0. DOCID:23356 SCORE: 0.00333276309012482
DOCNO: 7649244
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: V Darley-Usmar V
AUTHOR: H Wiseman H
AUTHOR: B Halliwell B
AFFILIATION: Biology Division Wellcome Research Laboratories, Kent, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: FEBS letters.
COUNTRY: NETHERLANDS
TITLE: Nitric oxide and oxygen radicals: a question of balance.
PUBDATE: 19950801
The production of superoxide and nitric oxide individually has been associated with the development of several diseases but only recently has it been realised that interactions between them may also be important in disease pathology. The central hypothesis which is emerging is that the balance between nitric oxide and superoxide generation is a critical determinant in the aetiology of many human diseases including atherosclerosis, neurodegenerative disease, ischaemia-reperfusion and cancer. These ideas are discussed in this short overview and placed in the context of the current and future status of therapies which could modulate the balance between nitric oxide and superoxide.


1. DOCID:23766 SCORE: 0.00208651430536494
DOCNO: 7890588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: G Villeirs G
AUTHOR: M Mortier M
AUTHOR: C De Potter C
AUTHOR: M Kunnen M
AFFILIATION: Dienst Radiologie, Universitair Ziekenhuis, Gent.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal belge de radiologie.
COUNTRY: BELGIUM
TITLE: [Breast calcifications]
PUBDATE: 19950201
Calcifications are found in many women undergoing mammography. The majority of these calcifications are benign. Calcifications suggestive for malignancy prove to be cancer in about 30% of cases after biopsy. Study and personal experience should result in ready recognition of characteristically benign calcifications. Calcifications suggestive for malignancy should be biopsied and the ratio of malignant over benign biopsies should be as high as possible. The purpose of this paper is to present a practical approach to the evaluation of breast calcification, by means of a survey of the pattern of calcifications in breast pathology. We describe six types of typically benign calcifications and six criteria that entail an increased risk of malignancy.


2. DOCID:27209 SCORE: 0.00117794350496282
DOCNO: 9795714
AUTHOR: D Hader D
AUTHOR: K Moss K
AUTHOR: N Geier N
AFFILIATION: Community Memorial Hospital, Menomonee Falls, Wis., USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: AORN journal.
COUNTRY: UNITED STATES
TITLE: Sentinel lymph node biopsy using lymphoscintigraphy.
PUBDATE: 19981001
Cancer surgery has existed as an elective treatment modality for more than 150 years, yet it is relatively unsophisticated in light of the advances seen in other medical disciplines. Using the nuclear medicine technique of lymphoscintigraphy (i.e., mapping lymph nodes using a radioactive isotope), the surgeon can perform a sentinel lymph node biopsy that targets only the lymph nodes that first drain a primary tumor site. This procedure can provide accurate staging information without risking the potential morbidity associated with lymph node dissection. This type of precise biopsy is made possible by using a gamma-detecting instrument coupled with an ultrasensitive probe designed for intraoperative use.


3. DOCID:17843 SCORE: 0.00117560343067312
DOCNO: 2200131
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: I C Henderson IC
AFFILIATION: Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Basic principles in the use of adjuvant therapy.
PUBDATE: 19900801
Data from collaborative trials clearly indicate that the primary effect of adjuvant therapy is to delay death from breast cancer by months or years. However, adjuvant chemotherapy does not appear to prolong the survival of women aged 50 years or older, and tamoxifen has not yet been shown to improve the survival of women younger than age 50. In three trials involving node-negative patients, all showed a highly significant improvement in disease-free survival despite different chemotherapeutic regimens and durations of regimens.


4. DOCID:29369 SCORE: 0.00110111596973868
DOCNO: 14769524
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: isolation & purification
AUTHOR: Karine Rollot K
AUTHOR: Jean David Albert JD
AUTHOR: Stéphanie Werner S
AUTHOR: Pierre Tattevin P
AUTHOR: Isabelle Cozic I
AUTHOR: Aleth Perdriger A
AUTHOR: Gérard Chalès G
AUTHOR: Pascal Guggenbuhl P
AFFILIATION: Rheumatology Department, CHU Hôpital Sud 16, Boulevard de Bulgarie, 35056 Rennes cedex 2, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Joint, bone, spine : revue du rhumatisme.
COUNTRY: France
TITLE: Campylobacter fetus septic arthritis revealing a malignancy.
PUBDATE: 20040101
Campylobacter fetus is a rare cause of bone and joint infection. We report a new case in a patient who also had endocarditis due to the same organism. This type of infection usually occurs in immunocompromised hosts. Investigations in our patient found a cancer of the prostate.


5. DOCID:27100 SCORE: 0.000867907692579213
DOCNO: 9601170
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Competence
DESCRIPTOR: General Practice, Dental
QUALIFIER: etiology
AUTHOR: J Yellowitz J
AUTHOR: A M Horowitz AM
AUTHOR: H S Goodman HS
AUTHOR: M T Canto MT
AUTHOR: N S Farooq NS
AFFILIATION: University of Maryland, Baltimore College of Dental Surgery, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dental Association (1939)
COUNTRY: UNITED STATES
TITLE: Knowledge, opinions and practices of general dentists regarding oral cancer: a pilot survey.
PUBDATE: 19980501
The authors mailed a pilot survey to 500 randomly selected general dentists. Although most dentists reported their knowledge of oral cancer to be current, their actual knowledge of oral cancer risk factors and signs and symptoms was inconsistent. Conflicting data were also found between their level of knowledge and their provision of oral cancer examinations. Most respondents agreed that patients should undergo an oral cancer examination annually, yet many do not provide this service.


6. DOCID:27382 SCORE: 0.000867897784744832
DOCNO: 12532841
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: W Wang W
AUTHOR: T J Tong TJ
AFFILIATION: Department of Biochemistry and Molecular Biology, Beijing Medical University, Beijing 100083.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Sheng li ke xue jin zhan [Progress in physiology].
COUNTRY: China
TITLE: [The key enzyme of cholesterol synthesis pathway: HMG-CoA reductase and disease]
PUBDATE: 19990101
In eukaryotes, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non-sterol isoprenoids, mevalonate. The regulation of the enzyme activity occurs at the transcription, post-transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non-sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers. At present, the enzyme is the target of several drugs effective against atherosclerosis.


7. DOCID:22738 SCORE: 0.000858387162787678
DOCNO: 7797833
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Second Primary
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: D G Begos DG
AUTHOR: S Kuan S
AUTHOR: J Dobbins J
AUTHOR: T S Ravikumar TS
AFFILIATION: Department of General Surgery, Yale University of School of Medicine, New Haven, CT 06510, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Metachronous small-bowel adenocarcinoma in celiac sprue.
PUBDATE: 19950401
Celiac sprue, or nontropical sprue, is associated with an increased incidence of digestive tract malignancy. We report a patient with celiac sprue who developed two primary adenocarcinomas of the jejunum > 2 years apart. The second cancer was asymptomatic and detected by surveillance computed tomography. Small-bowel cancers are unusual, and frequency of follow-up has not been established, so that it is important to have a high index of suspicion for these malignancies in celiac patients with vague gastrointestinal symptoms.


8. DOCID:23769 SCORE: 0.000858375708055757
DOCNO: 7890994
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hematoporphyrin Photoradiation
QUALIFIER: blood supply
QUALIFIER: drug therapy
AUTHOR: P Sieg P
AUTHOR: J Rosperich J
AUTHOR: A Walther A
AFFILIATION: Medizinische Universität zu Lübeck, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of oral and maxillofacial surgery.
COUNTRY: DENMARK
TITLE: Laser blood-flow measurements in malignant tumors during photodynamic therapy (PDT)--an experimental study.
PUBDATE: 19941201
Laser blood-flow measurements were made on the tumor surface of 18 human oral cancer tumors growing on the shank of nude mice during and up to 6 h after photodynamic therapy (PDT) to detect changes in microcirculation. In eight animals, the same procedure was done without PDT. Simultaneously, the skin microcirculation in the contralateral leg was measured to detect systemically caused changes in microcirculation. Two days later, specimens of the tumor region were taken and analyzed histologically. Our results suggest a mainly direct effect of PDT on the tumor cells rather than tumor necrosis caused by decreased microcirculation.


9. DOCID:21573 SCORE: 0.000858370767243661
DOCNO: 7712635
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R A Gatti RA
AFFILIATION: Department of Pathology and Laboratory Medicine, University of California Los Angeles School of Medicine, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Dermatologic clinics.
COUNTRY: UNITED STATES
TITLE: Ataxia-telangiectasia.
PUBDATE: 19950101
Ataxia-telangiectasia is a complex syndrome that includes a very high cancer risk in children with a progressive cerebellar ataxia, the onset of which occurs in early infancy. Ocular telangiectasiae often do not appear until several years after the ataxia. The most common type of malignancy is lymphoma, usually of the B-cell type. Leukemias also occur. Failure to diagnose ataxia-telangiectasia in an infant with lymphoma or leukemia may result in radiation therapy with conventional dosages, which is contraindicated in ataxia-telangiectasia patients.


10. DOCID:21245 SCORE: 0.000858365742281108
DOCNO: 7731448
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Larynx, Artificial
DESCRIPTOR: Speech, Alaryngeal
QUALIFIER: rehabilitation
AUTHOR: J H Boyd JH
AUTHOR: M Varvares M
AUTHOR: S Fitzmaurice S
AFFILIATION: Department of Otolaryngology, Head and Neck Surgery, St. Louis University Health Sciences Center, MO 63110, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Missouri medicine.
COUNTRY: UNITED STATES
TITLE: Voice rehabilitation after laryngectomy.
PUBDATE: 19950301
Unfortunately, laryngeal cancer commonly presents at a stage necessitating total laryngectomy. Voice rehabilitation in the past has primarily been with the electrolarynx or esophageal speech. Tracheoesophageal puncture (TEP) is a technique that has replaced the other two methods as the rehabilitative procedure of choice in most total laryngectomy patients. This report details this technique, as well as a brief discussion of the etiology and treatment of laryngeal cancer.


11. DOCID:31887 SCORE: 0.000602281889643255
DOCNO: 15340416
AUTHOR: Steven A Rosenberg SA
AUTHOR: James C Yang JC
AUTHOR: Nicholas P Restifo NP
AFFILIATION: Surgery Branch of the Center for Cancer Research at the National Cancer Institute, Building 10, Room 2B42, 10 Center Drive, MSC 1502 Bethesda, Maryland 20892-1502, USA. sar@mail.nih.gov
PUBTYPE: Journal Article
JOURNALTITLE: Nature medicine.
COUNTRY: United States
TITLE: Cancer immunotherapy: moving beyond current vaccines.
PUBDATE: 20040901
Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.


12. DOCID:29710 SCORE: 0.000559081441338509
DOCNO: 15549090
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: Charles Sawyers C
AFFILIATION: Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, 10833 LeConte Avenue, Los Angeles, California 90095, USA. csawyers@mednet.ucla.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: England
TITLE: Targeted cancer therapy.
PUBDATE: 20041101
Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progress in understanding the molecular changes that underlie cancer development offer the prospect of specifically targeting malfunctioning molecules and pathways to achieve more effective and rational cancer therapy.


13. DOCID:30843 SCORE: 0.000559062212416127
DOCNO: 14577822
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prosthesis Design
QUALIFIER: instrumentation
QUALIFIER: therapy
AUTHOR: Filiz Keyf F
AUTHOR: Nesrin Sahin N
AUTHOR: Yavuz Aslan Y
AFFILIATION: Department of Prosthodontics at Faculty of Dentistry, Hacettepe University, Ankara, Turkey. dkeyf@e-kolay.net
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.
COUNTRY: United States
TITLE: Alternative impression technique for a speech-aid prosthesis.
PUBDATE: 20031101
OBJECTIVE: Prosthetic treatment for speech disorders attributable to surgically acquired soft palate defects are introduced. CASE: A patient who underwent soft palate resection for cancer is presented. The resected portion of the soft palate was confined to the posterior segments. A prosthesis with a speech bulb was adapted to the patient. CONCLUSION: Excellent restoration of speech and improvement of velopharyngeal function was achieved following placement of the special prosthesis.


14. DOCID:31189 SCORE: 0.000559055891984326
DOCNO: 14698790
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: pharmacokinetics
QUALIFIER: metabolism
QUALIFIER: pharmacokinetics
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: C J Smith CJ
AUTHOR: W A Volkert WA
AUTHOR: T J Hoffman TJ
AFFILIATION: Radiopharmaceutical Sciences Institute, University of Missouri, Columbia, MO 65211, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nuclear medicine and biology.
COUNTRY: England
TITLE: Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: a concise update.
PUBDATE: 20031101
The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocrine origin including prostate, breast, and small cell lung cancer. This concise review outlines some of the efforts currently underway to develop new GRP receptor specific radiopharmaceuticals by employing a variety of radiometal chelation systems.