0. DOCID:31379 SCORE: 0.00236742866640118
DOCNO: 15602654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: immunology
AUTHOR: Madhav V Dhodapkar MV
AFFILIATION: Laboratory of Tumor Immunology and Immunotherapy, Rockefeller University, New York, NY 10021, USA. dhodapm@rockefeller.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer immunology, immunotherapy : CII.
COUNTRY: Germany
TITLE: Harnessing host immune responses to preneoplasia: promise and challenges.
PUBDATE: 20050501
Preneoplastic lesions are more common than clinical cancer and define a population at increased risk for the development of malignancy. Recent studies suggest that the immune system has the capacity to recognize these lesions, and enrichment of preneoplasia-specific immune effectors can be detected in the tumor bed of some preneoplastic lesions such as monoclonal gammopathies. Here, I discuss the promise and challenges of harnessing the immune response against preneoplasia. Approaches to boost the natural host response to these lesions may have a major impact on reducing net cancer burden.


1. DOCID:31667 SCORE: 0.00206471111426028
DOCNO: 15217149
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: Bernard Paule B
AFFILIATION: Service d'Urologie, Hôpital Henri Mondor Créteil, France. bepaule@wanadoo.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie.
COUNTRY: France
TITLE: [New therapeutic targets in testicular cancer: contribution of molecular biology]
PUBDATE: 20040401
Testicular cancer is curable by conventional cytotoxic drugs. Despite these excellent results, a group of patients remain incurable with standard chemotherapy, including patients who progress despite high-dose salvage chemotherapy, patients with malignant transformation of teratomas and patients with late recurrence. Tyrosine kinase receptors constitute a group of proteins which includes EGFr (Epidermal Growth Factor receptor) and c-Kit. The recent possibility of treatments targeted to the molecular level, particularly using agents directed against c-Kit and EGFr raise new hopes for the effective treatment of refractory testicular cancer.


2. DOCID:29317 SCORE: 0.00206354196889364
DOCNO: 12559068
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sentinel Lymph Node Biopsy
QUALIFIER: diagnosis
AUTHOR: I Tytler I
AUTHOR: A Hayes A
AUTHOR: M Kissin M
AFFILIATION: Breast Unit and St Lukes Cancer Centre, Royal Surrey County Hospital, Egerton Road, Guildford GU2 7XX, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: England
TITLE: Intramammary sentinel nodes in early breast cancer: can we find them and do they matter?
PUBDATE: 20030201
Intramammary nodes identified using the sentinel node biopsy technique can play an important prognostic role in early breast cancer. Two cases of intramammary nodes found by sentinel node biopsy are discussed from the Guildford perspective.


3. DOCID:28869 SCORE: 0.00085024606995126
DOCNO: 12109812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: chemistry
QUALIFIER: therapeutic use
AUTHOR: S S W Ng SS
AUTHOR: M Brown M
AUTHOR: W D Figg WD
AFFILIATION: Molecular Pharmacology Section, Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.
COUNTRY: France
TITLE: Thalidomide, an antiangiogenic agent with clinical activity in cancer.
PUBDATE: 20020601
Despite the teratogenic past of thalidomide, there is recent evidence indicating the drug's efficacy in the management of various diseases from immune disorders to cancers. The history, pharmacodynamic and pharmacokinetic properties of thalidomide in the clinic are discussed in this review article.


4. DOCID:31514 SCORE: 0.000850172791632607
DOCNO: 15517115
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: J Weitz J
AUTHOR: M Koch M
AUTHOR: J Kleeff J
AUTHOR: M W Müller MW
AUTHOR: J Schmidt J
AUTHOR: H Friess H
AUTHOR: M W Büchler MW
AFFILIATION: Abteilung für Allgemein-, Visceral- und Unfallchirurgie, Chirurgische Universitätsklinik Heidelberg.
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: Germany
TITLE: [Kausch-Whipple pancreaticoduodenectomy. Technique and results]
PUBDATE: 20041101
The Kausch-Whipple operation is the standard procedure for resection of pancreatic head cancer, distal bile duct cancer, and periampullary cancers. It is also used for some cases of chronic pancreatitis. Traditionally, this operation is associated with high perioperative morbidity and mortality. The aim of our study was to present our current technique for Kausch-Whipple pancreaticoduodenectomy and to demonstrate that acceptable perioperative and long-term outcomes can be achieved by a standardised technique in a high-volume centre.


5. DOCID:29960 SCORE: 0.000850158012396905
DOCNO: 15928434
OWNER: NLM
STATUS: In-Process
AUTHOR: S Khurana S
AUTHOR: M L Dubey ML
AUTHOR: N Malla N
AFFILIATION: Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Indian journal of medical microbiology.
COUNTRY: India
TITLE: Association of parasitic infections and cancers.
PUBDATE: 20050401
Recent advances in the fields of molecular biology, epidemiology and infectious diseases have led to significant revelations to clarify the relationship between cancer and infective agents. This article reviews the relationship between parasitic infections and carcinogenesis and the possible mechanisms involved. Few parasites, e.g., Schistosoma haematobium and Opisthorchis viverrini have been found to be strongly associated with bladder cancer and cholangiocarcinoma respectively. The evidence for the association of several other parasites and cancers has also been postulated.


6. DOCID:31018 SCORE: 0.000850158007417347
DOCNO: 12628368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: trends
QUALIFIER: methods
QUALIFIER: trends
QUALIFIER: therapeutic use
QUALIFIER: genetics
AUTHOR: Kenneth Lundstrom K
AFFILIATION: Regulon Inc./BioXtal., Chemin des Croisettes 22, CH-1066 Epalinges, Switzerland. kenneth.lundstrom@mepnet.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biotechnology.
COUNTRY: England
TITLE: Latest development in viral vectors for gene therapy.
PUBDATE: 20030301
Gene therapy includes the application of various viral vectors, which represent most types and families of viruses, suitable for infection of mammalian host cells. Both hereditary diseases and acquired illnesses, such as cancer, can be targeted. Because of the various properties of each viral vector, the definition of their application range depends on factors such as packaging capacity, host range, cell- or tissue-specific targeting, replication competency, genome integration and duration of transgene expression. Recent engineering of modified viral vectors has contributed to improved gene delivery efficacy.


7. DOCID:29499 SCORE: 0.000850139552053651
DOCNO: 12573442
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Profiling
QUALIFIER: classification
AUTHOR: Edison T Liu ET
AFFILIATION: Genome Institute of Singapore, Singapore Science Park II, Singapore. gisliue@nus.edu.sg
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: England
TITLE: Classification of cancers by expression profiling.
PUBDATE: 20030201
Expression profiling using microarray technology has refined the classification of cancer. The greatest advances have been in lymphomas, leukaemias, and breast cancer where array information identified new diagnostic categories not achievable by standard microscopic or molecular means. These sub-categories often have distinct prognostic profiles. The same investigations have clarified the cellular lineage of cancer types, highlighted the importance of biochemical pathways in determining the expression 'phenotype', and identified potential new diagnostic markers and therapeutic targets.


8. DOCID:30756 SCORE: 0.000843915578150871
DOCNO: 12527493
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: David Johnson D
AUTHOR: Christopher M Pyke CM
AUTHOR: Deborah L Norris DL
AUTHOR: Graham F Adkins GF
AFFILIATION: Department of Surgery, University of Queensland, Mater Adult Hospital, South Brisbane, Queensland, Australia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Asian journal of surgery / Asian Surgical Association.
COUNTRY: China
TITLE: Atypical ductal hyperplasia of the breast in young women: two case reports.
PUBDATE: 20030101
Atypical ductal hyperplasia of the breast is a benign proliferative condition that is associated with an increased risk of development of breast cancer in either the ipsilateral or contralateral breast. Following diagnosis at biopsy, respective management options range from observation to chemoprophylaxis to prophylactic surgery. We present two cases in young women, facing prolonged follow-up, one managed with observation only, and the other managed with ipsilateral mastectomy and reconstruction.


9. DOCID:31529 SCORE: 0.000838432843391328
DOCNO: 15094758
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: pharmacokinetics
QUALIFIER: pharmacology
QUALIFIER: pharmacokinetics
QUALIFIER: pharmacology
AUTHOR: J F R Robertson JF
AUTHOR: M Harrison M
AFFILIATION: Unit of Surgery, City Hospital, Nottingham NG5 1PB, UK. john.robertson@nottingham.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Fulvestrant: pharmacokinetics and pharmacology.
PUBDATE: 20040301
Fulvestrant is a new type of oestrogen receptor (ER) antagonist with no agonist activity and a novel pharmacological profile. Fulvestrant has been shown to significantly reduce cellular levels of the ER and progesterone receptor in both preclinical studies and in clinical trials of postmenopausal women with primary breast cancer. This paper reviews the pharmacokinetics and metabolism of fulvestrant, which support the rationale for drug delivery as a single, once-monthly intramuscular injection, and show that this agent has minimal potential to be the subject, or cause, of significant cytochrome p450-mediated drug interactions.


10. DOCID:31592 SCORE: 0.000838432244417354
DOCNO: 15628052
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: drug therapy
AUTHOR: Małgorzata Rozwodowska M
AUTHOR: Tomasz Drewa T
AUTHOR: Alina Woźniak A
AUTHOR: Celestyna Mila-Kierzenkowska C
AUTHOR: Lukasz Drewa L
AUTHOR: Roman Makarewicz R
AUTHOR: Radosław Maciak R
AUTHOR: Dariusz Musiałkiewicz D
AFFILIATION: Katedra i Zakład Biologii Medycznej AM w Bydgoszczy.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: Poland
TITLE: [Changes in arylsulphatase activity in blood serum in patients with breast cancer before and after treatment]
PUBDATE: 20040901
We evaluated arylsulphatase activity in 52 women with breast cancer. In women with breast cancer this enzyme activity is 2,5-fold higher than in healthy women. After operation and chemiotherapy arylsulphatase activity decreased to normal values. There is correlation between enzyme activity and tumor size and number of metastases. In group with bigger tumor and higher number of metastases arylsulphatase activity is markedly higher.


11. DOCID:28435 SCORE: 0.000837086897103384
DOCNO: 15620615
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: Peter C Seline PC
AUTHOR: Ronald J Siegle RJ
AFFILIATION: Center for Surgical Dermatology, 1080 Polaris Parkway, Suite 200, Columbus, OH 43240, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Dermatologic clinics.
COUNTRY: United States
TITLE: Forehead reconstruction.
PUBDATE: 20050101
The article focuses on forehead reconstruction of surgical wounds following skin cancer resection. Reconstruction options are presented for three forehead subunits. Preserving motor and, when possible, sensory nerve function, maintaining eyebrow position, and camouflaging incisions are priorities for successful reconstruction. Most forehead defects that cannot be closed primarily are usually reconstructed with laterally based advancement flaps.


12. DOCID:30368 SCORE: 0.000685579772028176
DOCNO: 15478047
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: C Jackisch C
AUTHOR: M Rezai M
AUTHOR: W Eiermann W
AUTHOR: W Jonat W
AUTHOR: M Kaufmann M
AFFILIATION: Klinik für Gynäkologie, Gynäkologische Endokrinologie und Onkologie, Klinikum der Phillipps-Universität Marburg. jackisch@med.uni-marburg.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zentralblatt für Gynäkologie.
COUNTRY: Germany
TITLE: [Management of breast cancer treatment -- a multidisciplinary approach]
PUBDATE: 20041001
The management of breast cancer care poses very high expectations on implementing the treatment recommendations and guidelines for diagnostic procedures into routine treatment. Most recently a majority of these tasks has been transferred to the responsibilities of the breast centers being established all over Germany these days. Guidelines on treatment and diagnostic procedures and minimal invasive techniques have therefore been discussed among 1 300 colleagues and experts at the Duesseldorfer Symposium in June 2004.


13. DOCID:31232 SCORE: 0.000552572412725929
DOCNO: 16450951
OWNER: NLM
STATUS: In-Process
AUTHOR: Ridha Mahouachi R
AUTHOR: Imen Ben Abdelkrim I
AUTHOR: Amel Chtourou A
AUTHOR: Sofia Taktak S
AUTHOR: Rym Elgharbi R
AUTHOR: Houda Kallel H
AUTHOR: Ikram Drira I
AUTHOR: Ali Ben Kheder A
AFFILIATION: Service de Pneumologie du Pr Ali BENKHEDER, Hôpital Abderrramene Mami, Ariana, Tunisie.
PUBTYPE: Journal Article
JOURNALTITLE: La Tunisie médicale.
COUNTRY: Tunisia
TITLE: [Lung cancer and chondromatous hamartoma: a case report]
PUBDATE: 20051201
The association lung cancer with chondromatous hamartoma is frequent. We present a case of synchronous primary lung adenocarcinoma and chondromatous hamartoma. Although hamartoma is generally considered to be a benign tumor, there have been several reports of increased risk of lung cancer in patients with a chondromatous hamartoma. Therefore we recommend that patients with hamartoma should be submitted to a complete evaluation and to regular follow up, considering the risk of associated synchronous malignancy.


14. DOCID:31157 SCORE: 0.000552572176075493
DOCNO: 15965665
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: L Radbruch L
AUTHOR: F Elsner F
AFFILIATION: Klinik für Palliativmedizin, RWTH Aachen, .
PUBTYPE: Journal Article
JOURNALTITLE: Der Internist.
COUNTRY: Germany
TITLE: [Palliative pain therapy, cannabinoids.]
PUBDATE: 20051001
Cancer pain treatment should follow the recommendations of the World Health Organisation. Treatment should be with oral application, regular application times and following the analgesic step-ladder. Nonopioids such as dipyrone or nonsteroidals are used for slight to moderate pain, step-2 opioids such as tramadol or tilidine/naloxone for moderate pain and step-3 opioids such as morphine, oxycodone or hydromorphone for severe pain. Transdermal application of fentanyl or buprenorphine offer a non-invasive parenteral alternative for patients with stable pain syndromes.Cannabinoids such as tetrahydrocannabinol offer a valuable add-on option for cancer patients with refractory pain, spasticity, nausea or appetite loss.