0. DOCID:17778 SCORE: 0.00267432608998779
DOCNO: 2238093
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adjuvants, Immunologic
DESCRIPTOR: Immunosuppressive Agents
QUALIFIER: pharmacology
AUTHOR: V St Georgiev V
AFFILIATION: Division of Life Sciences, Orion Research and Technologies Corporation, FL 33601-0463.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in pharmacological sciences.
COUNTRY: ENGLAND
TITLE: Immunomodulatory activity of small peptides.
PUBDATE: 19900901
The activity of the immune system can be modulated by a wide variety of natural and synthetic peptides. Here, Vassil St Georgiev summarizes the actions of some of the immunostimulatory and immunosuppressant small peptides that have shown most promise as therapeutic agents. Some are already in use as vaccine adjuvants or to prevent graft rejection. There are now indications that these peptides may also be of benefit in conditions in which the immune system is compromised, in autoimmune disease and in cancer.


1. DOCID:19444 SCORE: 0.00176258928555613
DOCNO: 1968033
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 11
DESCRIPTOR: Polymorphism, Restriction Fragment Length
AUTHOR: V Huff V
AUTHOR: D A Compton DA
AUTHOR: L C Strong LC
AUTHOR: G F Saunders GF
AFFILIATION: Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
PUBTYPE: Journal Article
JOURNALTITLE: Human genetics.
COUNTRY: GERMANY, WEST
TITLE: A panel of restriction fragment length polymorphisms for chromosomal band 11p13.
PUBDATE: 19900201
A panel of seven chromosome 11p13 restriction fragment length polymorphisms (RFLPs) detected by five DNA probes is described. Two alleles were identified for each polymorphism, and Mendelian segregation of alleles was observed. Allele frequencies range from 0.13/0.87 to 0.44/0.56. This panel of 11p13 RFLPs will be useful for linkage studies investigating the role of 11p13 genes in Wilms' tumor, aniridia, and genitourinary anomalies. Additionally, these RFLPs will be important tools for studying tumor-specific 11p13 alterations in Wilms' tumor and other cancers.


2. DOCID:17630 SCORE: 0.00146031519191733
DOCNO: 2328216
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: C M Goodman CM
AUTHOR: A W Ritchie AW
AUTHOR: G D Chisholm GD
AFFILIATION: University Department of Surgery/Urology, Western General Hospital, Edinburgh, UK.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Measures of mortality in prostatic cancer.
PUBDATE: 19900301
The use of different expressions of mortality in prostate cancer can lead to difficulty in comparing reported data. We have used different measures of mortality in the same group of 438 patients presenting consecutively with histologically proven adenocarcinoma of the prostate, in order to assess the values and deficiencies of each method. The use of expected and relative survival is shown to be valuable in allowing indirect but objective assessment of disease specific mortality in prostatic cancer.


3. DOCID:19675 SCORE: 0.00145873695235298
DOCNO: 1428926
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aneuploidy
QUALIFIER: pathology
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: H P Rutz HP
AUTHOR: J M Calmès JM
AUTHOR: F Burri F
AUTHOR: J C Givel JC
AUTHOR: R O Mirimanoff RO
AFFILIATION: Laboratoire de radiobiologie, Centre hospitalier universitaire vaudois (CHUV), Lausanne.
PUBTYPE: Journal Article
JOURNALTITLE: Helvetica chirurgica acta.
COUNTRY: SWITZERLAND
TITLE: Detection of aneuploid subpopulations in colon cancer biopsies by cultivation in vitro prior to flow cytometric analysis.
PUBDATE: 19920801
Flow cytometry offers a relatively simple method to determine the DNA content of colorectal cancers. However, the technique can not discover minor changes in karyotype which may characterize near-diploid tumors, nor will it detect very small populations of aneuploid cells. In an attempt to improve the detection of such cells, we incubated biopsy material prior to analysis. This method revealed an aneuploid subpopulation in one of two biopsies studied. This simple protocol may ultimately lead to a more accurate assessment of the ploidy in colon cancer.


4. DOCID:18949 SCORE: 0.00115482449692798
DOCNO: 1507439
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Methicillin Resistance
QUALIFIER: microbiology
QUALIFIER: microbiology
QUALIFIER: drug effects
AUTHOR: R Sugita R
AFFILIATION: Department of Otorhinolaryngology, Juntendo Urayasu Hospital, Juntendo University School of Medicine.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [MRSA infections in otorhinolaryngology]
PUBDATE: 19920501
Infections caused by MRSA in otorhinolaryngology were evaluated in this study. From October 1990 to the end of September 1991, MRSA was detected in one hospitalized patient and 14 outpatients of the otorhinolaryngology department. MRSA was detected in the tonsils of five patients other patients--including four with cancer and other underlying diseases. In two of the four patients with chronic otitis media, otorrhea was stopped by disinfecting external ear toxin. Osteomyelitis of the upper jaw in neonates and infants must be treated in consideration of MRSA, as it is a hospital infection caused by cephem-resistant Staphylococcus.


5. DOCID:16950 SCORE: 0.00115482345000547
DOCNO: 2260866
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: Y Hayashi Y
AUTHOR: M Takahashi M
AUTHOR: H Yoshimura H
AFFILIATION: Division of Pathology, National Institute of Hygienic Sciences.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Carcinogenicity of anticancer agents]
PUBDATE: 19901201
Chemotherapeutic treatment for cancer has been successful in prolonging survival but it has also been demonstrated that survivors of cancer patients who had received chemotherapy with alkylating agents have an increased risk of second malignancies, mostly acute non-lymphatic leukemia. The purpose of this paper is to show practical problems pertaining to the development and clinical use of anticancer agents in terms of prevention of second cancers.


6. DOCID:17395 SCORE: 0.00114434327747054
DOCNO: 8513108
AUTHOR: L S Freedman LS
AUTHOR: D N Midthune DN
AUTHOR: C C Brown CC
AUTHOR: V Steele V
AUTHOR: G J Kelloff GJ
AFFILIATION: Biometry Branch, National Cancer Institute, Bethesda, Maryland 20892.
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: Statistical analysis of animal cancer chemoprevention experiments.
PUBDATE: 19930301
We explore the use of a statistical model proposed by Kokoska (1987, Biometrics 43, 525-534) for the analysis of animal cancer chemoprevention experiments. We show, using an example, that the results derived from the method can be sensitive to the parametric forms of the distributions that are assumed, particularly to the distribution of the number of tumors per animal. We propose goodness-of-fit tests to aid in the choice of the distributions.


7. DOCID:17447 SCORE: 0.00114434321678247
DOCNO: 1702234
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laser Surgery
QUALIFIER: surgery
AUTHOR: L Horák L
AUTHOR: F Rehák F
AUTHOR: J Marek J
AUTHOR: K Hamal K
AFFILIATION: III. chirurgická klinika FN II s FP UNZ NVP, Praha.
PUBTYPE: Journal Article
JOURNALTITLE: Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti.
COUNTRY: CZECHOSLOVAKIA
TITLE: [Initial experience in the use of the Nd:YAG Medicalas laser in the treatment of rectal cancer]
PUBDATE: 19901001
The authors tested experimentally and in clinical practice the Czechoslovak Nd:YAG laser Medicalas in the treatment of rectal and rectosigmoid cancer. The advantage of the apparatus is work two vavelengths: 1.064 microns and 1.32 microns. For treatment they use two steps with in an interval of 4-5 days. Hitherto assembled experience with the laser technique is favourable.


8. DOCID:17096 SCORE: 0.000850926223610562
DOCNO: 8290825
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: J Fleischmann J
AUTHOR: G Goldberg G
AFFILIATION: Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urology.
COUNTRY: UNITED STATES
TITLE: Management of superficial transitional cell carcinoma of the bladder.
PUBDATE: 19931101
Intravesical therapy for the treatment of existing bladder cancer or for prophylaxis of recurrent disease should be chosen according to the stage of transitional-cell cancer. Papillary disease (stages Ta, T1) may be treated effectively with either an alkylating agent or with BCG. BCG is the agent of choice for the treatment of Tis, provided that the treatment course includes 12 weekly and 12 monthly instillations.


9. DOCID:16175 SCORE: 0.000850925588558616
DOCNO: 2173148
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: prevention & control
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
AUTHOR: E F Ferguson EF
AUTHOR: B T McKibben BT
AFFILIATION: Department of Surgery, University of Florida School of Medicine, Jacksonville.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Preventing colorectal cancer.
PUBDATE: 19901101
Knowledgeable patients should not die of colorectal cancer. Increasing the intake of dietary fiber, decreasing fat consumption, and increasing the use of modern technology to detect adenomatous polyps and early cancer can greatly decrease the mortality associated with colorectal cancer.


10. DOCID:19547 SCORE: 0.000850920868685527
DOCNO: 8221674
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: drug therapy
AUTHOR: F Formelli F
AUTHOR: L Cleris L
AFFILIATION: Division of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity.
PUBDATE: 19931101
Fenretinide or N-(4-hydroxyphenyl) retinamide (4HPR) is a synthetic retinoid currently being tested clinically, which can inhibit the development and the growth of breast and prostate cancers in rodents. The efficacy of 4HPR alone and in combination with cisplatin was tested against the human ovarian carcinoma IGROV-1 xenograft i.p. Administration p.o. of 4HPR was not effective, whereas intracavitary treatment significantly increased the survival time of treated mice. It also enhanced the antitumor activity of cisplatin. These findings suggest that 4HPR may be an active agent against epithelial ovarian tumors.


11. DOCID:19830 SCORE: 0.00085091570238888
DOCNO: 1962775
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: M K Ferguson MK
AFFILIATION: Department of Surgery, University of Chicago, Illinois.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: ENGLAND
TITLE: Diagnosing and staging of non-small cell lung cancer.
PUBDATE: 19901201
Lung cancer remains the most common cause of death due to neoplasm in the United States. Despite recent efforts, early diagnosis provided through screening studies has not resulted in improved survival. Most lung cancer victims are symptomatic at presentation, and 50% have distant metastases. The diagnosis, often suspected on plain chest radiograph, can usually be confirmed with bronchoscopy or sputum cytology. The most useful routine staging evaluation, in addition to history and physical examination, is computed tomography. The routine use of other staging modalities is not recommended. A new staging system, currently in use throughout North America, western Europe, and Japan, permits accurate estimation of prognosis and assignment to therapeutic groups.


12. DOCID:18875 SCORE: 0.000850899824206057
DOCNO: 1548884
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: G M Boike GM
AUTHOR: S E Sightler SE
AUTHOR: H E Averette HE
AFFILIATION: Department of Obstetrics and Gynecology, Jackson Memorial Medical Center/University of Miami School of Medicine, Florida.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Treatment of small intestinal fistulas with octreotide, a somatostatin analog.
PUBDATE: 19920101
Three patients with external small bowel fistulas were successfully treated with bowel rest, total parenteral nutrition, and the somatostatin analog, octreotide. Two of the patients had received prior multimodality therapy, including radiation, for gynecologic cancer. The time intervals to fistula closure were 2 days, 10 days, and 5 weeks after initiation of octreotide therapy. The efficacy of octreotide combined with total parenteral nutrition in the treatment of external enteric fistulas supports its routine use, especially in previously irradiated patients.


13. DOCID:19568 SCORE: 0.000849833005525072
DOCNO: 1383517
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hospitals, District
DESCRIPTOR: Hospitals, General
DESCRIPTOR: Hospitals, Teaching
QUALIFIER: mortality
QUALIFIER: surgery
AUTHOR: R D Kingston RD
AUTHOR: S Walsh S
AUTHOR: J Jeacock J
AFFILIATION: Department of Clinical Studies, Trafford General Hospital, Manchester, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: SCOTLAND
TITLE: Colorectal surgeons in district general hospitals produce similar survival outcomes to their teaching hospital colleagues: review of 5-year survivals in Manchester.
PUBDATE: 19920801
A study of 578 patients treated for colorectal cancer in the North-west region comparing survival after surgery in teaching and non-teaching hospitals was performed. All patients had a minimum of 5 years follow-up. A greater proportion of elderly and emergency patients were treated in the non-teaching hospitals. The number of operative mortalities and 5-year survival figures for all causes of death and for colorectal deaths alone were similar in teaching and non-teaching hospital patients.


14. DOCID:18383 SCORE: 0.00054746512364527
DOCNO: 2183150
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: I Romics I
AUTHOR: C Rüssel C
AUTHOR: D Bach D
AFFILIATION: St. Agnes Hospital, Urológiai Osztály, Bocholt, NSZK.
PUBTYPE: Journal Article
JOURNALTITLE: Orvosi hetilap.
COUNTRY: HUNGARY
TITLE: [Experience with transrectal ultrasonic studies in patients with prostatic tumors]
PUBDATE: 19900201
The authors present the most typical forms of the prostatic cancer imaged by transrectal ultrasound. They compared the results of investigations of two tumor markers [prostatic specific antigen (PSA), prostatic acid phosphatase (PAP),] the transrectal ultrasound and the rectal palpation. The sensibility of PSA, the ultrasound and the digital investigation were almost the same. The valuability of the transrectal ultrasound investigation in the early diagnosis is limited, but important to determine the stage of the disease, monitoring the process, control of the proper treatment, and in some differential diagnostical problems of the prostate.