0. DOCID:23781 SCORE: 0.00377015519157891
DOCNO: 10136203
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Protocols
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: S G Yackzan SG
AFFILIATION: Saint Louis University Hospital, MO.
PUBTYPE: Journal Article
JOURNALTITLE: Topics in hospital pharmacy management / Aspen Systems Corporation.
COUNTRY: UNITED STATES
TITLE: Chemotherapy administration.
PUBDATE: 19940701
The administration of cancer chemotherapy is a unique combination of scientific exercise and clinical practice. The clinical practice involves the holistic care of a human being whose cancer and normal physiology are unique. The scientific exercise includes the manipulation of doses, combinations, and administration schemes of the small number of chemicals known as chemotherapy. Bringing science and clinical practice together to formulate a treatment plan that offers the most favorable outcomes and that minimizes short- and long-term toxicities is a challenge. This article discusses the scientific rationale for various methods of chemotherapy administration and outlines the specific clinical steps necessary to achieve the most safe and efficacious administration plan possible.

1. DOCID:18608 SCORE: 0.00354941957189094
DOCNO: 7798818
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: A Panich A
AUTHOR: L Charnvej L
AFFILIATION: Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Thailand.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
COUNTRY: THAILAND
TITLE: Comparison of morphine slow release tablet (MST) and morphine sulphate solution (MSS) in the treatment of cancer pain.
PUBDATE: 19931201
A cross-over, single blind trial of MST and MSS in relieving pain of advanced cancer patients is described. Forty-nine cases completed the study. Both MST and MSS gave equally excellent pain relief in the patients as judged by the pain score of VAS and pain rating scale by a nurse, and the duration of sleep. The daily effective dose was 55.5 +/- 19.7 mg for MST and 61.0 +/- 11.0 mg of MSS.

2. DOCID:22642 SCORE: 0.00354037718717013
DOCNO: 8847778
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sepsis Syndrome
QUALIFIER: physiology
QUALIFIER: etiology
AUTHOR: T Kawamura T
AFFILIATION: Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Masui. The Japanese journal of anesthesiology.
COUNTRY: JAPAN
TITLE: [Cytokines during the perisurgical period]
PUBDATE: 19960501
Systematic inflammatory response syndrome, SIRS, is one of the biological responses to surgical and anesthetic invasions. SIRS itself is a defense response, but excessive SIRS may result in post-operative failure of major organs. There is evidence that inflammatory cytokines play an important role in SIRS. Therefore it may be treated by regulating these inflammatory cytokines. Changes in inflammatory cytokines during the perisurgical period were discussed in relation to post-operative organ injury in patients who had undergone highly invasive procedures such as open heart surgery or resection of esophageal cancer to explore the possibility of anticytokine therapy.

3. DOCID:22747 SCORE: 0.00303533152516375
DOCNO: 7719485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: metabolism
QUALIFIER: analysis
AUTHOR: T M Phillips TM
AFFILIATION: Immunochemistry Laboratory, George Washington University Medical Center, Washington, D.C. 20037.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography. B, Biomedical applications.
COUNTRY: NETHERLANDS
TITLE: Immunoaffinity measurement of recombinant granulocyte colony stimulating factor in patients with chemotherapy-induced neutropenia.
PUBDATE: 19941201
A high-performance immunoaffinity chromatographic technique has been developed for the measurement of recombinant human granulocyte colony stimulating factor in human patients receiving this agent, following neutropenia, arising from cancer chemotherapy. The technique employs a short, biocompatible polymer column packed with minute, antibody-coated glass beads. This system was applied to the analysis of recombinant human granulocyte colony stimulating factor in three different human body fluids. A reasonable degree of correlation was achieved when comparing the immunoaffinity technique to a conventional immunoassay, although the immunoaffinity technique displayed greater specificity.

4. DOCID:22162 SCORE: 0.00297089403419083
DOCNO: 8066936
AUTHOR: H F Jespersen HF
AUTHOR: M E Cortsen ME
AUTHOR: H Videbaek H
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Intracranial venous thrombosis]
PUBDATE: 19940701
Thrombosis of intracranial sinuses and veins is a rare but potentially lethal syndrome. It often affects young adults, but occurs in all ages. It is frequently seen in association with hormonal changes (puerperium, pregnancy and the use of oral contraceptives), inflammatory bowel disease, cancer, and various states of hypercoagulability, or as a consequence of infection. The clinical picture is extremely variable and the diagnosis can be difficult unless one specifically searches for it. The combination of magnetic resonance imaging and magnetic resonance angiography is a powerful and non-invasive tool for diagnosing the syndrome. Treatment with heparin (and for the septic form antibiotics) improves the outcome.

5. DOCID:19617 SCORE: 0.00287802877331552
DOCNO: 1991303
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: U Lönn U
AUTHOR: S Lönn S
AUTHOR: U Nylen U
AUTHOR: G Winblad G
AUTHOR: B Stenkvist B
AFFILIATION: Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Amplification of oncogenes in mammary carcinoma shown by fine-needle biopsy.
PUBDATE: 19910301
A procedure that measures the amplification of oncogenes in human cancer cells is described. The cells were obtained by fine-needle biopsy to allow repeated sampling from individual metastases. A drawback was the low number of cells obtained, but this could be overcome by using a slot-blot hybridization technique to measure gene amplification. Two patients with mammary cancer (primary tumors or metastases), analyzed for the levels of amplification of the oncogene erb-B2, are described in detail. This technique is suitable for analyzing alterations occurring during cancer progression and for identifying subgroups of mammary cancer with different characteristics.

6. DOCID:18853 SCORE: 0.00269779453849065
DOCNO: 8256943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: A D Tabuenca AD
AUTHOR: D R Aitken DR
AUTHOR: J K Ihde JK
AUTHOR: J Smith J
AUTHOR: C Garberoglio C
AFFILIATION: Dept. of Surgery, Loma Linda University Medical Center, CA 92354.
PUBTYPE: Journal Article
JOURNALTITLE: The American surgeon.
COUNTRY: UNITED STATES
TITLE: Factors influencing survival in advanced gastric cancer.
PUBDATE: 19931201
Even though the incidence of gastric carcinoma is decreasing, the prognosis remains poor. A review of 88 patients with advanced gastric cancer was evaluated by univariate and multivariate analysis to determine prognostic factors. Univariate analysis showed that both "curative" resection (P = 0.006) and adjuvant chemotherapy (P = 0.02) were important therapy variables. These factors were not independent when evaluated by multivariate analysis. However, when they were combined and re-evaluated by multivariate analysis, the combination of "curative" surgery and adjuvant chemotherapy significantly improved survival in advanced gastric cancer (P = 0.04).

7. DOCID:18922 SCORE: 0.00269779342367443
DOCNO: 2297418
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: G J Petruzzelli GJ
AUTHOR: J T Johnson JT
AUTHOR: E J de Vries EJ
AFFILIATION: Department of Otolaryngology, University of Pittsburgh, School of Medicine, Eye and Ear Institute, PA 15213.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Neutropenic enterocolitis. A new complication of head and neck cancer chemotherapy.
PUBDATE: 19900201
Neutropenic enterocolitis is a recognized complication of immunosuppression or chemotherapy for leukemia. It presents as severe abdominal pain and tenderness, fever, and diarrhea associated with granulocytopenia. Gastrointestinal symptoms associated with chemotherapy for head and neck neoplasms include nausea and emesis, but not acute abdominal distress. We present, to our knowledge, the first case of neutropenic enterocolitis in a patient receiving cisplatin and fluorouracil chemotherapy for metastatic head and neck cancer.

8. DOCID:22952 SCORE: 0.00258766054064321
DOCNO: 7562398
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood-Brain Barrier
QUALIFIER: pharmacokinetics
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: physiology
AUTHOR: T Tsuruo T
AFFILIATION: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
COUNTRY: JAPAN
TITLE: [Mechanism of resistance to antitumor agents--its involvement in blood-brain barrier]
PUBDATE: 19950701
Resistance of tumors to a variety of chemotherapeutic agents presents a major problem in cancer treatment. The gene responsible for multidrug resistance, termed mdr1, encodes a membrane glycoprotein (P-glycoprotein) that acts as a pump to transport various cytotoxic agents. The P-glycoprotein has been shown to bind anticancer drugs and several resistance-reversing agents including calcium channel blockers, and to be an ATPase. The P-glycoprotein was found to function in the blood-brain barrier. The physiological function of the P-glycoprotein in relation to therapy is discussed.

9. DOCID:22937 SCORE: 0.0025876605351073
DOCNO: 7914827
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: O Hino O
AUTHOR: H Mitani H
AUTHOR: H Katsuyama H
AUTHOR: Y Kubo Y
AFFILIATION: Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: IRELAND
TITLE: A novel cancer predisposition syndrome in the Eker rat model.
PUBDATE: 19940801
Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extrarenal primary tumors occurring in Eker rats late in life (at 2 years) additionally revealed pituitary adenomas (17/31 = 54.8% (carrier) vs 7/32 = 21.9% (non-carrier siblings of affected animals), P < 0.01), sarcomas of the spleen (21/31 = 67.7% vs. 0/32 = 0%, P < 0.001) and sarcomas (of probable stromal origin) of the uterus (8/17 = 47.1% vs. 0/15 = 0%, P < 0.01). Thus, the Eker rat might provide a novel animal model of cancer predisposition syndromes.

10. DOCID:22382 SCORE: 0.00258492273607669
DOCNO: 7501539
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: J M Robison JM
AUTHOR: D J Wilkie DJ
AUTHOR: B Campbell B
AFFILIATION: School of Nursing, Lewis-Clark State College, Lewiston, Idaho, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Nursing clinics of North America.
COUNTRY: UNITED STATES
TITLE: Sublingual and oral morphine administration. Review and new findings.
PUBDATE: 19951201
Clinical reports rave about the efficacy of sublingual morphine, but most research data suggest that sublingual morphine lacks the necessary physical characteristics to be absorbed through sublingual tissues. This article clarifies these assertions by reviewing the clinical literature that supports sublingual administration, the theories relevant to sublingual morphine administration, and the pharmacokinetic research that supports or negates the benefit of this route. Recommendations for clinical nursing practice are provided to guide decision-making in care of patients with cancer pain.

11. DOCID:22918 SCORE: 0.00253357630610132
DOCNO: 7675283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Diseases
QUALIFIER: secretion
AUTHOR: P Cottu P
AUTHOR: M L Cossu ML
AUTHOR: A M Scanu AM
AUTHOR: A Gadeddu A
AUTHOR: G Noya G
AUTHOR: G Dettori G
AFFILIATION: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi, Sassari.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Mammary secretion: retrospective study of diagnostic and therapeutic problems]
PUBDATE: 19950401
Nipple secretion is an important clinical symptom in the context of breast pathology second only, in terms of incidence and diagnostic role, to the presence of a mammary nodule. Its importance derives from its possible association with cancer (from 3% to 47%) of which it may be the earliest sign, even if it is most often in relation to a benign pathology. The authors report their experience from 1988 to the present in 60 cases of mammary secretion out of 1200 patients attending the clinic.

12. DOCID:18403 SCORE: 0.0024798270571459
DOCNO: 8389419
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: L Gutmann L
AUTHOR: D Weidman D
AUTHOR: A Gutiérrez A
AFFILIATION: Department of Neurology, West Virginia University Health Sciences Center, Morgantown 26506.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Muscle & nerve.
COUNTRY: UNITED STATES
TITLE: Lambert-Eaton myasthenic syndrome with prominent postexercise exhaustion.
PUBDATE: 19930701
A 66-year-old man with Lambert-Eaton myasthenic syndrome, polyneuropathy, and small cell lung cancer, developed profound muscle weakness with a prolonged period of ventilatory dependency. Electrophysiological studies demonstrated very small compound muscle action potentials in response to supramaximal nerve stimulation, limited tetanic and postexercise facilitation, and prolonged prominent postexercise exhaustion (40-60% of baseline value) persisting up to 20 minutes. It is hypothesized that these changes may reflect both a severe defect in acetylcholine release and decreased availability of releasible acetylcholine from the terminal axon.

13. DOCID:22914 SCORE: 0.00245905917695414
DOCNO: 7494130
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Tanaka S
AUTHOR: Y Kimura Y
AUTHOR: M Furukawa M
AFFILIATION: Department of Otorhinolaryngology, School of Medicine, Kanazawa University, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: Pseudoaneurysm of the carotid artery with haemorrhage into the hypopharynx.
PUBDATE: 19950901
Pseudoaneurysms of the extracranial carotid arteries are rarely seen following irradiation for cancers of the head and neck. We present a patient with a pseudoaneurysm of the common carotid artery following a radical neck dissection and irradiation for thyroid carcinoma 20 years earlier. Following oesophagoscopical examination, a pseudoaneurysm of the right common carotid artery ruptured into the piriform sinus. The common carotid artery was embolized with multiple coils and the bleeding was halted. The relationship between the carotid artery aneurysm and irradiation, and the treatment of carotid artery aneurysm, is discussed.

14. DOCID:17841 SCORE: 0.00242871280243848
DOCNO: 2269520
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J H Grendell JH
AFFILIATION: University of California, San Francisco.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastroenterology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Idiopathic acute pancreatitis.
PUBDATE: 19901201
In most patients presenting with acute pancreatitis, the cause can be established on the basis of initial history, physical examination, laboratory studies, and abdominal sonography. Patients with unexplained pancreatitis at that point are often considered to have idiopathic disease. However, a cause and, often, effective treatment to prevent recurrent pancreatitis are possible in many of these patients if an aggressive diagnostic approach is taken to discover undiagnosed hyperlipidemia, occult gallstones, abnormalities of the bile and pancreatic ducts, sphincter of Oddi dysfunction, pancreatic cancer and other tumors, and cystic fibrosis (in children and young adults).