0. DOCID:3321 SCORE: 0.0045750381527776
DOCNO: 198026
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: B G Borzenko BG
AUTHOR: G I Vornovitskaia GI
AUTHOR: I M Belousov IM
AUTHOR: G Gets G
AUTHOR: K A Drel' KA
AUTHOR: V S Shapot VS
PUBTYPE: Journal Article
JOURNALTITLE: Biokhimii︠a︡ (Moscow, Russia)
COUNTRY: USSR
TITLE: [Enzymes of anabolic and catabolic nucleic acid pathways in human hepatomas, in liver of healthy persons, and in liver of patients with cancer of gastrointestinal tract]
PUBDATE: 19770701
The activities of enzymes catalyzing the formation of nucleic acid precursors, nucleoside kinases, as well as of those involved in the degradation of nucleic acids, were studied in nuclei of the liver of healthy persons, human hepatomas and the liver of patients with cancer of gastrointestinal tract. The activities of thymydine kinase and uridine kinase in the human hepatoma nuclear sap were found to increase 40- to 50-fold and 120- to 150-fold, respectively, as compared to those in normal human liver. The activities of DNase and RNase in the fraction of chromatin protein of human hepatomas, on the contrary, decreased almost to zero. As to the liver of patients with cancer of gastrointestinal tract, drastic alterations in the activities of nucleoside kinases and nucleases in the direction characteristic of tumors themselves were observed. This phenomenon is regarded as a manifestation of the systemic effects of the tumor on the host.


1. DOCID:1732 SCORE: 0.00377795270124278
DOCNO: 981675
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neutrons
QUALIFIER: radiotherapy
AUTHOR: E J Hall EJ
AUTHOR: U Kraljevic U
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Repair of potentially lethan radiation damage: comparison of neutron and X-ray RBE and implications for radiation therapy.
PUBDATE: 19761201
Experiments with Chinese hamster cells have shown that neutron irradiation does not result in repair of potentially lethal damage (PLD), i.e., that which can be influenced by changes in environmental conditions following irradiation. Since PLD is presumed to be repaired in tumors but not in normal tissues, this absence of differential sparing of tumor cells relative to normal tissues--a feature characteristic of irradiation with x rays--represents an advantage of neutrons in addition to their reduced oxygen effect. At a given dose, the difference in relative biological effectiveness (RBE) between tumors and normal tissues corresponds to a 5% increase in tumor dose with no concomitant increase in dose to normal tissues, which could be significant in cancer therapy.


2. DOCID:1830 SCORE: 0.00324831745401801
DOCNO: 947030
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H J Kesseler HJ
AUTHOR: W R Grier WR
AUTHOR: I Seidman I
AUTHOR: S J McIlveen SJ
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Bilateral primary breast cancer.
PUBDATE: 19760701
Primary carcinoma of breast was treated in 967 patients from 1962 through 1972. Thirty-five of these patients had a second primary tumor of which 50% were discovered simultaneously. A family history for cancer was recorded in 26% of the patients with bilateral cancer. Patients found their tumor more often than the physician except in the simultaneous cases where the physician was more successful. Pathological examination showed 10% of the tumors were comedo, lobular carcinoma in situ, papillary, or tubular cancers. In the metachronous group, 50% of the axillae were involved on both sides. In the simultaneous cases the axilla was less frequently involved. Mammography, biopsies of the second breast, and prophylactic mastectomy in certain high-risk patients should improve survival rates.


3. DOCID:3615 SCORE: 0.00322364088179897
DOCNO: 1225106
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Andrieu-Guitancourt J
AUTHOR: M Brossard-Legrand M
AUTHOR: J L Happich JL
AUTHOR: J M Lamy JM
PUBTYPE: Journal Article
JOURNALTITLE: Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris.
COUNTRY: FRANCE
TITLE: [Routine endoscopy of the esophagus in buccal, pharyngeal and laryngeal cancers]
PUBDATE: 19751201
We practiced a systematic endoscopy of the upper part of the aero-digestive tract on 160 patients suffering from a cancer in the mouth, the pharynx and the upper part of the larynx. This unit, going from the mouth to the cardia does really exist: it has the same epithelial coating, the same function and is liable to suffer the same damages. It is the seat of many well-known cancerous localizations that always need to be searched for on principle when face to face with any cancer. The endoscopic examination so conceived allowed the authors to find a cancerous association on the very level of the upper sero-digestive tract among 14 per cent of the patients; 4 out of these 14 per cent having oesophageal damages impossible to detect clinically on one hand, and often radiologically on the other hand. Morever, 3 out of 7 of lesions were tiny: from 1 to 3 millimetres, extending the limits of the diagnosis of the cancer of the aesophagus and perhaps leaving better therapeutic possibilities.


4. DOCID:3689 SCORE: 0.00267611952115202
DOCNO: 142934
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypophysectomy
QUALIFIER: metabolism
AUTHOR: G C Lachelin GC
AUTHOR: S C Yen SC
AUTHOR: J F Alksne JF
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Hormonal changes following hypophysectomy in humans.
PUBDATE: 19770901
Pituitary function was studied before and after surgery in 1 patient who underwent chryohypophysectomy and 5 patients who underwent transsphenoidal excision hypophysectomy for metastatic breast cancer ablation therapy. Changes in serum luteinizing hormone, follicle stimulating hormone, growth hormone, thyrotropin stimulating hormone, pituitary prolactin (PRL), and steroid hormone levels of estrone, estradiol, testosterone, and rostenedione, and dehydroepiandrosterone levels were determined. All of the above were assessed before and from 6 weeks to 10 months after hypophysectomy. Pituitary hormone release in response to sequential stimuli of arginine infusion, thyrotropic releasing factor (TRF), and luteinizing hormone-releaseing factor was analyzed. In 3 patients, hypophysectomy was considered incomplete because of the presence of measurable amounts of circulating pituitary hormones and their release in response to stimuli, although all levels except PRL were markedly reduced. In 3 patients, hypophysectomy was considered nearly complete. Basal PRL levels remained unchanged whether the procedure was considered complete or not. PRL release was absent in response to TRF or arginine stimulation in 4 patients with substantial residual pituitary function. Hypophysectomy was followed by a marked reduction in circulating levels of estrogens and androgens. The assessment of quantitative release of pituitary hormones in response to stimuli is an improved direct measure of residual functioning pituitary tissue.


5. DOCID:2726 SCORE: 0.00239893312098272
DOCNO: 1176199
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hepatitis B Antigens
QUALIFIER: epidemiology
AUTHOR: A M Prince AM
AUTHOR: W Szmuness W
AUTHOR: J Michon J
AUTHOR: J Demaille J
AUTHOR: G Diebolt G
AUTHOR: J Linhard J
AUTHOR: C Quenum C
AUTHOR: M Sankale M
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: A case/control study of the association between primary liver cancer and hepatitis B infection in Senegal.
PUBDATE: 19750901
A case/control study has been carried out to determine by radioimmunoassay and passive hemagglutination techniques the prevalence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) in patients with primary liver cancer (PLC) and age/sex-matched hospital controls with cancers of other sites (OCC) and similarly matched controls without cancer (NCC). HBsAg was found in 61.2% of 165 cases of PLC as compared to 11.7% of 328 NCC. The frequency of HBsAg in PLC patients was significantly higher (72.2%) in those with detectable alpha fetoprotein as compared to those without (40.3%). There was no difference in the frequency of HBsAg in PLC patients with and without accompanying cirrhosis. No significant difference in potential hepatitis exposure history was found in the three study groups.


6. DOCID:3758 SCORE: 0.00239735508439555
DOCNO: 986262
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Barkas T
AUTHOR: S F AL-Khateeb SF
AUTHOR: W J Irvine WJ
AUTHOR: N M Davidson NM
AUTHOR: P Roscoe P
PUBTYPE: Journal Article
JOURNALTITLE: Clinical and experimental immunology.
COUNTRY: ENGLAND
TITLE: Inhibition of antibody-dependent cell-mediated cytotoxicity (ADCC) as a means of detection of immune complexes in the sera of patients with thyroid disorders and bronchogenic carcinoma.
PUBDATE: 19760801
Circulating immune complexes in the sera of patients with thyroid disorders or bronchogenic carcinoma were investigated using an assay system based on the inhibition of the ADCC activity of rat spleen cells. Increased inhibition, as compared with that of the sera of age and sex matched controls, was found in patients with thashimoto thyroiditis, primary hypothyroidism and bronchogenic carcinoma. The degree of inhibition in the first two groups was markedly increased compared with control sera of the same IgG content. However, the results in the lung cancer group were slightly but not significantly greater than in controls with the same level of IgG. Increased IgG levels were found in patients with thashimoto thyroiditis and thyrotoxicosis, and also in patients with bronchogenic carcinoma who had mediastinal gland involvement. The lower level of sensitivity of the assay system was approximately 600 ng added aggregated IgG, corresponding to a concentration of 6mu g/ml in the sample assayed. It is possible that circulating immune complexes may exist in lung cancer, but at a level below that of the present assay system.


7. DOCID:3087 SCORE: 0.00214806598694761
DOCNO: 327894
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: therapy
QUALIFIER: pathology
QUALIFIER: therapy
AUTHOR: R R Reimer RR
AUTHOR: B A Chabner BA
AUTHOR: R C Young RC
AUTHOR: R Reddick R
AUTHOR: R E Johnson RE
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Lymphoma presenting in bone: results of histopathology, staging, and therapy.
PUBDATE: 19770701
Lymphoma presenting in bone (that is "reticulum cell sarcoma of bone") is a form of extranodal lymphoma historically described as frequently localized (this is, stage IE or stage IIE). Between 1970 and 1975, 14 patients with this entity were seen at the National Cancer Institute. This group had a variety of histologic subtypes of diffuse lymphoma. Thorough staging showed extensive disease (stage IV) in 12 of these patients (86%). In 10 of these the metastatic disease was unsuspected clinically. Seven patients achieved complete remissions after treatment was combination chemotherapy alone (two patients), irradiation alone (one patient), surgery alone (one patient), and both chemotherapy and irradiation (three patients) and are alive and free of disease 11 + to 70 + months after diagnosis. The other seven patients did not achieve complete remission status and have all died. Although lymphomas presenting in bone may occasionally be localized, careful staging in this series frequently showed extensive disease and altered the therapeutic approach.


8. DOCID:2905 SCORE: 0.00212568090035017
DOCNO: 218258
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: M Brunet M
AUTHOR: J Berlié J
PUBTYPE: Journal Article
JOURNALTITLE: Revue d'épidémiologie et de santé publique.
COUNTRY: FRANCE
TITLE: [Cancer epidemiology and French medical data (author's transl)]
PUBDATE: 19770601
The authors remind: cancerous disease's possibilities of description before any treatment through its topography, its morphology and its clinical medicine; the modalities for taking surgical, actinic, chemical, immunologic therapeutics in account; the technics of the cancerous disease supervision after treatment, from the vital points of view (study of observed and relative survival, and of recovery) and from the carcinologic and fonctionnal points of view. They insist on the possibilities of these languages that go from the simple notation of information to the taking of these sundries modalities in account. The disposable datums in France are schematicly described. They concern: the study of survival from hospitable series; mortality by cancer for the whole of the country. The authors consider that no entry must be undertaken without the purposes, in the same way as the considered modalities for analysis, being precisely fixed. They insist on the notion of information level, of which three levels are schematicly defined, according as descriptive epidemiology or epidemiologic research or clinical research is in question.


9. DOCID:1630 SCORE: 0.00185534352498218
DOCNO: 866105
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Utilization
QUALIFIER: therapeutic use
PUBTYPE: Journal Article
JOURNALTITLE: Nordisk medicin.
COUNTRY: SWEDEN
TITLE: [Large potential market for estrogens in Scandinavian countries]
PUBDATE: 19770501
In the U.S., about half of the women over 50 years of age use oral estrogen preparations to counter climacteric afflictions compared with 2% in Norway and 4% in Sweden. The use of synthetic estrogens in Norway decreased due to an indication of increased risk of endometrial cancer in women using them, after an initial increase among women over 50 with climacteric afflictions from 1.5% in 1973 to 2.1% in 1976. In Sweden, there was a 64% increase in the use of estrogens by women with climacteric afflictions, mostly in women between 45-74 years of age. A stagnation in the increase of women using estrogens to counteract climacteric afflictions followed in 1976 in Sweden. It costs about 100 Swedish kronar per year to use estrogens in treating climacteric afflictions.


10. DOCID:1508 SCORE: 0.00185242274977389
DOCNO: 870411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mutagens
QUALIFIER: adverse effects
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: W Burgdorf W
AUTHOR: K Kurvink K
AUTHOR: J Cervenka J
PUBTYPE: Journal Article
JOURNALTITLE: Human genetics.
COUNTRY: GERMANY, WEST
TITLE: Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic.
PUBDATE: 19770401
An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/mitosis. Chromosome breakage analysis revealed no difference between the two groups. SCE rate has been shown to be elevated in a variety of systems where cell cultures or experimental animals were exposed to known mutagens and carcinogens. We suggest that the relationship carcinogen exposure-elevated SCE rate-cancer may also be valid in humans treated with arsenic.


11. DOCID:3860 SCORE: 0.0015814756059938
DOCNO: 998871
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Postoperative Complications
QUALIFIER: surgery
AUTHOR: A S Hermreck AS
AUTHOR: D G Crawford DG
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: The esophageal anastomotic leak.
PUBDATE: 19761201
Sixty-three esophageal anastomoses were performed on adult patients with esophageal or gastric cancer. A total of thirteen anastomotic leaks occurred, resulting in death in seven patients and serious morbidity in an additional patients. Twelve patients had esophagocolostomy, with five anastomotic leaks. Four leaks occurred in the cervical region and were easily managed by local drainage and irrigation, while the other patient had an intrapleural leak resulting in sepsis and death. Twenty-eight patients had esophagogastrostomy, with a total of five leaks. All anastomoses were intrapleurally located, and death ensued in four patients. Fourteen Roux-en-Y and three loop esophagojejunostomies were performed, with no leaks. Two additional deaths occurred from leakage in the pleural cavity and left upper abdomen after jejunal interposition (3 patients) and esophagoduodenostomy (3 patients). In this study, impaired blood supply of the anastomotic end appeared to be the major cause of anastomotic failure. In addition, postoperative shock appeared to predispose to anastomotic leakage, whereas microscopic tumor at the lineof resection, duration of operation and operations for palliation did not appear to increase the leakage rate. The high mortality with esophageal anastomotic leak occurs when diagnosis is delayed and when the site of leakage is in the pleural cavity or left upper abdomen. Conservative treatment is uniformly fatal, whereas operative intervention offers the only chance for survival.


12. DOCID:3832 SCORE: 0.00158007197578197
DOCNO: 563857
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: P Schenk P
PUBTYPE: Journal Article
JOURNALTITLE: HNO.
COUNTRY: GERMANY, WEST
TITLE: [Cytoplasmic microfilaments in laryngeal carcinoma malignant keratinocytes (author's transl)]
PUBDATE: 19771201
The fine structure of malignant keratinocytes of invasive squamous cell carcinoma of the human larynx was studied by electron microscopy. In these malignant cells a system organized 50--70 A microfilaments is prominent in the cortical cytoplasm of the lateral and basal cell surfaces. The microfilaments are arranged either in oriented bundles or form a complex filamentous network. The bundles may lie parallel to the plasma membrane and to the long axis of the cell. The microfilaments are situated at the base of the pseudopodia-like cell processes or are found extending into microvillous cytoplasmic extensions. In some places the bundles are some associated with the plasmalemma displaying electron-dense attachment sites. Desmosomes or other types of junctional complexes invariably remain free of microfilaments. At higher magnification the individual microfilaments are seen to be interconnected transversely by a polygonal interfilamentous meshwork. Within the bundles of microfilaments focal regions of increased electron density, similar to the Z-band of sarcomeres, are observed. Organized bundles of oriented 50--70 A microfilaments do not occur in normal squamous epithelial cells of laryngeal mucosa. By analogy with various motile microfilament containing cell systems which have been shown biochemically to contain the contractile protein actin, these cytoplasmic microfilaments may be the structural elements responsible for the migratory invasive properties of malignant keratinocytes in cancer of the larynx.


13. DOCID:2451 SCORE: 0.0015799407353909
DOCNO: 164137
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunoglobulin G
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: G V Smith GV
AUTHOR: J B Grogan JB
AUTHOR: J Stribling J
AUTHOR: J Lockard J
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Immunochemotherapy of hepatoma in rats.
PUBDATE: 19750201
Immunoglobulin G prepared by immunization of rabbits with rat Novikoff ascites tumor cells was prepared and found to by cytotoxic to Novikoff cells and rat lymphocytes. A chlorambucil conjugate was prepared and found to have similar qualities in vitro. Three day culture systems were prepared with various test substances and the immunoglobulin was shown to markedly depress cell multiplication. The chlorambucil conjugate appeared to be more efficacious than the immunoglobulin alone in inhibiting cell growth. In vivo studies revealed a total inhibition of tumor formation in animals treated with the immunoglobulin-chlorambucil conjugate whereas all control groups had 50 to 100 per cent mortality. No systemic toxicity was apparent. These studies indicate that tumor-specific immunoglobulin bound to chlorambucil presents a feasible method of delivering tumoricidal drugs to cancer in body cavities and of treating tumors with an accessible blood supply.


14. DOCID:915 SCORE: 0.00138564519740506
DOCNO: 819782
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nutrition
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: E L Wynder EL
PUBTYPE: Journal Article
JOURNALTITLE: MMW, Münchener medizinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: [Nutrition and cancer (author's transl)]
PUBDATE: 19750801
There is evidence of the epidemiological role of nutrition in the pathogenesis of various forms of human diseases; several components of nutrition are known to have a carcinogenic effect in man. In terms of epidemiology, however, alcoholism is most important which through the development of malnutrition enhances the risk of carcinosis of the upper gastrointestinal tract particularly in smokers. Nutritional deficiences have an influence on the incidence of cancer of the stomach, cervix and thyroid. Overnutrition favours the development of certain forms of cancer such as malignant diseases of the colon, pancreas, kidney, mamma, ovary, endometrium and prostate.