0. DOCID:23781 SCORE: 0.00377015519157891
DOCNO: 10136203
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Protocols
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: S G Yackzan SG
AFFILIATION: Saint Louis University Hospital, MO.
PUBTYPE: Journal Article
JOURNALTITLE: Topics in hospital pharmacy management / Aspen Systems Corporation.
COUNTRY: UNITED STATES
TITLE: Chemotherapy administration.
PUBDATE: 19940701
The administration of cancer chemotherapy is a unique combination of scientific exercise and clinical practice. The clinical practice involves the holistic care of a human being whose cancer and normal physiology are unique. The scientific exercise includes the manipulation of doses, combinations, and administration schemes of the small number of chemicals known as chemotherapy. Bringing science and clinical practice together to formulate a treatment plan that offers the most favorable outcomes and that minimizes short- and long-term toxicities is a challenge. This article discusses the scientific rationale for various methods of chemotherapy administration and outlines the specific clinical steps necessary to achieve the most safe and efficacious administration plan possible.


1. DOCID:18608 SCORE: 0.00354941957189094
DOCNO: 7798818
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: A Panich A
AUTHOR: L Charnvej L
AFFILIATION: Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Thailand.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
COUNTRY: THAILAND
TITLE: Comparison of morphine slow release tablet (MST) and morphine sulphate solution (MSS) in the treatment of cancer pain.
PUBDATE: 19931201
A cross-over, single blind trial of MST and MSS in relieving pain of advanced cancer patients is described. Forty-nine cases completed the study. Both MST and MSS gave equally excellent pain relief in the patients as judged by the pain score of VAS and pain rating scale by a nurse, and the duration of sleep. The daily effective dose was 55.5 +/- 19.7 mg for MST and 61.0 +/- 11.0 mg of MSS.


2. DOCID:22642 SCORE: 0.00354037718717013
DOCNO: 8847778
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sepsis Syndrome
QUALIFIER: physiology
QUALIFIER: etiology
AUTHOR: T Kawamura T
AFFILIATION: Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Masui. The Japanese journal of anesthesiology.
COUNTRY: JAPAN
TITLE: [Cytokines during the perisurgical period]
PUBDATE: 19960501
Systematic inflammatory response syndrome, SIRS, is one of the biological responses to surgical and anesthetic invasions. SIRS itself is a defense response, but excessive SIRS may result in post-operative failure of major organs. There is evidence that inflammatory cytokines play an important role in SIRS. Therefore it may be treated by regulating these inflammatory cytokines. Changes in inflammatory cytokines during the perisurgical period were discussed in relation to post-operative organ injury in patients who had undergone highly invasive procedures such as open heart surgery or resection of esophageal cancer to explore the possibility of anticytokine therapy.


3. DOCID:27426 SCORE: 0.0032230461843606
DOCNO: 11766910
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fruit
DESCRIPTOR: Vegetables
QUALIFIER: etiology
AUTHOR: Y I Kim YI
AFFILIATION: Department of Medicine, University of Toronto, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: United States
TITLE: Vegetables, fruits, and colorectal cancer risk: what should we believe?
PUBDATE: 20011201
Among dietary factors implicated in the development of colorectal cancer (CRC), the inverse relationship between vegetable and fruit consumption and CRC risk has long been believed to represent the strongest epidemiologic evidence. However, recently published large prospective studies have produced conflicting results and the results of one randomized intervention human trial do not support the protective role of vegetable and fruit consumption in colorectal carcinogenesis. Conflicting data with regard to the effect of dietary factors, including vegetables and fruits, on CRC risk likely reflect inherent, probably irresolvable, limitations of currently available tools to detect a real beneficial or harmful effect associated with these factors.


4. DOCID:31719 SCORE: 0.00320996290492176
DOCNO: 16197338
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Monoclonal
DESCRIPTOR: Antibodies, Neoplasm
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: immunology
AUTHOR: Mark C Glassy MC
AUTHOR: Michael E McKnight ME
AFFILIATION: The Rajko Medenica Research Foundation, San Diego, CA 92121, USA. markglassy@aol.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert opinion on biological therapy.
COUNTRY: England
TITLE: Requirements for human antibody cocktails for oncology.
PUBDATE: 20051001
Cancer patients receiving antibodies as monotherapy have benefited from these treatments. However, significant improvements can be made that should make the therapy more effective. Applying lessons learned from the natural oligoclonal antibody response that cancer patients mount to their own tumours suggests that cocktails of monoclonal antibodies could be formulated, which may be more effective in treating cancers. The next phase of antibody immunotherapy will include cocktails of monoclonal antibodies. Various requirements for human antibody cocktails are discussed, as well as potential limitations of this approach.


5. DOCID:31349 SCORE: 0.00320995306645334
DOCNO: 16359023
OWNER: NLM
STATUS: In-Process
AUTHOR: Toshiharu Tabata T
AUTHOR: Y Okada Y
AUTHOR: T Kondo T
AFFILIATION: Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Kyobu geka. The Japanese journal of thoracic surgery.
COUNTRY: Japan
TITLE: [Lung cancer with polyarthropathy due to parvovirus B19: report of a case]
PUBDATE: 20051201
We reported a case of lung cancer with polyarthropathy induced by human parvovirus B19. A 60-year-old female with lung cancer was admitted to our hospital with polyarthropathy similar to rheumatoid arthritis. Although the abnormal accumulation of 99mTc-MDP in the bone scan film and rheumatoid factor positive were detected before operation, we diagnosed polyarthropathy induced by parvovirus B19 through the detection of parvovirus B19 IgM and B19 DNA. The joint pain gradually improved after surgical treatment for lung cancer.


6. DOCID:31618 SCORE: 0.00320987034278628
DOCNO: 16305443
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: Dileep Padinjarae Vangasseri DP
AUTHOR: Su-Ji Han SJ
AUTHOR: Leaf Huang L
AFFILIATION: Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current drug delivery.
COUNTRY: United Arab Emirates
TITLE: Lipid-protamine-DNA-mediated antigen delivery.
PUBDATE: 20051001
The development of novel 'new generation' vaccine systems that is based on proteins, peptides or DNA is of great current interest. However, due to the lower efficiencies of these new generation vaccines, they are seldomly used alone. Rather, their formulations often contain adjuvants, either to enhance the immune responses or to reduce dosing. The present chapter will provide a brief overview of the recent advances in peptide-based cancer vaccine adjuvants, focusing mainly on Liposome-Protamine-DNA (LPD) nanoparticle-mediated antigen delivery.


7. DOCID:27334 SCORE: 0.00315689260540416
DOCNO: 11573372
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gallbladder Neoplasms
DESCRIPTOR: Polyps
AUTHOR: S Afzal S
AUTHOR: V B Kristiansen VB
AUTHOR: J Rosenberg J
AFFILIATION: Kirurgisk afdeling D, Amtssygehuset i Glostrup.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Gallbladder polyps]
PUBDATE: 20010901
Polyps in the gall bladder are detected in 4-5% of the population and most of them are benign. However, they can be premalignant and the prognosis for gall bladder carcinoma is still poor. As with other cancers, treatment at an early stage is therefore, considered essential to improve the prognosis. Because of the very low morbidity after laparoscopic cholecystectomy we recommend laparoscopic cholecystectomy when a polyp in the gall bladder is detected by ultrasonography. A wait and see attitude with repeated ultrasonography twice a year may be chosen, if there are contra-indications to laparoscopic cholecystectomy. If the lesion increases in size, cholecystectomy should be performed.


8. DOCID:22747 SCORE: 0.00303533152516375
DOCNO: 7719485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: metabolism
QUALIFIER: analysis
AUTHOR: T M Phillips TM
AFFILIATION: Immunochemistry Laboratory, George Washington University Medical Center, Washington, D.C. 20037.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography. B, Biomedical applications.
COUNTRY: NETHERLANDS
TITLE: Immunoaffinity measurement of recombinant granulocyte colony stimulating factor in patients with chemotherapy-induced neutropenia.
PUBDATE: 19941201
A high-performance immunoaffinity chromatographic technique has been developed for the measurement of recombinant human granulocyte colony stimulating factor in human patients receiving this agent, following neutropenia, arising from cancer chemotherapy. The technique employs a short, biocompatible polymer column packed with minute, antibody-coated glass beads. This system was applied to the analysis of recombinant human granulocyte colony stimulating factor in three different human body fluids. A reasonable degree of correlation was achieved when comparing the immunoaffinity technique to a conventional immunoassay, although the immunoaffinity technique displayed greater specificity.


9. DOCID:22162 SCORE: 0.00297089403419083
DOCNO: 8066936
AUTHOR: H F Jespersen HF
AUTHOR: M E Cortsen ME
AUTHOR: H Videbaek H
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Intracranial venous thrombosis]
PUBDATE: 19940701
Thrombosis of intracranial sinuses and veins is a rare but potentially lethal syndrome. It often affects young adults, but occurs in all ages. It is frequently seen in association with hormonal changes (puerperium, pregnancy and the use of oral contraceptives), inflammatory bowel disease, cancer, and various states of hypercoagulability, or as a consequence of infection. The clinical picture is extremely variable and the diagnosis can be difficult unless one specifically searches for it. The combination of magnetic resonance imaging and magnetic resonance angiography is a powerful and non-invasive tool for diagnosing the syndrome. Treatment with heparin (and for the septic form antibiotics) improves the outcome.


10. DOCID:30922 SCORE: 0.00288451373124616
DOCNO: 16035420
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Melanoma
DESCRIPTOR: Skin Neoplasms
PUBTYPE: Guideline
PUBTYPE: Journal Article
PUBTYPE: Practice Guideline
JOURNALTITLE: Dermatology nursing / Dermatology Nurses' Association.
COUNTRY: United States
TITLE: Melanoma: treatment guidelines for patients (part 2).
PUBDATE: 20050601
The mutual goal of the National Comprehensive Cancer Network (NCCN) and the American Cancer Society partnership is to provide patients and the generalpublic with state of the art cancer treatment information in understandable language. This treatment information is based on the professional guidelines developed by the NCCN. It is intended to assist patients in a discussion with their doctor about the treatment that is best for their specific situation. Part I of these guidelines addressed melanoma risk factors, prevention, diagnosis, stages, prevention, and clinical trials (Vol. 17, No 2, pp. 119-131). Part II describes decision trees for evaluation and treatment.


11. DOCID:19617 SCORE: 0.00287802877331552
DOCNO: 1991303
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: U Lönn U
AUTHOR: S Lönn S
AUTHOR: U Nylen U
AUTHOR: G Winblad G
AUTHOR: B Stenkvist B
AFFILIATION: Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Amplification of oncogenes in mammary carcinoma shown by fine-needle biopsy.
PUBDATE: 19910301
A procedure that measures the amplification of oncogenes in human cancer cells is described. The cells were obtained by fine-needle biopsy to allow repeated sampling from individual metastases. A drawback was the low number of cells obtained, but this could be overcome by using a slot-blot hybridization technique to measure gene amplification. Two patients with mammary cancer (primary tumors or metastases), analyzed for the levels of amplification of the oncogene erb-B2, are described in detail. This technique is suitable for analyzing alterations occurring during cancer progression and for identifying subgroups of mammary cancer with different characteristics.


12. DOCID:26677 SCORE: 0.00284390859614366
DOCNO: 10530960
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
AUTHOR: H B Mereyala HB
AUTHOR: R R Gadikota RR
AUTHOR: M Joe M
AUTHOR: S K Arora SK
AUTHOR: S G Dastidar SG
AUTHOR: S Agarwal S
AFFILIATION: Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad. root@csiict.ren.nic.in
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: ENGLAND
TITLE: Synthesis and antitumor activity of goniofufurone analogues.
PUBDATE: 19990901
Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.


13. DOCID:18853 SCORE: 0.00269779453849065
DOCNO: 8256943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: A D Tabuenca AD
AUTHOR: D R Aitken DR
AUTHOR: J K Ihde JK
AUTHOR: J Smith J
AUTHOR: C Garberoglio C
AFFILIATION: Dept. of Surgery, Loma Linda University Medical Center, CA 92354.
PUBTYPE: Journal Article
JOURNALTITLE: The American surgeon.
COUNTRY: UNITED STATES
TITLE: Factors influencing survival in advanced gastric cancer.
PUBDATE: 19931201
Even though the incidence of gastric carcinoma is decreasing, the prognosis remains poor. A review of 88 patients with advanced gastric cancer was evaluated by univariate and multivariate analysis to determine prognostic factors. Univariate analysis showed that both "curative" resection (P = 0.006) and adjuvant chemotherapy (P = 0.02) were important therapy variables. These factors were not independent when evaluated by multivariate analysis. However, when they were combined and re-evaluated by multivariate analysis, the combination of "curative" surgery and adjuvant chemotherapy significantly improved survival in advanced gastric cancer (P = 0.04).


14. DOCID:18922 SCORE: 0.00269779342367443
DOCNO: 2297418
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: G J Petruzzelli GJ
AUTHOR: J T Johnson JT
AUTHOR: E J de Vries EJ
AFFILIATION: Department of Otolaryngology, University of Pittsburgh, School of Medicine, Eye and Ear Institute, PA 15213.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Neutropenic enterocolitis. A new complication of head and neck cancer chemotherapy.
PUBDATE: 19900201
Neutropenic enterocolitis is a recognized complication of immunosuppression or chemotherapy for leukemia. It presents as severe abdominal pain and tenderness, fever, and diarrhea associated with granulocytopenia. Gastrointestinal symptoms associated with chemotherapy for head and neck neoplasms include nausea and emesis, but not acute abdominal distress. We present, to our knowledge, the first case of neutropenic enterocolitis in a patient receiving cisplatin and fluorouracil chemotherapy for metastatic head and neck cancer.