containing (8 +/- 0.5%) O2; irradiation of 108 patients was performed in the air. The method of hypoxic radiotherapy of stomach cancer is described. The authors present some data on radiation reactions, tumor regression, the condition of tumorous and normal tissue after radiotherapy under the conditions of hypoxia which permitted an increase in a tumor radiation dose and a decrease in the number and gravity of radiation reactions. The above method of large field preoperative irradiation made it possible to improve short-term results of combined therapy of stomach cancer patients.


11. DOCID:12235 SCORE: 0.00204009553215366
DOCNO: 3759516
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: K Dahlem K
AUTHOR: L Osterwald L
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: HNO.
COUNTRY: GERMANY, WEST
TITLE: [Examples for possible tumor induction by immunosuppressive and cytostatic drugs (case studies)]
PUBDATE: 19860801
The problems of immunosuppressive and cancer therapy are discussed based on five case reports. In each case neoplasms were observed, which appear to have been caused by the previous treatment. A tumor is particularly tragic when it follows immunosuppression for chronic inflammatory disease (eg. uveitis, rheumatoid arthritis).


12. DOCID:15081 SCORE: 0.00203457063893747
DOCNO: 2649461
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: S B Balmukhanov SB
AUTHOR: A A Beisebaev AA
AUTHOR: Z I Aitkoolova ZI
AUTHOR: J S Mustaphin JS
AUTHOR: V I Philippenko VI
AUTHOR: R S Rismuhamedova RS
AUTHOR: A M Aisarova AM
AUTHOR: J N Abdrahmanov JN
AFFILIATION: Kazakh Research Institute of Oncology and Radiology, Alma Ata, USSR.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: International journal of radiation oncology, biology, physics.
COUNTRY: UNITED STATES
TITLE: Intratumoral and parametrial infusion of metronidazole in the radiotherapy of uterine cervix cancer: preliminary report.
PUBDATE: 19890401
In a recently started clinical trial, the short-term effects of radiotherapy of cervix cancer Stage IIb and III in combination with topical infusion of metronidazole solution were evaluated by determining the local clearance rate and cytologic damage in randomized and non-randomized cases. In regard to the short term effects the combined treatment was found to be superior to treatment without metronidazole.


13. DOCID:15385 SCORE: 0.00202718742011932
DOCNO: 3954946
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: O C Hadjimichael OC
AUTHOR: C A Boyle CA
AUTHOR: J W Meigs JW
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Abortion before first livebirth and risk of breast cancer.
PUBDATE: 19860201
The present study examined the association between abortion prior to a first livebirth and breast cancer risk among a cohort of 3,315 women who had been delivered of liveborn children between 1946 and 1965 in a group of private gynaecology practices in Connecticut and followed through 1980 for the incidence of cancer. Among women with one livebirth at the time of cohort identification, a spontaneous abortion before this livebirth was associated with a 3.5-fold increase in the risk of breast cancer. The elevation in risk was independent of some of the major risk factors of breast cancer and became more pronounced as the number of years since the abortion increased.


14. DOCID:14242 SCORE: 0.00197251800084597
DOCNO: 2432206
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cytotoxicity, Immunologic
QUALIFIER: pathology
QUALIFIER: immunology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Vinzenz K
AUTHOR: M Micksche M
PUBTYPE: Journal Article
JOURNALTITLE: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
COUNTRY: UNITED STATES
TITLE: Natural cytotoxicity in draining lymph nodes of squamous cell cancer in the maxillofacial region.
PUBDATE: 19870101
There is at present very little information available, including the presented preliminary data, concerning NK activity in patients with head and neck cancer. The objective of the present investigation was to study NK activity in peripheral blood (PB) and regional lymph nodes (LNs) in patients with different stages of head and neck cancer. Furthermore, phenotypic characterization of lymph node cells was performed. Finally, the in vitro response of mononuclear cells isolated from blood and lymph nodes to interferon was investigated.