0. DOCID:27426 SCORE: 0.0032230461843606
DOCNO: 11766910
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fruit
DESCRIPTOR: Vegetables
QUALIFIER: etiology
AUTHOR: Y I Kim YI
AFFILIATION: Department of Medicine, University of Toronto, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: United States
TITLE: Vegetables, fruits, and colorectal cancer risk: what should we believe?
PUBDATE: 20011201
Among dietary factors implicated in the development of colorectal cancer (CRC), the inverse relationship between vegetable and fruit consumption and CRC risk has long been believed to represent the strongest epidemiologic evidence. However, recently published large prospective studies have produced conflicting results and the results of one randomized intervention human trial do not support the protective role of vegetable and fruit consumption in colorectal carcinogenesis. Conflicting data with regard to the effect of dietary factors, including vegetables and fruits, on CRC risk likely reflect inherent, probably irresolvable, limitations of currently available tools to detect a real beneficial or harmful effect associated with these factors.

1. DOCID:31719 SCORE: 0.00320996290492176
DOCNO: 16197338
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Monoclonal
DESCRIPTOR: Antibodies, Neoplasm
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: immunology
AUTHOR: Mark C Glassy MC
AUTHOR: Michael E McKnight ME
AFFILIATION: The Rajko Medenica Research Foundation, San Diego, CA 92121, USA. markglassy@aol.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert opinion on biological therapy.
COUNTRY: England
TITLE: Requirements for human antibody cocktails for oncology.
PUBDATE: 20051001
Cancer patients receiving antibodies as monotherapy have benefited from these treatments. However, significant improvements can be made that should make the therapy more effective. Applying lessons learned from the natural oligoclonal antibody response that cancer patients mount to their own tumours suggests that cocktails of monoclonal antibodies could be formulated, which may be more effective in treating cancers. The next phase of antibody immunotherapy will include cocktails of monoclonal antibodies. Various requirements for human antibody cocktails are discussed, as well as potential limitations of this approach.

2. DOCID:31349 SCORE: 0.00320995306645334
DOCNO: 16359023
OWNER: NLM
STATUS: In-Process
AUTHOR: Toshiharu Tabata T
AUTHOR: Y Okada Y
AUTHOR: T Kondo T
AFFILIATION: Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Kyobu geka. The Japanese journal of thoracic surgery.
COUNTRY: Japan
TITLE: [Lung cancer with polyarthropathy due to parvovirus B19: report of a case]
PUBDATE: 20051201
We reported a case of lung cancer with polyarthropathy induced by human parvovirus B19. A 60-year-old female with lung cancer was admitted to our hospital with polyarthropathy similar to rheumatoid arthritis. Although the abnormal accumulation of 99mTc-MDP in the bone scan film and rheumatoid factor positive were detected before operation, we diagnosed polyarthropathy induced by parvovirus B19 through the detection of parvovirus B19 IgM and B19 DNA. The joint pain gradually improved after surgical treatment for lung cancer.

3. DOCID:31618 SCORE: 0.00320987034278628
DOCNO: 16305443
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: Dileep Padinjarae Vangasseri DP
AUTHOR: Su-Ji Han SJ
AUTHOR: Leaf Huang L
AFFILIATION: Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current drug delivery.
COUNTRY: United Arab Emirates
TITLE: Lipid-protamine-DNA-mediated antigen delivery.
PUBDATE: 20051001
The development of novel 'new generation' vaccine systems that is based on proteins, peptides or DNA is of great current interest. However, due to the lower efficiencies of these new generation vaccines, they are seldomly used alone. Rather, their formulations often contain adjuvants, either to enhance the immune responses or to reduce dosing. The present chapter will provide a brief overview of the recent advances in peptide-based cancer vaccine adjuvants, focusing mainly on Liposome-Protamine-DNA (LPD) nanoparticle-mediated antigen delivery.

4. DOCID:27334 SCORE: 0.00315689260540416
DOCNO: 11573372
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gallbladder Neoplasms
DESCRIPTOR: Polyps
AUTHOR: S Afzal S
AUTHOR: V B Kristiansen VB
AUTHOR: J Rosenberg J
AFFILIATION: Kirurgisk afdeling D, Amtssygehuset i Glostrup.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Gallbladder polyps]
PUBDATE: 20010901
Polyps in the gall bladder are detected in 4-5% of the population and most of them are benign. However, they can be premalignant and the prognosis for gall bladder carcinoma is still poor. As with other cancers, treatment at an early stage is therefore, considered essential to improve the prognosis. Because of the very low morbidity after laparoscopic cholecystectomy we recommend laparoscopic cholecystectomy when a polyp in the gall bladder is detected by ultrasonography. A wait and see attitude with repeated ultrasonography twice a year may be chosen, if there are contra-indications to laparoscopic cholecystectomy. If the lesion increases in size, cholecystectomy should be performed.

5. DOCID:30922 SCORE: 0.00288451373124616
DOCNO: 16035420
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Melanoma
DESCRIPTOR: Skin Neoplasms
PUBTYPE: Guideline
PUBTYPE: Journal Article
PUBTYPE: Practice Guideline
JOURNALTITLE: Dermatology nursing / Dermatology Nurses' Association.
COUNTRY: United States
TITLE: Melanoma: treatment guidelines for patients (part 2).
PUBDATE: 20050601
The mutual goal of the National Comprehensive Cancer Network (NCCN) and the American Cancer Society partnership is to provide patients and the generalpublic with state of the art cancer treatment information in understandable language. This treatment information is based on the professional guidelines developed by the NCCN. It is intended to assist patients in a discussion with their doctor about the treatment that is best for their specific situation. Part I of these guidelines addressed melanoma risk factors, prevention, diagnosis, stages, prevention, and clinical trials (Vol. 17, No 2, pp. 119-131). Part II describes decision trees for evaluation and treatment.

6. DOCID:26677 SCORE: 0.00284390859614366
DOCNO: 10530960
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
AUTHOR: H B Mereyala HB
AUTHOR: R R Gadikota RR
AUTHOR: M Joe M
AUTHOR: S K Arora SK
AUTHOR: S G Dastidar SG
AUTHOR: S Agarwal S
AFFILIATION: Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad. root@csiict.ren.nic.in
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: ENGLAND
TITLE: Synthesis and antitumor activity of goniofufurone analogues.
PUBDATE: 19990901
Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.

7. DOCID:24356 SCORE: 0.00256147873539054
DOCNO: 10459365
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
AUTHOR: D Shoupe D
AFFILIATION: University of Southern California School of Medicine, Los Angeles, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Hospital practice (Office ed.)
COUNTRY: UNITED STATES
TITLE: Hormone replacement therapy: reassessing the risks and benefits.
PUBDATE: 19990801
Although the association between postmenopausal hormone use and breast cancer has not been clarified, there is nothing indefinite about the survival advantage conferred by hormone replacement therapy. Cardiovascular and fracture-related deaths so outnumber breast cancer deaths that even women with family histories of the latter are likely to benefit from low-potency estrogen replacement.

8. DOCID:26688 SCORE: 0.00251834875180475
DOCNO: 10210489
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Circulating Cells
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
AUTHOR: A E Kim AE
AUTHOR: L B Haramati LB
AUTHOR: D Janus D
AUTHOR: A Borczuk A
AFFILIATION: Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of thoracic imaging.
COUNTRY: UNITED STATES
TITLE: Pulmonary tumor embolism presenting as infarcts on computed tomography.
PUBDATE: 19990401
Pulmonary tumor embolism is a rare cause of respiratory failure in patients with cancer and is only infrequently diagnosed during life. Chest radiographs are usually normal. Dilated and beaded peripheral pulmonary arteries may be present on computed tomography scans. The authors describe an unusual case of pulmonary tumor embolism presenting on computed tomography scans as bilateral, peripheral, wedge-shaped opacities. On autopsy, these opacities corresponded to areas of pulmonary infarction.

9. DOCID:26034 SCORE: 0.00243916085363937
DOCNO: 11480546
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemistry
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: J J Hélesbeux JJ
AUTHOR: D Séraphin D
AUTHOR: O Duval O
AUTHOR: P Richomme P
AUTHOR: J Bruneton J
AFFILIATION: SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, France.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pharmacy and pharmacology.
COUNTRY: England
TITLE: Studies on the reactivity of a tertiary allylic alcohol in an acetophenonic series, a model for natural products synthesis.
PUBDATE: 20010701
The synthesis of benzopyranic simplified analogues of dibenzopyranic natural compounds is described, together with the access to a precursor of a new furobenzopyranic natural product. These natural products have anti-cancer activity. The 1,3-diacetoxy-2-acetyl-4-(3-hydroxy-3-methylbut-1-enyl)benzene synthone is used as a common precursor to these structures.

10. DOCID:29281 SCORE: 0.0024254627786307
DOCNO: 16459520
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: isolation & purification
AUTHOR: J J Millichap JJ
AUTHOR: A I McKendrick AI
AUTHOR: V S Drelichman VS
AFFILIATION: American University of the Caribbean School of Medicine, Sint Maarten, Netherlands Antilles. millichapj@mail.ecu.edu
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The West Indian medical journal.
COUNTRY: Jamaica
TITLE: Streptococcus intermedius liver abscesses and colon cancer: a case report.
PUBDATE: 20051001
Certain species of bacteria are known to be associated with colorectal cancer. We report a case of adenocarcinoma of the colon with bacteraemia and liver abscesses due to Streptococcus intermedius. The isolation of this organism should prompt investigation for colorectal neoplasm, which may be present but asymptomatic, without metastases, and therefore at a curative stage.

11. DOCID:29227 SCORE: 0.0024254626014751
DOCNO: 16299785
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: David S Schrump DS
AUTHOR: Dao M Nguyen DM
AFFILIATION: Thoracic Oncology Section, Surgery Branch, National Cancer Institute, Bethesda, Maryland.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: United States
TITLE: Novel molecular targeted therapy for esophageal cancer.
PUBDATE: 20051201
Esophageal cancers are highly lethal neoplasms which are generally refractory to conventional multidisciplinary interventions. Recent elucidation of the mechanisms of esophageal carcinogenesis, as well as preclinical studies utilizing chromatin remodeling agents and inhibitors of oncogene signaling in conjunction with conventional chemotherapeutic agents provide new opportunities for the development of potentially efficacious molecular targeted therapies for these malignancies. J. Surg. Oncol. 2005;92:257-261. (c) 2005 Wiley-Liss, Inc.

12. DOCID:29462 SCORE: 0.00242546204685278
DOCNO: 16274521
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Phytotherapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Wigdan Al-Sukhni W
AUTHOR: Ami Grunbaum A
AUTHOR: Neil Fleshner N
AFFILIATION: Division of Urology, The Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian journal of urology.
COUNTRY: Canada
TITLE: Remission of hormone-refractory prostate cancer attributed to Essiac.
PUBDATE: 20051001
Essiac is a popular complementary and alternative medicine (CAM) that is utilized by many cancer patients in North America. Much anecdotal reporting exists about its cancer-fighting qualities, but so far no clinical trials have been preformed to validate those claims. We describe here the case of a 64-year-old man whose hormone-refractory prostate cancer responded well to Essiac tea.

13. DOCID:29465 SCORE: 0.00242546203402888
DOCNO: 15606337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: enzymology
QUALIFIER: therapeutic use
AUTHOR: Mark A Pearson MA
AUTHOR: Doriano Fabbro D
AFFILIATION: Novartis Institutes for Biomedical Research Basel, Oncology, Novartis Pharma AG, WKL.125.4.16, CH-4002, Basel, Switzerland. mark_andrew.pearson@pharma.novartis.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert review of anticancer therapy.
COUNTRY: England
TITLE: Targeting protein kinases in cancer therapy: a success?
PUBDATE: 20041201
The fundamental role of kinases in cancer progression has promoted the development of a plethora of therapeutic inhibitors. Despite the promise of effective treatment with little associated toxicity, the clinical experience with these agents has been mixed. This review will summarize recent advances made in the development of kinase inhibitors to highlight emerging issues and the strategies by which they being addressed.

14. DOCID:29425 SCORE: 0.00222062626724961
DOCNO: 15387660
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
AUTHOR: Leonard A McDonald LA
AUTHOR: Laurel R Barbieri LR
AUTHOR: Valerie S Bernan VS
AUTHOR: Jeffrey Janso J
AUTHOR: Peter Lassota P
AUTHOR: Guy T Carter GT
AFFILIATION: Wyeth-Research, 401 North Middletown Road, Pearl River, New York 10965, USA. mcdonal@wyeth.com
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: 07H239-A, a new cytotoxic eremophilane sesquiterpene from the marine-derived Xylariaceous fungus LL-07H239.
PUBDATE: 20040901
07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC(50) = 0.9 microg/mL).