0. DOCID:31379 SCORE: 0.00236742866640118
DOCNO: 15602654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: immunology
AUTHOR: Madhav V Dhodapkar MV
AFFILIATION: Laboratory of Tumor Immunology and Immunotherapy, Rockefeller University, New York, NY 10021, USA. dhodapm@rockefeller.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer immunology, immunotherapy : CII.
COUNTRY: Germany
TITLE: Harnessing host immune responses to preneoplasia: promise and challenges.
PUBDATE: 20050501
Preneoplastic lesions are more common than clinical cancer and define a population at increased risk for the development of malignancy. Recent studies suggest that the immune system has the capacity to recognize these lesions, and enrichment of preneoplasia-specific immune effectors can be detected in the tumor bed of some preneoplastic lesions such as monoclonal gammopathies. Here, I discuss the promise and challenges of harnessing the immune response against preneoplasia. Approaches to boost the natural host response to these lesions may have a major impact on reducing net cancer burden.

1. DOCID:31667 SCORE: 0.00206471111426028
DOCNO: 15217149
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: Bernard Paule B
AFFILIATION: Service d'Urologie, Hôpital Henri Mondor Créteil, France. bepaule@wanadoo.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie.
COUNTRY: France
TITLE: [New therapeutic targets in testicular cancer: contribution of molecular biology]
PUBDATE: 20040401
Testicular cancer is curable by conventional cytotoxic drugs. Despite these excellent results, a group of patients remain incurable with standard chemotherapy, including patients who progress despite high-dose salvage chemotherapy, patients with malignant transformation of teratomas and patients with late recurrence. Tyrosine kinase receptors constitute a group of proteins which includes EGFr (Epidermal Growth Factor receptor) and c-Kit. The recent possibility of treatments targeted to the molecular level, particularly using agents directed against c-Kit and EGFr raise new hopes for the effective treatment of refractory testicular cancer.

2. DOCID:29317 SCORE: 0.00206354196889364
DOCNO: 12559068
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sentinel Lymph Node Biopsy
QUALIFIER: diagnosis
AUTHOR: I Tytler I
AUTHOR: A Hayes A
AUTHOR: M Kissin M
AFFILIATION: Breast Unit and St Lukes Cancer Centre, Royal Surrey County Hospital, Egerton Road, Guildford GU2 7XX, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: England
TITLE: Intramammary sentinel nodes in early breast cancer: can we find them and do they matter?
PUBDATE: 20030201
Intramammary nodes identified using the sentinel node biopsy technique can play an important prognostic role in early breast cancer. Two cases of intramammary nodes found by sentinel node biopsy are discussed from the Guildford perspective.

3. DOCID:21510 SCORE: 0.00196669711139119
DOCNO: 7591403
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Forecasting
DESCRIPTOR: Skin Neoplasms
AUTHOR: R Marks R
AUTHOR: A W Kopf AW
AFFILIATION: University of Melbourne, Department of Medicine, St. Vincent's Hospital, Victoria, Australia.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of dermatology.
COUNTRY: UNITED STATES
TITLE: Cancer of the skin in the next century.
PUBDATE: 19950701
One can confidently predict that the 21st century will be a span of intense activity in unraveling the precise molecular and biochemical events that lead to the various forms of cutaneous cancers. These discoveries will lead to new approaches in our therapeutic armamentarium that currently do not exist. Eventually, the incidence rates and mortality rates from cancers of the skin will markedly decline--the finite goal of all the combined endeavors of the scientific and practicing medical community.

4. DOCID:19322 SCORE: 0.00195838308655899
DOCNO: 1809160
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: J S Harington JS
AFFILIATION: Department of Community Medicine, Mount Sinai Medical Center, New York, New York 10029.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the New York Academy of Sciences.
COUNTRY: UNITED STATES
TITLE: The carcinogenicity of chrysotile asbestos.
PUBDATE: 19911201
In in vitro test systems, chrysotile is markedly toxic, causes chromosomal aberrations, and is capable of inducing morphological and preneoplastic transformation. In carefully designed animal experiments, chrysotile produces lung cancer and mesothelioma as effectively as do the amphiboles tested. Human population studies do not refute these experimental results. Chrysotile asbestos is carcinogenic to humans, especially for the induction of lung cancer and mesothelioma in exposed populations. For cancers of other sites, with the exception of laryngeal and possibly gastrointestinal cancer, the evidence for association with exposure to all forms of asbestos, including chrysotile, is not yet adequate for evaluation.

5. DOCID:20594 SCORE: 0.00174108817512043
DOCNO: 7613963
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: L P Faber LP
AFFILIATION: Department of Cardiovascular-Thoracic Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Chest surgery clinics of North America.
COUNTRY: UNITED STATES
TITLE: Sleeve lobectomy.
PUBDATE: 19950501
Sleeve lobectomy is the alternative procedure to pneumonectomy. It can be an operation of choice for lung cancer, if technically feasible, and is the ideal procedure for low grade pulmonary malignancies and inflammatory bronchial strictures. Precise radiologic bronchoscopic assessment defines the need and probability for sleeve lobectomy. Close adherence to precise technical principles will achieve excellent clinical results with a low morbidity and mortality.

6. DOCID:16605 SCORE: 0.00171795760243996
DOCNO: 2203235
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: D A Leaf DA
AFFILIATION: UCLA School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Overweight: assessment and management issues.
PUBDATE: 19900901
Obesity is associated with an increased risk of coronary artery disease, hypertension, diabetes, hypercholesterolemia, cancer and other conditions. Although generalized obesity is associated with increased risk, the android pattern of body fat distribution may be a more sensitive predictor of coronary artery disease. A gradual weight reduction program, including adherence to a low-fat, calorie-restricted diet and participation in daily exercise, is the best approach to reduce weight and body fat.

7. DOCID:18222 SCORE: 0.00171794686300168
DOCNO: 2183266
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Staging
QUALIFIER: pathology
AUTHOR: F P Stitik FP
AFFILIATION: Virginia Medical School, Norfolk.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Staging of lung cancer.
PUBDATE: 19900501
Lung cancer is in epidemic proportions throughout the world. It is imperative that a simple, accurate staging system be used to direct treatment and evaluate its effects on long-term survival. The staging system must be the basis for current and future research on the newer adjuvant treatments for lung cancer. It should be internationally accepted, enabling a worldwide effort to improve survival. The new AJCC staging system meets these requirements, with early international reports confirming its usefulness and validity. The diagnostic radiologist, often directs the pretreatment workup of these patients and should be familiar with this new system.

8. DOCID:19294 SCORE: 0.00153127309209383
DOCNO: 8491322
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: O Parise O
AUTHOR: R Nayar R
AUTHOR: B Luboinski B
AFFILIATION: Département de Chirurgie Cervico-faciale et ORL, Institut Gustave-Roussy, Villejuif, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: ENGLAND
TITLE: Prevertebral fascia flap in hypopharyngeal reconstruction: a preliminary report.
PUBDATE: 19930401
Ablative surgery for pyriform sinus cancer often leaves a defect which cannot be closed primarily. Many techniques for hypopharyngeal reconstruction have been described but no single technique can be recommended for use in all situations. The prevertebral fascia flap described in this article provides an alternative to hypopharyngeal repair when a more complex technique is contra-indicated. It is a one stage procedure, fashioned with locally available tissue, and technically simple. Its use in two anecdotal cases is described herewith.

9. DOCID:18978 SCORE: 0.00146373174757191
DOCNO: 1704923
AUTHOR: G S Gerber GS
AUTHOR: G W Chodak GW
AFFILIATION: Department of Surgery, University of Chicago, Ill 60637.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Routine screening for cancer of the prostate.
PUBDATE: 19910301
The value of screening for prostate cancer remains unclear. Although digital rectal examination, transrectal ultrasonography, and determination of serum prostate-specific antigen levels may lead to early detection of a malignancy, these procedures have never been shown to reduce disease-specific mortality from prostate cancer. Unfortunately, several potential errors found in uncontrolled trials may suggest benefit from screening where none exists. Only a large, randomized, controlled clinical study demonstrating decreased mortality from prostate cancer can prove that screening is beneficial. Until such a study is performed, patients should be informed of both the potential benefits and the risks of screening and treatment.

10. DOCID:23147 SCORE: 0.00145065880434149
DOCNO: 8854779
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hepatectomy
DESCRIPTOR: Infusion Pumps, Implantable
QUALIFIER: pathology
QUALIFIER: administration & dosage
QUALIFIER: prevention & control
QUALIFIER: secondary
QUALIFIER: prevention & control
AUTHOR: N Umekita N
AUTHOR: T Maeshiro T
AUTHOR: S Miyamoto S
AUTHOR: F Yamada F
AUTHOR: Y Awane Y
AFFILIATION: Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Indication of prophylactic hepatic arterial-infusion chemotherapy after hepatic resection for liver metastases from colorectal cancer]
PUBDATE: 19960901
The purpose of this study was to clarify the indication of prophylactic hepatic arterial-infusion chemotherapy (PHAIC) after hepatic resection for liver metastases from colorectal cancer. Sixty-one patients underwent curative hepatectomy, and 27 of them were treated with PHAIC using implantable port. According to clinicopathological factors of primary colorectal cancer and liver metastases, the prognoses were analyzed. In conclusion, PHAIC was not useful for patients who had distant lymph node metastases (paraaortic lymph node) from primary cancer.

11. DOCID:27831 SCORE: 0.00144731036964979
DOCNO: 10222439
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: A Das A
AUTHOR: F H Hochberg FH
AUTHOR: S McNelis S
AFFILIATION: National University of Singapore, Singapore.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of neuro-oncology.
COUNTRY: NETHERLANDS
TITLE: A review of the therapy of paraneoplastic neurologic syndromes.
PUBDATE: 19990101
The therapy of paraneoplastic neurologic syndromes remains unclear and warrants a systematic review of the literature. Reports in English and foreign language literature were abstracted. Data were sorted by the primary paraneoplastic neurologic syndrome, the primary malignancy, and the methods of treatment. Neurologic improvement follows surgical, chemotherapeutic, and radiation treatments. Adjuvant immunosuppressive therapy with steroids, plasmapheresis, or immunoglobulin may help stabilize the progression of neurologic symptoms. Syndromes characterized by inflammation or neurotransmitter production without neuronal loss are most responsive to therapy. While treatment of the underlying cancer with appropriate surgery, chemotherapy, and radiation is recommended, the paraneoplastic syndrome should probably be managed with immunosuppressive therapy.

12. DOCID:21752 SCORE: 0.00143444467208273
DOCNO: 8655338
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: N A Koshurnikova NA
AUTHOR: G D Bysogolov GD
AUTHOR: M G Bolotnikova MG
AUTHOR: V F Khokhryakov VF
AUTHOR: V V Kreslov VV
AUTHOR: P V Okatenko PV
AUTHOR: S A Romanov SA
AUTHOR: N S Shilnikova NS
AFFILIATION: Public Health Ministry of the Russian Federation, Biophysics Institute Branch NI, Chelyabinsk-65, Russian Federation.
PUBTYPE: Journal Article
JOURNALTITLE: Health physics.
COUNTRY: UNITED STATES
TITLE: Mortality among personnel who worked at the Mayak complex in the first years of its operation.
PUBDATE: 19960701
Epidemiological studies revealed increased cancer mortality among persons who began working at the Mayak complex during the period 1948-1958. Estimation of cancer risk was carried out for the sites of cancer that showed increased mortality and dependence on dose of external gamma- or internal alpha-irradiation.

13. DOCID:27487 SCORE: 0.00143235639116313
DOCNO: 10088637
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: genetics
AUTHOR: I Garcia-Higuera I
AUTHOR: Y Kuang Y
AUTHOR: A D D'Andrea AD
AFFILIATION: Dana-Farber Cancer Institute, Department of Pediatric Oncology, Boston, MA 02115, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in hematology.
COUNTRY: UNITED STATES
TITLE: The molecular and cellular biology of Fanconi anemia.
PUBDATE: 19990301
Fanconi anemia is a rare autosomal recessive disease characterized by multiple congenital abnormalities, bone marrow failure, and cancer susceptibility. The mean age of onset of anemia is 8 years, and the mean survival is 16 years. Death usually results from complications of bone marrow failure. Considerable progress in Fanconi anemia research has resulted from the recent identification and cloning of three Fanconi anemia genes. The current review describes the structure and function of the Fanconi anemia genes and describes the role of the encoded Fanconi anemia proteins in a cellular pathway controlling chromosome stability.

14. DOCID:16317 SCORE: 0.00142178415993623
DOCNO: 7680177
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: R Hrebinko R
AUTHOR: S R Taylor SR
AUTHOR: R R Bahnson RR
AFFILIATION: Division of Urologic Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Carcinoma of prostate metastatic to parotid gland.
PUBDATE: 19930301
A rare case of prostate cancer with metastasis to the parotid salivary gland is reported. The prostatic origin of the mass was proven by incisional biopsy and immunohistochemical staining for prostate-specific antigen. Additional studies of the tumor included ultrastructural and quantitative deoxyribonucleic acid (DNA) analysis.