0. DOCID:3321 SCORE: 0.0045750381527776
DOCNO: 198026
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: B G Borzenko BG
AUTHOR: G I Vornovitskaia GI
AUTHOR: I M Belousov IM
AUTHOR: G Gets G
AUTHOR: K A Drel' KA
AUTHOR: V S Shapot VS
PUBTYPE: Journal Article
JOURNALTITLE: Biokhimii︠a︡ (Moscow, Russia)
COUNTRY: USSR
TITLE: [Enzymes of anabolic and catabolic nucleic acid pathways in human hepatomas, in liver of healthy persons, and in liver of patients with cancer of gastrointestinal tract]
PUBDATE: 19770701
The activities of enzymes catalyzing the formation of nucleic acid precursors, nucleoside kinases, as well as of those involved in the degradation of nucleic acids, were studied in nuclei of the liver of healthy persons, human hepatomas and the liver of patients with cancer of gastrointestinal tract. The activities of thymydine kinase and uridine kinase in the human hepatoma nuclear sap were found to increase 40- to 50-fold and 120- to 150-fold, respectively, as compared to those in normal human liver. The activities of DNase and RNase in the fraction of chromatin protein of human hepatomas, on the contrary, decreased almost to zero. As to the liver of patients with cancer of gastrointestinal tract, drastic alterations in the activities of nucleoside kinases and nucleases in the direction characteristic of tumors themselves were observed. This phenomenon is regarded as a manifestation of the systemic effects of the tumor on the host.

1. DOCID:6458 SCORE: 0.00410871956826065
DOCNO: 529220
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: M Gautherie M
PUBTYPE: Journal Article
JOURNALTITLE: Journal de radiologie.
COUNTRY: FRANCE
TITLE: [State of the art and prospects on the use of radiofrequency and microwave hyperthermia in cancer treatment (author's transl)]
PUBDATE: 19791101
The use of microwave hyperthermia for cancer treatment is dealt with, first analyzing the present state of the art, second from a prospective viewpoint. Follow current topics are considered: a) biological data from experiments in vitro and of animals; b) fundamental therapeutic modalities: total body hyperthermia, local hyperthermia; c) technological problems: irradiation frequency, applicators, dosimetry (non-interfering probes, microwave radiometers); d) results of preliminary clinical investigations. Prospects refer to following topics: a) technological: improvement or design of systems for producing and controlling hyperthermia; b) fundamental: models, phantoms and postoperative specimens; dielectric and thermal properties on tissues; part of the vascularization; c) clinical: treatment procedures, long-term therapeutic trials (exclusive or combined hyperthermia, cancerous and healthy tissues).

2. DOCID:1732 SCORE: 0.00377795270124278
DOCNO: 981675
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neutrons
QUALIFIER: radiotherapy
AUTHOR: E J Hall EJ
AUTHOR: U Kraljevic U
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Repair of potentially lethan radiation damage: comparison of neutron and X-ray RBE and implications for radiation therapy.
PUBDATE: 19761201
Experiments with Chinese hamster cells have shown that neutron irradiation does not result in repair of potentially lethal damage (PLD), i.e., that which can be influenced by changes in environmental conditions following irradiation. Since PLD is presumed to be repaired in tumors but not in normal tissues, this absence of differential sparing of tumor cells relative to normal tissues--a feature characteristic of irradiation with x rays--represents an advantage of neutrons in addition to their reduced oxygen effect. At a given dose, the difference in relative biological effectiveness (RBE) between tumors and normal tissues corresponds to a 5% increase in tumor dose with no concomitant increase in dose to normal tissues, which could be significant in cancer therapy.

3. DOCID:1830 SCORE: 0.00324831745401801
DOCNO: 947030
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H J Kesseler HJ
AUTHOR: W R Grier WR
AUTHOR: I Seidman I
AUTHOR: S J McIlveen SJ
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Bilateral primary breast cancer.
PUBDATE: 19760701
Primary carcinoma of breast was treated in 967 patients from 1962 through 1972. Thirty-five of these patients had a second primary tumor of which 50% were discovered simultaneously. A family history for cancer was recorded in 26% of the patients with bilateral cancer. Patients found their tumor more often than the physician except in the simultaneous cases where the physician was more successful. Pathological examination showed 10% of the tumors were comedo, lobular carcinoma in situ, papillary, or tubular cancers. In the metachronous group, 50% of the axillae were involved on both sides. In the simultaneous cases the axilla was less frequently involved. Mammography, biopsies of the second breast, and prophylactic mastectomy in certain high-risk patients should improve survival rates.

4. DOCID:3615 SCORE: 0.00322364088179897
DOCNO: 1225106
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Andrieu-Guitancourt J
AUTHOR: M Brossard-Legrand M
AUTHOR: J L Happich JL
AUTHOR: J M Lamy JM
PUBTYPE: Journal Article
JOURNALTITLE: Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris.
COUNTRY: FRANCE
TITLE: [Routine endoscopy of the esophagus in buccal, pharyngeal and laryngeal cancers]
PUBDATE: 19751201
We practiced a systematic endoscopy of the upper part of the aero-digestive tract on 160 patients suffering from a cancer in the mouth, the pharynx and the upper part of the larynx. This unit, going from the mouth to the cardia does really exist: it has the same epithelial coating, the same function and is liable to suffer the same damages. It is the seat of many well-known cancerous localizations that always need to be searched for on principle when face to face with any cancer. The endoscopic examination so conceived allowed the authors to find a cancerous association on the very level of the upper sero-digestive tract among 14 per cent of the patients; 4 out of these 14 per cent having oesophageal damages impossible to detect clinically on one hand, and often radiologically on the other hand. Morever, 3 out of 7 of lesions were tiny: from 1 to 3 millimetres, extending the limits of the diagnosis of the cancer of the aesophagus and perhaps leaving better therapeutic possibilities.

5. DOCID:14043 SCORE: 0.00308434568625384
DOCNO: 3029002
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: metabolism
QUALIFIER: diagnostic use
QUALIFIER: analysis
AUTHOR: K Onodera K
AUTHOR: A Okubo A
AUTHOR: K Yasumoto K
AUTHOR: T Suzuki T
AUTHOR: G Kimura G
AUTHOR: K Nomoto K
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of cancer research : Gann.
COUNTRY: JAPAN
TITLE: 31P nuclear magnetic resonance analysis of lung cancer: the perchloric acid extract spectrum.
PUBDATE: 19861201
31P-NMR spectra were obtained from the perchloric acid extracts of normal lung and lung cancer tissues obtained at surgery, and from extracts of neoplastic cells cultured in vitro. The perchloric acid extract of lung cancer tissue gave rise to a signal whose chemical shift was 3.2 ppm at pH 8.0. This signal was not observed in the extract of normal tissue of the lung from the same patient. The compound giving this signal was identified as phosphorylcholine.

6. DOCID:11090 SCORE: 0.00301878212921246
DOCNO: 6716657
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J Egawa J
AUTHOR: Y Kawada Y
AUTHOR: M Abe M
AUTHOR: H Miki H
AUTHOR: A Fujinuma A
AUTHOR: Y Utsunomia Y
AUTHOR: H Kawano H
AUTHOR: H Kawaguchi H
AUTHOR: S Kuroiwa S
AUTHOR: A Saito A
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Effect of porcine calcitonin on pain caused by cancer-induced bone destruction]
PUBDATE: 19840301
The analgesic effect of porcine calcitonin (PCT) was studied in 32 patients with cancer-induced bone destruction. Twenty patients (62.5%) showed some response among them 10 of 13 patients who had suffered from uncontrollable pain despite other treatment methods such as radiotherapy, and or the administration of other analgesics. The effect was observed about 10 days after the administration of the drug. Combined therapy with PCT and other modalities such as radiotherapy, chemotherapy and hormone therapy had a marked effect in controlling the pain.

7. DOCID:6457 SCORE: 0.00296184812188405
DOCNO: 531259
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: urine
QUALIFIER: diagnosis
AUTHOR: Y Oshiumi Y
AUTHOR: H Yagi H
AUTHOR: H Nishitani H
AUTHOR: H Yamawaki H
AUTHOR: C Nakayama C
AUTHOR: I Kamoi I
AUTHOR: K Matsuura K
AUTHOR: S Momose S
PUBTYPE: Journal Article
JOURNALTITLE: Radioisotopes.
COUNTRY: JAPAN
TITLE: [Clinical significance of urinary CEA measurement as a screening test of bladder cancer (author's transl)]
PUBDATE: 19790601
Non-infected urine samples of twenty six preoperative bladder cancers were examined by urinary CEA radioimmunoassay and exfoliative cytology. There were 65% of urinary CEA positivity and 58% of cytological positivity (class III, IV, V). CEA measurements were positive in 8 of 11 negative cytology cases (class I and II). Exfoliative cytological examination failed to detect most of well differentiated transitional cell carcinomas, while urinary CEA study detected 4 of 6 such cases. Combination of both urinary CEA measurement and cytology resulted in 85% of positivity. Therefore we recommend routine use of this combination as a screening system of bladder cancer.

8. DOCID:13782 SCORE: 0.00282299870161203
DOCNO: 2918872
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: H Vainio H
AUTHOR: T Partanen T
AFFILIATION: Institute of Occupational Health, Helsinki, Finland.
PUBTYPE: Journal Article
JOURNALTITLE: Mutation research.
COUNTRY: NETHERLANDS
TITLE: Population burden of lung cancer due to environmental tobacco smoke.
PUBDATE: 19890201
The population burden of lung cancer due to environmental tobacco smoke is significant because a large fraction of the population is exposed. The risks are, of course, lower than those to smokers themselves; but smoking is self-inflicted, passive smoking is involuntary. Making various assumptions, the proportion of lung cancer cases among non-smokers that could reasonably be attributed to environmental tobacco smoke can be calculated to be about 20-30% in western countries. Thus, non-smokers in the society could benefit considerably from diminishing exposures to other people's smoke.

9. DOCID:10500 SCORE: 0.00273916485166324
DOCNO: 6410999
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: drug effects
QUALIFIER: immunology
AUTHOR: N Saijo N
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Effect of chemotherapy on anticancer immune effector cells]
PUBDATE: 19830301
In clinical practice, a number of tests are conducted to determine the immune reactivity of the patients. The principal cell in immunological surveillance against cancer has been thought to be the T cell. However, multiple immunological methods to evaluate the T cell function have failed to confirm a major role for the T cell in immunological surveillance. The role of other potential effector cells such as NK cells, K cells, macrophages and granulocytes needs more intensive investigation. In this report the effects of anticancer agents on immune effector cells were analyzed and the possibility about the development of a reliable monitoring procedure for determining a potent treatment protocol was discussed.

10. DOCID:15853 SCORE: 0.00273552533235437
DOCNO: 2595881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: N Javadpour N
AUTHOR: P Daloni P
AFFILIATION: Division of Urology, University of Maryland, School of Medicine, Baltimore.
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Histopathologic changes of transitional cell carcinoma of bladder after M-VAC chemotherapy.
PUBDATE: 19891201
Over the past several years, we have utilized methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) as definitive, neoadjuvant, and adjuvant therapy for various stages of transitional cell carcinoma with reduced toxicities. Currently, there is little information concerning the histopathologic changes after M-VAC therapy. We report on the histopathologic changes of bladder transitional cell carcinoma following M-VAC chemotherapy in our protocol for treatment of bladder cancer. The main histopathologic findings after M-VAC therapy are squamous metaplasia, necrosis, fibrosis, and persistent transitional cell carcinoma. In 2 cases, there were persistent adenocarcinoma and squamous cell carcinoma. The importance of these observations in terms of diagnostic and therapeutic implications is reviewed.

11. DOCID:15785 SCORE: 0.00273552233107121
DOCNO: 2729474
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: African Americans
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: ethnology
QUALIFIER: statistics & numerical data
AUTHOR: W J Mayer WJ
AUTHOR: W P McWhorter WP
AFFILIATION: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of public health.
COUNTRY: UNITED STATES
TITLE: Black/white differences in non-treatment of bladder cancer patients and implications for survival.
PUBDATE: 19890601
Analysis of 20,764 White and 882 Black bladder cancer patients diagnosed during 1978-85 indicates that Black patients were more likely than White patients to go untreated following diagnosis after adjustment for age- and stage-at-diagnosis, sex, and tumor histology (OR = 1.80, 95% CI = 1.33, 2.43). Treatment status was found to be a significant predictor of five-year survival after adjustment (treated/untreated odds ratio = 3.16, 95% CI = 2.08, 4.79). Results suggest that differences in initial therapy may contribute to the survival differential between Black and White bladder cancer patients.

12. DOCID:10241 SCORE: 0.0027121053838896
DOCNO: 6839689
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M C Wiemann MC
AUTHOR: P Calabresi P
PUBTYPE: Journal Article
JOURNALTITLE: Comprehensive therapy.
COUNTRY: UNITED STATES
TITLE: Principles of current cancer chemotherapy.
PUBDATE: 19830301
Cancer chemotherapy is an established therapeutic modality capable of achieving cures, either alone or in combination with surgery and radiation therapy. New drugs and therapeutic approaches with potent effects on both tumor and normal host tissues are being introduced into clinical use. Clinical management of the patient with cancer, however, continues to be based upon established principles. Knowledge of these principles will guide the clinician in the appropriate use of the growing list of effective chemotherapeutic agents. Although standard therapy for specific tumors will undoubtedly change during the next few years, future therapy will still be founded on fundamental concepts and basic principles of tumor biology and clinical oncology.

13. DOCID:7915 SCORE: 0.00268748693665449
DOCNO: 464750
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: anatomy & histology
QUALIFIER: anatomy & histology
QUALIFIER: innervation
AUTHOR: G Kudoh G
AUTHOR: K Hoshi K
AUTHOR: T Murakami T
PUBTYPE: Journal Article
JOURNALTITLE: Archivum histologicum Japonicum. Nippon soshikigaku kiroku.
COUNTRY: JAPAN
TITLE: Fluorescence microscopic and enzyme histochemical studies of the innervation of the human spleen.
PUBDATE: 19790401
The innervation of the human spleen was investigated by the fluorescence method for adrenergic nerve fibers (52 cases) and the enzyme histochemical method for cholinergic nerve fibers (27 cases). The spleens examined were removed by laparotomy chiefly for gastric cancer. Adrenergic nerve fibers were demonstrated at the medioadventitial junction and the media in the trabecular arteries, whereas they occurred at the medioadventitial junction in the central and penicillar arteries. They were not found in the trabecular and pulp veins and venules, sheathed capillaries, avascular trabeculae, white and red pulp, and capsule. Nerves containing only a few adrenergic fibers and nerves without adrenergic fibers occurred close to the trabecular arteries. It was also demonstrated that nerves close to the trabecular arteries contain cholinergic fibers. The present study first verifies histochemically that the human spleen is innervated doubly by adrenergic and cholinergic nerve fibers.

14. DOCID:6349 SCORE: 0.00268669288908645
DOCNO: 638951
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: anatomy & histology
QUALIFIER: epidemiology
QUALIFIER: diagnosis
AUTHOR: P M Krook PM
AUTHOR: T Carlile T
AUTHOR: W Bush W
AUTHOR: M H Hall MH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Mammographic parenchymal patterns as a risk indicator for prevalent and incident cancer.
PUBDATE: 19780301
Different mammographic parenchymal patterns have been found to be associated with significantly different rates for the development of breast cancer in a screening program of self-referred women. These differences are qualitatively similar but of lesser magnitude than those in previous reports by Wolfe which were based on symptomatic women who had had a previous negative mammogram. In addition, this report indicates a small difference in the rate of breast cancer at first mammographic examination, using the same parenchymal classifications. These findings, coupled with other risk factors, may permit the concentration of mammographic screening on a smaller segment of the population at risk, thus improving the benefit to risk ratio.