0. DOCID:7704 SCORE: 0.000865092651627536
DOCNO: 7229433
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiation effects
QUALIFIER: radiation effects
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: I Willis I
AUTHOR: J M Menter JM
AUTHOR: H J Whyte HJ
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of investigative dermatology.
COUNTRY: UNITED STATES
TITLE: The rapid induction of cancers in the hairless mouse utilizing the principle of photoaugmentation.
PUBDATE: 19810501
We report a method for rapidly inducing cancer in the hairless mouse utilizing regimen in which an exposure to highly erythemogenic, but otherwise clinically noninjurious, dose of broad spectrum (290-400 nm) ultraviolet light is increased by 20% every 6th day. Clinical and histological observations reveal the presence of squamous cell cancer after as little as 18 days of irradiation. The rate of cancer induction is enhanced by the 320-400 nm component and this enhancement is shown to be a photoaugmentative effect. The results support the idea that stratum corneum and/or malpighian layer thickening produced in early stages of tumor induction tends to protect against the detrimental effects of UV radiation. Strict monitoring of both the spectral distribution and output of the radiation source is imperative for reproducible rates of tumor induction.


1. DOCID:7547 SCORE: 0.000865092442616577
DOCNO: 699228
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: L Beluffi L
AUTHOR: F Lungarotti F
AUTHOR: M Sebastiani M
AUTHOR: A Sensini A
PUBTYPE: Journal Article
JOURNALTITLE: Chirurgia italiana.
COUNTRY: ITALY
TITLE: [Personal experience with anterior resection of the rectum]
PUBDATE: 19781001
Authors experience in the Dixon's operation regarding the surgical treatment of cancer of the rectum and recto-sigmoid junction is reviewed. It consists in 224 cases of malignant lesions which were treated by Miles operation (106 cases--47%), Dixon's operation (49 cases--21%), palliation anterior resection (16 cases--7%), other operations (53 cases--24%). After a brief discussion on anatomo-pathological conditions and tecniques, the Authors consider their results: operatory mortality 4%; complications: total anastomosis dehiscence 1 case, partial anastomosis dehiscence 14%; local repetitions 10%; hepatic metastasis within 5 ys 40%; survival at 5 ys 46%. Functional results were always very good. The Authors conclude that, even considering the large rate (56%) of wide-spread cancers treated, Dixon's operation, at least in their experience, doesn't seem to satisfy those needs of radically requested by a correct surgical therapy, which only Miles' operation guarantees.


2. DOCID:6242 SCORE: 0.000865091535048666
DOCNO: 6930985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K W Barwick KW
AUTHOR: A G Huvos AG
AUTHOR: J Smith J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients.
PUBDATE: 19800801
In a review of more than 1000 patients with osteogenic sarcoma of bone, the vertebral column was the site of the primary tumor in 10 patients. The vertebral osteogenic sarcoma in 4 of the 10 patients was secondary; to Paget's disease of bone in 3, and to irradiation received for a prior cancer in 1. Frequently, cord compression caused severe neurologic symptoms. Prognosis was always poor. Seven patients died of their disease within a year of histologic diagnosis. The differential diagnoses between osteogenic sarcoma and three benign tumors are reviewed, osteoblastoma being the tumor most frequently confused with osteogenic sarcoma. The radiologic and histologic criteria for distinguishing between the two are discussed.


3. DOCID:4156 SCORE: 0.000865087881975828
DOCNO: 505833
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cardia
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: A A Rusanov AA
AUTHOR: M I Dolgorukov MI
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Surgical treatment of cardial and gastroesophageal neoplasms]
PUBDATE: 19790701
The experience in surgical treatment of cancer of the proximal portion of the stomach in 1003 patients is described. The transpleural access was used in 452 operations. The authors believe that long-term results of the surgery are mostly dependent on the spread of tumour and the type of tumour growth.


4. DOCID:6287 SCORE: 0.00085821793806081
DOCNO: 7352201
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: M Moskowitz M
AUTHOR: P Gartside P
AUTHOR: J A Wirman JA
AUTHOR: C McLaughlin C
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Proliferative disorders of the breast as risk factors for breast cancer in a self-selected screened population: pathologic markers.
PUBDATE: 19800201
A study was done to quantify the pathologic risk of subsequent breast cancer in women whose biopsies demonstrated proliferative histologic conditions. Out of a total of 10,530 patients, 1,408 had biopsies which were classified as either bland fibrocystic or hyperplastic. The behavior of the disease in these patients was compared to that of the general screened population. It was concluded that women whose biopsies reveal hyperplastic disorder, primarily atypical hyperplasia and fibroadenoma, run the greatest risk of getting cancer. For women with atypical hyperplasia, the risk is 13 times that of the general population, and for those with fibroadenoma it is three times greater.


5. DOCID:7897 SCORE: 0.000556143032176953
DOCNO: 7008762
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: B N Gray BN
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Colorectal cancer: the modern treatment of disseminated disease - a review.
PUBDATE: 19801201
Most patients who develop cancer of the large bowel will eventually develop recurrence and will therefore be considered for treatment of that recurrence. There exists very great confusion as to the efficacy of the various treatment options available. This review has attempted to evaluate critically the claim for therapeutic efficacy of the various treatment options, with particular regard to patients with liver metastases from primary tumours of the large bowel. A case can be made out for surgical removal of recurrent or disseminated colorectal cancer, but there is no evidence that any form of treatment other than total surgical excision will result in prolonged patient survival. All forms of treatment can be effective in palliating symptomatic patients. Therefore, with the exception of total surgical excision of recurrent tumour, treatment should be reserved for those patients with symptoms, and the choice of treatment offered should be weighed against possible side-effects.


6. DOCID:5755 SCORE: 0.000556141027494608
DOCNO: 6969375
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: utilization
AUTHOR: W H Isbister WH
PUBTYPE: Journal Article
JOURNALTITLE: The New Zealand medical journal.
COUNTRY: NEW ZEALAND
TITLE: Flexible fibreoptic sigmoidoscopy--an alternative to colonoscopy?
PUBDATE: 19801001
The results of 166 colonoscopic examinations are reported with particular reference to site and nature of the lesion identified. One hundred and fifty-five polyps and 13 colorectal cancers were found, 62 polyps and five cancers being beyond 50 cm from the anal verge. It is suggested that the number of lesions beyond the reach of a flexible fibreoptic sigmoidoscope would be unacceptably high and that there can be no justification for the purchase of such an instrument as an alternative to a full length colonoscope. Whilst the fibreoptic instrument does have advantages as a sigmoidoscope its cost will preclude its widespread use in New Zealand at the present time.


7. DOCID:4352 SCORE: 0.000556135777318518
DOCNO: 706829
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: epidemiology
AUTHOR: B Junod B
AUTHOR: F Lévi F
PUBTYPE: Journal Article
JOURNALTITLE: Sozial- und Präventivmedizin.
COUNTRY: SWITZERLAND
TITLE: [Morphologic distribution of tumors occuring in the canton of Vaud]
PUBDATE: 19780801
After a short presentation of the methodological aspects of cancer registration and morphological coding, the results concerning cancer of the upper digestive tract, lung, testis and ovary were discussed. Some distributions of the main histological types are analysed by age, sex, site and multiple primaries. Known statistical associations are described between morphology and sex for lung cancer and between morphology and controlateral tumor for ovary.


8. DOCID:5570 SCORE: 0.000556134649771594
DOCNO: 7318402
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: P Sherlock P
AUTHOR: S J Winawer SJ
PUBTYPE: Journal Article
JOURNALTITLE: Comprehensive therapy.
COUNTRY: UNITED STATES
TITLE: Colon and rectal cancer: etiology and screening.
PUBDATE: 19811201
Our ultimate goal is primary prevention of colorectal cancer by delineating the etiologic factors in the pathogenesis of the disease and eliminating or modifying these factors. Further research is needed to accomplish this goal. In the meantime, early detection of colorectal cancer and its precursor lesions can be accomplished by methods currently available. Ultimately, a simple biochemical or immunologic test may become available which will identify individuals at high risk for colon cancer and may indicate that a very early lesion is present. This is the ultimate goal for secondary cancer prevention since the disease would then be discovered at a curable stage in almost all patients.


9. DOCID:7903 SCORE: 0.000556134189576733
DOCNO: 6986082
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: epidemiology
QUALIFIER: prevention & control
AUTHOR: H D Costello HD
AUTHOR: D E Snider DE
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: The incidence of cancer among participants in controlled, randomized isoniazid preventive therapy trial.
PUBDATE: 19800101
Cancer morbidity and mortality were examined among 11,894 Puerto Rican participants in a US Public Health Service preventive therapy trial begun in 1957. The mean duration of follow-up was 18 years (range 16-19 years). No statistically significant difference in overall cancer rates was observed between the participants in the trial assigned isoniazid and those assigned placebo. There were also no significant differences between the groups when rates for specific types of cancer and age-specific cancer rates were compared. No trend toward an increasing cancer rate in the isoniazid group was observed with the passage of time. The mortality rate due to cancer was similar in the two groups. These data coupled with other information reported in the literature provide substantial evidence that isoniazid, when given in the usual therapeutic doses, is not carcinogenic in humans.


10. DOCID:7654 SCORE: 0.000556134041955985
DOCNO: 7235946
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: R C Hickey RC
AUTHOR: N A Samaan NA
AUTHOR: G L Jackson GL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Hypercalcemia in patients with breast cancer. Osseous metastases, hyperplastic parathyroid tissue, or pseudohyperparathyroidism?
PUBDATE: 19810501
Breast cancer is the malignant neoplasm most commonly associated with hypercalcemia. At the University of Texas M. D. Anderson Hospital, Houston, during the fiscal year 1977 to 1978, of 16,887 patients having calcium determinations, 7.8% had hypercalcemia. From 1969 to 1979, 13 patients had proved and three had presumed primary hyperparathyroidism associated with breast cancer. Two other patients had pseudohyperparathyroidism. Selective neck vein catheterization was used in 17 of the 18 patients and helped localize and confirm the diagnosis of primary hyperparathyroidism. Chloride-phosphate ratios were elevated in 13 of the 14 patients with proved or presumed primary hyperparathyroidism. This condition may mimic osseous metastases by producing brown tumors or compression fractures. In patients with breast cancer and hypercalcemia, particularly without osseous metastases, a careful diagnostic evaluation is warranted to rule out primary hyperparathyroidism.


11. DOCID:6528 SCORE: 0.000556132264142446
DOCNO: 6167921
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: R Hartenstein R
AUTHOR: H Ehrhart H
AUTHOR: K Possinger K
PUBTYPE: Journal Article
JOURNALTITLE: Onkologie.
COUNTRY: SWITZERLAND
TITLE: [Current status of chemotherapy of gastric and colorectal cancer]
PUBDATE: 19810401
The group of gastric and colorectal carcinomas has the highest cancer mortality in Western Germany. The possibilities of treatment with chemotherapy only have palliative character. 5-Fluourouracil is the therapeutic of choice on the metastasized colorectal cancer. However, a prolongation of survival time by treatment of the colorectal tumor could neither be recorded in applying 5-Fluorouracil as a single agent, nor through combination chemotherapy. The treatment of the metastasized gastric carcinoma with combinations consisting of the 5-Fluorouracil and Adriamycin could be of future value. Also effective with this tumour as a palliative measure is the combined treatment with 5-Fluorouracil and irradiation. The advantage of an adjuvant therapy of a chemotherapeutical, radiological or immunological kind could so far not be proved.


12. DOCID:5691 SCORE: 0.000556129921087888
DOCNO: 210657
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: A Afroudakis A
AUTHOR: S M Bhuta SM
AUTHOR: K A Ranganath KA
AUTHOR: N Kaplowitz N
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of digestive diseases.
COUNTRY: UNITED STATES
TITLE: Obstructive jaundice caused by hepatocellular carcinoma. Report of three cases.
PUBDATE: 19780701
A cholestatic syndrome secondary to extrahepatic biliary obstruction as the presenting manifestation of hepatocellular carcinoma is described in three cases. The mechanism is related to the invasion of intrahepatic bile ducts by the carcinoma. The consequent mechanical obstruction is due to either a continuous distally growing tumor cast of the biliary tree, distal migration of a necrotic tumor fragment, or hemobilia. In the cirrhotic patient with a predisposition for the development of liver cancer, the physician should be aware of the presentation with obstructive jaundice as a mechanical complication of hepatocellular carcinoma.


13. DOCID:4001 SCORE: 0.00055612940843174
DOCNO: 631702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
AUTHOR: E H Graul EH
PUBTYPE: Journal Article
JOURNALTITLE: Fortschritte der Medizin.
COUNTRY: GERMANY, WEST
TITLE: [Nuclearmedical tumor diagnosis]
PUBDATE: 19780301
Nuclear medicine diagnosis is an important discipline in cancer searching. By using reliable radiopharmaceuticals practically all organs can be investigated, especially bone cancer.


14. DOCID:7915 SCORE: 0.00055612893828839
DOCNO: 464750
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: anatomy & histology
QUALIFIER: anatomy & histology
QUALIFIER: innervation
AUTHOR: G Kudoh G
AUTHOR: K Hoshi K
AUTHOR: T Murakami T
PUBTYPE: Journal Article
JOURNALTITLE: Archivum histologicum Japonicum. Nippon soshikigaku kiroku.
COUNTRY: JAPAN
TITLE: Fluorescence microscopic and enzyme histochemical studies of the innervation of the human spleen.
PUBDATE: 19790401
The innervation of the human spleen was investigated by the fluorescence method for adrenergic nerve fibers (52 cases) and the enzyme histochemical method for cholinergic nerve fibers (27 cases). The spleens examined were removed by laparotomy chiefly for gastric cancer. Adrenergic nerve fibers were demonstrated at the medioadventitial junction and the media in the trabecular arteries, whereas they occurred at the medioadventitial junction in the central and penicillar arteries. They were not found in the trabecular and pulp veins and venules, sheathed capillaries, avascular trabeculae, white and red pulp, and capsule. Nerves containing only a few adrenergic fibers and nerves without adrenergic fibers occurred close to the trabecular arteries. It was also demonstrated that nerves close to the trabecular arteries contain cholinergic fibers. The present study first verifies histochemically that the human spleen is innervated doubly by adrenergic and cholinergic nerve fibers.