0. DOCID:7837 SCORE: 0.002865799572796
DOCNO: 7317745
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: immunology
QUALIFIER: urine
AUTHOR: S Kumar S
AUTHOR: C B Costello CB
AUTHOR: R W Glashan RW
AUTHOR: B Björklund B
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: The clinical significance of tissue polypeptide antigen (TPA) in the urine of bladder cancer patients.
PUBDATE: 19811201
A 2-stage study has been carried out to evaluate the usefulness of urinary tissue polypeptide antigen (TPA) levels in patients with bladder cancer as an adjunct to the routine procedures for detection of bladder tumours. Two-hour urine samples were collected from 83 bladder cancer patients and normal individuals for the first part of the study, 24-h samples from 54 patients and normal individuals for the second part. Urinary TPA was determined using radioimmunoassay. In 2-h samples there was no significant difference in the amounts of TPA/l in any of the groups. In contrast, the TPA results of 24-h urine samples (n = 54) were markedly different from 2-h samples and the former correlated very well with the presence or absence of bladder cancer. A reason for this difference may be circadian rhythm effects.


1. DOCID:4734 SCORE: 0.00275660634032966
DOCNO: 343596
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: R S Freedman RS
AUTHOR: J T Wharton JT
AUTHOR: F Rutledge F
AUTHOR: J G Sinkovics JG
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Transfer factor and possible applications in gynecology.
PUBDATE: 19780301
Dialyzable transfer factor (TFd) is reviewed against its historical background, preparation methods, physiochemical properties, possible mechanisms of action, pharmacology, and clinical studies, including several areas relating to gynecology. The possible role of TFd as an adjunct in the treatment of cancer is discussed. The discussion centers on gynecologic cancer in several patients who have received TFd. The difficulties and future possibilities for this modality of treatment are considered.


2. DOCID:4706 SCORE: 0.0027566051011449
DOCNO: 7345007
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: antagonists & inhibitors
QUALIFIER: chemically induced
QUALIFIER: pharmacology
QUALIFIER: chemically induced
QUALIFIER: antagonists & inhibitors
AUTHOR: M Habs M
AUTHOR: D Schmähl D
PUBTYPE: Journal Article
JOURNALTITLE: Hepato-gastroenterology.
COUNTRY: GERMANY, WEST
TITLE: Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats.
PUBDATE: 19811001
Male Sprague-Dawley rats received 0.1 mg/kg of diethyl-nitrosamine orally five times a week for life with or without additional subsequent administration of 5 ml/rat/day of a 25% aqueous solution of ethanol. The additional treatment with ethanol significantly reduced the induction of liver cancer, but not of esophageal tumors. These findings do not support speculations based on epidemiologic studies as to a cancer-causing effect of alcohol.


3. DOCID:6207 SCORE: 0.00267036639027582
DOCNO: 497912
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: C F McCullogh CF
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Trans-sphincteric approach to the rectum.
PUBDATE: 19790901
In 28 cases the trans-sphincteric approach has been used to remove lesions of the lower and mid-rectum; in 4 cases the combined abdominal and trans-sphincteric approach was used. Complications were minor and were easily treated and the operation was well tolerated by poor-risk patients. No patient had altered anal continence. The author emphasizes the need for careful identification and reconstruction of the anatomical structures. The trans-sphincteric approach gives excellent exposure of the mid- and lower rectum and has been particularly useful in managing large villous adenomas. The trans-sphincteric approach alone is not adequate for the treatment of cancer, but makes possible sphincter-preserving resections of lesions that might otherwise be treated by more radical procedures.


4. DOCID:7055 SCORE: 0.00262412988974821
DOCNO: 6101748
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Enzyme Tests
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: R C Coombes RC
AUTHOR: T J Powles TJ
AUTHOR: J C Gazet JC
AUTHOR: A G Nash AG
AUTHOR: H T Ford HT
AUTHOR: A McKinna A
AUTHOR: A M Neville AM
PUBTYPE: Clinical Trial
PUBTYPE: Controlled Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Assessment of biochemical tests to screen for metastases in patients with breast cancer.
PUBDATE: 19800201
Of ten tumour markers measured every 3 months after mastectomy in patients with apparently localised primary breast cancer, plasma levels of alkaline phosphatase, carcinoembryonic antigen, and gamma-glutamyl transpeptidase were the most useful in detecting metastatic disease. With these three tests a "lead interval" of 3 months or more was obtained in about half the 23 patients who developed overt metases. Clinical examination, chest X-ray, and these three markers proved the most useful combination of tests in screening for metastases, since at least one test was abnormal in 46 of 47 patients at the time of the development of metastases as judged by more detailed physical tests.


5. DOCID:6673 SCORE: 0.00238698978193605
DOCNO: 7453450
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: C T Yarington CT
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: A protocol for combined treatment of cancer of the oral cavity and tongue.
PUBDATE: 19801201
A protocol for combined treatment of carcinoma of the oral cavity and tongue as practiced at the Mason Clinic for the past five years is presented. This protocol combines surgery with postoperative radiation therapy, and the initial results are presented. Comparison of the results at this institution at the one, three, and five year level for tongue, oral, and pharyngeal cancer compared to other peer group reporting rates, as surveyed by the Commission on Cancer Audit of the American College of Surgeons, indicates that our results compare favorably to those of other institutions. Apparent increase in local control, a probable increased cure rate, together with marked decrease in hospital time and multiple-staged procedures are noted. Disseminated distal metastasis has not been a major problem and is discussed.


6. DOCID:5217 SCORE: 0.00232741198259832
DOCNO: 6265733
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: D Montaudon D
AUTHOR: J C Louis JC
AUTHOR: J Robert J
PUBTYPE: Journal Article
JOURNALTITLE: Lipids.
COUNTRY: UNITED STATES
TITLE: Phospholipid acyl group composition in normal and tumoral nerve cells in culture.
PUBDATE: 19810501
We have studied the fatty acid composition of total phosphoglycerides from various types of nerve cells in culture. Primary cell cultures were compared with tumoral cell strains. Glial cells exhibited no characteristic pattern when compared to neurons. Tumoral cell phosphoglycerides contained much higher levels of octadecenoic acid and lower levels of C-20 to C-22 polyunsaturated fatty acids than normal cell phosphoglycerides. This observation seems to be a general feature in tumoral cell membranes. It could be of interest in respect to the membrane fluidity of cancer cells.


7. DOCID:7679 SCORE: 0.00226461114238684
DOCNO: 484956
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
QUALIFIER: secondary
QUALIFIER: etiology
AUTHOR: J W Popp JW
AUTHOR: R H Schapiro RH
AUTHOR: A L Warshaw AL
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Extrahepatic biliary obstruction caused by metastatic breast carcinoma.
PUBDATE: 19791001
We describe our experience with seven patients who had extrahepatic biliary obstruction caused by metastatic breast cancer. The interval from the original diagnosis of breast cancer to the development of jaundice averaged 40 months, with a range of 9 months to 8 years. All patients were treated with surgical decompression, radiation, transhepatic catheter drainage, chemotherapy, or a combination of these modalities. Resolution of jaundice was achieved in six patients. Prolonged survival was realized in three; one patient lived for more than 6 years after surgical bypass, and two are alive and well at present (greater than 11 months after relief of biliary obstruction). Extrahepatic biliary obstruction by metastatic breast carcinoma should be distinguished from jaundice due to hepatic parenchymal destruction by this tumor; while the latter implies end-stage cancer, the former has the potential for significant palliation and prolonged survival.


8. DOCID:7751 SCORE: 0.00221931476840493
DOCNO: 7257136
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammary Glands, Animal
QUALIFIER: etiology
QUALIFIER: veterinary
AUTHOR: H M Hayes HM
AUTHOR: K L Milne KL
AUTHOR: C P Mandell CP
PUBTYPE: Journal Article
JOURNALTITLE: The Veterinary record.
COUNTRY: ENGLAND
TITLE: Epidemiological features of feline mammary carcinoma.
PUBDATE: 19810501
An epidemiological survey involving 132 cats with mammary neoplasia, seen at 15 North American veterinary medical teaching hospitals, was conducted. The ratio of malignant to benign tumours was 9:1. There were 113 cases of carcinomas of all types (including two males), with adenocarcinoma being the predominant cell-type. Relative risk analysis indicated that the Siamese breed had twice the risk (P less than 0.01) of developing mammary carcinoma compared to all breeds combined. The age at diagnosis in Siamese females tended to be younger than in other breeds. Comparison of clinical and pathological features of breast cancer suggests that the cat is an appropriate surrogate for the experimental study of human breast cancer. The apparent lack of oestrogen dependency in feline breast cancer also suggests that the cat may be especially suited for evaluating therapeutic regimens for breast cancers that do not respond to hormonal manipulation.


9. DOCID:7022 SCORE: 0.00220149957348113
DOCNO: 688225
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: L W Engel LW
AUTHOR: N A Young NA
AUTHOR: T S Tralka TS
AUTHOR: M E Lippman ME
AUTHOR: S J O'Brien SJ
AUTHOR: M J Joyce MJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.
PUBDATE: 19781001
Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that of the parental tumors; (b) presence of receptors for estrogen and other steroid hormones; and (c) growth responsiveness to estrogen and/or progesterone. All three cell lines possess human karyotypes that differ from one another in modal chromosome number as well as in characteristic marker chromosomes. Two of the cultures (ZR-75-27 and ZR-75-30), although derived from the same patient, have stable differences in their karyotypes.


10. DOCID:6217 SCORE: 0.00219118000695926
DOCNO: 675192
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: R Berchtold R
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Should patients with portal hypertension undergo surgery?]
PUBDATE: 19780701
There is a noticeable similarity between the surgery of cancer and that of portal hypertension secondary to hepatic cirrhosis. The problems associated with the basic disease and with the surgical techniques used for its treatment are such that therapy should be determined by selection criteria, both when bleeding occurs and between bleeds. Highly experienced internists and surgeons are required and it is therefore advantageous if portal hypertension patients are referred to and concentrated in a small number of specialist centers. There the decision to operate should continue to be based on predetermined criteria, bearing in mind the patient's basic disease. If cirrhosis is in the foreground, as is so often the case, long-term social care should receive greater emphasis than hitherto in planning postoperative management.


11. DOCID:7972 SCORE: 0.00211030217504505
DOCNO: 286089
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: W Weiss W
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Changing incidence of thyroid cancer.
PUBDATE: 19790501
The incidence of thyroid cancer was examined temporally and geographically by age and sex from data provided by tumor registries in the United States and abroad. The temporal trends in Connecticut showed an increase in annual incidence after 1945, with an especially sudden increase in incidence in females. The increase occurred predominantly in older males and younger females. The increase in young females was confirmed by cohort analysis. The rates rose with age in both sexes, but recently females have developed a secondary peak in the fourth decade of life. The same phenomenon was observed in other U.S. data but not as clearly in data from ten foreign registries. These observations are consistent with the hypothesis that X-radiation therapy for benign conditions of the head and neck in childhood was a factor in the increased incidence of thyroid cancer in U.S. females, but some other etiologic or modifying factor should be sought to explain the increased incidence in U.S. males.


12. DOCID:7131 SCORE: 0.00209802834295031
DOCNO: 97956
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B Adelusi B
AUTHOR: J A Smith JA
AUTHOR: T A Junaid TA
PUBTYPE: Journal Article
JOURNALTITLE: African journal of medicine and medical sciences.
COUNTRY: ENGLAND
TITLE: Histopathological studies of carcinoma of cervix uteri in Ibadan.
PUBDATE: 19780301
Carcinoma of the cervix is by far the commonest gynecologic malignancy in Ibadan. In a histopathologic study of the disease, 93.9% of all the cases were found to be of the squamous cell carcinoma variety while 6.1% were of the adenocarcinoma group. It was found that most patients with the well differentiated squamous cell carcinoma were above the age of 45 years in contrast to the undifferentiated carcinoma. Even though the difference was not statistically significant, it was speculated that cervical cancer manifesting itself before the age of 45 years may be more aggressive than that occurring in older women. Similarly, it was shown that increasing age, more frequent marriages and parity may augment the possibilities, at least in the negro population, of a woman developing adenocarcinoma of the cervix.


13. DOCID:7212 SCORE: 0.00205657649892547
DOCNO: 7357548
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: K Morimoto K
AUTHOR: S Wolff S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Increase of sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites.
PUBDATE: 19800401
Benzene, which has been associated with human cancers, is metabolized to produce several major metabolites that could be responsible for the biological effects. Tests have now been carried out on human lymphocytes in culture to determine if benzene or its metabolites, phenol, catechol, and hydroquinone, induce cytogenetic changes and affect the cell cycle. The results indicate that benzene itself does not induce sister chromatid exchanges or affect cell cycle kinetics over a wide range of doses. Phenol has an effect only at very high doses. On the other hand, catechol is a potent compound that induces sister chromatid exchanges and delays cell division very readily. Hydroquinone is also potent, but less so than catechol. Thus, the formation of catechol and hydroquinone is the most likely cause of benzene toxicity.


14. DOCID:6815 SCORE: 0.00193936257016979
DOCNO: 698971
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Receptors, Estrogen
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: W Jonat W
AUTHOR: H Maass H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Some comments on the necessity of receptor determination in human breast cancer.
PUBDATE: 19781101
Estrogen receptors (ER's) were determined by agar gel electrophoresis in 105 human mammary tumor biopsies. Fifty-three tumor specimens revealed measurable amounts of receptor, and 64% of these patients showed an objective remission after endocrine treatment. If we also include cases with partial remission, previous response, and arrested growth but no actual remission, the benefit rate increases to 87%. The corresponding percentage in the ER-negative groups is 13%. In a retrospective study of 42 patients with human breast cancer, a correlation between ER finding and remission rate after chemotherapy was found. Of the ER-negative patients, 71% showed an objective remission after polychemotherapy, whereas only 43% of the ER-positive cases revealed such remission. The presented data are discussed with special regard to their clinical relevance.