0. DOCID:22911 SCORE: 0.00294378937995075
DOCNO: 7488419
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Family Health
DESCRIPTOR: Mothers
QUALIFIER: etiology
AUTHOR: B Gustafsson B
AUTHOR: J Ludvigsson J
AUTHOR: J Carstensen J
AFFILIATION: Department of Paediatrics, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: ENGLAND
TITLE: Adult cancer risks among the mothers of children with cancer.
PUBDATE: 19950901
We investigated cancer risk among mothers of 2365 children who were diagnosed with cancer between 1973 and 1989 in Sweden. From the date of birth of the child until 31 December 1989, 38 cases of cancer were diagnosed among the mothers. The expected number of cases, according to national rates, was 30.9. Cancer of the thyroid was the only site showing a significantly increased risk among the mothers (observed = 6, expected = 1.2, P < 0.01), but two cases were medullary cancer associated with an inheritable syndrome, and inherited by their children.

1. DOCID:18908 SCORE: 0.00181878777844546
DOCNO: 2142831
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: statistics & numerical data
QUALIFIER: etiology
QUALIFIER: therapy
AUTHOR: R R Seals RR
AUTHOR: D J Seals DJ
PUBTYPE: Journal Article
JOURNALTITLE: Texas dental journal.
COUNTRY: UNITED STATES
TITLE: Dental care for cancer patients: a survey of Texas dental school graduates.
PUBDATE: 19900601
A survey of recent Texas dental school graduates regarding their preparedness for addressing the oral health care needs of cancer patients in their practices suggests several trends. Many graduates (26%) do not feel adequately prepared to manage and provide oral care for cancer patients. Over 95% of the dentists surveyed expressed interest in locally sponsored continuing education courses on the oral health care of cancer patients. Clearly, both predoctoral and postdoctoral dental education must recognize the need for formalized instruction on the oral cre of cancer patients if general dentists are to provide high-quality, comprehensive dental care for these patients.

2. DOCID:21584 SCORE: 0.00179096134625676
DOCNO: 8206413
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications, Neoplastic
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: B A Fine BA
AUTHOR: T R Baker TR
AUTHOR: R E Hempling RE
AUTHOR: M Intengan M
AFFILIATION: Department of Gynecologic Oncology, Roswell Park Cancer Institute.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Pregnancy coexisting with serous papillary adenocarcinoma involving both uterus and ovary.
PUBDATE: 19940601
Less than 100 cases have been reported involving coexistent pregnancy and endometrial cancer of epithelial ovarian cancer. Only one case, histologically an endometrioid adenocarcinoma, demonstrated simultaneous involvement of endometrium and ovary. We report an additional case involving both uterus and ovary coexisting with pregnancy but of a serous papillary histology. A viable preterm infant was delivered. The mother is currently without evidence of disease on cisplatin-based chemotherapy.

3. DOCID:22588 SCORE: 0.00179023199324887
DOCNO: 7919922
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 17
DESCRIPTOR: Oncogenes
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: M A Brown MA
AUTHOR: E Solomon E
AFFILIATION: Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: Towards cloning the familial breast-ovarian cancer gene on chromosome 17.
PUBDATE: 19940601
The past year has seen a great deal of excitement in the field of breast cancer genetics. Since linkage of the familial breast-ovarian cancer gene (BRCA1) to chromosome 17, the critical region has been narrowed to 1.0-1.5 Mb by recombination studies, a detailed physical map has been constructed and much of the region has been cloned in yeast artificial chromosome, bacteriophage P1 and cosmid vectors. The focus now lies on identifying the genes housed within the BRCA1 region and scanning them for oncogenic mutations.

4. DOCID:22628 SCORE: 0.00170269164657202
DOCNO: 8921558
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Predisposition to Disease
DESCRIPTOR: Pharmacogenetics
QUALIFIER: genetics
AUTHOR: E J Calabrese EJ
AFFILIATION: Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst 01003, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Regulatory toxicology and pharmacology : RTP.
COUNTRY: UNITED STATES
TITLE: Biochemical individuality: the next generation.
PUBDATE: 19960801
This paper provides an historical assessment of the development of the concepts of pharmaco- and ecogenetics, including their relationship to major developments in the areas of pharmacology, industrial hygiene, and cancer research in animal models as well as the assessment of inborn metabolic disorders. How this information may be used to evaluate the range of human genetic diversity and its relationship to differential responses to environmental toxins is also considered. The paper concludes by providing a brief summary of several specific conditions in which human genetics traits affect susceptibility to toxic substances.

5. DOCID:18345 SCORE: 0.0016620666383385
DOCNO: 1931775
AUTHOR: I Chin-Yee I
AUTHOR: A T Porter AT
AUTHOR: R C Lohmann RC
AFFILIATION: Department of Hematology/Blood Bank, Victoria Hospital Corporation, London, Ontario, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical oncology (Royal College of Radiologists (Great Britain))
COUNTRY: ENGLAND
TITLE: Acute non-lymphocytic leukaemia and myelofibrosis following sequential hemibody irradiation for prostatic carcinoma.
PUBDATE: 19910901
Sequential hemibody radiotherapy (SHBI) is currently being evaluated in clinical trials as adjuvant treatment in cancer patients who are potential long-term survivors. The potential late adverse effects of this therapeutic modality on the bone marrow may place patients at risk for the complications of aplasia, leukaemia, and myeloproliferative syndromes. We describe a case of acute non-lymphocytic leukaemia and myelofibrosis following SHBI for prostate carcinoma. The possible role of radiation in the induction of these abnormalities is discussed.

6. DOCID:21948 SCORE: 0.0014092178651989
DOCNO: 8677161
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: T Izbicki T
AUTHOR: T Laskowska-Klita T
AUTHOR: M Liebhart M
AUTHOR: L Lipińska L
AFFILIATION: Zakład Onkologii Chirurgicznej Instytutu Matki i Dziecka w Warszawie.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pediatria polska.
COUNTRY: POLAND
TITLE: [Prognostic factors in neuroblastoma in children]
PUBDATE: 19951101
The paper presents the review of prognostic factors which were investigated from the first interests of neuroblastoma, as a model for cancer biology in pediatric oncology. The authors on the basis of other authors experiences and on the own observations, as well stress the importance of basic sciences from the field of molecular biology, cytogenetics and biochemistry, leading to better understanding of the nature of neuroblastoma and to introduction of rational treatment. The stratification of neuroblastoma patients according to the known prognostic variables influenced favourably treatment results.

7. DOCID:23176 SCORE: 0.00140918961611254
DOCNO: 7655520
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: P Graziotti P
AUTHOR: A Losa A
AUTHOR: R Hurle R
AUTHOR: A Lembo A
AFFILIATION: Divisione Urologia, Ospedali Riuniti Bergamo.
PUBTYPE: Journal Article
JOURNALTITLE: Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia.
COUNTRY: ITALY
TITLE: [Our current indications for radical prostatectomy]
PUBDATE: 19950601
Radical prostatectomy is the golden standard for localized prostate cancer. The identification of patients with intraprostatic disease who can be cured and will live long enough to benefit from a surgical therapy represents the primary goal of the authors. Target of this article is underlining the importance of an accurate preoperative staging through ultrasound-guided biopsy of seminal vesicles and periprostatic spaces. The positivity of the surgical margin after radical prostatectomy is also taken into account as it represents, according to the authors, an extremely important but often overlooked parameter.

8. DOCID:21321 SCORE: 0.00124805729957532
DOCNO: 8689619
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Fragility
DESCRIPTOR: Chromosomes, Human, Pair 3
QUALIFIER: genetics
QUALIFIER: ultrastructure
AUTHOR: T S Sundareshan TS
AUTHOR: M Augustus M
AFFILIATION: Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Normal expression of fra(3)(p14.2) in lymphocytes of lung cancer patients.
PUBDATE: 19960701
Fragile site (FS) analysis was performed in 10 bronchogenic carcinoma families (non-small cell type) each represented by the patient and one adult offspring. Twenty age- and sex-matched controls were evaluated simultaneously for FS expression. The question whether increased fragility at band 3p14 exists in lung cancer patients or their offspring was examined. The expression level was found to be similar among patients, offspring, and controls.

9. DOCID:17033 SCORE: 0.0011239932350116
DOCNO: 8310247
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: G Biaunie G
AUTHOR: B Kalis B
AFFILIATION: Service de dermatologie, hôpital Sébastopol, Reims.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Cutaneous complications of massive obesity]
PUBDATE: 19931001
Massive obesity leads to nonspecific skin disorders. Skin folds are more numerous and deeper in the obese subject, and can become the site of various disorders. Hence the difficulty of diagnosis and treatment is increased. Acanthosis nigricans should be recognized, but not solely attributed to obesity, since other causes, particularly cancer, may be involved. Finally, leg ulcerations, a frequent consequence of the venous insufficiency inherent in obesity, should not lead to overlook other underlying causes, particularly in diabetic patients.

10. DOCID:18157 SCORE: 0.0011238484243965
DOCNO: 2143401
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: R K Portenoy RK
AFFILIATION: Memorial Sloan-Kettering Cancer Center.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Pain and quality of life: clinical issues and implications for research.
PUBDATE: 19900501
Cancer pain is a subjective, multidimensional experience that strongly influences quality of life of cancer patients. Although quality of life research has recognized the potential impact of pain, there is very little information about the relationship. Key components of cancer pain that may influence quality of life include severity, chronicity, the perceived availability of relief, the meaning of the pain in relation to the underlying disease, and the psychosocial disturbances attributable to the pain. Multidimensional assessment of both pain and quality of life is needed to characterize this relationship.

11. DOCID:17947 SCORE: 0.00112380848229877
DOCNO: 1703198
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: R D Miller RD
AUTHOR: T D Walsh TD
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Psychosocial aspects of palliative care in advanced cancer.
PUBDATE: 19910101
One hundred patients with advanced cancer referred to a palliative care service were evaluated for psychosocial distress using a standard questionnaire. A high incidence of emotional upset, financial distress, and home-care problems was found. Psychosocial distress is common among patients (and their families) with advanced cancer and may have a significant impact on provision of optimal care. Community services are often inadequate. A dedicated palliative care service employing a multidisciplinary approach can best provide care. We make specific recommendations about how to combat psychosocial distress using specific administrative and management techniques.

12. DOCID:19791 SCORE: 0.00112368577831125
DOCNO: 1509119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: urine
QUALIFIER: chemically induced
QUALIFIER: pharmacokinetics
QUALIFIER: urine
AUTHOR: C I Chappel CI
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Regulatory toxicology and pharmacology : RTP.
COUNTRY: UNITED STATES
TITLE: A review and biological risk assessment of sodium saccharin.
PUBDATE: 19920601
Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have shown that saccharin does not increase the risk of bladder cancer in humans and laboratory investigations have shown that sodium saccharin is not mutagenic and does not bind to DNA. Recent research indicates that the urothelium in male rats is damaged under conditions of high urinary pH and sodium levels by a mechanism that involves alpha 2u-globulin and possibly silicate crystalluria. These studies and their implications for human health risk are reviewed.

13. DOCID:20382 SCORE: 0.00111560130734119
DOCNO: 8017816
AUTHOR: W J Smellie WJ
AUTHOR: M Yeatman M
AUTHOR: A G Nash AG
AFFILIATION: Royal Marsden Hospital, Sutton, Surrey.
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: A single axillary crease incision for wide local excision and axillary clearance in breast cancer.
PUBDATE: 19940501
Wide local excision and axillary clearance or sampling has become the standard surgical treatment for many breast cancers. We describe a single incision that allows good access to the primary tumour and the axilla, lies parallel to Kraissl's lines of the skin and gives good cosmetic results.

14. DOCID:21511 SCORE: 0.00111542520218734
DOCNO: 7586138
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Heat
QUALIFIER: metabolism
QUALIFIER: biosynthesis
AUTHOR: M Watanabe M
AUTHOR: K Suzuki K
AUTHOR: S Kodama S
AUTHOR: T Sugahara T
AFFILIATION: Department of Health Sciences, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Carcinogenesis.
COUNTRY: ENGLAND
TITLE: Normal human cells at confluence get heat resistance by efficient accumulation of hsp72 in nucleus.
PUBDATE: 19951001
We investigated the heat-sensitivity of normal human cells and cells derived from human cancers (cancer cells) heated at 43 degrees C under different culture conditions. Primary human cells which keep in contact with each other show heat resistance, but cancer cells do not. This does not correlate with the total cellular amount of heat shock protein 72, but rather with accumulation of the protein in the nucleus after heating.