0. DOCID:7543 SCORE: 0.00412281743914777
DOCNO: 35626
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: D S Shimm DS
AUTHOR: G L Logue GL
AUTHOR: A A Maltbie AA
AUTHOR: S Dugan S
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Medical management of chronic cancer pain.
PUBDATE: 19790601
Management of the chronic pain of cancer is a common and difficult problem. In addition to a medical examination of the patient, it is necessary to perform a psychological assessment of his premorbid personality, current mental status, and coping mechanisms to devise an individualized approach to his pain. The mainstay of cancer pain control are the narcotics, which differ primarily in potency and duration of action. Nonnarcotic analgesics are equianalgesic with the less potent narcotics. Antipsychotic drugs are useful as tranquilizers, antiemetics, and analgesic potentiators. Antidepressants and hypnotics permit the patient a more normal life-style. Stimulants such as cocaine and amphetamines both potentiate narcotic analgesia and reduce narcotic-induced somnolence and respiratory depression. Tetrahydrocannabinol offers no advantage over traditional analgesics. With care and patience, the physician can render practically any cancer patient pain-free.


1. DOCID:7502 SCORE: 0.00363447587772375
DOCNO: 6795457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: W Lock W
PUBTYPE: Journal Article
JOURNALTITLE: MMW, M√ľnchener medizinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: [Epidemiology of carcinosis. 105 years of mortality statistics (author's transl)]
PUBDATE: 19811001
Cancer mortality in Hamburg, calculated per 10,000 living inhabitants of each age group of men and women for the years 1873 to 1978 proved to be essentially constant after eliminating sources of statistical error. Calculation or organ involvement by the same method for 1933 to 1978 showed that the increase in mortality for one type of location is compensated by a decrease elsewhere, so that altogether the constancy remains. This behavior can be explained if it be assumed. This behavior can be explained if it be assumed that a certain constant percentage of the population is prone to cancer and - possibly due to the action of exogenous noxae - becomes ill when the necessary age is reached. The nature of a determining factor which is most probably present is not known. Comparison with international figure shows that the results of the Hamburg Study can be considered a model case.


2. DOCID:7271 SCORE: 0.00249855056444293
DOCNO: 459966
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: H T Lynch HT
AUTHOR: H A Guirgis HA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Childhood cancer and the SBLA syndrome.
PUBDATE: 19790101
Two nuclear families showing characteristics of the SBLA syndrome are described wherein progeny of breast cancer-affected mothers manifested early childhood malignant neoplasms. These observations have led us to postulate a novel type genetic-environmental interactive model which incorporates Knudsen's "two-hit" hypothesis as a partial explanation for the exceedingly early onset of cancer in the subject progeny. Given the assumption that the first hit was germinal with transfer of the deleterious SBLA gene at conception, we postulate that the second or somatic-hit occurred early on in utero. This may have involved a complex mechanism of one or more factors including tumor cell products, tumor specific antigens, immunosuppression, de-repressed oncogene, or an activated oncogenic virus via a transplacental communicable phenomenon. The testing of this new hypothesis dealing with carcinogenesis in the SBLA syndrome should employ immunologicalgenetic parameters concurrently in fetuses and mothers.


3. DOCID:3067 SCORE: 0.00233138888091828
DOCNO: 134201
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laryngoscopy
QUALIFIER: diagnosis
AUTHOR: W Steiner W
AUTHOR: H J Pesch HJ
PUBTYPE: Journal Article
JOURNALTITLE: Laryngologie, Rhinologie, Otologie.
COUNTRY: GERMANY, WEST
TITLE: [Endoscopic-histological differential diagnosis of rare benign endolaryngeal proliferations (author's transl)]
PUBDATE: 19760201
In the period from 1961 to August, 1975, 2,222 microlaryngoscopic examinations were carried out at the ENT Department of the University. A correlation was seen between the increase in the number of examination in the last few years and the increase in the number of malignant tumours of the larynx, while malignant growths in the hypopharynx were found to be only slightly increased. An anlysis of 1,027 microlaryngoscopies carried out under anaesthesia over the last 2 2/3 years showed almost 50% cancers and precancers. In 5% of the case at most more rare laryngeal findings were also seen. Of these, the granular cell tumour, plasmocytoma, oncocytic cystadenoma and amyloid-tumour of the larynx, but also tuberculous laryngitis, are represented. The modern endoscopic examinations and the fundamental bioptic histomorphological examination of proliferations allow an exact differentiation of these changes in the tissues of the endolarynx. In this connection, a valuable technical aid is the v. Stuckard low-power magnifying laryngoscope, that has been in use for the past six months.


4. DOCID:3164 SCORE: 0.00214419955887907
DOCNO: 1173645
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
AUTHOR: B B Lurie BB
AUTHOR: M S Loewenstein MS
AUTHOR: N Zamcheck N
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Elevated carcinoembryonic antigen levels and biliary tract obstruction.
PUBDATE: 19750701
Circulating carcinoembryonic antigen (CEA) levels and their relation to liver function test values were studied in 29 jaundiced patients with benign extrahepatic biliary tract obstruction and inflammation. During the obstructive and inflammatory phase, 15 (52%) of the patients had CEA levels greater than 2.5 ng/ml. Elevated CEA levels were associated more frequently with common bile duct stones (and cholangitis) than with gallbladder stones (and cholecystitis) alone, although this difference was not statistically significant. The former often had values greater than 5.0 ng/ml. The highest values were found in two patients with liver abscesses. T'HE CEA levels returned to normal following relief of obstruction in seven of ten patients and increased in two patients who had progressive inflammation. Serum alkaline phosphatase and bilirubin levels were significantly higher in the patients with elevated CEA levels (p smaller than .05). Serum alkaline phosphatase levels showed a significant positive correlation with CEA levels (p smaller than .02). Patients with obstructive jaundice and elevated CEA levels do not necessarily have cancer.


5. DOCID:995 SCORE: 0.00195901599060315
DOCNO: 236622
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: therapy
AUTHOR: M von Ardenne M
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Theoretical aspects of fighting cancer recurrence (author's transl)]
PUBDATE: 19750101
The noticeable improvement in the supply of glucose and oxygen to surviving cancer cells located far from the capillary region (primarily very slowly proliferating or non-proliferating cancer cells) can be taken as the main reason for cancer recurrence in the wake of successful tumour treatment with destruction of a high percentage of cancer cells. On the basis of theoretical and experimental research work on substrate supply, cell kinetics and therapy mechanisms in the intercapillary region, therapeutic steps are formulated which act on cancer cells situated at a greater distance from the capillaries and, therefore, against the genesis of cancer recurrence as such.


6. DOCID:2241 SCORE: 0.00191916693033333
DOCNO: 1268845
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Kawana T
AUTHOR: J D Cornish JD
AUTHOR: M F Smith MF
AUTHOR: L Aurelian L
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Frequency of antibody to a virus-induced tumor-associated antigen (AG-4) in Japanese sera from patients with cervical cancer and controls.
PUBDATE: 19760601
Microquantitative complement fixation was used to detect antibody to AG-4, a tumor-associated herpesvirus type 2-induced antigen, in sera from Japanese patients with cervical neoplasia. The prevalence of antibody to AG-4 in cervical cancer patients is 47% as compared to 7% in control women. That AG-4 antibody is less prevalent in Japanese than in American cancer patients reflects the frequency of genital herpesvirus type 2 infections in Japan. These findings confirm the association of AG-4 with cervical cancer in a proportion of Japanese patients with neoplastic disease; they implicate factors other than herpesvirus type 2 in another proportion of cervical cancer patients. The possibility that herpesvirus type 1 is one of these factors is considered.


7. DOCID:1343 SCORE: 0.00180541323469552
DOCNO: 889551
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aerospace Medicine
DESCRIPTOR: Hospitalization
QUALIFIER: epidemiology
AUTHOR: W T Morioka WT
AUTHOR: R L Fassett RL
PUBTYPE: Journal Article
JOURNALTITLE: Aviation, space, and environmental medicine.
COUNTRY: UNITED STATES
TITLE: Naval aviators admitted to a Naval hospital.
PUBDATE: 19770801
This paper discusses the hospitalization of aviators at the Naval Regional Medical Center, San Diego, Ca. The areas covered include cancer, trauma, cardiac cases, alcoholics, and the effect of hospitalization on the flying status of aviators. The variety of diagnoses accumulated in 2 years was suprising. Further follow-up of cardiac cases must be pursued, especially post-coronary artery bypass. Alcoholism as a diagnosis in hospitalized patients may be a larger problem than elicited in this series. Hopefully this paper will not be just a statistical study. We should think of prevention and care to decrease the number of aviators who have their wings clipped due to medical problems.


8. DOCID:3230 SCORE: 0.0017769826172191
DOCNO: 165299
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diet
DESCRIPTOR: Housing, Animal
DESCRIPTOR: Wood
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: W E Heston WE
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Testing for possible effects of cedar wood shavings and diet on occurrence of mammary gland tumors and hepatomas in C3H-A-vy and C3H-Avy-fB mice.
PUBDATE: 19750401
C3H-A-vy and C3H-A-VY-FB mice transferred from our colony to the laboratory of Dr. J. R. Sabine in Australia had a markedly reduced incidence of both hepatomas and mammary tumors. Sabine and co-workers (J Natl Cancer Inst 50: 1237-1242, 1973) attributed the low incidence of tumors in their laboratory compared to the high incidence in this laboratory to the fact that we routinely use red cedar shavings in the bedding, whereas they use sawdust, predominantly Doublas fir. Results of tests in this laboratory showed that the difference in occurrence of tumors could not be attributed directly to either a difference in diet or bedding. There was no evidence that the cedar shavings were carcinogenic. The animals in Australia on bedding without cedar shavings were not as healthy as our animals, in that they did not grow as well and were infested with ectoparasites; apparently these factors caused the reduced occurrence of tumors.


9. DOCID:3546 SCORE: 0.00174062085156058
DOCNO: 69489
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
DESCRIPTOR: Immunosuppression
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: B S Wang BS
AUTHOR: A M Badger AM
AUTHOR: R R Nimberg RR
AUTHOR: S R Cooperband SR
AUTHOR: K Schmid K
AUTHOR: J A Mannick JA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Suppression of tumor-specific cell-mediated cytotoxicity by immunoregulatory alpha-globulin and by immunoregulatory alpha-globulin-like peptides from cancer patients.
PUBDATE: 19770901
The suppression of tumor-specific cell-mediated cytotoxicity by human immunoregulatory alpha-globulin (IRA), by a peptide fraction derived from IRA, and by IRA-like peptides from the serum of cancer patients was studied in a syngeneic murine tumor-host system. Splenic lymphocytes from tumor-immunized mice were cytotoxic specific tumor cells in vitro as measured by the [125]-iododeoxyuridine release microcytotoxicity assay. However, this effect was significantly depressed if 1.25 to 5 mg of IRA per ml were added to the cultures. Pooled lyophilized normal human serum protein was inactive. IRA peptide and IRA-like peptide fractions from cancer patients were also highly suppressive of cell-mediated cytotoxicity at much lower concentrations (0.05 to 0.5 mg/ml). Control human serum peptide, which failed to inhibit the induction of hemolytic plaque-forming cells in sheep erythrocyte-injected mice, had no effect on cell-mediated cytotoxicity. IRA and IRA-like peptide fractions were not cytotoxic to the effector lymphocytes or to the target cells at the concentrations used.


10. DOCID:3520 SCORE: 0.00158089592422092
DOCNO: 767228
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: P R Armitstead PR
AUTHOR: G Gowland G
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Migration inhibition with various cell fractions in human colorectal cancer.
PUBDATE: 19751201
The unseparated leucocytes, separated mononuclear cells and granulocytes of six control subjects and nine patients with colorectal cancer have been studied by a direct cell migration inhibition technique. A migratory index was calculated from the migration in the presence and absence of a perchloric acid extract of large bowel tumours. In 10% homologous AB serum, no significant migration inhibition occurred with any of the cells from control subjects. Five of the nine cancer patients showed significant inhibition with their unseparated leucocytes, seven of seven with their mononuclear cells, and none of nine with their granulocytes. In 10% autologous serum, some controls exhibited migration inhibition with their unseparated leucocytes and their granulocyte fraction, but not with the mononuclear cell fraction. Migration inhibition was also now apparent in the granulocyte fraction of the cancer patients. It is concluded that, with a soluble tumour antigen preparation, a mononuclear cell population increases the sensitivity of the direct migration inhibition test and that autologous serum may interfere directly with the migration of granulocytes, by an action not dependent upon the release of inhibitory factors from sensitized lymphocytes. This could explain some of the inconsistencies of the assay when using an unseparated leucocyte population.


11. DOCID:3380 SCORE: 0.00158032145792879
DOCNO: 936019
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: M C Veidenheimer MC
AUTHOR: F W Nugent FW
AUTHOR: R C Haggitt RC
PUBTYPE: Journal Article
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Ulcerative colitis or Crohn's colitis. Is differentiation necessary?
PUBDATE: 19760601
Three types of colitis are now recognized. In the late 1950's and early 1960's, 51 per cent of our patients having colectomy had classic chronic ulcerative colitis. Of our patients operated on at that time, 39 per cent had Crohn's colitis and 10 per cent had colitis of indeterminate type. These three types of colitis should be differentiated because of the high risk of cancer of the colon in patients with long-standing chronic ulcerative colitis. We have not seen an increased risk of carcinoma associated with Crohn's colitis. We performed resection with anastomosis in approximately one third of patients with Crohn's colitis, but recurrent disease developed in two thirds. In contrast, recurrent Crohn's disease developed in only 5.7 per cent of patients having colectomy with ileostomy. Toxic megacolon associated with Crohn's colitis has been seen only in the early clinical stage of the disease. From the standpoint of management and prognosis, attempts to differentiate between the two major types of colitis are appropriate. We have outlined some of the basic clinical and pathologic differences between these two types of colitis.


12. DOCID:3340 SCORE: 0.00151230461254743
DOCNO: 1116103
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: R H Creech RH
AUTHOR: R B Catalano RB
AUTHOR: M J Mastrangelo MJ
AUTHOR: P F Engstrom PF
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: An effective low-dose intermittent cyclophosphamide, methotrexate, and 5-fluorouracil treatment regimen for metastatic breast cancer.
PUBDATE: 19750401
A low-dose, three-drug regimen, C.M.F. (cyclophosphamide 50 mg, p.o., days 1-14; methotrexate, 25 mg, and 5-fluorouracil, 500 mg, i.v., days 1 and 8; cycled every 28 days) was used in 46 consecutive chemtherapy-eligible women (41 previously hormonally treated) with recurrent breast cancer. Thirteen percent of the patients had complete regressions (C.R.); 33% had partial regressions (P.R.); 26% stabilized; and 28% progressed. In evaluating response by sites of metastases, lymph nodes (30%), lung nodules (22%), and subcutaneous deposits (2/3) had the highest incidence of C.R.; 46-71% of patients with lymph node, lung, subcutaneous, liver, breast, or peritoneal disease showed C.R. or P.R. Skin and pleural disease responded in 30% of patients whereas no patients had radiographic healing of bony metastases. The toxicity was minimal: 7% gastrointestinal, 26% marrow-suppressive, and 7% infectious. This low-dose C.M.F. regimen resulted in regression resulted in regression rates similar to higher dose C.M.F. protocols, which use approximately twice these drug dosages with commensurate toxicity.


13. DOCID:3209 SCORE: 0.00148785963945349
DOCNO: 953973
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
AUTHOR: W M Christopherson WM
AUTHOR: F E Lundin FE
AUTHOR: W M Mendez WM
AUTHOR: J E Parker JE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Cervical cancer control: a study of morbidity and mortality trends over a twenty-one-year period.
PUBDATE: 19760901
Data from a 21-year period are presented to evaluate the effects of a mass cytologic screening program on uterine cancer morbidity and mortality in Louisville, Jefferson County, Kentucky. The success of screening was greatest in the younger age groups. There was a fall-off after age 45 years, especially in those age 60 years or older. Women at highest risk for cervical cancer, in the low socioeconomic quartile, had a better initial screening rate than the two middle-income quartiles, and had the highest rate of all women for subsequent rescreening. The greatest decrease in both morbidity and mortality was in women under the age of 50 years. Women age 30-39 and 50-59 years benefitted the most, as measured by mortality, with a decrease of 70.8 and 69.0%, respectively. There was no change in mortality rates for those age 70 years or older. Although the average annual age-adjusted rate increased from 13.2 to 15.3/100,000 women over the 21-year period.


14. DOCID:2332 SCORE: 0.00145183720108913
DOCNO: 12229501
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Contraceptives, Oral
DESCRIPTOR: Contraceptives, Oral, Combined
DESCRIPTOR: Endometrial Neoplasms
DESCRIPTOR: Estrogens
DESCRIPTOR: Liver
DESCRIPTOR: Menopause
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: United States
TITLE: More critics raise voices against estrogen therapy.
PUBDATE: 19760201
Estrogen use for treating symptoms of menopause and in oral contraception is under growing attack Recent findings have shown negative correlations between oral contraceptive (OC) use and myocardial infarction, elevated risk of breast cancer, endometrial cancers among wo men between 21 and 39 years of age (especially among those using sequent ial pills) and benign tumors of the liver. Studies have also linked prolonged estrogen therapy in menopausal women with increasing incidence of endometrial cancer. An estimated 5.6-fold increase in endometrial cancer risk has been figured for women who have been using estrogen from 1 to 4.9 years. Consequently, the FDA has announced plans to label all estrogen products with strong restrictive warnings. There is a possibility that sequentials will be removed completely from the market The increasing number of reports of various effects of estrogen still await resolution.