0. DOCID:3538 SCORE: 0.00474162970621273
DOCNO: 1180587
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Intestinal Polyps
DESCRIPTOR: Neoplasm Recurrence, Local
AUTHOR: L G Henry LG
AUTHOR: R E Condon RE
AUTHOR: W J Schulte WJ
AUTHOR: C Aprahamian C
AUTHOR: J J DeCosse JJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Risk of recurrence of colon polyps.
PUBDATE: 19751001
At Wood Veterans Administration Center, 268 patients who had a polypectomy have been followed up to 20 years with semiannual proctosigmoidoscopic and barium enema examinations. For the present review of benign polyp disease, patients having coexisting carcinoma, chronic inflammatory disease, and those lost to followup have been excluded; 154 patients followed for a mean of 7 years comprise the study group. Thirty per cent of patients developed recurrent polyps. The risk of recurrence during the first year was 16 times that expected in a population of similar age and sex, but thereafter diminished steadily. After 48 months risk of polyp recurrence was little higher than the incidence expected in a normal population. Neither patient age, presenting symptoms nor the site or size of the initial polyp(s) were of any prognostic value regarding recurrence. Patients presenting with a villous adenoma or with more than 3 polyps had a significantly increased risk of recurrence may persist indefinitely. The overall incidence of colonic carcinoma may have been increased, but the location of subsequent cancer was not related to the site of a previously excised polyp.

1. DOCID:7122 SCORE: 0.00429076883069997
DOCNO: 418978
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: G L Pride GL
AUTHOR: A E Schultz AE
AUTHOR: T W Chuprevich TW
AUTHOR: D A Buchler DA
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Primary invasive squamous carcinoma of the vagina.
PUBDATE: 19790201
Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%. Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV.

2. DOCID:3083 SCORE: 0.00428442649775816
DOCNO: 922665
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
AUTHOR: G M Brodeur GM
AUTHOR: G Sekhon G
AUTHOR: M N Goldstein MN
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Chromosomal aberrations in human neuroblastomas.
PUBDATE: 19771101
Six human neuroblastomas were analyzed by Giemsa and fluorescence banding techniques to identify chromosomal aberrations. Two neuroblastomas were primary tumors from untreated children, and four were well lines established from human neuroblastomas. Five of the six tumors studied were diploid or near diploid; one was near tetraploid. A 1p- was found in three of the neuroblastomas examined. The 1p-was present in both primary tumors, and in one it was the only abnormality detected. This deletion was also found in the cells of an established line, in addition to other abnormalities. Giant markers of different origins were found in the four cell lines, and no double-minute chromosomes were found in the primaries or the cell lines studied. Thus, a 1p-deletion was the most consistent abnormality found in the six human neuroblastomas examined in this study. We attempt to correlate this finding with Knudson's hypothesis on the origin of childhood cancer. Additional studies of primary tumors should clarify whether this specific chromosomal abnormality is related to the the acquisition of malignant behavior in human neuroblastomas.

3. DOCID:2456 SCORE: 0.00398718954723935
DOCNO: 409478
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: W F Whitmore WF
AUTHOR: M A Batata MA
AUTHOR: B S Hilaris BS
AUTHOR: G N Reddy GN
AUTHOR: A Unal A
AUTHOR: M A Ghoneim MA
AUTHOR: H Grabstald H
AUTHOR: F Chu F
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A comparative study of two preoperative radiation regimens with cystectomy for bladder cancer.
PUBDATE: 19770901
This report surveys the results of two programs of preoperative irradiation with radical cystectomy for bladder cancer in 205 patients. Irradiating the true pelvis to 4000 rads in 4 weeks with radical cystectomy after 6 weeks was implemented in 119 patients (Group 1) from 1959 to 1965; 2000 rads given in 1 week to the true pelvis and radical cystectomy within the following week was implemented in 86 patients (Group 2) from 1966 to 1970. Determinate survival without evidence of recurrence at 5 years was 43% in Group 1 and 42% in Group 2. Mortality with recurrence of bladder cancer in 5 or more years was 44% in group 1 and 42% in group 2. Pelvic complications occurred in 13% of group 1 and 9% of group 2.

4. DOCID:1409 SCORE: 0.00321871218041533
DOCNO: 1192421
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cytotoxicity Tests, Immunologic
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G E Pierce GE
AUTHOR: B DeVald B
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Microcytotoxicity assays of tumor immunity in patients with bronchogenic carcinoma correlated with clinical status.
PUBDATE: 19751201
Peripheral blood lymphocytes from patients with bronchogenic carcinoma were tested in microcytotoxicity assays against cultured bronchogenic cancer cells, other types of tumor cells, and skin fibroblasts. Lymphocytes from patients who were postresection with no clinical evidence of residual or recurrent tumor were more frequently toxic against bronchogenic carcinoma than were lymphocytes from normal donors or from patients with clinically evident disease. Lymphocytes from patients with minimal or no tumor were more frequently toxic against bronchogenic cancer than against skin fibroblasts. Serum samples from a few patients rendered lymphocytes toxic for bronchogenic cancer cells, but this serum activity could not be correlated with the patient's clinical status.

5. DOCID:2695 SCORE: 0.00321656474213887
DOCNO: 1225514
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: K Kovacs K
AUTHOR: E Horvath E
PUBTYPE: Journal Article
JOURNALTITLE: Endokrinologie.
COUNTRY: GERMANY, EAST
TITLE: Gonadotrophs following removal of the ovaries: a fine structural study of human pituitary glands.
PUBDATE: 19750901
The fine structure of gonadotrophs has been investigated in surgically removed pituitary glands of 12 women who because of disseminated breast cancer, underwent bilateral ovariectomy at various periods before hypophysectomy. Compared with the adenohypophyses of 3 non-ovariectomized female subjects with diabetes mellitus, electron microscopy revealed that two cell types were affected by gonadectomy. These cell types corresponded to those which were regarded as FSH gonadotrophs and LH gonadotrophs in previous studies. In addition in the adenohypophyses stimulated by removal of the ovaries, intermediary cell types began to appear suggesting a transformation of LH gonadotrophs to FSH gonadotrophs. The most conspicuous change following gonadectomy was the formation of castration cells. These cells arose from FSH gonadotrophs and exhibited ultrastructural features interpreted as representing the morphologic manifestations of sustained hypersecretion of gonadotrophins. It seemed that castration cells have a limited life span and in their advanced stages of development they show ultrastructural signs indicative of irreversible involution.

6. DOCID:4598 SCORE: 0.00320468601411046
DOCNO: 7306923
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: S Lodrini S
AUTHOR: M Savoiardo M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Metastases of carcinoma to intracranial meningioma: report of two cases and review of the literature.
PUBDATE: 19811201
Two cases of metastases from carcinoma to intracranial meningioma are presented. In the first case the presence of the malignant tumor was unsuspected at the time of intracranial operation. In the second case, a breast cancer had been previously removed, and unusual cranial computed tomographic findings were noted. The literature on metastases to intracranial tumors is reviewed, and the association of meningioma and carcinoma of the breast is emphasized.

7. DOCID:2707 SCORE: 0.00319058119063658
DOCNO: 895604
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: E Evans E
AUTHOR: O Harris O
AUTHOR: P Nicoll P
AUTHOR: R Quinn R
AUTHOR: C J Windsor CJ
AUTHOR: G Fielding G
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: A prospective study of gastric and oesophageal carcinoma.
PUBDATE: 19770601
A prospective study of carcinoma of the stomach and oesophagus has been carried out for 2 1/2 years. Seventy-three cases of carcinoma of the stomach, and 16 cases of carcinoma of the oesophagus have been documented. For carcinoma of the stomach, operability rate was 72-6% and resectability rate was 41-9%; overall survival was poor, 20-9% at 12 months. For those who underwent resection, survival at 12 months was 45-5%. No cases of early gastric cancer are among those studied. For carcinoma of the oesophagus, four patients had a resection, and only one has survived for more than 12 months. In the clinical sphere there is a need for early endoscopic as well as radiological investigation of dyspeptic symptoms. In the research field there is a need for studies of chemotherapy in combination with surgery in the initial treatment of gastric carcinoma.

8. DOCID:3811 SCORE: 0.00309903098231679
DOCNO: 1139485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: N C Delarue NC
AUTHOR: G Gale G
AUTHOR: A Ronald A
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Multiple fluoroscopy of the chest: carcinogenicity for the female breast and implications for breast cancer screening programs.
PUBDATE: 19750601
The risk of radiation carcinogenesis has been established for breast tissue from experience with total body irradiation and multiple fluoroscopy of the chest with the patient prone. The doubling dose has been estimated to lie between 20 and 50 rads. Before undertaking radiologic screening programs for breast cancer, therefore, it is necessary to determine whether exposures below this range are safe. Of 792 women who had had tuberculosis and were followed for a minimum of 20 years, 451 had had multiple fluoroscopy while supine; 341 had not had fluoroscopy. The first group received a total radiation dose to the breast averaging 17 rads (141.5 fluoroscopies); the incidence of breast cancer in this group was not increased. Had fluoroscopy been performed with the patient prone the total radiation dose would have averaged 308 rads. The difference is thought to explain the increased incidence of breast cancer attributable to fluoroscopy given with the patient prone. Mid-breast exposure with mammography or xeroradiography varies between 3 and 6 rads. Repetitive screening would, therefore, appear safe provided total exposure did not exceed 20 rads. With this restriction there would appear to be no reason to curtail screening of women for breast cancer.

9. DOCID:4621 SCORE: 0.00294751388833463
DOCNO: 740287
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
AUTHOR: D Fritze D
AUTHOR: J Fritze J
AUTHOR: M Kaufmann M
AUTHOR: P Drings P
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Immunodiagnostic aspects of breast cancer. The phenomenon of leukocyte adherence inhibition]
PUBDATE: 19781101
In 39 patients with breast cancer and in 38 female controls the leucocyte adherence was tested in glass tubes in the presence of a series of extracts of breast cancer and control tissues. It was shown that the adherence of leucocytes of patients with operable carcinoma of the breast (stage I/II) is selectively inhibited by extracts from breast cancer tissues. Leucocyte adherence inhibition tests could thus become important for immunodiagnostics.

10. DOCID:6688 SCORE: 0.00287767049354424
DOCNO: 87268
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: J K Willson JK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Pulmonary toxicity of antineoplastic drugs.
PUBDATE: 19781201
Drug-induced pulmonary disease is an infrequent, but clinically significant, toxic manifestation of antineoplastic drug therapy. Pulmonary toxicity has been associated primarily with bleomycin therapy but also has been described with busulfan, cyclophosphamide, methotrexate, and the nitrosoureas. Cytotoxic drug-induced pulmonary disease is characterized by an insidious and nonspecific presentation. The common pathologic process of a fibrosing alveolitis follows a variety of toxic mechanisms associated with the chemotherapeutic agents. The importance of close clinical monitoring is emphasized by the necessity for early withdrawal of the drug in order to halt or reverse potentially lethal pulmonary disease. At the same time, the nonspecific nature of the lung disease and the multitude of potential insults to the lung in a cancer patient make an early aggressive evaluation mandatory. A lung biopsy is almost always indicated.

11. DOCID:7666 SCORE: 0.00286617624701739
DOCNO: 7000060
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
DESCRIPTOR: Immunologic Techniques
DESCRIPTOR: Leukocyte Adherence Inhibition Test
QUALIFIER: immunology
AUTHOR: M Winter M
AUTHOR: D S Nelson DS
AUTHOR: G W Milton GW
PUBTYPE: Journal Article
JOURNALTITLE: Australian and New Zealand journal of medicine.
COUNTRY: AUSTRALIA
TITLE: Leucocyte adherence inhibition test for the detection of cell-mediated immunity to malignant melanoma.
PUBDATE: 19800801
A tube leucocyte adherence test was used to detect reactivity of melanoma patients to extracts of melanoma tissue. Breast cancer extracts were used as a control. Of 31 melanoma patients 22 gave a positive reaction (non-adherence index > 25%) to melanoma extracts whereas only three of 24 normal subjects did so. Fifteen of 16 patients with Stage 1 melanoma reacted but only seven of 15 patients with Stage 2 or Stage 3 disease did so. None of seven patients with breast cancer reacted to melanoma extract, but four of them reacted to breast cancer extract. None of four patients with benign breast disease reacted to either extract. It is concluded that leucocyte adherence inhibition is potentially useful in investigations of tumour-specific immune reactivity to melanoma and of melanoma antigens.

12. DOCID:7144 SCORE: 0.0028591775219598
DOCNO: 7272978
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Physicians, Family
QUALIFIER: diagnosis
AUTHOR: P A Williams PA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The responsibility of the family physician in the detection of gynecologic cancer.
PUBDATE: 19810701
The family physician's role in health maintenance and preventive medicine places him or her in a unique position in providing care for the gynecologic patient. Illness as well as health has been a traditionally matriarchal responsibility and therefore places the woman at risk for gynecologic cancer in contact with her family physician at a greater frequency than other specialties. Caring for the family's health needs should be used as an opportunity for the physician and the patient to discuss her own personal health care needs, which include those in the field of gynecology. Family physicians will not provide definitive treatment for major gynecologic malignancies; however physicians must know the best referral opportunities available to the patient and to the consultant. The family physician must further be able and willing to reassume follow-up care after definitive therapy has been effected.

13. DOCID:3627 SCORE: 0.00285315988583681
DOCNO: 409485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: D Sampson D
AUTHOR: T G Peters TG
AUTHOR: J D Lewis JD
AUTHOR: J Metzig J
AUTHOR: B E Kurtz BE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Dose dependence of immunopotentiation and tumor regression induced by levamisole.
PUBDATE: 19771001
Breast cancer was induced in female Sprague-Dawley rats by 7,12-dimethylbenz(a)anthracene. Once tumors had become established, they were treated with varying doses of the immunopotentiating drug, levamisole. Tumor growth was measured in the various dosage groups, and at 6 months after tumor induction the animals were sacrificed. Their immunological competence at this time was measured by the mitogen responses of splenic lymphocytes. Untreated animals with breast cancer were found to be immunosuppressed compared to normal animals. The drug levamisole resulted in immunopotentiation, but at high doses it was immunosuppressive. Tumor regression was observed at doses that resulted in immunopotentiation, but not at high doses. There was a significant correlation between immune competence and tumor regression. It is concluded that levamisole can cause regression of breast cancer in the rat but that this effect is critically dependent on the dose of the drug; these observations confirm previous studies carried out on human cells in vitro. It is recommended that high doses of the drug be avoided in human clinical trials and that the patients who receive this drug should have their immune responses carefully monitored.

14. DOCID:869 SCORE: 0.00278612109085003
DOCNO: 1201943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: P Szabó P
PUBTYPE: Journal Article
JOURNALTITLE: Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete.
COUNTRY: GERMANY, WEST
TITLE: [Clinical picture and roentgen therapy of lip carcinomas]
PUBDATE: 19751001
204 patients with lip cancer (squamous cell carcinoma and basal cell carcinoma) were irradiated with soft x-ray and cobalt-radiation respectively after histological examination of the tumor. Available observations were supplied by 190 patients. Distribution according to age and histology, the size of the tumor, as well as the therapeutic results and the recurrence rates are reported. 96,6% of the tumors which showed no metastases at the beginning of the treatment remained recurrence-free after radiation. Early diagnosis, the necessity of treatment and the problem of prophylaxis are emphasized.