0. DOCID:3538 SCORE: 0.00474162970621273
DOCNO: 1180587
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Intestinal Polyps
DESCRIPTOR: Neoplasm Recurrence, Local
AUTHOR: L G Henry LG
AUTHOR: R E Condon RE
AUTHOR: W J Schulte WJ
AUTHOR: C Aprahamian C
AUTHOR: J J DeCosse JJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Risk of recurrence of colon polyps.
PUBDATE: 19751001
At Wood Veterans Administration Center, 268 patients who had a polypectomy have been followed up to 20 years with semiannual proctosigmoidoscopic and barium enema examinations. For the present review of benign polyp disease, patients having coexisting carcinoma, chronic inflammatory disease, and those lost to followup have been excluded; 154 patients followed for a mean of 7 years comprise the study group. Thirty per cent of patients developed recurrent polyps. The risk of recurrence during the first year was 16 times that expected in a population of similar age and sex, but thereafter diminished steadily. After 48 months risk of polyp recurrence was little higher than the incidence expected in a normal population. Neither patient age, presenting symptoms nor the site or size of the initial polyp(s) were of any prognostic value regarding recurrence. Patients presenting with a villous adenoma or with more than 3 polyps had a significantly increased risk of recurrence may persist indefinitely. The overall incidence of colonic carcinoma may have been increased, but the location of subsequent cancer was not related to the site of a previously excised polyp.


1. DOCID:7122 SCORE: 0.00429076883069997
DOCNO: 418978
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: G L Pride GL
AUTHOR: A E Schultz AE
AUTHOR: T W Chuprevich TW
AUTHOR: D A Buchler DA
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Primary invasive squamous carcinoma of the vagina.
PUBDATE: 19790201
Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%. Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV.


2. DOCID:3083 SCORE: 0.00428442649775816
DOCNO: 922665
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
AUTHOR: G M Brodeur GM
AUTHOR: G Sekhon G
AUTHOR: M N Goldstein MN
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Chromosomal aberrations in human neuroblastomas.
PUBDATE: 19771101
Six human neuroblastomas were analyzed by Giemsa and fluorescence banding techniques to identify chromosomal aberrations. Two neuroblastomas were primary tumors from untreated children, and four were well lines established from human neuroblastomas. Five of the six tumors studied were diploid or near diploid; one was near tetraploid. A 1p- was found in three of the neuroblastomas examined. The 1p-was present in both primary tumors, and in one it was the only abnormality detected. This deletion was also found in the cells of an established line, in addition to other abnormalities. Giant markers of different origins were found in the four cell lines, and no double-minute chromosomes were found in the primaries or the cell lines studied. Thus, a 1p-deletion was the most consistent abnormality found in the six human neuroblastomas examined in this study. We attempt to correlate this finding with Knudson's hypothesis on the origin of childhood cancer. Additional studies of primary tumors should clarify whether this specific chromosomal abnormality is related to the the acquisition of malignant behavior in human neuroblastomas.


3. DOCID:15330 SCORE: 0.00399430880346287
DOCNO: 2654502
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunotherapy
DESCRIPTOR: Lymphokines
QUALIFIER: therapeutic use
QUALIFIER: immunology
QUALIFIER: therapy
AUTHOR: C M van Haelst-Pisani CM
AUTHOR: R J Pisani RJ
AUTHOR: J S Kovach JS
AFFILIATION: Department of Oncology, Mayo Clinic, Rochester, MN 55905.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mayo Clinic proceedings. Mayo Clinic.
COUNTRY: UNITED STATES
TITLE: Cancer immunotherapy: current status of treatment with interleukin 2 and lymphokine-activated killer cells.
PUBDATE: 19890401
In recent years, the medical community has witnessed a growing interest in the use of adoptive immunotherapy in patients with malignant lesions refractory to standard treatments. Systemic administration of interleukin 2, in combination with the adoptive transfer of a patient's own activated immune cells, has resulted in objective regression of several types of advanced cancers. Pronounced regression of tumor has also been observed with use of systemic interleukin 2 alone. This ability to augment the immune defense system of the host against cancer has stimulated intense clinical and laboratory investigations.


4. DOCID:2456 SCORE: 0.00398718954723935
DOCNO: 409478
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: W F Whitmore WF
AUTHOR: M A Batata MA
AUTHOR: B S Hilaris BS
AUTHOR: G N Reddy GN
AUTHOR: A Unal A
AUTHOR: M A Ghoneim MA
AUTHOR: H Grabstald H
AUTHOR: F Chu F
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A comparative study of two preoperative radiation regimens with cystectomy for bladder cancer.
PUBDATE: 19770901
This report surveys the results of two programs of preoperative irradiation with radical cystectomy for bladder cancer in 205 patients. Irradiating the true pelvis to 4000 rads in 4 weeks with radical cystectomy after 6 weeks was implemented in 119 patients (Group 1) from 1959 to 1965; 2000 rads given in 1 week to the true pelvis and radical cystectomy within the following week was implemented in 86 patients (Group 2) from 1966 to 1970. Determinate survival without evidence of recurrence at 5 years was 43% in Group 1 and 42% in Group 2. Mortality with recurrence of bladder cancer in 5 or more years was 44% in group 1 and 42% in group 2. Pelvic complications occurred in 13% of group 1 and 9% of group 2.


5. DOCID:23781 SCORE: 0.00377015519157891
DOCNO: 10136203
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Protocols
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: S G Yackzan SG
AFFILIATION: Saint Louis University Hospital, MO.
PUBTYPE: Journal Article
JOURNALTITLE: Topics in hospital pharmacy management / Aspen Systems Corporation.
COUNTRY: UNITED STATES
TITLE: Chemotherapy administration.
PUBDATE: 19940701
The administration of cancer chemotherapy is a unique combination of scientific exercise and clinical practice. The clinical practice involves the holistic care of a human being whose cancer and normal physiology are unique. The scientific exercise includes the manipulation of doses, combinations, and administration schemes of the small number of chemicals known as chemotherapy. Bringing science and clinical practice together to formulate a treatment plan that offers the most favorable outcomes and that minimizes short- and long-term toxicities is a challenge. This article discusses the scientific rationale for various methods of chemotherapy administration and outlines the specific clinical steps necessary to achieve the most safe and efficacious administration plan possible.


6. DOCID:18608 SCORE: 0.00354941957189094
DOCNO: 7798818
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: A Panich A
AUTHOR: L Charnvej L
AFFILIATION: Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Thailand.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
COUNTRY: THAILAND
TITLE: Comparison of morphine slow release tablet (MST) and morphine sulphate solution (MSS) in the treatment of cancer pain.
PUBDATE: 19931201
A cross-over, single blind trial of MST and MSS in relieving pain of advanced cancer patients is described. Forty-nine cases completed the study. Both MST and MSS gave equally excellent pain relief in the patients as judged by the pain score of VAS and pain rating scale by a nurse, and the duration of sleep. The daily effective dose was 55.5 +/- 19.7 mg for MST and 61.0 +/- 11.0 mg of MSS.


7. DOCID:22642 SCORE: 0.00354037718717013
DOCNO: 8847778
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sepsis Syndrome
QUALIFIER: physiology
QUALIFIER: etiology
AUTHOR: T Kawamura T
AFFILIATION: Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Masui. The Japanese journal of anesthesiology.
COUNTRY: JAPAN
TITLE: [Cytokines during the perisurgical period]
PUBDATE: 19960501
Systematic inflammatory response syndrome, SIRS, is one of the biological responses to surgical and anesthetic invasions. SIRS itself is a defense response, but excessive SIRS may result in post-operative failure of major organs. There is evidence that inflammatory cytokines play an important role in SIRS. Therefore it may be treated by regulating these inflammatory cytokines. Changes in inflammatory cytokines during the perisurgical period were discussed in relation to post-operative organ injury in patients who had undergone highly invasive procedures such as open heart surgery or resection of esophageal cancer to explore the possibility of anticytokine therapy.


8. DOCID:11832 SCORE: 0.00333017580150736
DOCNO: 6498670
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tobacco Smoke Pollution
QUALIFIER: analysis
AUTHOR: N E Collishaw NE
AUTHOR: J Kirkbride J
AUTHOR: D T Wigle DT
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Tobacco smoke in the workplace: an occupational health hazard.
PUBDATE: 19841101
Tobacco smoke, which contains over 50 known carcinogens and many other toxic agents, is a health hazard for nonsmokers who are regularly exposed to it while at work. Involuntary exposure to tobacco smoke annoys and irritates many healthy nonsmokers. Serious acute health effects are probably limited to the one fifth of the population with pre-existing health conditions that are aggravated by exposure to tobacco smoke. The consequences of long-term exposure include decreased lung function and lung cancer. Existing air quality standards for workplaces do not directly specify an acceptable level for tobacco smoke. The evidence on the composition of tobacco smoke and on the health hazards of involuntary exposure suggests that there may not be a "safe" level for such exposure.


9. DOCID:27426 SCORE: 0.0032230461843606
DOCNO: 11766910
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fruit
DESCRIPTOR: Vegetables
QUALIFIER: etiology
AUTHOR: Y I Kim YI
AFFILIATION: Department of Medicine, University of Toronto, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: United States
TITLE: Vegetables, fruits, and colorectal cancer risk: what should we believe?
PUBDATE: 20011201
Among dietary factors implicated in the development of colorectal cancer (CRC), the inverse relationship between vegetable and fruit consumption and CRC risk has long been believed to represent the strongest epidemiologic evidence. However, recently published large prospective studies have produced conflicting results and the results of one randomized intervention human trial do not support the protective role of vegetable and fruit consumption in colorectal carcinogenesis. Conflicting data with regard to the effect of dietary factors, including vegetables and fruits, on CRC risk likely reflect inherent, probably irresolvable, limitations of currently available tools to detect a real beneficial or harmful effect associated with these factors.


10. DOCID:1409 SCORE: 0.00321871218041533
DOCNO: 1192421
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cytotoxicity Tests, Immunologic
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G E Pierce GE
AUTHOR: B DeVald B
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Microcytotoxicity assays of tumor immunity in patients with bronchogenic carcinoma correlated with clinical status.
PUBDATE: 19751201
Peripheral blood lymphocytes from patients with bronchogenic carcinoma were tested in microcytotoxicity assays against cultured bronchogenic cancer cells, other types of tumor cells, and skin fibroblasts. Lymphocytes from patients who were postresection with no clinical evidence of residual or recurrent tumor were more frequently toxic against bronchogenic carcinoma than were lymphocytes from normal donors or from patients with clinically evident disease. Lymphocytes from patients with minimal or no tumor were more frequently toxic against bronchogenic cancer than against skin fibroblasts. Serum samples from a few patients rendered lymphocytes toxic for bronchogenic cancer cells, but this serum activity could not be correlated with the patient's clinical status.


11. DOCID:2695 SCORE: 0.00321656474213887
DOCNO: 1225514
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: K Kovacs K
AUTHOR: E Horvath E
PUBTYPE: Journal Article
JOURNALTITLE: Endokrinologie.
COUNTRY: GERMANY, EAST
TITLE: Gonadotrophs following removal of the ovaries: a fine structural study of human pituitary glands.
PUBDATE: 19750901
The fine structure of gonadotrophs has been investigated in surgically removed pituitary glands of 12 women who because of disseminated breast cancer, underwent bilateral ovariectomy at various periods before hypophysectomy. Compared with the adenohypophyses of 3 non-ovariectomized female subjects with diabetes mellitus, electron microscopy revealed that two cell types were affected by gonadectomy. These cell types corresponded to those which were regarded as FSH gonadotrophs and LH gonadotrophs in previous studies. In addition in the adenohypophyses stimulated by removal of the ovaries, intermediary cell types began to appear suggesting a transformation of LH gonadotrophs to FSH gonadotrophs. The most conspicuous change following gonadectomy was the formation of castration cells. These cells arose from FSH gonadotrophs and exhibited ultrastructural features interpreted as representing the morphologic manifestations of sustained hypersecretion of gonadotrophins. It seemed that castration cells have a limited life span and in their advanced stages of development they show ultrastructural signs indicative of irreversible involution.


12. DOCID:31719 SCORE: 0.00320996290492176
DOCNO: 16197338
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Monoclonal
DESCRIPTOR: Antibodies, Neoplasm
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: immunology
AUTHOR: Mark C Glassy MC
AUTHOR: Michael E McKnight ME
AFFILIATION: The Rajko Medenica Research Foundation, San Diego, CA 92121, USA. markglassy@aol.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert opinion on biological therapy.
COUNTRY: England
TITLE: Requirements for human antibody cocktails for oncology.
PUBDATE: 20051001
Cancer patients receiving antibodies as monotherapy have benefited from these treatments. However, significant improvements can be made that should make the therapy more effective. Applying lessons learned from the natural oligoclonal antibody response that cancer patients mount to their own tumours suggests that cocktails of monoclonal antibodies could be formulated, which may be more effective in treating cancers. The next phase of antibody immunotherapy will include cocktails of monoclonal antibodies. Various requirements for human antibody cocktails are discussed, as well as potential limitations of this approach.


13. DOCID:31349 SCORE: 0.00320995306645334
DOCNO: 16359023
OWNER: NLM
STATUS: In-Process
AUTHOR: Toshiharu Tabata T
AUTHOR: Y Okada Y
AUTHOR: T Kondo T
AFFILIATION: Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Kyobu geka. The Japanese journal of thoracic surgery.
COUNTRY: Japan
TITLE: [Lung cancer with polyarthropathy due to parvovirus B19: report of a case]
PUBDATE: 20051201
We reported a case of lung cancer with polyarthropathy induced by human parvovirus B19. A 60-year-old female with lung cancer was admitted to our hospital with polyarthropathy similar to rheumatoid arthritis. Although the abnormal accumulation of 99mTc-MDP in the bone scan film and rheumatoid factor positive were detected before operation, we diagnosed polyarthropathy induced by parvovirus B19 through the detection of parvovirus B19 IgM and B19 DNA. The joint pain gradually improved after surgical treatment for lung cancer.


14. DOCID:31618 SCORE: 0.00320987034278628
DOCNO: 16305443
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Delivery Systems
QUALIFIER: administration & dosage
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: administration & dosage
QUALIFIER: immunology
AUTHOR: Dileep Padinjarae Vangasseri DP
AUTHOR: Su-Ji Han SJ
AUTHOR: Leaf Huang L
AFFILIATION: Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current drug delivery.
COUNTRY: United Arab Emirates
TITLE: Lipid-protamine-DNA-mediated antigen delivery.
PUBDATE: 20051001
The development of novel 'new generation' vaccine systems that is based on proteins, peptides or DNA is of great current interest. However, due to the lower efficiencies of these new generation vaccines, they are seldomly used alone. Rather, their formulations often contain adjuvants, either to enhance the immune responses or to reduce dosing. The present chapter will provide a brief overview of the recent advances in peptide-based cancer vaccine adjuvants, focusing mainly on Liposome-Protamine-DNA (LPD) nanoparticle-mediated antigen delivery.