0. DOCID:14771 SCORE: 0.00145549895356354
DOCNO: 3202256
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
DESCRIPTOR: Occult Blood
QUALIFIER: epidemiology
AUTHOR: F C Chang FC
AUTHOR: T M Jackson TM
AUTHOR: C R Jackson CR
AFFILIATION: Department of Surgery, University of Kansas School of Medicine, Wichita.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Hemoccult screening for colorectal cancer.
PUBDATE: 19881201
A community hemoccult screening project for colorectal cancer resulted in the processing of 18,198 specimens. Positive test results were reported in 3 percent of the total, which ultimately resulted in the identification of 20 colorectal malignancies (0.1 percent) and 53 benign polyps (0.3 percent). The number of malignancies and polyps identified was disappointingly low. Our findings would challenge the concept of unsupervised mass screening from the viewpoint of cost-effectiveness; however, because of the numerous voluntary services and supplies, this particular project was useful in educating the public about early colon cancer detection.

1. DOCID:15688 SCORE: 0.001318878267654
DOCNO: 2777333
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: U P Shahi UP
AUTHOR: P Fernandes P
AUTHOR: N K Shukla NK
AUTHOR: S Chander S
AUTHOR: G K Rath GK
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of cancer.
COUNTRY: INDIA
TITLE: Electron beam irradiation in treatment of skin carcinoma.
PUBDATE: 19890301
Thirty seven cases of carcinoma of skin treated with electron-beam irradiation over a period of three years have been analysed retrospectively. Majority of lesions were in head and neck and basal-cell carcinoma was the commonest histological type. Of twenty-one patients followed, seventeen (81%) achieved complete remission and remained disease free for a period of one to three years. Cosmetic results were excellent. Role of electron-beam in the management of these superficial cancers and its advantage over the conventional radiation therapy methods have been highlighted. Radiation therapy utilising electron-beams form a very useful modality in the management of skin cancers, especially those arising in head and neck.

2. DOCID:13290 SCORE: 0.00112198205310509
DOCNO: 3600228
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: diagnosis
AUTHOR: I N Lozinskaia IN
AUTHOR: Ia E Vikman IaE
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Radioimmunological methods in the diagnosis of metastases of thyroid cancer]
PUBDATE: 19870601
The concentrations of thyrotropin, thyroglobulin, calcitonin and carcinoembryonic antigen were raised in the blood of thyroid cancer patients. The occurrence of relapses of regional and distant metastases was accompanied by a sharp increase in the levels of thyrotropin, thyroglobulin and carcinoembryonic antigen permitting the recommendation of these tests for the diagnosis of distant metastases in the absence of local spread of a process. Simultaneous determination of the levels of thyroglobulins and carcinoembryonic antigen was the most informative for defining metastatic involvement of the osseous system.

3. DOCID:15439 SCORE: 0.00112191039510687
DOCNO: 3304617
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: metabolism
AUTHOR: A A Spector AA
AUTHOR: C P Burns CP
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Biological and therapeutic potential of membrane lipid modification in tumors.
PUBDATE: 19870901
The membrane fatty acid composition of cancer cells can be modified either in culture or during growth in animals without disrupting basic membrane or cellular integrity. Only fatty acids are affected; no changes occur in membrane cholesterol, phospholipid, or protein content. There are changes in membrane physical properties and certain cellular functions, including carrier-mediated transport, receptor binding, ion channels, and eicosanoid production. Fatty acid modification also can enhance the sensitivity of the cells to hyperthermia and Adriamycin. This technique provides a new approach to understanding the membrane properties of neoplastic cells. Membrane fatty acid modification also may be of potential value as a therapeutic approach designed to augment the cytotoxicity of other antineoplastic therapies.

4. DOCID:12618 SCORE: 0.00112184793643708
DOCNO: 3804038
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: E O De Murua EO
AUTHOR: M George M
AUTHOR: M H Pejovic MH
AUTHOR: J Dewailly J
AUTHOR: J P Wolff JP
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Combination cyclophosphamide, adriamycin, and cis-platinum in recurrent and metastatic cervical carcinoma.
PUBDATE: 19870201
Thirty evaluable patients with recurrent and/or metastatic cervical cancer were treated with a combination of cyclophosphamide, adriamycin, and cis-platinum. We observed no complete response and three partial responses (10%). One year survival rate was 45%. CAP combination did not prove to be more effective than single agent cis-platinum.

5. DOCID:15885 SCORE: 0.00112110617177124
DOCNO: 3059063
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: S A Shain SA
AUTHOR: R I Huot RI
AFFILIATION: Department of Cellular and Molecular Biology, Southwest Foundation for Biomedical Research, San Antonio, TX 78284.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of steroid biochemistry.
COUNTRY: ENGLAND
TITLE: Antiandrogen effects in models of androgen responsive cancer.
PUBDATE: 19881001
The ability of antiandrogens to antagonize androgen effects in androgen responsive tissues is well established. Antiandrogens may diminish in vivo or in vitro proliferation of some androgen responsive cancer cells without causing cessation of multiplication. These model studies are representative of clinical experience in treatment of human prostate cancer with antiandrogen therapy. Recent studies in the AXC/SSh rat prostate cancer model show that these cancer cells elaborate polypeptide growth factors which stimulate their proliferation. If growth factor production by these cells is androgen independent, this may provide an explanation for failure of androgen ablation or antiandrogen treatment to effectively halt prostate cancer cell proliferation.

6. DOCID:15205 SCORE: 0.00112076619826535
DOCNO: 3658574
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: G J Escobar GJ
AUTHOR: M B Heyman MB
AUTHOR: W B Smith WB
AUTHOR: M M Thaler MM
AFFILIATION: Department of Pediatrics, University of California, San Francisco 94143.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Pediatrics.
COUNTRY: UNITED STATES
TITLE: Primary hemochromatosis in childhood.
PUBDATE: 19871001
Primary hemochromatosis is a genetic disorder rarely recognized in childhood; its long-term consequences include cirrhosis and liver cancer. We report a family with primary hemochromatosis affecting three generations, including a 7-year-old child and a 29-month-old child; these are the youngest children with primary hemochromatosis yet reported. The pathophysiology, genetics, and clinical findings of this disorder are reviewed. Serum ferritin and transferrin saturation are useful screening tests; definitive diagnosis, however, depends on determination of hepatic iron content. A plan for evaluating and treating affected patients is proposed. Physicians caring for children must learn to recognize this potentially treatable disorder.

7. DOCID:14050 SCORE: 0.000941008965953611
DOCNO: 3728630
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A M Putterman AM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of ophthalmology.
COUNTRY: UNITED STATES
TITLE: Conjunctival map biopsy to determine pagetoid spread.
PUBDATE: 19860701
Sebaceous adenocarcinoma (meibomian gland cancer) can be localized at times to one specific area of the eyelid; at other times, it spreads diffusely by pagetoid invasion throughout the conjunctiva. The pagetoid spread is often impossible to visualize. I used a map biopsy of the conjunctiva to determine the extent of involvement of sebaceous adenocarcinoma in 12 patients. Sixteen conjunctival biopsy specimens were taken from various areas of the palpebral and bulbar conjunctiva. An analysis of these specimens helped to delineate the area of tumor involvement, which aided in determining whether to treat these cases by full-thickness eyelid resection or orbital exenteration.

8. DOCID:14057 SCORE: 0.000941008824463638
DOCNO: 2970218
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: C I Falkson CI
AUTHOR: H C Falkson HC
AUTHOR: G Falkson G
AFFILIATION: Department of Medical Oncology, University of Pretoria, South Africa.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: American journal of clinical oncology.
COUNTRY: UNITED STATES
TITLE: High-dose medroxyprogesterone acetate plus mitomycin-C or vindesine in the treatment of advanced breast cancer.
PUBDATE: 19880801
Forty women with metastatic breast cancer were randomized to receive either mitomycin-C (MMC) (21 patients) or vindesine (19 patients) with high dose medroxyprogesterone acetate (MPA). Response rates were not significantly different (33% for MPA and MMC and 28% for MPA and vindesine); the duration of response was better for patients receiving the MMC combination (median of 10.5 months versus 6 months for those on the vindesine combination).

9. DOCID:15751 SCORE: 0.00091615167736187
DOCNO: 3950501
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: S Ali S
AUTHOR: R Tiwari R
AUTHOR: G B Snow GB
AUTHOR: I vd Waal I
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: Incidence of squamous cell carcinoma of the head and neck: report of 1,000 cases.
PUBDATE: 19860301
The purpose of this paper is to define the incidence of squamous cell carcinoma (SCC) of the head and neck as seen at the Free University Hospital, Amsterdam, the Netherlands, in the last six years, according to the latest revised classification system of the International Union against Cancer (UICC, 1982). In addition, male to female ratios, relative frequencies at the various sites, age distribution, incidence of second or third primary and the relationship of distant metastases to the nodal metastases and the T-stage of the primary lesion are reported. These incidences are compared with those in other countries and the major differences are discussed.

10. DOCID:15715 SCORE: 0.000916150215722029
DOCNO: 3339915
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Death
QUALIFIER: standards
QUALIFIER: psychology
AUTHOR: K A Wallston KA
AUTHOR: C Burger C
AUTHOR: R A Smith RA
AUTHOR: R J Baugher RJ
AFFILIATION: Health Care Research Project, School of Nursing, Vanderbilt University, Nashville, TN 37240.
PUBTYPE: Journal Article
JOURNALTITLE: Medical care.
COUNTRY: UNITED STATES
TITLE: Comparing the quality of death for hospice and non-hospice cancer patients.
PUBDATE: 19880201
In this secondary analysis of data from the National Hospice Study (NHS), a new measure, quality of death (QOD), was developed by weighting reports of cancer patients' last 3 days of life by what patients wanted their last 3 days to be like. Using analysis of covariance, the QOD scores were higher for terminally ill patients in hospices (either home-care [HC] or hospital-based [HB]) than similar patients who received conventional care (CC). The results are discussed in terms of verification of the hospice philosophy and other uses for a quality of death measure.

11. DOCID:12987 SCORE: 0.000826830221126069
DOCNO: 3818819
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Agents
DESCRIPTOR: Drug Evaluation, Preclinical
DESCRIPTOR: Drug Information Services
AUTHOR: M T Zehnacker MT
AUTHOR: R H Brennan RH
AUTHOR: G W Milne GW
AUTHOR: J A Miller JA
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chemical information and computer sciences.
COUNTRY: UNITED STATES
TITLE: The NCI Drug Information System. 5. DIS Biology Module.
PUBDATE: 19861101
The NCI drug screening program tests over 10,000 chemicals per year for activity against cancer. The associated Drug Information System (DIS) captures all the raw testing data and provides for its validation. The large quantity of numeric data gathered during testing is maintained within the DIS in a database that is interactively searchable and automatically updated at regular intervals.

12. DOCID:15357 SCORE: 0.00082678466173871
DOCNO: 2893617
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: enzymology
QUALIFIER: urine
AUTHOR: G Dowden G
AUTHOR: R Davey R
AFFILIATION: Bill Walsh Cancer Research Laboratory, Royal North Shore Hospital of Sydney, St. Leonards, N.S.W., Australia.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemistry international.
COUNTRY: AUSTRALIA
TITLE: The heterogeneity of arylsulphatase-A and arylsulphatase-B in normal human urine and urine from cancer patients.
PUBDATE: 19871001
Arylsulphatase-A and arylsulphatase-B heterogeneity in normal and cancer patient urine was investigated using high resolution agarose isoelectricfocusing. Normal urine contained up to nine forms of arylsulphatase-A activity with isoelectric points from 4.45 to 5.43 and at least 5 forms of arylsulphatase-B between 8.58 and 9.15 along with a broad zone of activity between pH 6.5 and 7.6. Although cancer patients had significantly higher levels of arylsulphatase-A and arylsulphatase-B activity, their pattern of activity was essentially the same as for the normals with only minor quantitative differences in some peaks.

13. DOCID:13029 SCORE: 0.000826744134605214
DOCNO: 2829095
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Leukemia, Myelocytic, Acute
DESCRIPTOR: Parotid Neoplasms
QUALIFIER: pathology
QUALIFIER: microbiology
AUTHOR: D D Damm DD
AUTHOR: B W Neville BW
AUTHOR: R H Geissler RH
AUTHOR: D K White DK
AUTHOR: J F Drummond JF
AUTHOR: G A Ferretti GA
AFFILIATION: Department of Oral Pathology, College of Dentistry, University of Kentucky, Lexington.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Oral surgery, oral medicine, and oral pathology.
COUNTRY: UNITED STATES
TITLE: Dentinal candidiasis in cancer patients.
PUBDATE: 19880101
Two examples of an unusual presentation of oropharyngeal candidiasis in cancer patients are offered. The light and scanning electron microscopic appearances of candidiasis involving the dentin of teeth are described. The potential significance of recognition of this form of candidiasis in cancer patients is discussed.

14. DOCID:14596 SCORE: 0.000826710392199361
DOCNO: 3489110
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: prevention & control
AUTHOR: Y Tomita Y
AUTHOR: K Fukuda K
AUTHOR: T Hirohata T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [The immunological role of carotenoids in the prevention of cancer]
PUBDATE: 19860501
Epidemiological studies have suggested that the intake of green-yellow vegetables decrease the risk of cancer. Vitamin A, which is abundantly present in green-yellow vegetables in the form of provitamin A, was demonstrated to inhibit chemical and viral-carcinogenesis in experimental animals. However, little is known about the mechanism of anti-carcinogenic effect of vitamin A. Our data seem to support a hypothesis that vitamin A may contribute to the prevention of cancer by augmenting an immunosurveillance system. We found that vitamin A and provitamin A, beta-carotene, enhanced tumor immunity using a syngeneic murine tumor system.