0. DOCID:3321 SCORE: 0.0045750381527776
DOCNO: 198026
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: B G Borzenko BG
AUTHOR: G I Vornovitskaia GI
AUTHOR: I M Belousov IM
AUTHOR: G Gets G
AUTHOR: K A Drel' KA
AUTHOR: V S Shapot VS
PUBTYPE: Journal Article
JOURNALTITLE: Biokhimii︠a︡ (Moscow, Russia)
COUNTRY: USSR
TITLE: [Enzymes of anabolic and catabolic nucleic acid pathways in human hepatomas, in liver of healthy persons, and in liver of patients with cancer of gastrointestinal tract]
PUBDATE: 19770701
The activities of enzymes catalyzing the formation of nucleic acid precursors, nucleoside kinases, as well as of those involved in the degradation of nucleic acids, were studied in nuclei of the liver of healthy persons, human hepatomas and the liver of patients with cancer of gastrointestinal tract. The activities of thymydine kinase and uridine kinase in the human hepatoma nuclear sap were found to increase 40- to 50-fold and 120- to 150-fold, respectively, as compared to those in normal human liver. The activities of DNase and RNase in the fraction of chromatin protein of human hepatomas, on the contrary, decreased almost to zero. As to the liver of patients with cancer of gastrointestinal tract, drastic alterations in the activities of nucleoside kinases and nucleases in the direction characteristic of tumors themselves were observed. This phenomenon is regarded as a manifestation of the systemic effects of the tumor on the host.


1. DOCID:6458 SCORE: 0.00410871956826065
DOCNO: 529220
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: M Gautherie M
PUBTYPE: Journal Article
JOURNALTITLE: Journal de radiologie.
COUNTRY: FRANCE
TITLE: [State of the art and prospects on the use of radiofrequency and microwave hyperthermia in cancer treatment (author's transl)]
PUBDATE: 19791101
The use of microwave hyperthermia for cancer treatment is dealt with, first analyzing the present state of the art, second from a prospective viewpoint. Follow current topics are considered: a) biological data from experiments in vitro and of animals; b) fundamental therapeutic modalities: total body hyperthermia, local hyperthermia; c) technological problems: irradiation frequency, applicators, dosimetry (non-interfering probes, microwave radiometers); d) results of preliminary clinical investigations. Prospects refer to following topics: a) technological: improvement or design of systems for producing and controlling hyperthermia; b) fundamental: models, phantoms and postoperative specimens; dielectric and thermal properties on tissues; part of the vascularization; c) clinical: treatment procedures, long-term therapeutic trials (exclusive or combined hyperthermia, cancerous and healthy tissues).


2. DOCID:1732 SCORE: 0.00377795270124278
DOCNO: 981675
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neutrons
QUALIFIER: radiotherapy
AUTHOR: E J Hall EJ
AUTHOR: U Kraljevic U
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Repair of potentially lethan radiation damage: comparison of neutron and X-ray RBE and implications for radiation therapy.
PUBDATE: 19761201
Experiments with Chinese hamster cells have shown that neutron irradiation does not result in repair of potentially lethal damage (PLD), i.e., that which can be influenced by changes in environmental conditions following irradiation. Since PLD is presumed to be repaired in tumors but not in normal tissues, this absence of differential sparing of tumor cells relative to normal tissues--a feature characteristic of irradiation with x rays--represents an advantage of neutrons in addition to their reduced oxygen effect. At a given dose, the difference in relative biological effectiveness (RBE) between tumors and normal tissues corresponds to a 5% increase in tumor dose with no concomitant increase in dose to normal tissues, which could be significant in cancer therapy.


3. DOCID:1830 SCORE: 0.00324831745401801
DOCNO: 947030
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H J Kesseler HJ
AUTHOR: W R Grier WR
AUTHOR: I Seidman I
AUTHOR: S J McIlveen SJ
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Bilateral primary breast cancer.
PUBDATE: 19760701
Primary carcinoma of breast was treated in 967 patients from 1962 through 1972. Thirty-five of these patients had a second primary tumor of which 50% were discovered simultaneously. A family history for cancer was recorded in 26% of the patients with bilateral cancer. Patients found their tumor more often than the physician except in the simultaneous cases where the physician was more successful. Pathological examination showed 10% of the tumors were comedo, lobular carcinoma in situ, papillary, or tubular cancers. In the metachronous group, 50% of the axillae were involved on both sides. In the simultaneous cases the axilla was less frequently involved. Mammography, biopsies of the second breast, and prophylactic mastectomy in certain high-risk patients should improve survival rates.


4. DOCID:3615 SCORE: 0.00322364088179897
DOCNO: 1225106
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Andrieu-Guitancourt J
AUTHOR: M Brossard-Legrand M
AUTHOR: J L Happich JL
AUTHOR: J M Lamy JM
PUBTYPE: Journal Article
JOURNALTITLE: Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris.
COUNTRY: FRANCE
TITLE: [Routine endoscopy of the esophagus in buccal, pharyngeal and laryngeal cancers]
PUBDATE: 19751201
We practiced a systematic endoscopy of the upper part of the aero-digestive tract on 160 patients suffering from a cancer in the mouth, the pharynx and the upper part of the larynx. This unit, going from the mouth to the cardia does really exist: it has the same epithelial coating, the same function and is liable to suffer the same damages. It is the seat of many well-known cancerous localizations that always need to be searched for on principle when face to face with any cancer. The endoscopic examination so conceived allowed the authors to find a cancerous association on the very level of the upper sero-digestive tract among 14 per cent of the patients; 4 out of these 14 per cent having oesophageal damages impossible to detect clinically on one hand, and often radiologically on the other hand. Morever, 3 out of 7 of lesions were tiny: from 1 to 3 millimetres, extending the limits of the diagnosis of the cancer of the aesophagus and perhaps leaving better therapeutic possibilities.


5. DOCID:6457 SCORE: 0.00296184812188405
DOCNO: 531259
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: urine
QUALIFIER: diagnosis
AUTHOR: Y Oshiumi Y
AUTHOR: H Yagi H
AUTHOR: H Nishitani H
AUTHOR: H Yamawaki H
AUTHOR: C Nakayama C
AUTHOR: I Kamoi I
AUTHOR: K Matsuura K
AUTHOR: S Momose S
PUBTYPE: Journal Article
JOURNALTITLE: Radioisotopes.
COUNTRY: JAPAN
TITLE: [Clinical significance of urinary CEA measurement as a screening test of bladder cancer (author's transl)]
PUBDATE: 19790601
Non-infected urine samples of twenty six preoperative bladder cancers were examined by urinary CEA radioimmunoassay and exfoliative cytology. There were 65% of urinary CEA positivity and 58% of cytological positivity (class III, IV, V). CEA measurements were positive in 8 of 11 negative cytology cases (class I and II). Exfoliative cytological examination failed to detect most of well differentiated transitional cell carcinomas, while urinary CEA study detected 4 of 6 such cases. Combination of both urinary CEA measurement and cytology resulted in 85% of positivity. Therefore we recommend routine use of this combination as a screening system of bladder cancer.


6. DOCID:7915 SCORE: 0.00268748693665449
DOCNO: 464750
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: anatomy & histology
QUALIFIER: anatomy & histology
QUALIFIER: innervation
AUTHOR: G Kudoh G
AUTHOR: K Hoshi K
AUTHOR: T Murakami T
PUBTYPE: Journal Article
JOURNALTITLE: Archivum histologicum Japonicum. Nippon soshikigaku kiroku.
COUNTRY: JAPAN
TITLE: Fluorescence microscopic and enzyme histochemical studies of the innervation of the human spleen.
PUBDATE: 19790401
The innervation of the human spleen was investigated by the fluorescence method for adrenergic nerve fibers (52 cases) and the enzyme histochemical method for cholinergic nerve fibers (27 cases). The spleens examined were removed by laparotomy chiefly for gastric cancer. Adrenergic nerve fibers were demonstrated at the medioadventitial junction and the media in the trabecular arteries, whereas they occurred at the medioadventitial junction in the central and penicillar arteries. They were not found in the trabecular and pulp veins and venules, sheathed capillaries, avascular trabeculae, white and red pulp, and capsule. Nerves containing only a few adrenergic fibers and nerves without adrenergic fibers occurred close to the trabecular arteries. It was also demonstrated that nerves close to the trabecular arteries contain cholinergic fibers. The present study first verifies histochemically that the human spleen is innervated doubly by adrenergic and cholinergic nerve fibers.


7. DOCID:6349 SCORE: 0.00268669288908645
DOCNO: 638951
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: anatomy & histology
QUALIFIER: epidemiology
QUALIFIER: diagnosis
AUTHOR: P M Krook PM
AUTHOR: T Carlile T
AUTHOR: W Bush W
AUTHOR: M H Hall MH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Mammographic parenchymal patterns as a risk indicator for prevalent and incident cancer.
PUBDATE: 19780301
Different mammographic parenchymal patterns have been found to be associated with significantly different rates for the development of breast cancer in a screening program of self-referred women. These differences are qualitatively similar but of lesser magnitude than those in previous reports by Wolfe which were based on symptomatic women who had had a previous negative mammogram. In addition, this report indicates a small difference in the rate of breast cancer at first mammographic examination, using the same parenchymal classifications. These findings, coupled with other risk factors, may permit the concentration of mammographic screening on a smaller segment of the population at risk, thus improving the benefit to risk ratio.


8. DOCID:3689 SCORE: 0.00267611952115202
DOCNO: 142934
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypophysectomy
QUALIFIER: metabolism
AUTHOR: G C Lachelin GC
AUTHOR: S C Yen SC
AUTHOR: J F Alksne JF
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Hormonal changes following hypophysectomy in humans.
PUBDATE: 19770901
Pituitary function was studied before and after surgery in 1 patient who underwent chryohypophysectomy and 5 patients who underwent transsphenoidal excision hypophysectomy for metastatic breast cancer ablation therapy. Changes in serum luteinizing hormone, follicle stimulating hormone, growth hormone, thyrotropin stimulating hormone, pituitary prolactin (PRL), and steroid hormone levels of estrone, estradiol, testosterone, and rostenedione, and dehydroepiandrosterone levels were determined. All of the above were assessed before and from 6 weeks to 10 months after hypophysectomy. Pituitary hormone release in response to sequential stimuli of arginine infusion, thyrotropic releasing factor (TRF), and luteinizing hormone-releaseing factor was analyzed. In 3 patients, hypophysectomy was considered incomplete because of the presence of measurable amounts of circulating pituitary hormones and their release in response to stimuli, although all levels except PRL were markedly reduced. In 3 patients, hypophysectomy was considered nearly complete. Basal PRL levels remained unchanged whether the procedure was considered complete or not. PRL release was absent in response to TRF or arginine stimulation in 4 patients with substantial residual pituitary function. Hypophysectomy was followed by a marked reduction in circulating levels of estrogens and androgens. The assessment of quantitative release of pituitary hormones in response to stimuli is an improved direct measure of residual functioning pituitary tissue.


9. DOCID:7214 SCORE: 0.00263899862032884
DOCNO: 6243882
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: L Ghosh L
AUTHOR: B C Ghosh BC
AUTHOR: T K Das Gupta TK
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Ultrastructural study of stroma in human mammary carcinoma.
PUBDATE: 19800201
This investigation was designed to study the origin of the stromal component of human mammary carcinoma. Tissues from 30 proved breast carcinomas were studied. Under a light microscope with special stains, an increased connective tissue component was seen in carcinoma. Gluteraldehyde-fixed tissue was examined under an electron microscope. The stroma appeared to be composed of fibroblastic, myofibroblastic, histiocytic and primitive mesenchymal cells. Elastic fibers were intimately intermingled with collagen and reticulin and seen in close association with carcinoma cells. In some areas they were seen inside the carcinoma cells with discontinuous cytoplasmic membrane, as if they were formed by the cancer cells. This observation suggests that breast carcinoma cells play an important role in the production of elastic fibers in association with stromal cells and also stimulate the proliferation of the stromal cellular component.


10. DOCID:7118 SCORE: 0.00245060180192507
DOCNO: 455251
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Follow-Up Studies
QUALIFIER: adverse effects
QUALIFIER: therapy
QUALIFIER: etiology
QUALIFIER: epidemiology
AUTHOR: R Makuch R
AUTHOR: R Simon R
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Recommendations for the analysis of the effect of treatment on the development of second malignancies.
PUBDATE: 19790701
Use of the person-years method for evaluating the association between treatment of a primary cancer and subsequent development of a second malignancy is reviewed. For this type of analysis, the risk of developing a second malignancy is implicitly assumed to remain constant during each patient's follow-up period; this assumption is shown to be inappropriate. When the oncogenic potential of two or more treatments is compared, results are biased unfavorably against the use of intensive treatments that prolong life. Misinterpretation of the oncogenic potential of such treatment regimens can therefore occur, and two alternative statistical techniques are proposed, each for use in a commonly encountered experimental situation. These fairly classic methods of survival analysis are recommended to ascertain the relationship between treatment and development of a second cancer.


11. DOCID:2726 SCORE: 0.00239893312098272
DOCNO: 1176199
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hepatitis B Antigens
QUALIFIER: epidemiology
AUTHOR: A M Prince AM
AUTHOR: W Szmuness W
AUTHOR: J Michon J
AUTHOR: J Demaille J
AUTHOR: G Diebolt G
AUTHOR: J Linhard J
AUTHOR: C Quenum C
AUTHOR: M Sankale M
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: A case/control study of the association between primary liver cancer and hepatitis B infection in Senegal.
PUBDATE: 19750901
A case/control study has been carried out to determine by radioimmunoassay and passive hemagglutination techniques the prevalence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) in patients with primary liver cancer (PLC) and age/sex-matched hospital controls with cancers of other sites (OCC) and similarly matched controls without cancer (NCC). HBsAg was found in 61.2% of 165 cases of PLC as compared to 11.7% of 328 NCC. The frequency of HBsAg in PLC patients was significantly higher (72.2%) in those with detectable alpha fetoprotein as compared to those without (40.3%). There was no difference in the frequency of HBsAg in PLC patients with and without accompanying cirrhosis. No significant difference in potential hepatitis exposure history was found in the three study groups.


12. DOCID:3758 SCORE: 0.00239735508439555
DOCNO: 986262
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Barkas T
AUTHOR: S F AL-Khateeb SF
AUTHOR: W J Irvine WJ
AUTHOR: N M Davidson NM
AUTHOR: P Roscoe P
PUBTYPE: Journal Article
JOURNALTITLE: Clinical and experimental immunology.
COUNTRY: ENGLAND
TITLE: Inhibition of antibody-dependent cell-mediated cytotoxicity (ADCC) as a means of detection of immune complexes in the sera of patients with thyroid disorders and bronchogenic carcinoma.
PUBDATE: 19760801
Circulating immune complexes in the sera of patients with thyroid disorders or bronchogenic carcinoma were investigated using an assay system based on the inhibition of the ADCC activity of rat spleen cells. Increased inhibition, as compared with that of the sera of age and sex matched controls, was found in patients with thashimoto thyroiditis, primary hypothyroidism and bronchogenic carcinoma. The degree of inhibition in the first two groups was markedly increased compared with control sera of the same IgG content. However, the results in the lung cancer group were slightly but not significantly greater than in controls with the same level of IgG. Increased IgG levels were found in patients with thashimoto thyroiditis and thyrotoxicosis, and also in patients with bronchogenic carcinoma who had mediastinal gland involvement. The lower level of sensitivity of the assay system was approximately 600 ng added aggregated IgG, corresponding to a concentration of 6mu g/ml in the sample assayed. It is possible that circulating immune complexes may exist in lung cancer, but at a level below that of the present assay system.


13. DOCID:6454 SCORE: 0.00232242990085241
DOCNO: 7353777
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hysterectomy
DESCRIPTOR: Hysterectomy, Vaginal
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: D Kalinkov D
AUTHOR: R Buchholz R
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [The treatment of female stress incontinence of urine combined with uterine and vaginal prolapse by vaginal hysterectomy, anterior and posterior colporrhaphy in 1,003 cases (author's transl)]
PUBDATE: 19800101
The type and intensity of pre-operative symptoms and the long term follow-up in 1,003 vaginal hysterectomies with anterior and posterior colporrhaphies are reported. The operative technique corresponds to that of the school of Vienna with emphasis on plication of the urethra with joining of the ischio-carverrosus muscles below the urethra. The pre-operative symptoms disappeared in almost all cases. Constipation and backache improved. Early complications were treated and remained without sequelae. Our method of treatment showed good results and cures the social handicap of stress incontinence. In addition a good prophylaxis against unterine cancer and excellent permanent contraception is provided.


14. DOCID:3087 SCORE: 0.00214806598694761
DOCNO: 327894
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: therapy
QUALIFIER: pathology
QUALIFIER: therapy
AUTHOR: R R Reimer RR
AUTHOR: B A Chabner BA
AUTHOR: R C Young RC
AUTHOR: R Reddick R
AUTHOR: R E Johnson RE
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Lymphoma presenting in bone: results of histopathology, staging, and therapy.
PUBDATE: 19770701
Lymphoma presenting in bone (that is "reticulum cell sarcoma of bone") is a form of extranodal lymphoma historically described as frequently localized (this is, stage IE or stage IIE). Between 1970 and 1975, 14 patients with this entity were seen at the National Cancer Institute. This group had a variety of histologic subtypes of diffuse lymphoma. Thorough staging showed extensive disease (stage IV) in 12 of these patients (86%). In 10 of these the metastatic disease was unsuspected clinically. Seven patients achieved complete remissions after treatment was combination chemotherapy alone (two patients), irradiation alone (one patient), surgery alone (one patient), and both chemotherapy and irradiation (three patients) and are alive and free of disease 11 + to 70 + months after diagnosis. The other seven patients did not achieve complete remission status and have all died. Although lymphomas presenting in bone may occasionally be localized, careful staging in this series frequently showed extensive disease and altered the therapeutic approach.