0. DOCID:31379 SCORE: 0.00236742866640118
DOCNO: 15602654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: immunology
AUTHOR: Madhav V Dhodapkar MV
AFFILIATION: Laboratory of Tumor Immunology and Immunotherapy, Rockefeller University, New York, NY 10021, USA. dhodapm@rockefeller.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer immunology, immunotherapy : CII.
COUNTRY: Germany
TITLE: Harnessing host immune responses to preneoplasia: promise and challenges.
PUBDATE: 20050501
Preneoplastic lesions are more common than clinical cancer and define a population at increased risk for the development of malignancy. Recent studies suggest that the immune system has the capacity to recognize these lesions, and enrichment of preneoplasia-specific immune effectors can be detected in the tumor bed of some preneoplastic lesions such as monoclonal gammopathies. Here, I discuss the promise and challenges of harnessing the immune response against preneoplasia. Approaches to boost the natural host response to these lesions may have a major impact on reducing net cancer burden.


1. DOCID:31667 SCORE: 0.00206471111426028
DOCNO: 15217149
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: Bernard Paule B
AFFILIATION: Service d'Urologie, Hôpital Henri Mondor Créteil, France. bepaule@wanadoo.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie.
COUNTRY: France
TITLE: [New therapeutic targets in testicular cancer: contribution of molecular biology]
PUBDATE: 20040401
Testicular cancer is curable by conventional cytotoxic drugs. Despite these excellent results, a group of patients remain incurable with standard chemotherapy, including patients who progress despite high-dose salvage chemotherapy, patients with malignant transformation of teratomas and patients with late recurrence. Tyrosine kinase receptors constitute a group of proteins which includes EGFr (Epidermal Growth Factor receptor) and c-Kit. The recent possibility of treatments targeted to the molecular level, particularly using agents directed against c-Kit and EGFr raise new hopes for the effective treatment of refractory testicular cancer.


2. DOCID:29317 SCORE: 0.00206354196889364
DOCNO: 12559068
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sentinel Lymph Node Biopsy
QUALIFIER: diagnosis
AUTHOR: I Tytler I
AUTHOR: A Hayes A
AUTHOR: M Kissin M
AFFILIATION: Breast Unit and St Lukes Cancer Centre, Royal Surrey County Hospital, Egerton Road, Guildford GU2 7XX, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: England
TITLE: Intramammary sentinel nodes in early breast cancer: can we find them and do they matter?
PUBDATE: 20030201
Intramammary nodes identified using the sentinel node biopsy technique can play an important prognostic role in early breast cancer. Two cases of intramammary nodes found by sentinel node biopsy are discussed from the Guildford perspective.


3. DOCID:27831 SCORE: 0.00144731036964979
DOCNO: 10222439
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: A Das A
AUTHOR: F H Hochberg FH
AUTHOR: S McNelis S
AFFILIATION: National University of Singapore, Singapore.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of neuro-oncology.
COUNTRY: NETHERLANDS
TITLE: A review of the therapy of paraneoplastic neurologic syndromes.
PUBDATE: 19990101
The therapy of paraneoplastic neurologic syndromes remains unclear and warrants a systematic review of the literature. Reports in English and foreign language literature were abstracted. Data were sorted by the primary paraneoplastic neurologic syndrome, the primary malignancy, and the methods of treatment. Neurologic improvement follows surgical, chemotherapeutic, and radiation treatments. Adjuvant immunosuppressive therapy with steroids, plasmapheresis, or immunoglobulin may help stabilize the progression of neurologic symptoms. Syndromes characterized by inflammation or neurotransmitter production without neuronal loss are most responsive to therapy. While treatment of the underlying cancer with appropriate surgery, chemotherapy, and radiation is recommended, the paraneoplastic syndrome should probably be managed with immunosuppressive therapy.


4. DOCID:27487 SCORE: 0.00143235639116313
DOCNO: 10088637
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: genetics
AUTHOR: I Garcia-Higuera I
AUTHOR: Y Kuang Y
AUTHOR: A D D'Andrea AD
AFFILIATION: Dana-Farber Cancer Institute, Department of Pediatric Oncology, Boston, MA 02115, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in hematology.
COUNTRY: UNITED STATES
TITLE: The molecular and cellular biology of Fanconi anemia.
PUBDATE: 19990301
Fanconi anemia is a rare autosomal recessive disease characterized by multiple congenital abnormalities, bone marrow failure, and cancer susceptibility. The mean age of onset of anemia is 8 years, and the mean survival is 16 years. Death usually results from complications of bone marrow failure. Considerable progress in Fanconi anemia research has resulted from the recent identification and cloning of three Fanconi anemia genes. The current review describes the structure and function of the Fanconi anemia genes and describes the role of the encoded Fanconi anemia proteins in a cellular pathway controlling chromosome stability.


5. DOCID:26179 SCORE: 0.00115377987648773
DOCNO: 11794059
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: D Chlapík D
AUTHOR: M Gogora M
AFFILIATION: Chirurgické oddelenie NsP, Trencín, Slovenská republika.
PUBTYPE: Journal Article
JOURNALTITLE: Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti.
COUNTRY: Czech Republic
TITLE: [Gastric carcinoma and mediastinal lymph nodes]
PUBDATE: 20011101
The objective of the work was to assess the impact of the shift of gastric cancer in an oral direction in the mediastinal lymph nodes. For this purpose a new miniinvasive lower mediastinoscopy was used in 30 patients. The method is safe and can be used also in other situations. Mediastinal metastases may occur in cancer in the distal and medium third of the stomach. They need not be present when cancer is in the upper third. The shift of gastric carcinoma did not influence the mediastinal nodes.


6. DOCID:26171 SCORE: 0.00115377986828672
DOCNO: 9759681
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: therapy
PUBTYPE: Guideline
PUBTYPE: Journal Article
PUBTYPE: Practice Guideline
PUBTYPE: Review
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults.
PUBDATE: 19980901
An estimated 97 million adults in the United States are overweight or obese, a condition that substantially raises their risk of morbidity from hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea and respiratory problems, and endometrial, breast, prostate, and colon cancers. Higher body weights are also associated with increases in all-cause mortality. Obese individuals may also suffer from social stigmatization and discrimination. As a major contributor to preventive death in the United States today, overweight and obesity pose a major public health challenge.


7. DOCID:26752 SCORE: 0.00114572843181957
DOCNO: 11089829
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: D Ratel D
AUTHOR: V Nasser V
AUTHOR: I Dupré I
AUTHOR: A L Benabid AL
AUTHOR: F Berger F
PUBTYPE: Letter
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Antibodies to endostatin in a multifocal glioblastoma patient.
PUBDATE: 20001101
Endostatin, a C-terminal fragment of collagen XVIII is involved in the regulation of neovascularisation in solid tumours in mice. However, few data are available on the concentration of endostatin protein in patients with cancer. Paradoxical results obtained in this way prompted us to investigate an antibody to endostatin. We detected antibodies to endostatin in the serum and in the tumour brain tissue of a patient with a multifocal glioblastoma, and in the serum samples from two patients with aggressive tumours. These data suggest that endostatin overexpression by tumour tissue might induce a humoral immune response.


8. DOCID:26804 SCORE: 0.00114572843175927
DOCNO: 11225443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: pathology
AUTHOR: A Tannapfel A
AFFILIATION: Institut für Pathologie, Universitätsklinikum Leipzig, Liebigstrasse 26, 04103 Leipzig. tana@medizin.uni-leipzig.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Der Pathologe.
COUNTRY: Germany
TITLE: [Carrent state of molecular pathology of stomach carcinomas]
PUBDATE: 20010101
Gastric carcinoma is one of the commonly diagnosed malignancies and remains an important cause of mortality in the Western hemisphere. Various sequences of genetic alterations may be responsible for the development of gastric cancer, as there exist two histological types: well-differentiated or intestinal-type and poorly differentiated or diffuse-type gastric cancers. While new genetic findings open new perspectives on carcinogenesis and molecular biology of gastric cancer, they have not been widely applied in routine diagnostic procedures, classification systems, disease monitoring, or prognostic assessment. We discuss the mechanisms molecular pathology in relation to their potential clinical relevance.


9. DOCID:27599 SCORE: 0.00114389938634857
DOCNO: 10588031
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: therapy
AUTHOR: K E Maher KE
AFFILIATION: Legacy Health System, Portland, OR, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: Organ preservation.
PUBDATE: 19991101
OBJECTIVES: To review organ preservation in cancer treatment within the context of organ function, treatment-related acute and late toxicities, outcome data, and quality of life. DATA SOURCES: Published review and research articles, proceedings of conferences, and oncology textbooks. CONCLUSIONS: The implementation of surgery, with sequential and/or concurrent chemoradiation, has advanced the success of organ preservation in multiple tumor types and organ systems. Integral to the discussion of organ preservation is consideration of quality of life. IMPLICATIONS FOR NURSING PRACTICE: An understanding of organ preservation in cancer treatment will allow oncology nurses to be more effective patient advocates by providing current information that can be integrated into patient care and education.


10. DOCID:27238 SCORE: 0.00113462687408202
DOCNO: 11489243
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunotherapy
QUALIFIER: therapy
AUTHOR: B I Rini BI
AUTHOR: E J Small EJ
AFFILIATION: University of California at San Francisco Comprehensive Cancer Center, 1600 Divisidero Street, 3rd floor, San Francisco, CA 94115, USA. brini@medicine.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current oncology reports.
COUNTRY: United States
TITLE: Immunotherapy for prostate cancer.
PUBDATE: 20010901
The components of an effective immune response have been elucidated in recent years. An understanding of the dysfunction of the immune response in cancer in one or more of these components has led to a variety of immunotherapeutic approaches. These therapeutic strategies are designed to stimulate dendritic cell proliferation, promote antigen uptake and processing, stimulate an effector cell response via direct antigen presentation, or target tumor cells via antibody therapy. Many approaches in prostate cancer have demonstrated successful induction of the desired immune response. Limited clinical success has also been seen.


11. DOCID:25022 SCORE: 0.001112803877893
DOCNO: 11091298
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: P L Manfredi PL
AUTHOR: S Shenoy S
AUTHOR: R Payne R
AFFILIATION: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Headache.
COUNTRY: UNITED STATES
TITLE: Sumatriptan for headache caused by head and neck cancer.
PUBDATE: 20001001
The use of sumatriptan for the treatment of migraine and cluster headache is well established. Sumatriptan has also been reported to be effective for the treatment of postdural puncture headache, postictal headache, and headache related to intravenous immunoglobulin infusion. We report two patients with headache caused by locally invasive head and neck cancer relieved by oral sumatriptan.


12. DOCID:28869 SCORE: 0.00085024606995126
DOCNO: 12109812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: chemistry
QUALIFIER: therapeutic use
AUTHOR: S S W Ng SS
AUTHOR: M Brown M
AUTHOR: W D Figg WD
AFFILIATION: Molecular Pharmacology Section, Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.
COUNTRY: France
TITLE: Thalidomide, an antiangiogenic agent with clinical activity in cancer.
PUBDATE: 20020601
Despite the teratogenic past of thalidomide, there is recent evidence indicating the drug's efficacy in the management of various diseases from immune disorders to cancers. The history, pharmacodynamic and pharmacokinetic properties of thalidomide in the clinic are discussed in this review article.


13. DOCID:31514 SCORE: 0.000850172791632607
DOCNO: 15517115
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: J Weitz J
AUTHOR: M Koch M
AUTHOR: J Kleeff J
AUTHOR: M W Müller MW
AUTHOR: J Schmidt J
AUTHOR: H Friess H
AUTHOR: M W Büchler MW
AFFILIATION: Abteilung für Allgemein-, Visceral- und Unfallchirurgie, Chirurgische Universitätsklinik Heidelberg.
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: Germany
TITLE: [Kausch-Whipple pancreaticoduodenectomy. Technique and results]
PUBDATE: 20041101
The Kausch-Whipple operation is the standard procedure for resection of pancreatic head cancer, distal bile duct cancer, and periampullary cancers. It is also used for some cases of chronic pancreatitis. Traditionally, this operation is associated with high perioperative morbidity and mortality. The aim of our study was to present our current technique for Kausch-Whipple pancreaticoduodenectomy and to demonstrate that acceptable perioperative and long-term outcomes can be achieved by a standardised technique in a high-volume centre.


14. DOCID:29960 SCORE: 0.000850158012396905
DOCNO: 15928434
OWNER: NLM
STATUS: In-Process
AUTHOR: S Khurana S
AUTHOR: M L Dubey ML
AUTHOR: N Malla N
AFFILIATION: Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Indian journal of medical microbiology.
COUNTRY: India
TITLE: Association of parasitic infections and cancers.
PUBDATE: 20050401
Recent advances in the fields of molecular biology, epidemiology and infectious diseases have led to significant revelations to clarify the relationship between cancer and infective agents. This article reviews the relationship between parasitic infections and carcinogenesis and the possible mechanisms involved. Few parasites, e.g., Schistosoma haematobium and Opisthorchis viverrini have been found to be strongly associated with bladder cancer and cholangiocarcinoma respectively. The evidence for the association of several other parasites and cancers has also been postulated.