0. DOCID:14043 SCORE: 0.00308434568625384
DOCNO: 3029002
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: metabolism
QUALIFIER: diagnostic use
QUALIFIER: analysis
AUTHOR: K Onodera K
AUTHOR: A Okubo A
AUTHOR: K Yasumoto K
AUTHOR: T Suzuki T
AUTHOR: G Kimura G
AUTHOR: K Nomoto K
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of cancer research : Gann.
COUNTRY: JAPAN
TITLE: 31P nuclear magnetic resonance analysis of lung cancer: the perchloric acid extract spectrum.
PUBDATE: 19861201
31P-NMR spectra were obtained from the perchloric acid extracts of normal lung and lung cancer tissues obtained at surgery, and from extracts of neoplastic cells cultured in vitro. The perchloric acid extract of lung cancer tissue gave rise to a signal whose chemical shift was 3.2 ppm at pH 8.0. This signal was not observed in the extract of normal tissue of the lung from the same patient. The compound giving this signal was identified as phosphorylcholine.


1. DOCID:13782 SCORE: 0.00282299870161203
DOCNO: 2918872
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: H Vainio H
AUTHOR: T Partanen T
AFFILIATION: Institute of Occupational Health, Helsinki, Finland.
PUBTYPE: Journal Article
JOURNALTITLE: Mutation research.
COUNTRY: NETHERLANDS
TITLE: Population burden of lung cancer due to environmental tobacco smoke.
PUBDATE: 19890201
The population burden of lung cancer due to environmental tobacco smoke is significant because a large fraction of the population is exposed. The risks are, of course, lower than those to smokers themselves; but smoking is self-inflicted, passive smoking is involuntary. Making various assumptions, the proportion of lung cancer cases among non-smokers that could reasonably be attributed to environmental tobacco smoke can be calculated to be about 20-30% in western countries. Thus, non-smokers in the society could benefit considerably from diminishing exposures to other people's smoke.


2. DOCID:15853 SCORE: 0.00273552533235437
DOCNO: 2595881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: N Javadpour N
AUTHOR: P Daloni P
AFFILIATION: Division of Urology, University of Maryland, School of Medicine, Baltimore.
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Histopathologic changes of transitional cell carcinoma of bladder after M-VAC chemotherapy.
PUBDATE: 19891201
Over the past several years, we have utilized methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) as definitive, neoadjuvant, and adjuvant therapy for various stages of transitional cell carcinoma with reduced toxicities. Currently, there is little information concerning the histopathologic changes after M-VAC therapy. We report on the histopathologic changes of bladder transitional cell carcinoma following M-VAC chemotherapy in our protocol for treatment of bladder cancer. The main histopathologic findings after M-VAC therapy are squamous metaplasia, necrosis, fibrosis, and persistent transitional cell carcinoma. In 2 cases, there were persistent adenocarcinoma and squamous cell carcinoma. The importance of these observations in terms of diagnostic and therapeutic implications is reviewed.


3. DOCID:15785 SCORE: 0.00273552233107121
DOCNO: 2729474
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: African Americans
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: ethnology
QUALIFIER: statistics & numerical data
AUTHOR: W J Mayer WJ
AUTHOR: W P McWhorter WP
AFFILIATION: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of public health.
COUNTRY: UNITED STATES
TITLE: Black/white differences in non-treatment of bladder cancer patients and implications for survival.
PUBDATE: 19890601
Analysis of 20,764 White and 882 Black bladder cancer patients diagnosed during 1978-85 indicates that Black patients were more likely than White patients to go untreated following diagnosis after adjustment for age- and stage-at-diagnosis, sex, and tumor histology (OR = 1.80, 95% CI = 1.33, 2.43). Treatment status was found to be a significant predictor of five-year survival after adjustment (treated/untreated odds ratio = 3.16, 95% CI = 2.08, 4.79). Results suggest that differences in initial therapy may contribute to the survival differential between Black and White bladder cancer patients.


4. DOCID:15040 SCORE: 0.00206171480852527
DOCNO: 3815298
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Twins
DESCRIPTOR: Twins, Dizygotic
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: L Jovanovic L
AUTHOR: M Babich M
AUTHOR: K Thomas K
AUTHOR: H J Goolsby HJ
AUTHOR: E Z Ezdinli EZ
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Simultaneous cloacogenic carcinoma in dizygotic twins.
PUBDATE: 19870301
Dizygotic twins developed cloacogenic carcinoma of the anus almost simultaneously. The patients, although separated from the time they were 20-years-old, had very similar life styles. There are several reports in the medical literature of synchronous tumors in mono and dizygotic twins. It is recommended that if a cancer diagnosis is made in one twin, the other undergo workup to exclude the presence of a tumor with similar histology. The establishment of state or national twin registries would provide valuable information regarding the role of genetic and environmental factors in the development of not only cancer but also of various nonmalignant disorders.


5. DOCID:15282 SCORE: 0.00193682544180147
DOCNO: 3450782
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liposomes
QUALIFIER: administration & dosage
AUTHOR: N C Phillips NC
AUTHOR: P P Major PP
AUTHOR: M Ishida M
AUTHOR: H Sikorska H
AFFILIATION: Montreal General Hospital Research Institute, Quebec, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of biological response modifiers.
COUNTRY: UNITED STATES
TITLE: Liposomal incorporation and immunogenicity of carcinoembryonic antigen.
PUBDATE: 19871201
The ability of liposomal carriers to act as immuno-adjuvants for carcinoembryonic antigen (CEA) has been evaluated. Liposomal incorporation was consistent with association with the aqueous phase of the liposome, little if any of the protein being associated with the phospholipid bilayer. The incorporation of CEA within liposomal carriers resulted in immunological recognition in mice at doses (0.1 microgram) significantly less than required in Freund's complete adjuvant (25 micrograms), maximal responsiveness being found with liposomal-CEA preparations containing a lipophilic immunoadjuvant, N-acetyl-muramyl-L-alanyl-D-isoglutamyl-glyceryl-dipalmitate. Such liposomal formulations may have utility as immunoadjuvants for cancer immunotherapy.


6. DOCID:14020 SCORE: 0.00193681019900743
DOCNO: 2463731
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Y Arase Y
AUTHOR: Y Endo Y
AUTHOR: M Hara M
AUTHOR: H Kumada H
AUTHOR: K Ikeda K
AUTHOR: A Yoshiba A
AFFILIATION: Department of Pathology, Toranomon Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: Hepatic squamous cell carcinoma with hypercalcemia in liver cirrhosis.
PUBDATE: 19880501
Primary squamous cell carcinoma of the liver is exceedingly rare and has previously been reported in association with hepatic teratoma, hepatic cyst or hepatolithiasis. This paper describes an autopsy case of squamous cell carcinoma which developed with hypercalcemia in a cirrhotic liver. This cancer was characterized histologically, immunohistologically and ultrastructurally, and was found to exhibit immunofluorescence positivity for anti-epidermal keratin monoclonal antibody, together with the presence of tonofilaments scattered sparsely in the cytoplasm of the cancer cells.


7. DOCID:14224 SCORE: 0.00193460357190216
DOCNO: 3287979
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: rehabilitation
AUTHOR: S H Kurtzman SH
AUTHOR: B Gardner B
AUTHOR: W S Kellner WS
AFFILIATION: Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Rehabilitation of the cancer patient.
PUBDATE: 19880601
Cancer patients often require extensive rehabilitation after treatment. Organization of a rehabilitation team and determination of its goals are a primary aim of such programs. Studies of job security and insurability demonstrate significant problems and biases toward the cancer patient. Discussion has been made of specific male and female sexual rehabilitation programs as well as programs directed at other physical disabilities secondary to head and neck or amputation surgery. Attention is drawn toward familiarizing the surgeon with these problems in order to enhance his treatment of the cancer patient.


8. DOCID:15368 SCORE: 0.00165203644612314
DOCNO: 3826182
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: A P Bond AP
AUTHOR: M J Diver MJ
AUTHOR: J C Davis JC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Plasma progesterone concentration in women with and without adenocarcinoma of the endometrium.
PUBDATE: 19870201
In the search for the postulated but elusive "estrogenic bias" in patients developing endometrial cancer, several authors have suggested lack of progesterone as the common denominator. In this study 21 patients at the time of diagnosis of Stage I disease are compared to stringently matched healthy control subjects. No significant difference was found in plasma progesterone concentrations between the two groups. These results, in conjunction with other calculated estrogenic indices based on these patients, provide no evidence of lack of progesterone at the onset of clinical disease. However, the effects of long-term progesterone lack related to chronic anovulation are not excluded by these findings.


9. DOCID:14965 SCORE: 0.00163193097477743
DOCNO: 3747163
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K Uesaka K
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Production and clinical study of monoclonal antibodies against liver ferritin]
PUBDATE: 19860801
Monoclonal antibody (mAb.) against liver ferritin was produced by immunization of human liver ferritin. Using this mAb., an RPHA system for measurement of the serum ferritin level was established. This system had a good correlation coefficient (0.8625) with the RIA method and could measure levels of more than 2 ng/ml. The reactivity to heart ferritin in this RPHA system was not distinguished from that to liver ferritin. The positive rate in various conditions was as follows: 68.6% in pancreatic cancer, 59.1% in hepatoma, and 18% in healthy individuals. In pancreatic cancer and hepatoma, the serum ferritin levels were statistically higher than in healthy subjects or those with chronic pancreatitis.


10. DOCID:14981 SCORE: 0.001631930938348
DOCNO: 3015031
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: N Watanabe N
AUTHOR: Y Niitsu Y
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Anti-tumor effect and the mechanism of action of human recombinant TNF]
PUBDATE: 19860401
TNF is cytokine derived from macrophages and holds strong promise for application to cancer therapy because of its marked antitumor effects and its high specificity to tumors. The clinical application (Phase I-II) of TNF has been started because human recombinant TNF (rH-TNF) can been produced on a large scale. In spite of notable antitumor effects, little is known concerning the mechanism of action of its cytotoxic activity. In this article, the antitumor effects of rH-TNF against human and murine tumors, the mechanism of its action and the synergistic effects of rH-TNF in combination with IFN-gamma or with cyclophosphamide are reviewed.


11. DOCID:14720 SCORE: 0.00149249484251852
DOCNO: 3036401
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: P K Buamah PK
AUTHOR: C Cornell C
AUTHOR: A W Skillen AW
AUTHOR: B M Cantwell BM
AUTHOR: A L Harris AL
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Initial assessment of tumor-associated antigen CA-125 in patients with ovarian, cervical, and testicular tumors.
PUBDATE: 19870701
Serum CA-125, a glycoprotein antigen, has been measured in serum of patients with ovarian cancer, cervical cancer, or nonseminomatous germ-cell tumor of testis. Increased concentrations were found in 21 of 27 patients with epithelial ovarian cancer and two of three patients with ovarian teratoma. Changes in CA-125 concentrations in serum during chemotherapy mirrored the progress of the disease as assessed by clinical and radiological evidence. Although CA-125 provides no real asset for diagnosis, it should have value as a marker for monitoring response to chemotherapy.


12. DOCID:15665 SCORE: 0.00137058376532137
DOCNO: 3009919
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pleural Effusion
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Y Niwa Y
AUTHOR: K Shimokata K
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Diagnostic significance of cancer antigen 125, pancreatic oncofetal antigen, and carcinoembryonic antigen in malignant and tuberculous pleural effusions.
PUBDATE: 19860301
Pleural fluid levels of cancer antigen 125 (CA 125), pancreatic oncofetal antigen (POA), and carcinoembryonic antigen (CEA) were determined in 56 patients with malignant pleural effusion and in 35 patients with tuberculous effusion. Malignant effusions had significantly higher pleural fluid CA 125 and CEA levels than those of tuberculous origin (p less than 0.005). No significant difference in POA titers was found between the two kinds of effusion. Assays of CA 125 and CEA in pleural fluid may be useful in separating malignant from tuberculous effusions. Concurrent measurement of CA 125 and CEA proved superior to determination of CEA alone in discriminating between the two groups.


13. DOCID:14419 SCORE: 0.00136721694167178
DOCNO: 2634542
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: D J Li DJ
AFFILIATION: Cancer Institute, Haerbin University of Medical Sciences, Haerbin.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [In vitro experimental expansion and induction of LAK cell of lymphocytes from human carcinomatous ascites]
PUBDATE: 19891101
Investigation on the in vitro expansion and induction of LAK cell activity of peritoneal exudate lymphocytes (PEL) from malignant ascites of advanced ovarian cancer patients is presented. The results indicated that to isolate PEL from malignant ascites was much more simple and economic than to isolate tumor infiltrating lymphocytes (TIL). PEL could be in vitro expanded 17-fold and induced to acquire LAK cell activity in the presence of rIL-2. Thus, PEL can be used as LAK cell precursor for adoptive immunotherapy of cancer.


14. DOCID:13092 SCORE: 0.00136720603916294
DOCNO: 2484298
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: methods
AUTHOR: E Bruera E
AFFILIATION: Palliative Care Unit Edmonton General Hospital, Alberta.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Continuing challenges in the management of cancer pain.
PUBDATE: 19890801
Four issues concerning the mechanisms of cancer pain are highlighted in this article. First is the need for a common language-a staging system-for assessing cancer pain. The author discusses the recently proposed Edmonton Staging System for Cancer Pain which classifies patients according to seven prognostic factors. The other issues addressed include: Optimal use of narcotic analgesics and adjuvant drugs; and intractable pain syndromes. All are areas of pain management where we are falling short.