0. DOCID:23994 SCORE: 0.00252467834079994
DOCNO: 7735643
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: N P Reddy NP
AUTHOR: K Patel K
AFFILIATION: Department of Biomedical Engineering, University of Akron, Ohio 44325-0302, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Medical engineering & physics.
COUNTRY: ENGLAND
TITLE: A mathematical model of flow through the terminal lymphatics.
PUBDATE: 19950301
Proper understanding of the mechanisms of fluid absorption and flow through the terminal lymphatics is essential for the control of several pathological conditions such as edema, bedsores and cancer. A mathematical model of the terminal lymphatics was developed using the principles of mechanics. Computer simulation results substantiate the hypothesis that fluid absorption and flow through the terminal lymphatics occur due to suction mechanisms of the adjacent contractile lymphatic segments and due to periodic fluctuations in the interstitial fluid pressure. In addition, the results suggested that increasing the length of a terminal lymphatic vessel beyond a certain limit does not cause further increase in fluid flow into the terminal lymphatic.


1. DOCID:22458 SCORE: 0.00239748234730241
DOCNO: 8740561
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: R J Youle RJ
AFFILIATION: Biochemistry Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1414, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Immunotoxins for central nervous system malignancy.
PUBDATE: 19960401
Current therapy for primary brain tumors, metastatic brain tumors and leptomeningeal carcinomatosus is inadequate. Monoclonal antibodies and certain biological ligands such as transferrin and epidermal growth factor bind selectively to tumors but in and of themselves have little therapeutic activity. Linking these binding moieties to protein toxins yields new molecules, called immunotoxins, that display enormous cell-type specific toxicity in vitro and could be valuable agents for treatment of CNS cancer. This review discusses our development of immunotoxins to treat brain tumors after systemic, intrathecal and intratumoral injection.


2. DOCID:22570 SCORE: 0.00239312850767678
DOCNO: 7894079
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Neoplastic
DESCRIPTOR: Genome, Human
QUALIFIER: analysis
QUALIFIER: genetics
AUTHOR: G Keith G
AUTHOR: G Dirheimer G
AFFILIATION: Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique, Strasbourg, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in biotechnology.
COUNTRY: ENGLAND
TITLE: Postlabeling: a sensitive method for studying DNA adducts and their role in carcinogenesis.
PUBDATE: 19950201
The covalent binding of xenobiotics to DNA is an important trigger of the multistage process that leads to carcinogenesis. 32P-postlabeling represents a highly sensitive method for biomonitoring exposure to genotoxic agents and for cancer risk assessment; it is capable of detecting less than one DNA adduct per human genome. Recent improvements to the technique have shown that the resistance of adducted DNA to enzyme digestion may lead to an overestimation of the number of different adducts present in a sample.


3. DOCID:23268 SCORE: 0.00223435270776394
DOCNO: 7544559
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: J J Tjandra JJ
AFFILIATION: Private Medical Centre, Royal Melbourne Hospital, Parkville, Victoria, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the Academy of Medicine, Singapore.
COUNTRY: SINGAPORE
TITLE: Surgical management of the locally advanced pelvic malignancy--the colorectal surgeon's view.
PUBDATE: 19950301
About 10% of patients with newly diagnosed colorectal cancer will have locally advanced disease without gross evidence of distant or discontiguous intraabdominal metastases. Long-term cure or disease-free survival frequently follows extended resection for a locally advanced primary colorectal carcinoma. The use of adjuvant combined chemo-radiation therapy is still being evaluated. While complete resection of recurrent disease sometimes provides the best long-term survival when compared with other treatment modalities, few patients are suitable candidates for curative resection. In our experience, major extended resection for recurrent pelvic disease is largely palliative and is rarely associated with long-term survival.


4. DOCID:21904 SCORE: 0.00205442306959272
DOCNO: 8137308
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Damage
DESCRIPTOR: DNA Repair
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: M S Satoh MS
AUTHOR: T Lindahl T
AFFILIATION: Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, United Kingdom.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Enzymatic repair of oxidative DNA damage.
PUBDATE: 19940401
Oxidative DNA damage, including both mutagenic and cytotoxic lesions, is implicated in aging and cancer. Studies of the processes which correct such damage in mammalian cells are, however, still in their early stages. Here we have summarized our recent work which demonstrates new features of mammalian oxidative DNA damage repair, such as (a) a functional role for poly(ADP-ribosyl)ation in the rejoining of DNA strand breaks and (b) the defective repair of oxidative DNA damage in xeroderma pigmentosum cells.


5. DOCID:22303 SCORE: 0.00202030197057972
DOCNO: 7591282
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, Tumor Suppressor
DESCRIPTOR: Mutation
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: M Bailly M
AUTHOR: C Bain C
AUTHOR: M C Favrot MC
AUTHOR: M Ozturk M
AFFILIATION: Laboratoire d'Oncologie Moleculaire, INSERM CJf 9302, Lyon, France.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers.
PUBDATE: 19951101
Somatic mutations of von Hippel Lindau (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 31 kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A:T base pairs. The frequency and the spectrum of mutations identified in kidney tumors from Europe were similar to those reported for tumors from other geographical locations.


6. DOCID:22850 SCORE: 0.00200065267547565
DOCNO: 8003396
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
QUALIFIER: methods
QUALIFIER: administration & dosage
QUALIFIER: physiopathology
QUALIFIER: drug therapy
AUTHOR: N Coyle N
AUTHOR: N I Cherny NI
AUTHOR: R K Portenoy RK
AFFILIATION: Department of Neurology, Memorial Sloan-Kettering Cancer Center.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Subcutaneous opioid infusions at home.
PUBDATE: 19940401
The ability to provide subcutaneous infusions in the home has had a major impact on patient care. The main indication for this approach in the cancer population is the need for prolonged parenteral administration of an opioid drug. Successful administration begins with proactive consideration of patient selection; choice of pump, drug, mode of infusion, and dosing schedule; the resources of the family and community health-care system; and cost and insurance coverage. Long-term management requires ongoing liaison among the hospital pain management team, home care infusion agency, and community physicians and nurses.


7. DOCID:22801 SCORE: 0.00200065212082792
DOCNO: 8885795
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnostic Errors
QUALIFIER: pathology
AUTHOR: R M DeMay RM
AFFILIATION: Section of Cytopathology, University of Chicago, IL 60637, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Cytopathology of false negatives preceding cervical carcinoma.
PUBDATE: 19961001
The Papanicolaou smear has been a remarkably effective tool in cancer prevention, but it is not a perfect test. Although the most important factor in failure of cervical cancer prevention is lack of adequate screening, other factors include problems with sampling, interpretation, and effective clinical follow-up. A small number of rapidly developing cervical cancers probably also arise in the interval between Papanicolaou smear screenings. Consequently, cervical cancer will develop in some women despite appropriate screening. This article will analyze some of the problems relating to diagnostic errors, which include abnormal cells that are few (< 100), small, or bland.


8. DOCID:23818 SCORE: 0.00199961754515564
DOCNO: 9103006
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: S O Kolset SO
AUTHOR: C A Drevon CA
AUTHOR: K Prydz K
AFFILIATION: Institutt for ernaeringsforskning, Universitetet i Oslo, Blindern.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Proteoglycans and pathology--new aspects]
PUBDATE: 19970301
It is well documented that proteoglycans are involved in a wide range of pathological conditions. Recently published results in international journals provide new information on the role of proteoglycans in such conditions. A mutation in the gene encoding for a cell surface proteoglycan has been demonstrated in overgrowth syndromes. A proteoglycan has been isolated from urine and shown to induce cachexia in cancer patients. Furthermore, in both achondrogenesis and colon cancer, the reduced ability to sulphate proteoglycans is due to genetic defects in cellular sulfate transporters. Finally, fibrosis has been inhibited in glomerulonephritic mice by transferring the gene for decorin, a transforming growth factor beta-1 binding proteoglycan, into muscle tissue.


9. DOCID:22150 SCORE: 0.00193891788091371
DOCNO: 7703555
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: S Blond S
AUTHOR: J Meynadier J
AFFILIATION: Unité de neurochirurgie fonctionnelle et stéréotaxique, hôpital B, CHRU, Lille, France.
PUBTYPE: Journal Article
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Drug therapy of pain in oncology: keep it simple!]
PUBDATE: 19940801
Pain is the most common symptom in patients suffering from cancer, in particular for advanced diseases. Unfortunately, one third of the patient do not benefit from optimal pain control. One must stress the importance of defining the etiology of pain and subsequently its pathophysiology. This thorough evaluation can help to formulate a proper strategy for a treatment of pain that could be adapted to the disease evolution. A multidisciplinary approach with respect to the WHO prescribing criteria is the most appropriate way to control severe cancer pain syndromes.


10. DOCID:22168 SCORE: 0.00193891726673058
DOCNO: 7938467
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radiation Tolerance
QUALIFIER: genetics
QUALIFIER: radiotherapy
AUTHOR: M Jung M
AUTHOR: A Dritschilo A
AFFILIATION: Department of Radiation Medicine, Georgetown University School of Medicine, Washington, D.C. 20007.
PUBTYPE: Journal Article
JOURNALTITLE: Radiation research.
COUNTRY: UNITED STATES
TITLE: Modification of the radiosensitivity of human testicular cancer cells by simian virus 40 sequences.
PUBDATE: 19941101
CRL7800 cells are of human testicular cancer origin and are sensitive to killing by ionizing radiation. After transfection with a plasmid expressing the T-antigen (pSC), cells show enhanced growth and an increased resistance to ionizing radiation. Cell cycle analysis reveals perturbation of a cell cycle checkpoint which, after irradiation, results in an increase in G2-phase arrest in CRL7800VA cells. These experiments demonstrate the modulation of radiation sensitivity and cell cycle arrest of human tumor cells by the introduction of viral genes.


11. DOCID:21876 SCORE: 0.00184977535310546
DOCNO: 8785367
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: standards
AUTHOR: A Herbert A
AUTHOR: J Johnson J
AUTHOR: J Patnick J
PUBTYPE: Guideline
PUBTYPE: Journal Article
JOURNALTITLE: Cytopathology : official journal of the British Society for Clinical Cytology.
COUNTRY: ENGLAND
TITLE: Achievable standards, benchmarks for reporting and criteria for evaluating cervical cytopathology.
PUBDATE: 19951001
The cervical smear test, like all screening tests, is not 100% effective in detecting abnormality. In order to prevent 80-90% of invasive cancers, cervical screening requires cervical smears to be taken competently at regular intervals and correctly interpreted. With laboratories following the guidelines in this report, the NHSCSP should be able to meet the Health of the Nation target to reduce the incidence of invasive cervical cancer to less than 12 cases per 100 000 women in the UK by the year 2000.


12. DOCID:22665 SCORE: 0.00182437553561057
DOCNO: 7988269
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Recurrence, Local
QUALIFIER: adverse effects
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: S Piantadosi S
AUTHOR: D W Moores DW
AUTHOR: M F McKneally MF
AFFILIATION: Johns Hopkins Oncology Center, Baltimore, MD 21205.
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: The adverse effect of perioperative blood transfusion in lung cancer.
PUBDATE: 19941201
Perioperative blood transfusion appears to increase the risk of recurrence and death in patients with surgically resected lung cancer. This finding is consistent with that in other cancers and several studies in lung cancer report similar risk elevations. We have reanalyzed the Lung Cancer Study Group data relevant to this question, assessing the potential confounding effects of some prognostic factors not examined previously. The results are nearly identical to those reported earlier, suggesting that increased risk is attributable to blood transfusion and not to confounding by known prognostic factors.


13. DOCID:22685 SCORE: 0.00182437551810896
DOCNO: 7781403
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A D Elias AD
AFFILIATION: Dana-Farber Cancer Institute, Boston, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Dose-intensive therapy for small cell lung cancer.
PUBDATE: 19950601
Enhancement of dose and dose intensity increases tumor response and may enhance long-term progression-free survival in patients with small cell lung cancer. Several strategies are identified to intensify therapy safely: a traditional induction/intensification mode, in which high-dose therapy with hematopoietic stem cell support is used to treat patients responding to conventional-dose therapy; and multicycle dose-intensive approaches, in which higher-dose therapy is administered over multiple cycles at initiation of therapy. This paper reviews some of the recently completed and activated trials (particularly those developed at the Dana-Farber Cancer Institute) exploring these concepts.


14. DOCID:23339 SCORE: 0.00181801143915001
DOCNO: 8965369
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: Y Satake Y
AFFILIATION: Department of Internal Medicine, Showa University Fujigaoka Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Early colorectal cancer]
PUBDATE: 19960501
Early colorectal cancer is situated at the field with a rich stock of topics in Japan. For this reason, there are increasing number of patients with colorectal cancer, many reports of depressed early cancer and rapid advances of molecular biology about colorectal neoplasm. Most of early colorectal cancers are discovered to be the protruded type by all accounts in spite that many cases of depressed type early cancer have been reported in many Japanese institutes. The final diagnosis of early colorectal cancer is usually made by histological examination after endoscopic resection, however invasive cancers with distinct endoscopic appearance of submucosal spread should be treated surgically from the beginning after diagnosis on biopsy specimens.