0. DOCID:7543 SCORE: 0.00412281743914777
DOCNO: 35626
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: D S Shimm DS
AUTHOR: G L Logue GL
AUTHOR: A A Maltbie AA
AUTHOR: S Dugan S
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Medical management of chronic cancer pain.
PUBDATE: 19790601
Management of the chronic pain of cancer is a common and difficult problem. In addition to a medical examination of the patient, it is necessary to perform a psychological assessment of his premorbid personality, current mental status, and coping mechanisms to devise an individualized approach to his pain. The mainstay of cancer pain control are the narcotics, which differ primarily in potency and duration of action. Nonnarcotic analgesics are equianalgesic with the less potent narcotics. Antipsychotic drugs are useful as tranquilizers, antiemetics, and analgesic potentiators. Antidepressants and hypnotics permit the patient a more normal life-style. Stimulants such as cocaine and amphetamines both potentiate narcotic analgesia and reduce narcotic-induced somnolence and respiratory depression. Tetrahydrocannabinol offers no advantage over traditional analgesics. With care and patience, the physician can render practically any cancer patient pain-free.


1. DOCID:7502 SCORE: 0.00363447587772375
DOCNO: 6795457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: W Lock W
PUBTYPE: Journal Article
JOURNALTITLE: MMW, M√ľnchener medizinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: [Epidemiology of carcinosis. 105 years of mortality statistics (author's transl)]
PUBDATE: 19811001
Cancer mortality in Hamburg, calculated per 10,000 living inhabitants of each age group of men and women for the years 1873 to 1978 proved to be essentially constant after eliminating sources of statistical error. Calculation or organ involvement by the same method for 1933 to 1978 showed that the increase in mortality for one type of location is compensated by a decrease elsewhere, so that altogether the constancy remains. This behavior can be explained if it be assumed. This behavior can be explained if it be assumed that a certain constant percentage of the population is prone to cancer and - possibly due to the action of exogenous noxae - becomes ill when the necessary age is reached. The nature of a determining factor which is most probably present is not known. Comparison with international figure shows that the results of the Hamburg Study can be considered a model case.


2. DOCID:7271 SCORE: 0.00249855056444293
DOCNO: 459966
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: H T Lynch HT
AUTHOR: H A Guirgis HA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Childhood cancer and the SBLA syndrome.
PUBDATE: 19790101
Two nuclear families showing characteristics of the SBLA syndrome are described wherein progeny of breast cancer-affected mothers manifested early childhood malignant neoplasms. These observations have led us to postulate a novel type genetic-environmental interactive model which incorporates Knudsen's "two-hit" hypothesis as a partial explanation for the exceedingly early onset of cancer in the subject progeny. Given the assumption that the first hit was germinal with transfer of the deleterious SBLA gene at conception, we postulate that the second or somatic-hit occurred early on in utero. This may have involved a complex mechanism of one or more factors including tumor cell products, tumor specific antigens, immunosuppression, de-repressed oncogene, or an activated oncogenic virus via a transplacental communicable phenomenon. The testing of this new hypothesis dealing with carcinogenesis in the SBLA syndrome should employ immunologicalgenetic parameters concurrently in fetuses and mothers.


3. DOCID:5391 SCORE: 0.00136265116016232
DOCNO: 7281085
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: G Anderson G
AUTHOR: T J Deeley TJ
AUTHOR: C Smith C
AUTHOR: J Jani J
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Thorax.
COUNTRY: ENGLAND
TITLE: Comparison of radiotherapy alone and radiotherapy with chemotherapy using adriamycin and 5-fluorouracil in bronchogenic carcinoma.
PUBDATE: 19810301
Eighty-two patients with histologically confirmed lung cancer were randomly allocated to receive either radiotherapy alone (2400-3200 rads, depending upon cell type) or the same dose of radiotherapy followed by four cycles of adriamycin and 5-fluorouracil. Eighty-one patients were evaluated and for the group as a whole survival was better in the undifferentiated group assigned to receive adjuvant chemotherapy but survival in the patients with squamous tumours was not significantly prolonged. The chemotherapy was not unduly toxic.


4. DOCID:6124 SCORE: 0.001362396011267
DOCNO: 631811
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Catholicism
DESCRIPTOR: Contraceptives, Postcoital
DESCRIPTOR: Contraceptives, Postcoital, Synthetic
DESCRIPTOR: Rape
QUALIFIER: adverse effects
AUTHOR: E F Diamond EF
PUBTYPE: Letter
JOURNALTITLE: Hospital progress.
COUNTRY: UNITED STATES
TITLE: Physician notes hazards of DES use to prevent pregnancy.
PUBDATE: 19780301
E.F. Diamond questions the use of DES (Diethylstilbestrol) as a method of pregnancy prevention after rape because of the increased risks of vaginal cancer in women exposed to DES in vitro; the relationship to congenital anomalies and to endometrial carcinoma; and the actual number of pregnancies resulting from rape. According to Diamond, studies have shown that an insignificant number of pregnancies occur because of rape and to support this claim he cites a study conducted in Minnesota where 4,000 rapes resulted in 0 pregnancies. Diamond also assails the Catholic health care institutions which permit the use of DES as a postcoital contraceptive claiming that they are in actuality performing early abortion by medication.


5. DOCID:5071 SCORE: 0.00124838883411361
DOCNO: 6159486
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: M L Samuels ML
AUTHOR: D E Johnson DE
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Adjuvant therapy of testis cancer: the role of vinblastine and bleomycin.
PUBDATE: 19800901
We studied 37 patients with testis cancer who received adjuvant chemotherapy with vinblastine and bleomycin. These patients included 5 with stage III disease who were down staged by a surgical procedure and 32 with stage II disease. Of the 32 patients 26 had stage IIB tumors, showing gross nodal disease. There have been 4 deaths, 2 of disease and 2 as a result of therapy. The remaining patients are free of disease and the estimated 5-year survival is 85 per cent.


6. DOCID:6597 SCORE: 0.0011785614174953
DOCNO: 231649
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Viral
DESCRIPTOR: Simplexvirus
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J R Shortland JR
AUTHOR: K M Mousawy KM
AUTHOR: R C Rees RC
AUTHOR: C W Potter CW
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pathology.
COUNTRY: ENGLAND
TITLE: Tumorgenicity of herpesvirus hominis type 2-transformed cells (line 333-8-9) in adult hamsters.
PUBDATE: 19791201
Inoculation of adult hamsters with greater than 1.5 X 10(2) Herpesvirus type 2 (HSV-2) transformed hamster embryo fibroblasts induced rapidly growing tumours at the site of inoculation, in more than 50 per cent of animals. The tumours were examined by light and electron microscopy, and were histologically anaplastic fibrosarcomas. Lung metastases were frequently found in tumour-bearing animals; these were usually only seen microscopically, and were cytologically similar to the primary tumours. The nature of tumour development showed similarities with naturally occurring tumours of man, and HSV-2 tumour is probably a better model of human cancer than other virus-induced tumours studied in the past.


7. DOCID:7486 SCORE: 0.00107893369042813
DOCNO: 734654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Yajima A
AUTHOR: K Teshima K
AUTHOR: K Noda K
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Cytologic changes of cervical cancer according to the degree of invasion.
PUBDATE: 19781101
Cellular samples (cervical scrapings) obtained with wooden spatulas from patients with carcinoma in situ, early invasive cancer, and advanced cancer of the uterine cervix were examined. The number of malignant cells in the preparation increased with extent of the lesion. The granular chromatin structures of the nuclei of abnormal cells were observed in almost all cases, and the occurrence of irregularly distributed coarsely granular chromatin increased gradually with the extent of the cancer. Hyperchromasia of malignant cell nuclei and irregular thickening of the nuclear envelope were seen in almost all cases of the lesions. The occurrence of malignant and dysplastic cells of the deep layer types decreased with progression of the lesion from carcinoma in situ to early invasive cancer, and to advanced cancer. There was also a relative increase in the ratio of malignant cells to dysplastic cells.


8. DOCID:6378 SCORE: 0.00107893342521183
DOCNO: 7359450
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Death
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: R Lonetto R
AUTHOR: G W Mercer GW
AUTHOR: S Fleming S
AUTHOR: B Bunting B
AUTHOR: M Clare M
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of psychology.
COUNTRY: UNITED STATES
TITLE: Death anxiety among university students in Northern Ireland and Canada.
PUBDATE: 19800101
Male and female university students in Northern Ireland (n = 315) and Canada (n = 255) completed Templer's Death Anxiety Scale (DAS) and the Taylor Manifest Anxiety Scale (MAS). Results of a discriminant function analysis indicated that Canadian students showed more concern about being afraid to die and thoughts of death, while students from the North of Ireland were more concerned about getting cancer, the shortness of life, and the viewing of a corpse. However, total DAS scores failed to show significance between group differences (p greater than .10). Correlations between DAS and MAS total scores were r = .34 for Northern Ireland and r = .31 for Canadian students.


9. DOCID:5093 SCORE: 0.00107891706419706
DOCNO: 712898
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: N M Heney NM
AUTHOR: J Daly J
AUTHOR: G R Prout GR
AUTHOR: P T Nieh PT
AUTHOR: J A Heaney JA
AUTHOR: N E Trebeck NE
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Biopsy of apparently normal urothelium in patients with bladder carcinoma.
PUBDATE: 19781101
We obtained 246 cold cup biopsies from pre-selected sites of apparently non-tumor-bearing bladder urothelium from 82 patients who presented with bladder cancer for the first time. Of 75 patients with transitional cell carcinoma 32 (43 per cent) suffered coincidental urothelial abnormalities, the most common being atypia. Significant abnormalities occurred more commonly (77 per cent) in association with high grade tumors than with low grade tumors (15 per cent).


10. DOCID:7683 SCORE: 0.00107889379952343
DOCNO: 438317
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: injuries
AUTHOR: C Viville C
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Traumatic lesions of the ureter in pelvic surgery. Apropos of 10 cases]
PUBDATE: 19790101
For ureteral lesions without loss of substance our preferences are, at the level of the lesion, either for end-to-end ureteral suture, or antireflux uretero-vesical reimplantation. For ureteral lesions with loss of substance we prefer the psoas bladder, if the bladder is healthy, large and supple, or inter-ureteral anastomosis if the bladder for some reason (radiotherapy, retracted bladder, small "blocked pelvis") is not available. Synthetic ureteral prosthesis may be a rapid and elegant solution in cancer patients with a limited hope of survival. Guided by these principles, we have repaired 10 ureters : 1 by ureterolysis, 2 by end-to-end suture, 3 by inter-ureteral anastomosis, 4 by antireflux uretero-vesico reimplantation. These 10 repairs gave 9 successes. The only failure (end-to-end ureteral suture) was due to our lack of experience, for in a similar case we would now perform an inter-ureteral anastomosis.


11. DOCID:7668 SCORE: 0.00107884578912729
DOCNO: 7387532
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neck Dissection
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: W F McGuirt WF
AUTHOR: B F McCabe BF
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Bilateral radical neck dissections.
PUBDATE: 19800701
Of 697 patients undergoing radical neck dissection for head and neck cancer, 91 (13%) had bilateral radical neck dissection. No operative deaths occurred. The complication rate was least for staged second neck dissections (17 patients). While overall surgical and medical complication rates for simultaneous bilateral neck dissections (11 patients) were greater than those after staged and delayed (53 patients) neck dissections, surgical complication rates alone for these three groups were comparable. The combined group of patients treated aggressively by simultaneous or staged second neck dissection had no greater complication rate than patients (ten) treated by second neck dissection when metastasis became clinically evident later. These findings and evidence that 55% of these patients were alive after five years or died of unrelated causes encourage us to support more aggressive surgical therapy in patients with manifest or likely occult bilateral metastases from a head and neck primary carcinoma.


12. DOCID:7868 SCORE: 0.00107845734742169
DOCNO: 698044
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: B Jasani B
AUTHOR: L J Donaldson LJ
AUTHOR: J G Ratcliffe JG
AUTHOR: G S Sokhi GS
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Mechanism of impaired glucose tolerance in patients with neoplasia.
PUBDATE: 19780801
The disappearance rate (k) of i.v. glucose was measured in cachectic and non-cachectic cancer patients and tumour-free controls. The respective k values were found to be 1.06 +/- 0.27 (mean +/- s.d.), 1.64 +/- 0.34 and 1.63 +/- 0.23. Of the other parameters measured, only plasma albumin level was found to vary significantly amongst the 3 categories, the mean level being the lowest in cachectic cancer patients. The means of total plasma protein, fasting blood glucose and plasma liver enzyme concentrations were similar in the 3 groups. Glucagon, a potent insulin secretogogue, failed to augment the fasting insulin level in cachectic but did so in non-cachectic cancer patients. Taken together, the findings suggest that the reduced glucose tolerance in patients with neoplasia is due to impairment of insulin release exhibited predominantly by ill-nourished advanced cancer patients having a moderate to sever degree of hypoalbuminemia.


13. DOCID:5890 SCORE: 0.000892929545916835
DOCNO: 392382
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Ortner A
AUTHOR: J Klammer J
AUTHOR: G Mikuz G
AUTHOR: O Dapunt O
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Onkologie.
COUNTRY: SWITZERLAND
TITLE: [Papillomatous changes in the cervix uteri]
PUBDATE: 19790801
A case of condyloma acuminatum of the uterine cervix and a case of papilloma on the cervix with concomitant adenocarcinoma of the cervix are described. The diagnostic biopsy revealed only the papillomatous lesion, whereas the adenocarcinoma was diagnosed in the surgical specimen after hysterectomy. Referring to the studies of Meisels et al. on condylomatous lesions of the cervix, the possible frequent incidence of this cervical lesion and its role as one possible first step in the pathogenesis of cervical cancer are discussed. The in toto excision is recommended because of diagnostic and therapeutic reasons. Clinical, colposcopic and cytologic check-up has to be done carefully for years after primary treatment.


14. DOCID:5839 SCORE: 0.000803339485396203
DOCNO: 7439651
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: W Pilgram W
AUTHOR: K Lendvai-Viragh K
AUTHOR: T Lendvai T
AUTHOR: R Michel R
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Treatment of malignant and premalignant diseases of the breast by subcutaneous mastectomy with simultaneous augmentation mammoplasty (author's transl)]
PUBDATE: 19801101
Among 6 patients with small intra-ductal carcinomas of the breast two had local recurrences of cancer following unilateral subcutaneous mastectomy. We therefore limit subcutaneous mastectomy to pre-cancerous conditions and then use a bilateral subcutaneous mastectomy with augmentation mammoplasty. Our methods and results in 28 cases are described. We think that the removal of approximately 95% of the breast tissue is enough assurance to the patient that no cancer will develop later. The patients are happy with the cosmetic results and abandon their cancerophobia generated by long term diagnostic observation.