0. DOCID:3748 SCORE: 0.00354715091774751
DOCNO: 1152159
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
AUTHOR: S Brosman S
AUTHOR: M Hausman M
AUTHOR: S Shacks S
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Immunologic alterations in patients with prostatic carcinoma.
PUBDATE: 19750601
The state of cell-mediated immunity was evaluated in 41 patients with prostatic carcinoma by determining their ability to demonstrate delayed cutaneous hypersensitivity with dinitrochlorobenzene and recall antigens, and to mount an inflammatory response to croton oil, as well as by measuring changes in monocyte chemotactic response. The patients were divided into 2 groups: those with localized disease and those with metastatic carcinoma. Monocyte chemotactic response provides an in vitro quantitative measure of effector cell function and was significantly depressed in the entire group of prostatic cancer patients as compared to non-cancer controls (p less than 0.05). Patients with metastatic carcinoma had a greater defect than those with localized disease (p less than 0.025). After radical prostatectomy a group of patients with localized disease tended to show improvement in monocyte chemotactic response (p less than 0.025). The ability of patients to develop a delayed cutaneous hypersensitivity response was impaired and correlated with the clinical stage of the disease. By using the cutaneous irritant, croton oil, the ability of these cancer patients to mount an inflammatory response was also found to be impaired and showed a close correlation between clinical stage and course of disease. Changes in response to croton oil tended to precede alterations in dinitrochlorobenzene response.


1. DOCID:3247 SCORE: 0.00204481910826996
DOCNO: 1192362
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: genetics
AUTHOR: S Kakati S
AUTHOR: I Hayata I
AUTHOR: M Oshimura M
AUTHOR: A A Sandberg AA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Chromosomes and causation of human cancer and leukemia. X. Banding patterns in cancerous effusions.
PUBDATE: 19751101
Cells from five cancer effusions (two ovarian carcinomas, two lung cancers, and one carcinoma of the breast) were analyzed by G-, C-, and Q-banding techniques. The following observations were made: 1) The origin of some marker chromosomes could be traced accurately by these banding techniques. 2) Several chromosomes, which appeared normal with conventional staining techniques, were found to be re-arranged ones and, hence, abnormal. 3) Chromosomes No. 1, No. 3 and No. 11 were the most frequently involved in aberrations, whereas No. 12, No. 13, No. 17-20, and No. 22 Were least frequently involved. Only in one case each was the X chromosome or the Y chromosome involved in aberrations. The Y chromosome was found to be missing in all cancer cells of one lung cancer. 4) Each effusion had characteristic markers, invariably present in each cell, whether the cells were near diploid, or polyploid. 5) No common markers were observed in the two ovarian carcinomas studied, whereas the two lung cancers had a few common markers.


2. DOCID:2596 SCORE: 0.00174410322253891
DOCNO: 300279
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Saxon A
AUTHOR: J Portis J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Lymphoid subpopulation changes in regional lymph nodes in squamous head and neck cancer.
PUBDATE: 19770401
Lymph nodes from 10 normal patients and regional lymph nodes (RLN) from 19 patients with squamous cancer of the head and neck were evaluated as to their lymphoid subpopulations. In comparison to normal lymph nodes, RLN from cancer patients demonstrated a marked increase in the proportion of cells with membrane immunoglobulin, the receptor for the third component of complement, and the receptor for the Fc portion of immunoglobulin G. The increased Fc receptor cells were not Fc-bearing thymus-derived lymphocytes, inasmuch as they separated with the non-sheep erythrocyte-lymphocyte rosette-forming population. The overall thymus-derived lymphocyte percentage in RLN was proportionally decreased. A transition from the normal lymph node composition to the altered lymphocyte profile seen in RLN was demonstrated on moving from distal lymph nodes to RLN within the lymphatic drainage of a tumor. Lymph nodes involved with tumor also showed the pattern of bursa equivalent cell population increases.


3. DOCID:3585 SCORE: 0.00174400181795057
DOCNO: 200253
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: R A Hawkins RA
AUTHOR: A Hill A
AUTHOR: B Freedman B
AUTHOR: S M Gore SM
AUTHOR: M M Roberts MM
AUTHOR: A P Forrest AP
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Reproducibility of measurements of oestrogen-receptor concentration in breast cancer.
PUBDATE: 19770901
The reproducibility of measurements of oestrogen-receptor activity has been examined in multiple specimens from a rabbit uterus, a rat mammary tumour and human breast tumours. The relationship between receptor concentration and tumour histology has also been investigated in 11 large primary tumours. In the animal tissues, receptor measurements were relatively reproducible (coefficient of variance: wet wt. basis 16-17%, protein basis 16-21%) but in human breast tumours receptor activity varied considerably (c.v.: wet wt. basis, 22-125%; protein basis, 28-72%). In addition to these variations in receptor activity within tumours, there was a difference between tumours, as demonstrated by an analysis of variance (P less than 0.01). In the 11 primary breast cancers selected for study, the level of receptor activity was related to menopausal status and the tumour content of the specimen. We conclude that the receptor activity detected varies within a tumour and depends upon the tumour content of the biopsy specimen. Predictions based on precise quantitation of receptor concentrations may therefore necessitate replicate tumour sampling and correction for the fraction of non-tumour tissue in each sample.


4. DOCID:3955 SCORE: 0.00144344208569866
DOCNO: 132791
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Documentation
DESCRIPTOR: Neoplasms
DESCRIPTOR: Periodicals
AUTHOR: L Sandor L
AUTHOR: R P Kraft RP
AUTHOR: G Wagner G
AUTHOR: R G Henzler RG
AUTHOR: M Wolff-Terroine M
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology.
COUNTRY: GERMANY, WEST
TITLE: Analysis of the structure of cancer literature based on SABIR-C. III. A survey of the distribution of the world oncological publications from 1969-1974.
PUBDATE: 19760601
The great number of disciplines involving oncology and the exponential growth in the number of publications make it increasingly more difficult to keep abreast of the important oncological literature appearing in a large number of periodicals. It is, therefore, essential for the oncologist to be up to date with the journals and to read the papers relevant to his specialty. The cancer literature information system SABIR-C developed by the French and German Cancer Research Centers was created for this purpose. The present paper analyses 54496 papers published in periodicals covered by the SABIR-C system in the period from January 1969 to October 1974. The tables included contain the titles of periodicals which are of particular relevance for cancer research. They permit a quick orientation with regard to the important sources of oncological publications. These tables also assist the librarian working in a cancer research institution in selecting the most important and quantitatively most productive periodicals. This is especially important since he usually has only limited financial resources at his disposal. Further tables give a survey of the countries of origin and the categories to which the latest oncological literature belongs.


5. DOCID:2133 SCORE: 0.00144339264242082
DOCNO: 903152
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, 1-3
DESCRIPTOR: Heterochromatin
QUALIFIER: genetics
AUTHOR: N B Atkin NB
AUTHOR: V J Pickthall VJ
PUBTYPE: Journal Article
JOURNALTITLE: Human genetics.
COUNTRY: GERMANY, WEST
TITLE: Chromosomes 1 in 14 ovarian cancers. Heterochromatin variants and structural changes.
PUBDATE: 19770801
Structurally rearranged chromosomes 1 were found in 9 out of 14 ovarian carcinomas and may also have been present in three others. In the remaining two, pericentric inversions involving the heterochromatic regions of chromosomes 1 were seen, and were also identified in one of the chromosomes 1 in the patient's normal cells (lymphocytes). Altogether, heterochromatin variants (variation in size and/or the presence of a pericentric inversion) were seen in the tumour cells of eight cases, and one or both types of variation were identified in the normal cells of six of these. The possibility of an association between the presence of chromosome 1 heterochromatin variants as a constitutional anomaly, a liability to ovarian (and perhaps other forms of) cancer and structural changes involving the chromosomes 1 in the tumour cells is considered.


6. DOCID:240 SCORE: 0.00114261900572933
DOCNO: 1234628
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: therapeutic use
AUTHOR: H J Buchsbaum HJ
AUTHOR: W C Keettel WC
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Radioisotopes in treatment of stage Ia ovarian cancer.
PUBDATE: 19751001
The role of radioisotopes in the treatment of ovarian carcinoma is discussed. The University of Iowa experience with prophylactic treatment of stage Ia ovarian cancer with radiogold is presented. Cumulative survival in 56 patients with epithelial cancers was 94.3%. In a prospective study, we compare the use of radiogold and total abdominal irradiation in the treatment of stage Ia ovarian carcinoma.


7. DOCID:3078 SCORE: 0.00114204789986455
DOCNO: 613232
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Asian Continental Ancestry Group
DESCRIPTOR: HLA Antigens
QUALIFIER: immunology
AUTHOR: M J Simons MJ
AUTHOR: N E Day NE
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Histocompatibility leukocyte antigen patterns and nasopharyngeal carcinoma.
PUBDATE: 19771201
Incidence patterns indicated the prominent role of genetic factors in this type of cancer. A histocompatibility leukocyte antigen (HLA) profile of A2 and B-locus antigen, Singapore 2 (Sin 2), was identified. An association between these genes and increased risk for nasopharyngeal carcinoma (NPC), was confirmed. The risk was restricted to the "co-occurrence" of A2, B-Sin 2, suggesting that the genotype predisposing to the development of NPC was the A, B-Sin 2 haplotype. Similar associations were found to exist in Malaysian and Hong Kong Chinese so the A2, B-Sin 2 phenotype is a feature common to Asian Chinese in at least three locations. Preliminary HLA studies of medium NPC incidence in Tunisians and Malays indicated that patients with NPC of both ethnic types have altered HLA antigen profiles. If the findings of a locus-B antigen deficit in Tunisians and the role of A9 with B-locus antigens in Malays can be confirmed and clarified, the histocompatibility genetic hypothesis of NPC predisposition would be substantially strengthened.


8. DOCID:3724 SCORE: 0.000902019744446357
DOCNO: 560730
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Division
QUALIFIER: pathology
AUTHOR: H Sato H
AUTHOR: M Goto M
AUTHOR: S Hosaka S
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Growth behavior of ascites tumor cells in three-dimensional agar culture.
PUBDATE: 19770601
Growth behavior in vitro of ascites tumor cells was examined for a model study on the invasion in cancer. For this purpose three-dimensional agar culture was used. Seventeen strains of tumor cells were used. These tumor cells grow floating in ascites as single isolated cells (single cell strain) or forming different per cent of cell aggregates (island type strain). Plating efficiencies of tumor cells were variable, depending on the kinds of tumor stain. It was noted that FM3A cells of the cultured cell line showed almost 100% plating efficiency irrespective of the number of cells inoculated. Tumor cells formed 3 types of colony; that is solid type, mushroom-shaped and disk-shaped colony. These three types of colony were observed in all the tumor strains tested, depending on the position in agar layer. The cells of single cell strains showed the tendency to form loose colonies in which cell contact was loose and cells were easy to liberate from the periphery of the colony. The cells of island type strains showed the tendency to form packed colonies in which cell contact was tight. Growth behavior of cells of ascites tumor in agar medium showed good correlation with that in susceptible animals.


9. DOCID:2125 SCORE: 0.000843578052952399
DOCNO: 1058997
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Recurrence, Local
DESCRIPTOR: Rectal Neoplasms
QUALIFIER: surgery
AUTHOR: R Winkler R
PUBTYPE: Journal Article
JOURNALTITLE: Langenbecks Archiv für Chirurgie.
COUNTRY: GERMANY, WEST
TITLE: [Recurrence of rectal cancer (author's transl)]
PUBDATE: 19750601
36 cases of recurrent rectal cancer are reported. There is a wide-spread spectrum in the appearance of the relapse. Indirect symptoms are dominating. The most frequent of them are caused by obstruction of the bowl or the urinary pathways and by irritation of (lumbo-) sacral nerves. Especially rare manifestations are stressed. Often they are hardly regarded early symptoms of the recurrent cancer. Curative therapy was made 5-times by amputation, 2-times by resection of an anastomosial recurrence. 3 of these patients reach a survival rate over 18 months until now. An isolated pulmonary late-metastasis was removed by lobectomy; this patients shows no recurrence for the last 3 years. Palliative procedures took place in 20 patients. The worth of radiation therapy is to be seen in a (temporary) reduction of pain. Chordotomy remains as ultima ratio for uninfluencable pain.


10. DOCID:2034 SCORE: 0.000841982137402983
DOCNO: 856458
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: P T Cole PT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Oral contraceptives and breast neoplasia.
PUBDATE: 19770401
The continued high prevalence of oral contraceptive (OC) use by young women warrants the careful study of these agents. At present, it appears that the risk of benign breast disease is reduced by use of OCs. This effect seems to be greater for fibrocystic disease than for fibroadenoma. Available information suggests that, as yet, OC use has not had any effect on breast cancer risk. The recent slight rise in breast cancer rates in younger women has not been shown to be due to OC use. The relationship between OCs and breast cancer may not become clear for another 5 to 10 years because of the long latent period of this disease. Meanwhile, for reasons presented, it would seem wise not to prescribe OCs for women with a history of benign breast disease and to withdraw them from women who develop these conditions.


11. DOCID:2585 SCORE: 0.000841979933361356
DOCNO: 930972
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pelvic Exenteration
AUTHOR: F N Rutledge FN
AUTHOR: J P Smith JP
AUTHOR: J T Wharton JT
AUTHOR: A G O'Quinn AG
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Pelvic exenteration: analysis of 296 patients.
PUBDATE: 19771201
An analysis of 296 patients who had pelvic exenteration discloses a high risk of postoperative complications and death; however, the safety has been improved by technical modifications for urinary diversion and treatment of the denuded pelvic cavity. Recurrent cancer of the cervix or vagina was the main reason for the operation. Prognostic factors were sought to improve selection of patients who are able to withstand operation, tolerate postoperative complications, and remain free of cancer. The five-year survival rate for 296 patients with various types of cancer calculated by the Berkson-Gage method was 56.5 per cent after death from all causes were deducted, the rate was 42.1 per cent. The five-year survival rate for 196 patients with recurrent carcinoma of the cervix calculated by the Berkson-Gage method was 48.3 per cent; after deaths from all causes were deducted, the rate was 33.8 per cent.


12. DOCID:3173 SCORE: 0.000841973967170388
DOCNO: 326386
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Receptors, Estrogen
DESCRIPTOR: Receptors, Progesterone
QUALIFIER: metabolism
AUTHOR: W L McGuire WL
AUTHOR: K B Horwitz KB
AUTHOR: O H Pearson OH
AUTHOR: A Segaloff A
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Current status of estrogen and progesterone receptors in breast cancer.
PUBDATE: 19770601
Breast cancer is often hormone responsive, since growth or regression of tumors can often be modulated by appropriate endocrine manipulations. Estrogen and progesterone appear to be major hormones involved in regulation of breast tumor growth. It has been recently argued that a more accurate marker of hormonal responsiveness might result if an end product of an intact estrogen response system were measured instead of the initial hormone binding step. Progesterone receptor (PgR) has been investigated in this regard since it can be readily measured in human breast tumors and there is clear evidence in experimental breast tumor model systems that PgR is under acute estrogen control. PgR is rarely found in ER- metastatic breast tumors but is present in approximately 59% of ER+ metastatic tumors, especially in those tumors with high levels of ER. Preliminary clinical correlation of ER, PgR and response to endocrine therapy is encouraging. The response rate is significantly higher if the tumor contains both ER and PgR than if the tumor contains ER alone.


13. DOCID:2672 SCORE: 0.000841958220708204
DOCNO: 1228258
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Streptococcus
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: T Hattori T
AUTHOR: M Nimoto M
AUTHOR: S Yamagata S
AUTHOR: T Tohge T
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Clinical studies on streptococcal preparation (OK-432) combined with mitomycin-C, 5-FU and cytosine arabinoside in advanced cancer patients.
PUBDATE: 19750901
Streptococcal preparation (OK-432), a new type of anti-cancer agent, was given to the patients with advanced cancer in combination with Mitomycin-C, 5-FU and Cytosine arabinoside. OK-432 was administered intramuscularly with a daily dose of 2.0 KE consecutively or locally into the tumor with a large-dose of 100 KE. Most cases tolerated the long term administration of OK-432 without any severe side effects and the highest dose reached was 314 KE during 161 days of treatment. Of the 53 patients evaluated, 31 were given the initial large dose intratumoral OK-432. Thirteen were judged 0-C and Category 1 according to the Karnofsky criteria for a response rate of 44.8 per cent as compared with 12.5 per cent in the group without the initial large-dose administration.


14. DOCID:1101 SCORE: 0.000841892177009934
DOCNO: 797264
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Famous Persons
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: R M Steckler RM
AUTHOR: D P Shedd DP
PUBTYPE: Biography
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: General Grant: his physicians and his cancer.
PUBDATE: 19761001
In early June 1884, seven years after leaving office as President of the United States, General Ulysses S. Grant was found to have carcinoma of the right tonsillar pillar. The General's physicians kept a detailed record of the course of their patient's disease. Speaking was quite painful for the patient, and his words and thoughts have been preserved on the scraps of paper on which he communicated to family, physicians, and friends. The diagnosis, symptomatic treatment, and inexorably progressive course of General Grant's mouth cancer taking place in an atmosphere of personal financial ruin are discussed in detail.