0. DOCID:3538 SCORE: 0.00474162970621273
DOCNO: 1180587
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Intestinal Polyps
DESCRIPTOR: Neoplasm Recurrence, Local
AUTHOR: L G Henry LG
AUTHOR: R E Condon RE
AUTHOR: W J Schulte WJ
AUTHOR: C Aprahamian C
AUTHOR: J J DeCosse JJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Risk of recurrence of colon polyps.
PUBDATE: 19751001
At Wood Veterans Administration Center, 268 patients who had a polypectomy have been followed up to 20 years with semiannual proctosigmoidoscopic and barium enema examinations. For the present review of benign polyp disease, patients having coexisting carcinoma, chronic inflammatory disease, and those lost to followup have been excluded; 154 patients followed for a mean of 7 years comprise the study group. Thirty per cent of patients developed recurrent polyps. The risk of recurrence during the first year was 16 times that expected in a population of similar age and sex, but thereafter diminished steadily. After 48 months risk of polyp recurrence was little higher than the incidence expected in a normal population. Neither patient age, presenting symptoms nor the site or size of the initial polyp(s) were of any prognostic value regarding recurrence. Patients presenting with a villous adenoma or with more than 3 polyps had a significantly increased risk of recurrence may persist indefinitely. The overall incidence of colonic carcinoma may have been increased, but the location of subsequent cancer was not related to the site of a previously excised polyp.


1. DOCID:3083 SCORE: 0.00428442649775816
DOCNO: 922665
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
AUTHOR: G M Brodeur GM
AUTHOR: G Sekhon G
AUTHOR: M N Goldstein MN
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Chromosomal aberrations in human neuroblastomas.
PUBDATE: 19771101
Six human neuroblastomas were analyzed by Giemsa and fluorescence banding techniques to identify chromosomal aberrations. Two neuroblastomas were primary tumors from untreated children, and four were well lines established from human neuroblastomas. Five of the six tumors studied were diploid or near diploid; one was near tetraploid. A 1p- was found in three of the neuroblastomas examined. The 1p-was present in both primary tumors, and in one it was the only abnormality detected. This deletion was also found in the cells of an established line, in addition to other abnormalities. Giant markers of different origins were found in the four cell lines, and no double-minute chromosomes were found in the primaries or the cell lines studied. Thus, a 1p-deletion was the most consistent abnormality found in the six human neuroblastomas examined in this study. We attempt to correlate this finding with Knudson's hypothesis on the origin of childhood cancer. Additional studies of primary tumors should clarify whether this specific chromosomal abnormality is related to the the acquisition of malignant behavior in human neuroblastomas.


2. DOCID:2456 SCORE: 0.00398718954723935
DOCNO: 409478
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: W F Whitmore WF
AUTHOR: M A Batata MA
AUTHOR: B S Hilaris BS
AUTHOR: G N Reddy GN
AUTHOR: A Unal A
AUTHOR: M A Ghoneim MA
AUTHOR: H Grabstald H
AUTHOR: F Chu F
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A comparative study of two preoperative radiation regimens with cystectomy for bladder cancer.
PUBDATE: 19770901
This report surveys the results of two programs of preoperative irradiation with radical cystectomy for bladder cancer in 205 patients. Irradiating the true pelvis to 4000 rads in 4 weeks with radical cystectomy after 6 weeks was implemented in 119 patients (Group 1) from 1959 to 1965; 2000 rads given in 1 week to the true pelvis and radical cystectomy within the following week was implemented in 86 patients (Group 2) from 1966 to 1970. Determinate survival without evidence of recurrence at 5 years was 43% in Group 1 and 42% in Group 2. Mortality with recurrence of bladder cancer in 5 or more years was 44% in group 1 and 42% in group 2. Pelvic complications occurred in 13% of group 1 and 9% of group 2.


3. DOCID:1409 SCORE: 0.00321871218041533
DOCNO: 1192421
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cytotoxicity Tests, Immunologic
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G E Pierce GE
AUTHOR: B DeVald B
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Microcytotoxicity assays of tumor immunity in patients with bronchogenic carcinoma correlated with clinical status.
PUBDATE: 19751201
Peripheral blood lymphocytes from patients with bronchogenic carcinoma were tested in microcytotoxicity assays against cultured bronchogenic cancer cells, other types of tumor cells, and skin fibroblasts. Lymphocytes from patients who were postresection with no clinical evidence of residual or recurrent tumor were more frequently toxic against bronchogenic carcinoma than were lymphocytes from normal donors or from patients with clinically evident disease. Lymphocytes from patients with minimal or no tumor were more frequently toxic against bronchogenic cancer than against skin fibroblasts. Serum samples from a few patients rendered lymphocytes toxic for bronchogenic cancer cells, but this serum activity could not be correlated with the patient's clinical status.


4. DOCID:2695 SCORE: 0.00321656474213887
DOCNO: 1225514
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: K Kovacs K
AUTHOR: E Horvath E
PUBTYPE: Journal Article
JOURNALTITLE: Endokrinologie.
COUNTRY: GERMANY, EAST
TITLE: Gonadotrophs following removal of the ovaries: a fine structural study of human pituitary glands.
PUBDATE: 19750901
The fine structure of gonadotrophs has been investigated in surgically removed pituitary glands of 12 women who because of disseminated breast cancer, underwent bilateral ovariectomy at various periods before hypophysectomy. Compared with the adenohypophyses of 3 non-ovariectomized female subjects with diabetes mellitus, electron microscopy revealed that two cell types were affected by gonadectomy. These cell types corresponded to those which were regarded as FSH gonadotrophs and LH gonadotrophs in previous studies. In addition in the adenohypophyses stimulated by removal of the ovaries, intermediary cell types began to appear suggesting a transformation of LH gonadotrophs to FSH gonadotrophs. The most conspicuous change following gonadectomy was the formation of castration cells. These cells arose from FSH gonadotrophs and exhibited ultrastructural features interpreted as representing the morphologic manifestations of sustained hypersecretion of gonadotrophins. It seemed that castration cells have a limited life span and in their advanced stages of development they show ultrastructural signs indicative of irreversible involution.


5. DOCID:2707 SCORE: 0.00319058119063658
DOCNO: 895604
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: E Evans E
AUTHOR: O Harris O
AUTHOR: P Nicoll P
AUTHOR: R Quinn R
AUTHOR: C J Windsor CJ
AUTHOR: G Fielding G
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: A prospective study of gastric and oesophageal carcinoma.
PUBDATE: 19770601
A prospective study of carcinoma of the stomach and oesophagus has been carried out for 2 1/2 years. Seventy-three cases of carcinoma of the stomach, and 16 cases of carcinoma of the oesophagus have been documented. For carcinoma of the stomach, operability rate was 72-6% and resectability rate was 41-9%; overall survival was poor, 20-9% at 12 months. For those who underwent resection, survival at 12 months was 45-5%. No cases of early gastric cancer are among those studied. For carcinoma of the oesophagus, four patients had a resection, and only one has survived for more than 12 months. In the clinical sphere there is a need for early endoscopic as well as radiological investigation of dyspeptic symptoms. In the research field there is a need for studies of chemotherapy in combination with surgery in the initial treatment of gastric carcinoma.


6. DOCID:3811 SCORE: 0.00309903098231679
DOCNO: 1139485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: N C Delarue NC
AUTHOR: G Gale G
AUTHOR: A Ronald A
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Multiple fluoroscopy of the chest: carcinogenicity for the female breast and implications for breast cancer screening programs.
PUBDATE: 19750601
The risk of radiation carcinogenesis has been established for breast tissue from experience with total body irradiation and multiple fluoroscopy of the chest with the patient prone. The doubling dose has been estimated to lie between 20 and 50 rads. Before undertaking radiologic screening programs for breast cancer, therefore, it is necessary to determine whether exposures below this range are safe. Of 792 women who had had tuberculosis and were followed for a minimum of 20 years, 451 had had multiple fluoroscopy while supine; 341 had not had fluoroscopy. The first group received a total radiation dose to the breast averaging 17 rads (141.5 fluoroscopies); the incidence of breast cancer in this group was not increased. Had fluoroscopy been performed with the patient prone the total radiation dose would have averaged 308 rads. The difference is thought to explain the increased incidence of breast cancer attributable to fluoroscopy given with the patient prone. Mid-breast exposure with mammography or xeroradiography varies between 3 and 6 rads. Repetitive screening would, therefore, appear safe provided total exposure did not exceed 20 rads. With this restriction there would appear to be no reason to curtail screening of women for breast cancer.


7. DOCID:3627 SCORE: 0.00285315988583681
DOCNO: 409485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: D Sampson D
AUTHOR: T G Peters TG
AUTHOR: J D Lewis JD
AUTHOR: J Metzig J
AUTHOR: B E Kurtz BE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Dose dependence of immunopotentiation and tumor regression induced by levamisole.
PUBDATE: 19771001
Breast cancer was induced in female Sprague-Dawley rats by 7,12-dimethylbenz(a)anthracene. Once tumors had become established, they were treated with varying doses of the immunopotentiating drug, levamisole. Tumor growth was measured in the various dosage groups, and at 6 months after tumor induction the animals were sacrificed. Their immunological competence at this time was measured by the mitogen responses of splenic lymphocytes. Untreated animals with breast cancer were found to be immunosuppressed compared to normal animals. The drug levamisole resulted in immunopotentiation, but at high doses it was immunosuppressive. Tumor regression was observed at doses that resulted in immunopotentiation, but not at high doses. There was a significant correlation between immune competence and tumor regression. It is concluded that levamisole can cause regression of breast cancer in the rat but that this effect is critically dependent on the dose of the drug; these observations confirm previous studies carried out on human cells in vitro. It is recommended that high doses of the drug be avoided in human clinical trials and that the patients who receive this drug should have their immune responses carefully monitored.


8. DOCID:869 SCORE: 0.00278612109085003
DOCNO: 1201943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: P Szabó P
PUBTYPE: Journal Article
JOURNALTITLE: Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete.
COUNTRY: GERMANY, WEST
TITLE: [Clinical picture and roentgen therapy of lip carcinomas]
PUBDATE: 19751001
204 patients with lip cancer (squamous cell carcinoma and basal cell carcinoma) were irradiated with soft x-ray and cobalt-radiation respectively after histological examination of the tumor. Available observations were supplied by 190 patients. Distribution according to age and histology, the size of the tumor, as well as the therapeutic results and the recurrence rates are reported. 96,6% of the tumors which showed no metastases at the beginning of the treatment remained recurrence-free after radiation. Early diagnosis, the necessity of treatment and the problem of prophylaxis are emphasized.


9. DOCID:1323 SCORE: 0.00257505498524737
DOCNO: 78158
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug therapy
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: urine
AUTHOR: D H Russell DH
AUTHOR: B G Durie BG
AUTHOR: S E Salmon SE
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Polyamines as predictors of success and failure in cancer chemotherapy.
PUBDATE: 19751001
Polyamines appear to have clinical utility for monitoring cancer therapy. Investigations on the patterns of urinary excretion of polyamines in patients receiving cancer chemotherapy and studies of the tritiated-thymidine labelling index of tumour cells in a subgroup of these patients form the basis for a hypothesis that spermidine can serve as a marker of tumour-cell kill, whereas putrescine appears to reflect the proliferative behaviour or "growth fraction" of the tumour. Although tests of this hypothesis are necessary to establish the predictive value of polyamines for monitoring cancer therapy, it is clear that polyamines may provide important new information on tumour cytokinetic parameters.


10. DOCID:3760 SCORE: 0.00255213791418305
DOCNO: 605627
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
AUTHOR: G Czok G
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Ernährungswissenschaft.
COUNTRY: GERMANY, WEST
TITLE: [Coffee and health]
PUBDATE: 19771201
Coffee as a rule develops stimulating effects on the central nervous system, heart and circulation which are mainly caused by caffeine. In certain cases coffee may also have a sedative effect and sometimes even it is useful to fall asleep quickly. Furthermore coffee may be advantageous in the treatment of some functional disorders caused by lacking of dopamine, because coffee is able to increase the dopamine formation in brain. Concerning the effects of coffee in the gastrointestinal-tract and liver-bile system caffeine is only of secondary importance. Hereby certain roasting substances, possibly also chlorogenic acid or caffeic acid should be responsible for the stimulating effects observed in these organs. These stimulating effects could be caused whether directly or indirect e.g. by liberating gastrin or other gastrointestinal hormones. Vitamin niacin, which is formed in greater amounts from trigonelline during the roasting process, may also be important from the nutritional standpoint. Therefore coffee may be prescribed as a true drug in cases of deficiency in vitamin niacin or also in the pellagra disease. By extensive epidemiological studies performed lately it could be demonstrated that there exists no correlation between coffee consumption and certain risk factors as hypertension, heart infarction, diabetes, gout or cancer diseases. Furthermore there was no evidence that coffee or its caffeine content are able to induce genetic alterations or even malformations.


11. DOCID:1010 SCORE: 0.00252720638891476
DOCNO: 825738
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: K J Lohe KJ
AUTHOR: J Baltzer J
AUTHOR: J Zander J
PUBTYPE: Journal Article
JOURNALTITLE: MMW, Münchener medizinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: [Histological diagnosis and individual treatment of cancer in gynecology (author's transl)]
PUBDATE: 19761001
Individualization of cancer therapy in gynecology is based on a perfectly precise histological diagnosis. This implies close cooperation between the clinician and the histopathologist. Making a reliable and therapeutically decisive histopathological diagnosis is possible by means of certain diagnostic interventions which provide a maximum of clinical and histological information on the uterus and the breast, and by means of a systematic fine structure processing of the surgical specimens in carcinomas of the uterus, vulva and breast. Only in this way can the clinician take the extraordinary responsibility of an individual treatment of cancer.


12. DOCID:1961 SCORE: 0.00251654733659118
DOCNO: 855826
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Specimen Handling
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R B Johnson RB
AUTHOR: R M Nakamura RM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Improved estrogen receptor assay in human mammary cancer. Technics for handling small tissue samples.
PUBDATE: 19770501
Studies of various technics that aid in performing estrogen receptor assays on small tissue samples from primary cancers of the breast are reported. It is shown how sufficient protein can be obtained from less than 100 mg of small primary tumor without ultracentrifugation to assay estrogen receptor by a simplified two-point Scatchard plot method. The resulting Kd and maximum binding site values with 36 tumor tissue samples approximated the values obtained with the more laborious, larger tissue sample-demanding six-point Scatchard plot. Target and nontarget tissue controls are easily included in an assay run of four to eight samples. For interpretive purposes the derivation of the characterizing value of the Kd for estrogen receptor is given and compared with nonspecific associating binders.


13. DOCID:3897 SCORE: 0.00251160759926533
DOCNO: 1148585
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Thermography
QUALIFIER: diagnosis
AUTHOR: C H Jones CH
AUTHOR: W P Greening WP
AUTHOR: J B Davey JB
AUTHOR: J A McKinna JA
AUTHOR: V J Greeves VJ
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of radiology.
COUNTRY: ENGLAND
TITLE: Thermography of the female breast: a five-year study in relation to the detection and prognosis of cancer.
PUBDATE: 19750701
More than 12,000 women have been examined thermographically in the Breast Unit of the Royal Marsden Hospital, London. Of these women 1,464 had biopsy and histology; 363(25 per cent) were found to have carcinoma and of these 68 per cent had abnormal thermograms, 13 per cent has some thermal asymmetry of doubtful significance and 19 per cent had normal thermal patterns. Fifty-seven per cent and 62 per cent of patients with Stage I and Stage II cancer, respectively, had abnormal thermograms whereas 83 per cent of patients with Stage III cancer had abnormal thermograms. Of 1,101 women who had benign lesions, 63 per cent had normal thermal patterns, 15 per cent had thermal asymmetry of doubtful significance and 22 per cent had abnormal thermograms. The subsequent histories of 172 cancer patients examined thermographically have been analysed and three-year survival rates have been correlated with thermography report, the clinical stage of the disease and the histotogical grade (Bloom, 1950) of the excised tumour. The mean three-year survival rates for patients with Stage II or Stage III cancer are 84 per cent for those with normal and 61 per cent for those with abnormal thermograms.


14. DOCID:2307 SCORE: 0.00251144190638289
DOCNO: 1247973
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: S J Cutler SJ
AUTHOR: M H Myers MH
AUTHOR: P L White PL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Who are we missing and why?
PUBDATE: 19760101
The concept of "missing" is defined as failure to diagnose cancer before it has spread beyond the organ of origin. Data are presented for the 11 sites at which cancer occurs most frequently in the United States. There is a clear association between the survival of patients with cancer of a particular site and the percentage of cancers of that site diagnosed in a localized stage. However, the reasons for variation in the proportion of cases discovered while localized, which varies from 79% for uterine corpus to 12% for pancreas, appear to be varied and complex. Available data suggest that the nature of the tumor-host relationship and metastatic potential of the neoplasm are probably more important than alertness on the part of the patient and the physician, and probably have a more profound influence on stage of disease at diagnosis than currently available screening techniques.