0. DOCID:19322 SCORE: 0.00195838308655899
DOCNO: 1809160
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: J S Harington JS
AFFILIATION: Department of Community Medicine, Mount Sinai Medical Center, New York, New York 10029.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the New York Academy of Sciences.
COUNTRY: UNITED STATES
TITLE: The carcinogenicity of chrysotile asbestos.
PUBDATE: 19911201
In in vitro test systems, chrysotile is markedly toxic, causes chromosomal aberrations, and is capable of inducing morphological and preneoplastic transformation. In carefully designed animal experiments, chrysotile produces lung cancer and mesothelioma as effectively as do the amphiboles tested. Human population studies do not refute these experimental results. Chrysotile asbestos is carcinogenic to humans, especially for the induction of lung cancer and mesothelioma in exposed populations. For cancers of other sites, with the exception of laryngeal and possibly gastrointestinal cancer, the evidence for association with exposure to all forms of asbestos, including chrysotile, is not yet adequate for evaluation.


1. DOCID:16605 SCORE: 0.00171795760243996
DOCNO: 2203235
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: D A Leaf DA
AFFILIATION: UCLA School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Overweight: assessment and management issues.
PUBDATE: 19900901
Obesity is associated with an increased risk of coronary artery disease, hypertension, diabetes, hypercholesterolemia, cancer and other conditions. Although generalized obesity is associated with increased risk, the android pattern of body fat distribution may be a more sensitive predictor of coronary artery disease. A gradual weight reduction program, including adherence to a low-fat, calorie-restricted diet and participation in daily exercise, is the best approach to reduce weight and body fat.


2. DOCID:18222 SCORE: 0.00171794686300168
DOCNO: 2183266
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Staging
QUALIFIER: pathology
AUTHOR: F P Stitik FP
AFFILIATION: Virginia Medical School, Norfolk.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Staging of lung cancer.
PUBDATE: 19900501
Lung cancer is in epidemic proportions throughout the world. It is imperative that a simple, accurate staging system be used to direct treatment and evaluate its effects on long-term survival. The staging system must be the basis for current and future research on the newer adjuvant treatments for lung cancer. It should be internationally accepted, enabling a worldwide effort to improve survival. The new AJCC staging system meets these requirements, with early international reports confirming its usefulness and validity. The diagnostic radiologist, often directs the pretreatment workup of these patients and should be familiar with this new system.


3. DOCID:19294 SCORE: 0.00153127309209383
DOCNO: 8491322
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: O Parise O
AUTHOR: R Nayar R
AUTHOR: B Luboinski B
AFFILIATION: D├ępartement de Chirurgie Cervico-faciale et ORL, Institut Gustave-Roussy, Villejuif, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: ENGLAND
TITLE: Prevertebral fascia flap in hypopharyngeal reconstruction: a preliminary report.
PUBDATE: 19930401
Ablative surgery for pyriform sinus cancer often leaves a defect which cannot be closed primarily. Many techniques for hypopharyngeal reconstruction have been described but no single technique can be recommended for use in all situations. The prevertebral fascia flap described in this article provides an alternative to hypopharyngeal repair when a more complex technique is contra-indicated. It is a one stage procedure, fashioned with locally available tissue, and technically simple. Its use in two anecdotal cases is described herewith.


4. DOCID:18978 SCORE: 0.00146373174757191
DOCNO: 1704923
AUTHOR: G S Gerber GS
AUTHOR: G W Chodak GW
AFFILIATION: Department of Surgery, University of Chicago, Ill 60637.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Routine screening for cancer of the prostate.
PUBDATE: 19910301
The value of screening for prostate cancer remains unclear. Although digital rectal examination, transrectal ultrasonography, and determination of serum prostate-specific antigen levels may lead to early detection of a malignancy, these procedures have never been shown to reduce disease-specific mortality from prostate cancer. Unfortunately, several potential errors found in uncontrolled trials may suggest benefit from screening where none exists. Only a large, randomized, controlled clinical study demonstrating decreased mortality from prostate cancer can prove that screening is beneficial. Until such a study is performed, patients should be informed of both the potential benefits and the risks of screening and treatment.


5. DOCID:16317 SCORE: 0.00142178415993623
DOCNO: 7680177
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: R Hrebinko R
AUTHOR: S R Taylor SR
AUTHOR: R R Bahnson RR
AFFILIATION: Division of Urologic Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Carcinoma of prostate metastatic to parotid gland.
PUBDATE: 19930301
A rare case of prostate cancer with metastasis to the parotid salivary gland is reported. The prostatic origin of the mass was proven by incisional biopsy and immunohistochemical staining for prostate-specific antigen. Additional studies of the tumor included ultrastructural and quantitative deoxyribonucleic acid (DNA) analysis.


6. DOCID:16452 SCORE: 0.00109027402387234
DOCNO: 1739541
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Psychological
DESCRIPTOR: Body Image
DESCRIPTOR: Social Identification
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: D Erdos D
PUBTYPE: Journal Article
JOURNALTITLE: Dermatology nursing / Dermatology Nurses' Association.
COUNTRY: UNITED STATES
TITLE: Redefining identity when appearance is altered.
PUBDATE: 19920201
Alteration in appearance, impacting on identity, can occur when cancer or other chronic illness strikes. Patients and families need assistance in coping with changes and redefining a sense of self during treatment and beyond. This article examines some common effects of therapy and disease on appearance and outlines a nursing plan of care to assist the patient in regaining acceptance in the outer world.


7. DOCID:18958 SCORE: 0.00108543163312782
DOCNO: 14731968
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: S Akhtar S
AUTHOR: R L Juliano RL
AFFILIATION: Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Trends in cell biology.
COUNTRY: England
TITLE: Cellular uptake and intracellular fate of antisense oligonucleotides.
PUBDATE: 19920501
Antisense oligonucleotides with sequences complementary to a given genetic target can enter cells in sufficient quantities to selectively inhibit gene expression. Thus, they have a potential therapeutic use in preventing undesirable gene expression in diseases such as cancer and AIDS. However, it is remarkable that these molecules, which have high molecular weights and are often charged, gain entry to cells at all. In this article, we review the possible mechanisms by which oligonucleotides enter cells and their subsequent intracellular fates. We also discuss current approaches for improving cellular uptake and delivery of antisense nucleic acids to their intended targets.


8. DOCID:17730 SCORE: 0.00105275768333681
DOCNO: 1709145
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food, Formulated
DESCRIPTOR: Palliative Care
QUALIFIER: therapy
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: G Richter G
AUTHOR: J Dehnert J
AFFILIATION: Abt. Gastroenterologie und Stoffwechsel, Philipps-Universit├Ąt Marburg.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Infusionstherapie (Basel, Switzerland)
COUNTRY: SWITZERLAND
TITLE: [Enteral feeding in oncology]
PUBDATE: 19901201
Nutrition therapy is accepted to represent an important part of therapeutic strategy in cancer patients. In correlation to general clinical state, nutritional condition and anti-cancer therapy, nutrition has to be planned according to a stepwise concept. Under certain circumstances, enteral tube feeding is indicated. This procedure is affected by tumor lesions, digestion, resorption and tumor related metabolic disorders, and side effects of particulate anti-cancer therapy. In tumor patients, elemental (chemically defined) diets are predominant. Polymeric diets, however, occasionally represent another possible nutritional tool.


9. DOCID:17580 SCORE: 0.000831761015195505
DOCNO: 8491120
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Emergency Service, Hospital
QUALIFIER: diagnosis
AUTHOR: E S Pollack ES
AFFILIATION: Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Emergency medicine clinics of North America.
COUNTRY: UNITED STATES
TITLE: Emergency department presentation of childhood malignancies.
PUBDATE: 19930501
The diagnosis of malignancy in childhood is challenging. Signs and symptoms are generally nonspecific, and children with an underlying malignancy rarely are seriously ill at the time of initial presentation. A thorough history and physical examination are the most important components of the emergency physician's assessment of children in whom cancer is suspected. There are a number of risk factors, physical findings, and clinical syndromes that indicate the need for careful evaluation of which the emergency physician should be aware.


10. DOCID:16835 SCORE: 0.000829570852681215
DOCNO: 8434414
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mice, Transgenic
DESCRIPTOR: Models, Genetic
DESCRIPTOR: Mutation
AUTHOR: J Gossen J
AUTHOR: J Vijg J
AFFILIATION: Harvard Medical School, Beth Israel Hospital, MA 02215.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in genetics : TIG.
COUNTRY: ENGLAND
TITLE: Transgenic mice as model systems for studying gene mutations in vivo.
PUBDATE: 19930101
Transgenic mice carrying bacterial reporter genes have been developed to study spontaneous or induced mutations in vivo. Mutations can be analysed upon the efficient retrieval of reporter genes from mouse genomic DNA into a suitable bacterial host. These systems allow, for the first time, the direct correlation of mutational mechanisms in vivo with their ultimate physiological endpoints, for example, cancer or ageing.


11. DOCID:17305 SCORE: 0.000829507202054104
DOCNO: 2081005
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nursing Theory
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: D P Hymovich DP
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses.
COUNTRY: UNITED STATES
TITLE: A theory for pediatric oncology nursing practice and research.
PUBDATE: 19901001
This article describes the development and application of a theoretical framework that can be used to guide pediatric oncology nursing practice and research. The framework's six dimensions provide the nurse with an approach to comprehensive assessment and intervention with families of children with cancer. These dimensions are: systems (individual, family, community, society); mediating variables (identifying characteristics, orientation to life); time; adaptation variables (stressors, coping strategies); level of functioning (tasks, capabilities, needs); and intervention.


12. DOCID:18286 SCORE: 0.000829382260969839
DOCNO: 2374490
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
QUALIFIER: diagnosis
QUALIFIER: methods
QUALIFIER: blood
AUTHOR: P S Phillips PS
AUTHOR: F G Herring FG
AFFILIATION: Department of Chemistry, University of British Columbia, Vancouver, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine.
COUNTRY: UNITED STATES
TITLE: Is the detection of fucose cancer markers by 2D 1H NMR unequivocal?
PUBDATE: 19900701
Fucose is believed to be a marker for cancer that may be detectable by the 2D proton NMR (COSY) of human plasma. However, the COSY technique is time consuming and prone to error. These problems may be alleviated by using the SUPERCOSY pulse sequence; this technique shows that there are many other cross peaks in the region (1.3, 4.2 ppm) which are not readily distinguishable from fucose.


13. DOCID:19191 SCORE: 0.000829381494161191
DOCNO: 8225448
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: K Krishnaswamy K
AUTHOR: M P Prasad MP
AUTHOR: T P Krishna TP
AUTHOR: S Pasricha S
AFFILIATION: Food & Drug Toxicology Research Centre, National Institute of Nutrition, Hyderabad.
PUBTYPE: Journal Article
JOURNALTITLE: The Indian journal of medical research.
COUNTRY: INDIA
TITLE: A case control study of selenium in cancer.
PUBDATE: 19930601
As selenium has been shown to be a risk modifier of cancer at several sites in a case-control approach, selenium nutriture was studied in oral and oesophageal cancer patients. The mean selenium level in oral cancer patients was 102.6 ng/ml and in oesophageal cancer 103.3 ng/ml, while in the matched controls it was 117.5 and 116.2 ng/ml respectively. Relative risk estimates were 3.16 (P < 0.02) and 16.0 (P < 0.01) in oral and oesophageal cancer patients respectively. The risk appears to increase with selenium levels lower than 115 ng/ml.


14. DOCID:18002 SCORE: 0.000829375281642691
DOCNO: 1653588
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: pathology
QUALIFIER: radiography
AUTHOR: R H Troupin RH
AUTHOR: S G Orel SG
AFFILIATION: University of Pennsylvania, Philadelphia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in radiology.
COUNTRY: UNITED STATES
TITLE: New insights into mammographic correlations in breast pathology.
PUBDATE: 19910801
Meticulous correlation of mammographic and pathologic findings is essential to improve detection and understanding of the many processes that affect the breast. A review of recent radiologic papers dealing with several breast cancer variants as well as two benign lesions, the radial scar and the breast hamartoma, is presented. Important papers from the pathologic, oncologic, and radiologic literature are reviewed. These papers described the evolving concepts of proliferative breast disease as risk markers, as well as insights into prognostic differences among the histologic subtypes of ductal carcinoma in situ.