0. DOCID:23356 SCORE: 0.00333276309012482
DOCNO: 7649244
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: V Darley-Usmar V
AUTHOR: H Wiseman H
AUTHOR: B Halliwell B
AFFILIATION: Biology Division Wellcome Research Laboratories, Kent, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: FEBS letters.
COUNTRY: NETHERLANDS
TITLE: Nitric oxide and oxygen radicals: a question of balance.
PUBDATE: 19950801
The production of superoxide and nitric oxide individually has been associated with the development of several diseases but only recently has it been realised that interactions between them may also be important in disease pathology. The central hypothesis which is emerging is that the balance between nitric oxide and superoxide generation is a critical determinant in the aetiology of many human diseases including atherosclerosis, neurodegenerative disease, ischaemia-reperfusion and cancer. These ideas are discussed in this short overview and placed in the context of the current and future status of therapies which could modulate the balance between nitric oxide and superoxide.


1. DOCID:23766 SCORE: 0.00208651430536494
DOCNO: 7890588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: G Villeirs G
AUTHOR: M Mortier M
AUTHOR: C De Potter C
AUTHOR: M Kunnen M
AFFILIATION: Dienst Radiologie, Universitair Ziekenhuis, Gent.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal belge de radiologie.
COUNTRY: BELGIUM
TITLE: [Breast calcifications]
PUBDATE: 19950201
Calcifications are found in many women undergoing mammography. The majority of these calcifications are benign. Calcifications suggestive for malignancy prove to be cancer in about 30% of cases after biopsy. Study and personal experience should result in ready recognition of characteristically benign calcifications. Calcifications suggestive for malignancy should be biopsied and the ratio of malignant over benign biopsies should be as high as possible. The purpose of this paper is to present a practical approach to the evaluation of breast calcification, by means of a survey of the pattern of calcifications in breast pathology. We describe six types of typically benign calcifications and six criteria that entail an increased risk of malignancy.


2. DOCID:22738 SCORE: 0.000858387162787678
DOCNO: 7797833
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Second Primary
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: D G Begos DG
AUTHOR: S Kuan S
AUTHOR: J Dobbins J
AUTHOR: T S Ravikumar TS
AFFILIATION: Department of General Surgery, Yale University of School of Medicine, New Haven, CT 06510, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Metachronous small-bowel adenocarcinoma in celiac sprue.
PUBDATE: 19950401
Celiac sprue, or nontropical sprue, is associated with an increased incidence of digestive tract malignancy. We report a patient with celiac sprue who developed two primary adenocarcinomas of the jejunum > 2 years apart. The second cancer was asymptomatic and detected by surveillance computed tomography. Small-bowel cancers are unusual, and frequency of follow-up has not been established, so that it is important to have a high index of suspicion for these malignancies in celiac patients with vague gastrointestinal symptoms.


3. DOCID:23769 SCORE: 0.000858375708055757
DOCNO: 7890994
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hematoporphyrin Photoradiation
QUALIFIER: blood supply
QUALIFIER: drug therapy
AUTHOR: P Sieg P
AUTHOR: J Rosperich J
AUTHOR: A Walther A
AFFILIATION: Medizinische Universität zu Lübeck, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of oral and maxillofacial surgery.
COUNTRY: DENMARK
TITLE: Laser blood-flow measurements in malignant tumors during photodynamic therapy (PDT)--an experimental study.
PUBDATE: 19941201
Laser blood-flow measurements were made on the tumor surface of 18 human oral cancer tumors growing on the shank of nude mice during and up to 6 h after photodynamic therapy (PDT) to detect changes in microcirculation. In eight animals, the same procedure was done without PDT. Simultaneously, the skin microcirculation in the contralateral leg was measured to detect systemically caused changes in microcirculation. Two days later, specimens of the tumor region were taken and analyzed histologically. Our results suggest a mainly direct effect of PDT on the tumor cells rather than tumor necrosis caused by decreased microcirculation.


4. DOCID:21573 SCORE: 0.000858370767243661
DOCNO: 7712635
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R A Gatti RA
AFFILIATION: Department of Pathology and Laboratory Medicine, University of California Los Angeles School of Medicine, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Dermatologic clinics.
COUNTRY: UNITED STATES
TITLE: Ataxia-telangiectasia.
PUBDATE: 19950101
Ataxia-telangiectasia is a complex syndrome that includes a very high cancer risk in children with a progressive cerebellar ataxia, the onset of which occurs in early infancy. Ocular telangiectasiae often do not appear until several years after the ataxia. The most common type of malignancy is lymphoma, usually of the B-cell type. Leukemias also occur. Failure to diagnose ataxia-telangiectasia in an infant with lymphoma or leukemia may result in radiation therapy with conventional dosages, which is contraindicated in ataxia-telangiectasia patients.


5. DOCID:21245 SCORE: 0.000858365742281108
DOCNO: 7731448
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Larynx, Artificial
DESCRIPTOR: Speech, Alaryngeal
QUALIFIER: rehabilitation
AUTHOR: J H Boyd JH
AUTHOR: M Varvares M
AUTHOR: S Fitzmaurice S
AFFILIATION: Department of Otolaryngology, Head and Neck Surgery, St. Louis University Health Sciences Center, MO 63110, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Missouri medicine.
COUNTRY: UNITED STATES
TITLE: Voice rehabilitation after laryngectomy.
PUBDATE: 19950301
Unfortunately, laryngeal cancer commonly presents at a stage necessitating total laryngectomy. Voice rehabilitation in the past has primarily been with the electrolarynx or esophageal speech. Tracheoesophageal puncture (TEP) is a technique that has replaced the other two methods as the rehabilitative procedure of choice in most total laryngectomy patients. This report details this technique, as well as a brief discussion of the etiology and treatment of laryngeal cancer.


6. DOCID:22976 SCORE: 0.000551826870806771
DOCNO: 9017586
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: E R Salomaa ER
AUTHOR: K Liippo K
AUTHOR: J Ellmen J
AUTHOR: J Komi J
AFFILIATION: Turku University Hospital, Department of Pulmonary Diseases and Clinical Allergology, Preitilä, Finland.
PUBTYPE: Clinical Trial
PUBTYPE: Clinical Trial, Phase II
PUBTYPE: Journal Article
JOURNALTITLE: Lung cancer (Amsterdam, Netherlands)
COUNTRY: IRELAND
TITLE: Ifosfamide combined with toremifene in the treatment of non-small cell lung cancer.
PUBDATE: 19961201
The efficacy and safety of toremifene-ifosfamide as a first-line chemotherapy in non-small cell lung cancer were assessed. Sixteen patients were treated with oral toremifene (420 mg on days 1-4 and 240 mg on day 5) followed by ifosfamide infusion 5 g/m2 on day 5 every 3 weeks 1-6 times. Toremifene at the doses used did not enhance the effect or toxicity of ifosfamide in previously untreated non-small cell lung cancer patients.


7. DOCID:21664 SCORE: 0.000551821055412381
DOCNO: 9280223
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: J C Ruckdeschel JC
AFFILIATION: H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612-9497, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Combined modality therapy of non-small cell lung cancer.
PUBDATE: 19970801
Combined modality therapy of locally advanced non-small cell lung cancer has become a widely used means of treatment with several reports of benefit found in randomized phase III trials. Progress in this area may, however, be less substantive than it appears. Phase III trials routinely take the better part of a decade to initiate, complete, and analyze, and the flood of phase II trials are largely unable to be compared because of a widespread failure to systematically use readily available staging techniques.


8. DOCID:22312 SCORE: 0.000551820856762121
DOCNO: 7761364
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: G Le Bouëdec G
AUTHOR: J P Buono JP
AUTHOR: M De Latour M
AUTHOR: E Toledano E
AUTHOR: T Vergote T
AUTHOR: J Dauplat J
AFFILIATION: Centre Jean Perrin, Clermont-Ferrand.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Presse médicale (Paris, France : 1983)
COUNTRY: FRANCE
TITLE: [Stewart-Treves syndrome. Immunohistochemical study apropos of 2 cases]
PUBDATE: 19950401
Two women (63 and 68 years) presented with primary angiosarcomas of the skin which had developed on an area of chronic lymphoedema after radiosurgical treatment for breast cancer 4 and 13 years earlier. Immunohistochemistry tests formally eliminated epithelial metastasis and produced evidence in favour of lymphatic or capillary vascular proliferation. Endothelial affinity for anti-factor VIII and positive tests for certain markers of intermediary filaments (actin, vimentin) confirmed the vascular and conjunctive tissue origin of the tumours.


9. DOCID:20846 SCORE: 0.000551820791771604
DOCNO: 9253392
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Odds Ratio
AUTHOR: A Morabia A
AUTHOR: T Ten Have T
AUTHOR: J R Landis JR
AFFILIATION: Clinical Epidemiology Division, University Hospital, Genève, Switzerland.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical epidemiology.
COUNTRY: ENGLAND
TITLE: Interaction fallacy.
PUBDATE: 19970701
We define interaction fallacy as the situation in which heterogeneity of odds ratios suggests an interaction that does actually not exist among the corresponding risk ratios. We provide a hypothetical example of interaction fallacy between the presence of the germ-line BRCA1 mutation, age at first live birth, and breast cancer risk based on data from the literature. More generally, we present a set of hypothetical conditions under which interaction fallacy may occur.


10. DOCID:20144 SCORE: 0.000551817909932664
DOCNO: 8939708
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
AUTHOR: L M Coussens LM
AUTHOR: Z Werb Z
AFFILIATION: Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0534, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chemistry & biology.
COUNTRY: ENGLAND
TITLE: Matrix metalloproteinases and the development of cancer.
PUBDATE: 19961101
Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multi-stage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.


11. DOCID:21806 SCORE: 0.000551817236729006
DOCNO: 8705897
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Hourany J
AUTHOR: R P Byrd RP
AUTHOR: T M Roy TM
AFFILIATION: Division of Pulmonary Medicine, James H. Quillen College of Medicine, Johnson City, TN, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tennessee medicine : journal of the Tennessee Medical Association.
COUNTRY: UNITED STATES
TITLE: Cardiac tamponade as the initial presentation of bronchioloalveolar cell carcinoma.
PUBDATE: 19960701
Bronchioloalveolar cell carcinoma (BCC) is a relatively uncommon form of bronchogenic cancer with an insidious onset and a variety of radiographic appearances. Although the World Health Organization currently classifies it as a subtype of adenocarcinoma, many investigators view BCC as a distinct tumor with characteristic clinical features. There are still uncertainties regarding its origin, as well as the significance of associated clinical findings such as cardiac tamponade.


12. DOCID:22641 SCORE: 0.000551816422998682
DOCNO: 8695926
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: F Eichler F
AUTHOR: R Keiling R
AFFILIATION: Service d'oncologie, CHU, Strasbourg, France.
PUBTYPE: Journal Article
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Survival results after 10 years of 39 patients with inflammatory breast cancer treated by two different neoadjuvant chemotherapy protocols]
PUBDATE: 19960301
The aim of this study was to compare the survival results at ten years of two groups of respectively 19 and 20 females who had an inflammatory breast cancer, treated with two different neoadjuvant chemotherapy protocols of six days for the first one, and of one day for the second one. Among these 39 patients, 16 are alive, 15 without any symptoms of disease since the end of the treatment. There is no statistically significant difference between the two groups for the disease free survival interval and for the survival population.


13. DOCID:20904 SCORE: 0.000551816238818009
DOCNO: 8795649
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: T R Williams TR
AUTHOR: N Love N
AFFILIATION: Boca Raton Community Hospital, Florida, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Treatment of localized prostate cancer. Choosing the best alternative.
PUBDATE: 19960901
Thousands of men will be faced with a diagnosis of prostate cancer this year and will turn to their primary care physician for advice about which treatment is best. Unfortunately, there are no easy answers, and multiple factors, including the patient's age, must be weighed in decision making. In this article, Drs Williams and Love sift through the pros and cons of the available treatment options for various profiles of organ-confined disease.


14. DOCID:23779 SCORE: 0.000551815114175504
DOCNO: 7936544
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Endometrial Neoplasms
DESCRIPTOR: Estrogen Replacement Therapy
DESCRIPTOR: Ovarian Neoplasms
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: F G Nason FG
AUTHOR: B E Nelson BE
AFFILIATION: Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Obstetrics and gynecology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Estrogen and progesterone in breast and gynecologic cancers. Etiology, therapeutic role, and hormone replacement.
PUBDATE: 19940601
Cancers of the endometrium, ovary, and breast share common risk factors, including obesity, high fat diet, and late menopause as well as an increased risk with a family and personal history of any of these cancers. Despite an extensive literature investigating the role of estrogen and progesterone in these malignancies, the exact etiologic capacity of these hormones is not yet determined. Until current studies mature, assessment of the possible risks and known benefits is the only platform on which to base treatment decisions for the individual patient.